scholarly journals A comprehensive preclinical assessment of late-term imaging markers of radiation-induced brain injury

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Tien T Tang ◽  
Janice A Zawaski ◽  
Shelli R Kesler ◽  
Christine A Beamish ◽  
Wilburn E Reddick ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Brain Injury ◽  
Side Effects ◽  
Morphological Changes ◽  
Gray Matter Volume ◽  
Image Features ◽  
Functional Markers ◽  
Tumor Treatment ◽  
Radiation Induced ◽  
Imaging Markers

Abstract Background Cranial radiotherapy (CRT) is an important part of brain tumor treatment, and although highly effective, survivors suffer from long-term cognitive side effects. In this study we aim to establish late-term imaging markers of CRT-induced brain injury and identify functional markers indicative of cognitive performance. Specifically, we aim to identify changes in executive function, brain metabolism, and neuronal organization. Methods Male Sprague Dawley rats were fractionally irradiated at 28 days of age to a total dose of 30 Gy to establish a radiation-induced brain injury model. Animals were trained at 3 months after CRT using the 5-choice serial reaction time task. At 12 months after CRT, animals were evaluated for cognitive and imaging changes, which included positron emission tomography (PET) and magnetic resonance imaging (MRI). Results Cognitive deficit with signs of neuroinflammation were found at 12 months after CRT in irradiated animals. CRT resulted in significant volumetric changes in 38% of brain regions as well as overall decrease in brain volume and reduced gray matter volume. PET imaging showed higher brain glucose uptake in CRT animals. Using MRI, irradiated brains had an overall decrease in fractional anisotropy, lower global efficiency, increased transitivity, and altered regional connectivity. Cognitive measurements were found to be significantly correlated with six image features that included myelin integrity and local organization of the neural network. Conclusions These results demonstrate that CRT leads to late-term morphological changes, reorganization of neural connections, and metabolic dysfunction. The correlation between imaging markers and cognitive deficits can be used to assess late-term side effects of brain tumor treatment and evaluate efficacy of new interventions.

scholarly journals MR Image Changes of Normal-Appearing Brain Tissue after Radiotherapy

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1573
Author(s):  
Katharina Witzmann ◽  
Felix Raschke ◽  
Esther G. C. Troost
Keyword(s):  
Brain Injury ◽  
Side Effects ◽  
Brain Tissue ◽  
Radiation Treatment ◽  
Diffusion Imaging ◽  
Normal Brain ◽  
Survival Times ◽  
Curative Intent ◽  
Adequate Treatment ◽  
Radiation Induced

Radiotherapy is part of the standard treatment of most primary brain tumors. Large clinical target volumes and physical characteristics of photon beams inevitably lead to irradiation of surrounding normal brain tissue. This can cause radiation-induced brain injury. In particular, late brain injury, such as cognitive dysfunction, is often irreversible and progressive over time, resulting in a significant reduction in quality of life. Since 50% of patients have survival times greater than six months, radiation-induced side effects become more relevant and need to be balanced against radiation treatment given with curative intent. To develop adequate treatment and prevention strategies, the underlying cause of radiation-induced side-effects needs to be understood. This paper provides an overview of radiation-induced changes observed in normal-appearing brains measured with conventional and advanced MRI techniques and summarizes the current findings and conclusions. Brain atrophy was observed with anatomical MRI. Changes in tissue microstructure were seen on diffusion imaging. Vascular changes were examined with perfusion-weighted imaging and susceptibility-weighted imaging. MR spectroscopy revealed decreasing N-acetyl aspartate, indicating decreased neuronal health or neuronal loss. Based on these findings, multicenter prospective studies incorporating advanced MR techniques as well as neurocognitive function tests should be designed in order to gain more evidence on radiation-induced sequelae.

Effects of cisplatin treatment on the rat neurohypophysis

1986 ◽  
Vol 44 ◽  
pp. 122-123
Author(s):  
J.M. Fadool ◽  
P.J. Boyer ◽  
S.K. Aggarwal
Keyword(s):  
Side Effects ◽  
Urine Output ◽  
Morphological Changes ◽  
Limiting Factor ◽  
Antineoplastic Drugs

Cisplatin (CDDP) is currently one of the most valuable antineoplastic drugs available. However, it has severe toxic side effects of which nephrotoxicity is the major dose limiting factor in its use. It induces morphological changes in the kidney with hampered urine output. The present study is an effort to determine the influence of the drug on the neurohypophysis for any antidiuretic effects on the kidney.

Mitigation of Radiation-induced Gastrointestinal System Injury using Resveratrol or Alpha-lipoic Acid: A Pilot Histopathological Study

2020 ◽  
Vol 19 (4) ◽  
pp. 413-424
Author(s):  
Bagher Farhood ◽  
Gholamreza Hassanzadeh ◽  
Peyman Amini ◽  
Dheyauldeen Shabeeb ◽  
Ahmed Eleojo Musa ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Gamma Ray ◽  
Morphological Changes ◽  
Gastrointestinal System ◽  
Alpha Tocopherol ◽  
Whole Body ◽  
Histopathological Study ◽  
Alpha Lipoic Acid ◽  
Pilot Investigation ◽  
Radiation Induced

Aim: In this study, we aimed to determine possible mitigation of radiationinduced toxicities in the duodenum, jejunum and colon using post-exposure treatment with resveratrol and alpha-lipoic acid. Background: After the bone marrow, gastrointestinal system toxicity is the second critical cause of death following whole-body exposure to radiation. Its side effects reduce the quality of life of patients who have undergone radiotherapy. Resveratrol has an antioxidant effect and stimulates DNA damage responses (DDRs). Alpha-lipoic acid neutralizes free radicals via the recycling of ascorbic acid and alpha-tocopherol. Objective: This study is a pilot investigation of the mitigation of enteritis using resveratrol and alpha-lipoic acid following histopathological study. Methods: 60 male mice were randomly assigned to six groups; control, resveratrol treatment, alpha-lipoic acid treatment, whole-body irradiation, irradiation plus resveratrol, and irradiation plus alpha-lipoic acid. The mice were irradiated with a single dose of 7 Gy from a cobalt-60 gamma-ray source. Treatment with resveratrol or alpha-lipoic acid started 24 h after irradiation and continued for 4 weeks. All mice were sacrificed after 30 days for histopathological evaluation of radiation-induced toxicities in the duodenum, jejunum and colon. Results and Conclusion: Exposure to radiation caused mild to severe damages to vessels, goblet cells and villous. It also led to significant infiltration of macrophages and leukocytes, especially in the colon. Both resveratrol and alpha-lipoic acid were able to mitigate morphological changes. However, they could not mitigate vascular injury. Conclusion: Resveratrol and alpha-lipoic acid could mitigate radiation-induced injuries in the small and large intestine. A comparison between these agents showed that resveratrol may be a more effective mitigator compared to alpha-lipoic acid.

An application of neutrosophic hypersoft mapping to diagnose brain tumor and propose appropriate treatment

2021 ◽  
pp. 1-23
Author(s):  
Muhmmad Saeed ◽  
Muhmmad Ahsan ◽  
Atiqe Ur Rahman ◽  
Muhammad Haris Saeed ◽  
Asad Mehmood
Keyword(s):  
Brain Tumor ◽  
Side Effects ◽  
Brain Tumors ◽  
Causes Of Death ◽  
Scientific Modeling ◽  
Inverse Mapping ◽  
Appropriate Treatment ◽  
Fuzzy Interval

Brain tumors are one of the leading causes of death around the globe. More than 10 million people fall prey to it every year. This paper aims to characterize the discussions related to the diagnosis of tumors with their related problems. After examining the side effects of tumors, it encases similar indications, and it is hard to distinguish the precise type of tumors with their seriousness. Since in practical assessment, the indeterminacy and falsity parts are frequently dismissed, and because of this issue, it is hard to notice the precision in the patient’s progress history and cannot foresee the period of treatment. The Neutrosophic Hypersoft set (NHS) and the NHS mapping with its inverse mapping has been design to overcome this issue since it can deal with the parametric values of such disease in more detail considering the sub-parametric values; and their order and arrangement. These ideas are capable and essential to analyze the issue properly by interfacing it with scientific modeling. This investigation builds up a connection between symptoms and medicines, which diminishes the difficulty of the narrative. A table depending on a fuzzy interval between [0, 1] for the sorts of tumors is constructed. The calculation depends on NHS mapping to adequately recognize the disease and choose the best medication for each patient’s relating sickness. Finally, the generalized NHS mapping is presented, which will encourage a specialist to extricate the patient’s progress history and to foresee the time of treatment till the infection is relieved.

scholarly journals Cardiooncology—dealing with modern drug treatment, long-term complications, and cancer survivorship

2021 ◽  
Author(s):  
Claudia de Wall ◽  
Johann Bauersachs ◽  
Dominik Berliner
Keyword(s):  
Side Effects ◽  
Checkpoint Inhibitors ◽  
Heart Diseases ◽  
Tumor Therapy ◽  
Treatment Strategies ◽  
Tumor Treatment ◽  
Cardiac Side Effects ◽  
Cardiovascular Side Effects ◽  
Modern Drug

AbstractModern treatment strategies have improved prognosis and survival of patients with malignant diseases. The key components of tumor treatment are conventional chemotherapy, radiotherapy, targeted therapies, and immunotherapy. Cardiovascular side-effects may occur in the early phase of tumor therapy or even decades later. Therefore, knowledge and awareness of acute and long-lasting cardiac side effects of anti-cancer therapies are essential. Cardiotoxicity impairs quality of life and overall survival. The new cardiologic subspecialty ‘cardio-oncology’ deals with the different cardiovascular problems arising from tumor treatment and the relationship between cancer and heart diseases. Early detection and treatment of cardiotoxicity is of crucial importance. A detailed cardiac assessment of patients prior to administration of cardiotoxic agents, during and after treatment should be performed in all patients. The current review focusses on acute and long-term cardiotoxic side effects of classical cytotoxic and selected modern drug treatments such as immune checkpoint inhibitors and discusses strategies for the diagnosis of treatment-related adverse cardiovascular effects in cancer patients.

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