scholarly journals RADI-09. DEFINING PROGRESSION IN PATIENTS TREATED WITH TEN OR MORE BRAIN METASTASES FOLLOWING STEREOTACTIC RADIOSURGERY

2019 ◽  
Vol 1 (Supplement_1) ◽  
pp. i23-i23
Author(s):  
Sirisha Devi Viswanatha ◽  
Zaker Rana ◽  
Matthew Ehrlich ◽  
Michael Schulder ◽  
Anuj Goenka
Keyword(s):  
Overall Survival ◽  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Tumor Volume ◽  
Univariate Analysis ◽  
Tumor Control ◽  
Initial Increase ◽  
Lesion Volume ◽  
Brain Volumes ◽  
Mri Scans

Abstract BACKGROUND: An increasing trend has been to elect for Stereotactic Radiosurgery (SRS) for the treatment of brain metastases. Progression following treatment is typically defined as a 20% increase in the initial lesion volume treated. Challenges in defining progression can arise as the reported incidence of pseudoprogression or radiation necrosis following treatment ranges from 5%-30%. The purpose of this study was to assess patterns of failure in patients treated with 10 or more brain metastases. METHODS: From March 2014 to April 2018, fifty-five patients with 10 or more total brain metastases were retrospectively reviewed following frame-based radiosurgery to a dose of 12–20 Gy. Post-treatment MRI scans were used to assess tumor response in 3 month intervals. Tumor control was defined as tumor volume ≤ 1.2 times the baseline tumor volume at each measured interval. RESULTS: Fifty-five patients received 75 total radiosurgery treatments to 692 tumors. Forty patients received synchronous treatment, while 15 received metachronous treatment. 20 patients (36%) and 72 tumors (10%) experienced progression following treatment. 46 tumors were larger after first MRI in 15 patients (28%). Of these 15 patients, eight had complete resolution in 15 tumors on subsequent scan. Of the eight patients who had resolution, six patients received immunotherapy during and after treatment and all but one patient saw an initial increase >100% of their initial tumor volume. Median overall survival was 11 months. Univariate analysis revealed an association between larger brain volumes irradiated with 12 Gy and decreased overall survival (p < 0.05). CONCLUSION: It is important to consider tumor growth velocity and concurrent therapy when assessing true progression after SRS treatment of brain metastases.

Outcomes and Prognostic Factors for Patients With Brainstem Metastases Undergoing Stereotactic Radiosurgery

Neurosurgery ◽  
2011 ◽  
Vol 69 (4) ◽  
pp. 796-806 ◽  
Author(s):  
Mustafa Aziz Hatiboglu ◽  
Eric L Chang ◽  
Dima Suki ◽  
Raymond Sawaya ◽  
David M Wildrick ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Factors ◽  
Confidence Interval ◽  
Stereotactic Radiosurgery ◽  
Tumor Volume ◽  
Local Tumor Control ◽  
Tumor Control ◽  
Lesion Volume ◽  
Local Tumor ◽  
Local Progression

Abstract BACKGROUND: Treatment of tumors metastatic to the brainstem with stereotactic radiosurgery (SRS) has not been widely studied. OBJECTIVE: To identify the effects of SRS on patients with brainstem metastases by assessing duration of local progression-free survival (LPFS) and overall survival. METHODS: We retrospectively reviewed clinical data collected from 60 patients undergoing linear accelerator-based SRS for tumors metastatic to the brainstem between August 1994 and December 2007. The LPFS and overall survival were calculated with the Kaplan-Meier method. Prognostic factors were evaluated with the log-rank test and Cox proportional hazards model. RESULTS: The median age of patients was 61 years (range, 39-85 years); the median treated lesion volume was 1.0 mL (range, 0.1-8.7 mL); and the median SRS dose was 15 Gy (range, 8-18 Gy). The median overall survival interval after SRS was 4 months (95% confidence interval, 3.4-4.9 months); crude local tumor control was 76%; and median LPFS was 5.7 months (95% confidence interval, 3.0-8.4 months). Shorter overall survival was associated with a pretreatment tumor volume ≥4 mL (P < .001) and male sex (P = .03). Shorter LPFS was associated with a pretreatment tumor volume ≥4 mL (P = .008), a melanoma primary tumor (P = .002), and the presence of necrosis in pre-SRS magnetic resonance imaging (P = .04). A Basic Score for Brain Metastases of 2 to 3 vs 1 (P = .007) and a Score Index for Radiosurgery >5 (P = .003) were significantly associated with longer survival. Twelve patients (20%) developed SRS-related complications. CONCLUSION: Stereotactic radiosurgery provides noninvasive treatment and favorable local tumor control for patients with brainstem metastases.

Resection of brain metastases previously treated with stereotactic radiosurgery

2005 ◽  
Vol 102 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Giacomo G. Vecil ◽  
Dima Suki ◽  
Marcos V. C. Maldaun ◽  
Frederick F. Lang ◽  
Raymond SaWaya
Keyword(s):  
Overall Survival ◽  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Surgical Complications ◽  
Univariate Analysis ◽  
Conventional Surgery ◽  
Recurrence Rates ◽  
Content Type ◽  
Previously Treated ◽  
Fine Print

Object. To date, no report has been published on outcomes of patients undergoing resection for brain metastases who were previously treated with stereotactic radiosurgery (SRS). Consequently, the authors reviewed their institutional experience with this clinical scenario to assess the efficacy of surgical intervention. Methods. Sixty-one patients (each harboring three or fewer brain lesions), who were treated at a single institution between June 1993 and August 2002 were identified. Patient charts and their neuroimaging and pathological reports were retrospectively reviewed to determine overall survival rates, surgical complications, and recurrence rates. A univariate analysis revealed that patient preoperative recursive partitioning analysis (RPA) classification, primary disease status, preoperative Karnofsky Performance Scale score, type of focal treatment undergone for nonindex lesions, and major postoperative surgical complications were factors that significantly affected survival (p ≤ 0.05). In contrast, only the RPA class and focal (conventional surgery or SRS) treatment of nonindex lesions significantly (or nearly significantly) affected survival in the multivariate analysis. Major neurological complications occurred in only 2% of patients. The median time to distant recurrence after resection was 8.4 months; that to local recurrence was not reached. The overall median survival time was 11.1 months, with 25% of patients surviving 2 or more years. Conventional surgery facilitated tapering of steroid administration. Conclusions. The complication, morbidity, survival, and recurrence rates are consistent with those seen after conventional surgery for recurrent brain metastases. Our results indicate that in selected patients with a favorable RPA class in whom nonindex lesions are treated with focal modalities, surgery can provide long-term control of SRS-treated lesions and positively affect overall survival.

scholarly journals RADI-34. USE OF LOW-DOSE STEREOTACTIC RADIOSURGERY FOR ADVANCED BRAIN METASTASES

2019 ◽  
Vol 1 (Supplement_1) ◽  
pp. i28-i28
Author(s):  
Daniel Yang ◽  
James Yu ◽  
Veronica Chiang
Keyword(s):  
Overall Survival ◽  
Brain Metastases ◽  
Disease Progression ◽  
Stereotactic Radiosurgery ◽  
Low Dose ◽  
Treatment Time ◽  
Standard Dose ◽  
Braf V600e ◽  
Tumor Control ◽  
Poor Performance Status

Abstract BACKGROUND: Gamma knife stereotactic radiosurgery (GKSRS) is commonly used to treat brain metastases. However, treatment time significantly increases as a function of increasing dose and number of lesions treated. In patients with large number of brain metastases, advanced disease, and poor performance status, low-dose GKSRS may be better tolerated and allows for safer re-treatment with radiotherapy should tumors recur. METHODS: We queried our institutional GKSRS database and identified patients treated with low-dose GKSRS for brain metastases as defined by a prescription of 12–15 Gy margin dose. Overall survival was measured from time of initial low-dose GKSRS to death or study exit. A composite endpoint of time to additional GKSRS, whole brain radiotherapy (WBRT), craniotomy, or death was used to examine disease progression. RESULTS: We identified 30 patients treated with low-dose GKSRS at a single institution between 2008 to 2018. A total of 428 brain metastases were treated, with a median of 12 (IQR=4–20) brain metastases per patient. Thirteen patients received immunotherapy concurrent with low-dose GKSRS, and 23 patients received mutation-targeted therapy or immunotherapy. Median overall survival was 238 (IQR 91–580) days, and median composite time to disease progression was 121 (IQR = 33–371) days. The two longest survivors in our cohort are alive at over three years. One had testicular cancer, and the other had melanoma. The metastatic melanoma patient had a BRAF V600E tumor and received mutation-targeted systemic therapy. He received standard-dose GKSRS and WBRT prior to low-dose GKSRS, as well as immunotherapy prior to and concurrent with low-dose GKSRS. CONCLUSIONS: A heterogenous population with large number of brain metastases was treated with low-dose GKSRS, with acceptable but varied results in terms of survival and tumor control. Further study with larger cohorts is warranted to optimize selection criteria and timing of low-dose GKSRS with other radiotherapy and systemic agent.

COMPARISON OF EARLY COMPLICATIONS FOR PATIENTS WITH CONVEXITY AND PARASAGITTAL MENINGIOMAS TREATED WITH EITHER STEREOTACTIC RADIOSURGERY OR FRACTIONATED STEREOTACTIC RADIOTHERAPY

Neurosurgery ◽  
2008 ◽  
Vol 62 (suppl_5) ◽  
pp. A19-A28 ◽  
Author(s):  
Michael R. Girvigian ◽  
Joseph C.T. Chen ◽  
Javad Rahimian ◽  
Michael J. Miller ◽  
Michael Tome
Keyword(s):  
Stereotactic Radiosurgery ◽  
Stereotactic Radiotherapy ◽  
Univariate Analysis ◽  
Tumor Location ◽  
Fractionated Stereotactic Radiotherapy ◽  
Tumor Control ◽  
Lesion Volume ◽  
Group A ◽  
Group B

ABSTRACT OBJECTIVE Patients with convexity and parasagittal (CPS) meningiomas treated with stereotactic radiosurgery (SRS) have been shown to be at risk for posttreatment symptomatic peritumoral edema (SPTE). We sought to analyze the pattern of this complication and compare it with the SPTE experienced in our patients treated with fractionated stereotactic radiotherapy. METHODS From January 2003 to October 2005, 32 patients with CPS meningiomas were treated. Thirty patients with a total of 38 lesions had sufficient follow-up for analysis. Group A (n = 14) patients were treated with single fraction SRS, and Group B (n = 16) patients were treated with fractionated stereotactic radiotherapy. The lesion volume was different between the two groups with the Group B median volume (7.46 cm3) being larger than that for Group A (2.84 cm3) (P = 0.0008). Conversely age, follow-up, sex, prior surgical events, number of lesions, tumor location, and atypical histology did not differ between these groups. The median marginal dose for patients in Group A was 14 Gy (range, 12.5–18 Gy). For Group B, six patients received a median marginal dose of 50.4 Gy in 28 fractions, and 10 patients received a marginal dose of 25 Gy in five fractions. RESULTS Seven of the 30 patients treated in this series developed posttreatment SPTE. The incidence of SPTE in Group A (six of 14 patients) was significantly higher than that in Group B (one of 16 patients) (P = 0.031). The median time to onset of SPTE in the six patients in Group A was 4 months. In Group B, one patient had onset of SPTE in 3 months. On univariate analysis, larger tumor volume (P = 0.0014) and tumor margin dose >14 Gy in patients undergoing SRS (P = 0.031) was associated with onset of SPTE. Age, previous surgery, and tumor location were not associated with onset of SPTE. CONCLUSION Despite larger lesion volumes, fractionated stereotactic radiotherapy is associated with less risk of posttreatment SPTE than SRS for patients with CPS meningiomas in our series. For patients treated with SRS, smaller volume and dose <14 Gy seems to be safe. Longer follow-up will be required to compare late complications and tumor control rates in these patients.

scholarly journals Comparison of treatment results between 3- and 2-stage Gamma Knife radiosurgery for large brain metastases: a retrospective multi-institutional study

2019 ◽  
Vol 131 (1) ◽  
pp. 227-237 ◽  
Author(s):  
Toru Serizawa ◽  
Yoshinori Higuchi ◽  
Masaaki Yamamoto ◽  
Shigeo Matsunaga ◽  
Osamu Nagano ◽  
...  
Keyword(s):  
Overall Survival ◽  
Adverse Events ◽  
Brain Metastases ◽  
Tumor Progression ◽  
Gamma Knife ◽  
Tumor Volume ◽  
Gamma Knife Radiosurgery ◽  
Tumor Control ◽  
Treatment Results ◽  
Matched Study

OBJECTIVEIn order to obtain better local tumor control for large (i.e., > 3 cm in diameter or > 10 cm3 in volume) brain metastases (BMs), 3-stage and 2-stage Gamma Knife surgery (GKS) procedures, rather than a palliative dose of stereotactic radiosurgery, have been proposed. Here, authors conducted a retrospective multi-institutional study to compare treatment results between 3-stage and 2-stage GKS for large BMs.METHODSThis retrospective multi-institutional study involved 335 patients from 19 Gamma Knife facilities in Japan. Major inclusion criteria were 1) newly diagnosed BMs, 2) largest tumor volume of 10.0–33.5 cm3, 3) cumulative intracranial tumor volume ≤ 50 cm3, 4) no leptomeningeal dissemination, 5) no more than 10 tumors, and 6) Karnofsky Performance Status 70% or better. Prescription doses were restricted to between 9.0 and 11.0 Gy in 3-stage GKS and between 11.8 and 14.2 Gy in 2-stage GKS. The total treatment interval had to be within 6 weeks, with at least 12 days between procedures. There were 114 cases in the 3-stage group and 221 in the 2-stage group. Because of the disproportion in patient numbers and the pre-GKS clinical factors between these two GKS groups, a case-matched study was performed using the propensity score matching method. Ultimately, 212 patients (106 from each group) were selected for the case-matched study. Overall survival, tumor progression, neurological death, and radiation-related adverse events were analyzed.RESULTSIn the case-matched cohort, post-GKS median survival time tended to be longer in the 3-stage group (15.9 months) than in the 2-stage group (11.7 months), but the difference was not statistically significant (p = 0.65). The cumulative incidences of tumor progression (21.6% vs 16.7% at 1 year, p = 0.31), neurological death (5.1% vs 6.0% at 1 year, p = 0.58), or serious radiation-related adverse events (3.0% vs 4.0% at 1 year, p = 0.49) did not differ significantly.CONCLUSIONSThis retrospective multi-institutional study showed no differences between 3-stage and 2-stage GKS in terms of overall survival, tumor progression, neurological death, and radiation-related adverse events. Both 3-stage and 2-stage GKS performed according to the aforementioned protocols are good treatment options in selected patients with large BMs.

Stereotactic radiosurgery as primary and salvage treatment for brain metastases from breast cancer

2011 ◽  
Vol 114 (3) ◽  
pp. 792-800 ◽  
Author(s):  
Douglas Kondziolka ◽  
Hideyuki Kano ◽  
Gillian L. Harrison ◽  
Huai-che Yang ◽  
Donald N. Liew ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Radiation Effects ◽  
Tumor Volume ◽  
Progression Free Survival ◽  
Tumor Control ◽  
Karnofsky Performance Scale ◽  
Factors Associated ◽  
Total Tumor Volume

Object To evaluate the role of stereotactic radiosurgery (SRS) in the management of brain metastases from breast cancer, the authors assessed clinical outcomes and prognostic factors for survival. Methods The records from 350 consecutive female patients who underwent SRS for 1535 brain metastases from breast cancer were reviewed. The median patient age was 54 years (range 19–84 years), and the median number of tumors per patient was 2 (range 1–18 lesions). One hundred seventeen patients (33%) had a single metastasis to the brain, and 233 patients (67%) had multiple brain metastases. The median tumor volume was 0.7 cm3 (range 0.01–48.9 cm3), and the median total tumor volume for each patient was 4.9 cm3 (range 0.09–74.1 cm3). Results Overall survival after SRS was 69%, 49%, and 26% at 6, 12, and 24 months, respectively, with a median survival of 11.2 months. Factors associated with a longer survival included controlled extracranial disease, a lower recursive partitioning analysis (RPA) class, a higher Karnofsky Performance Scale score, a smaller number of brain metastases, a smaller total tumor volume per patient, the presence of deep cerebral or brainstem metastases, and HER2/neu overexpression. Sustained local tumor control was achieved in 90% of the patients. Factors associated with longer progression-free survival included a better RPA class, fewer brain metastases, a smaller total tumor volume per patient, and a higher tumor margin dose. Symptomatic adverse radiation effects occurred in 6% of patients. Overall, the condition of 82% of patients improved or remained neurologically stable. Conclusions Stereotactic radiosurgery was safe and effective in patients with brain metastases from breast cancer and should be considered for initial treatment.

The results of resection after stereotactic radiosurgery for brain metastases

2009 ◽  
Vol 111 (4) ◽  
pp. 825-831 ◽  
Author(s):  
Hideyuki Kano ◽  
Douglas Kondziolka ◽  
Oscar Zorro ◽  
Javier Lobato-Polo ◽  
John C. Flickinger ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Surgical Navigation ◽  
Systemic Disease ◽  
Univariate Analysis ◽  
Tumor Control ◽  
Karnofsky Performance Scale ◽  
Surgical Removal ◽  
Local Progression

Object Radiosurgery for brain metastasis fails in some patients, who require further surgical care. In this paper the authors' goal was to evaluate prognostic factors that correlate with the survival of patients who require a resection of a brain metastasis after stereotactic radiosurgery (SRS). Methods During the last 14 years when surgical navigation systems were routinely available, the authors identified 58 patients who required resection for various brain metastases after SRS. The median patient age was 54 years. Prior adjuvant treatment included whole-brain radiation therapy alone (17 patients), chemotherapy alone (9 patients), both radiotherapy and chemotherapy (10 patients), and prior resection before SRS (8 patients). The median target volumes at the time of SRS and resection were 7.7 cm3 (range 0.5–24.9 cm3) and 15.5 cm3 (range 1.3–81.2 cm3), respectively. Results At a median follow-up of 7.6 months, 8 patients (14%) were living and 50 patients (86%) had died. The survival after surgical removal was 65, 30, and 16% at 6, 12, and 24 months, respectively (median survival after resection 7.7 months). The local tumor control rate after resection was 71, 62, and 43% at 6, 12, and 24 months, respectively. A univariate analysis revealed that patient preoperative recursive partitioning analysis classification, Karnofsky Performance Scale status, systemic disease status, and the interval between SRS and resection were factors associated with patient survival. The mortality and morbidity rates of resection were 1.7 and 6.9%, respectively. Conclusions In patients with symptomatic mass effect after radiosurgery, resection may be warranted. Patients who had delayed local progression after SRS (> 3 months) had the best outcomes after resection.

Risk Factors for Posttreatment Edema in Patients Treated With Stereotactic Radiosurgery for Meningiomas

Neurosurgery ◽  
2011 ◽  
Vol 70 (3) ◽  
pp. 639-645 ◽  
Author(s):  
Keith R. Unger ◽  
Christopher E. Lominska ◽  
June Chanyasulkit ◽  
Pamela Randolph-Jackson ◽  
Robert L. White ◽  
...  
Keyword(s):  
Risk Factors ◽  
Stereotactic Radiosurgery ◽  
Tumor Volume ◽  
Univariate Analysis ◽  
World Health ◽  
Tumor Control ◽  
Peritumoral Edema ◽  
Large Tumor ◽  
Single Fraction ◽  
Increased Risk

Abstract Background: Peritumoral edema is a recognized complication following stereotactic radiosurgery (SRS). Objective: To evaluate the risk of posttreatment peritumoral edema following SRS for intracranial meningiomas and determine predictive factors. Methods: Between 2002 and 2008, 173 evaluable patients underwent CyberKnife or Gamma Knife SRS for meningiomas. Eighty-four patients (49%) had prior surgical resections, 13 patients had World Health Organization grade II (atypical) meningiomas, and 117 patients had a neurological deficit before SRS. Sixty-two tumors were in parasagittal, parafalcine, and convexity locations. The median tumor volume was 4.7 mL (range, 0.1–231.8 mL). The median prescribed dose and median prescribed biologically equivalent dose were 15 Gy (range, 9–40 Gy) and 67 Gy (range, 14–116 Gy), respectively. Ninety-seven patients were treated with single-fraction SRS, 74 received 2 to 5 fractions, and 2 received >5 fractions. Results: The median follow-up was 21.0 months. Thirteen patients (8%) developed symptomatic peritumoral edema, with a median onset time of 4.5 months (range, 0.2– 9.5 months). The 3-, 6-, 12-, and 24-month actuarial symptomatic edema rates were 2.9%, 4.9%, 7.7%, and 8.5%, respectively. The crude tumor control rate was 94%. On univariate analysis, large tumor volume (P = .01) and single-fraction SRS (P = .04) were predictive for development of posttreatment edema. Conclusion: SRS meningioma treatment demonstrated a low incidence of toxicity; however, large tumor volumes and single-fraction SRS treatment had an increased risk for posttreatment edema. Risk factors for edema should be considered in meningiomas treatment.

Sign in / Sign up

Export Citation Format

Share Document