scholarly journals Outcomes of Methicillin Susceptible Staphylococcus aureus Blood Stream Infections With Various Beta-Lactam Therapy

2016 ◽  
Vol 3 (suppl_1) ◽  
Author(s):  
Ashley Gale ◽  
Milena M. Mclaughlin ◽  
Viktorija O. Barr ◽  
Hankyung Cho ◽  
Michael Postelnick ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Blood Stream ◽  
Beta Lactam ◽  
Blood Stream Infections

scholarly journals Staphylococcus aureus blood stream infections in Cambodian adults

2012 ◽  
Vol 16 ◽  
pp. e437
Author(s):  
E. Vlieghe ◽  
T. Phe ◽  
M. Hallin ◽  
O. Denis ◽  
A. Deplano ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Blood Stream ◽  
Blood Stream Infections

scholarly journals Susceptibility Pattern of Pathogens Causing Blood Stream Infections in a Tertiary Care Hospital: A Two-year Retrospective Study from Southern Nigeria

2021 ◽  
pp. 53-60
Author(s):  
Bassey Ewa Ekeng ◽  
Ubleni Ettah Emanghe ◽  
Bernard Ekpan Monjol ◽  
Anthony Achizie Iwuafor ◽  
Ernest Afu Ochang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Blood Culture ◽  
Blood Stream ◽  
Multidrug Resistant ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Blood Stream Infections ◽  
Gram Negative ◽  
Antimicrobial Sensitivity ◽  
Culture Positive

Aim: Bloodstream infections are a major cause of morbidity and mortality worldwide. The prevalence of causative microorganisms varies from one geographical region to another. This study was aimed at determining the etiological agents prevalent in our environment and their susceptibility profile. Study design: This is a retrospective study carried out at the University of Calabar Teaching Hospital, Calabar, Nigeria. Methodology: Blood culture results of patients documented over a two-year period were retrieved and analyzed. Blood culture positive isolates were detected using conventional method and Oxoid signal blood culture systems. Antimicrobial sensitivity tests were carried out by Kirby-Bauer disc diffusion method. Methicillin resistance in Staphylococcus aureus and coagulase negative Staphylococcus species (CoNS) was detected by disk diffusion method using 30 µg cefoxitin disk. ESBL production was detected by phenotypic confirmatory disc diffusion test (PCDDT) and the double disc synergy test (DDST). Results: A total of 413 blood culture antimicrobial susceptibility test results were analyzed, of which 116 (28.09%) were identified as culture positive. Sixty-nine (59%) of the positive isolates were from female patients. Out of 116 positive cultures, 58.62% (68/116) were Gram positive organisms, 40.52% (47/116) were Gram negative organisms, non albicans Candida accounted for 0.86% (1/116).  Staphylococcus aureus (n=41, 35.3%) was the predominant isolate and showed high sensitivity to levofloxacin (100%), Linezolid (100%) and Amikacin (100%). Twelve isolates of S. aureus were methicillin resistant, while 1 isolate was inducible clindamycin resistant. Of the 116 isolates identified in this study, forty-three (43) were multidrug resistant with highest number of multidrug resistant isolates from Staphylococcus aureus (n=20). 21.28% (n=10) of the Gram-negative isolates were positive for extended spectrum beta lactamases. Conclusion: A high rate of antimicrobial resistance is observed among microorganisms causing blood stream infections. This emphasizes the need for antimicrobial sensitivity testing in the management of blood stream infections.

scholarly journals Bacterial aerobic Bacteraemia at AL- Kindi Teaching Hospital 2007-2009: Etiology diversity, Clinical features, and Outcome.

2012 ◽  
Vol 6 (1) ◽  
pp. 3-9
Author(s):  
Suzan I. Majeed ◽  
Khawlah J. Khalaf ◽  
Mazin K. Ameen
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Clinical Features ◽  
Teaching Hospital ◽  
Blood Stream ◽  
Salmonella Typhi ◽  
Blood Stream Infections ◽  
Blood Samples

Data regarding the incidence, etiology and outcome of Bacteraemia taken from AL-Kindi hospital were collected, and compared the situation between the three years: 2007, 2008, 2009. A total number of blood samples was (505), from this number only (70) (13.8%) is positive. The rate of positivity was significant greater in 2009 (17.7%) than 2008 (11.8%) and 2007 (9.1%). The calculated incidence of significant episodes of bacteraemia was 12.6% .The five most commonly isolated microorganisms were: Salmonella typhi30(46.8%), Staphylococcus aureus 12 (18.7%), Escherichia coli 10 (15.6%),Klebsiella 4(6.2%) and Enterobacter sp.3(4.6%) varied throughout this period, significant increase was noted in 2009. The acquisition of blood stream infections was nosocomial in 8.5% of cases.60% of Salmonella typhi were Amoxicillin resistant. Also Staph.aureus isolates, 58%were resistant to Amoxicillin and Erythromycin. Cephalexin-resistant E.coli in70% of the isolates and Gentamycin-resistant Klebsiella occurred in 75% of the isolates. The incidence of BSI did not differ significantly from other reported studies.

Outcome Of Escherichia Coli (E.coli) Blood Stream Infections (BSI) In Haematology-Oncology Patients- Hematopoetic Stem Cell Transplantation (HSCT) Is Not Associated With Increased Mortality

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 5455-5455
Author(s):  
Zena Salih ◽  
Felicity Fergusson ◽  
Andrew Stevens ◽  
Katalina Balassa ◽  
Theingi Yin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Intensive Therapy ◽  
Univariate Analysis ◽  
Blood Stream ◽  
Cell Transplant ◽  
Haematological Malignancies ◽  
Beta Lactam ◽  
Oncology Patients ◽  
Blood Stream Infections ◽  
The Impact

Abstract Introduction E.coli are one of the commonest organisms causing blood stream infections (BSI) in oncology and hematology patients. With the growing incidence of extended spectrum beta lactam resistance (ESBL) this single centre retrospective analysis was undertaken to identify the predictors of outcome of E.coli septicaemia in hemato-oncology patients. From 2002 to 2012, 1089 patients with haematological malignancies had 3528 episodes of BSI and of them 257 in 177 patients (7.3%) were with E.coli. Methods 177 (M: 114, F: 63; median age: 52yr., range: 16-89) patients with haematological malignancies treated from April 2002 to April 2012 were included in analysis. Underlying diagnosis was AML (n=47), ALL (n=23), Lymphoma (n=73), MDS (n=6), myeloma (n=19) or other conditions (n=9). There were 257 episodes of E.coli septicaemia in 177 patients and each episode was analysed as an individual event. Of the 257 episodes, 34 (13%) developed following stem cell transplant (Allo=18, Auto=16), 85 (33%) following intensive chemotherapy, 55 (21%) after non-intensive therapy, 47 (18%) after various other forms of chemotherapy and 36 (14%) did not have any therapy prior to BSI. E.coli were isolated from peripheral blood (PB, n=112, 44%), central venous access (Line, n=130, 51%) or unspecified source (NK, n=15, 6%). At the time of developing E.coli BSI, ANC was below 0.5 in 136 cases (53%), 167 (65%) had platelet count below 100, 78 (30%) had BUN above 10, 69(27%) had creatinine above 120, 74(29%) had serum bilirubin above 34 and 129 (50%) had trans-aminitis. E.coli BSI increased significantly from year 2007 onwards (110/2073, 5% vs. 137/1455, 9%; p=0.0001). Mortality within 30 days of BSI with E.coli was used as a marker to estimate the impact of the event. 28 of 257 episodes (10.9%) resulted in death within 30 days. In univariate analysis, mortality was significantly higher with age above 45yr. (26/185 vs. 2/72, p=0.01), GGT more than 50 (25/180 vs. 3/77, p=0.02), BUN above 10 (17/78 vs. 11/179, p=0.0002), creatinine above 120 (12/22 vs. 16/188, p=0.035) and PB as source of BSI (18/112 vs. 10/145, p=0.02). In Cox multivariate analysis, PB as source (HR: 2.2, 95% CI: 1.0-4.9, p=0.048), GGT above 50 (HR: 4.4, 95% CI: 1.2-15.5, p=0.022), age above 45 yr. (HR: 4.5, 95% CI: 1.1-19.6, p=0.04) and creatinine above 120 (HR: 3.1, 95% CI: 1.1-8.7, p=0.03) were independently associated with mortality within 30 days of E.coli BSI. Mortality increased significantly with the number of risk factors [0-1: 2/68 (3%), 2-3: 22/140 (16%), 4: 8/25 (32%), HR: 3.9, 95% CI: 2.0-7.4, p=0.0001]. 16% of E.coli were resistant to beta lactam antibiotics but the number was too small to assess the impact on mortality. HSCT was not associated with increased mortality. Conclusion E.coli BSI are associated with significant mortality that is not associated with underlying diagnosis but with the age and associated organ dysfunction. Continued surveillance is needed to assess the impact of ESBL incidence, status and its clinical significance. Disclosures: Cavet: Celgene: Consultancy, Honoraria; Eli Lilly: Honoraria.

scholarly journals Staphylococcus aureus

2008 ◽  
Vol 29 (3) ◽  
pp. 113
Author(s):  
Graeme Nimmo ◽  
Geoffrey W Coombs
Keyword(s):  
Staphylococcus Aureus ◽  
Mortality Rate ◽  
Lower Respiratory Tract ◽  
Meta Analysis ◽  
Healthcare Setting ◽  
Blood Stream ◽  
Soft Tissue Infections ◽  
Blood Stream Infections ◽  
Invasive Infections ◽  
The Mean

Staphylococcus aureus is one of the major bacterial pathogens of man, causing a variety of diseases from mild skin and soft-tissue infections to severe invasive infections with high mortality. In the healthcare setting it is the most frequent cause of surgical site, lower respiratory tract and cardiovascular infections and the second most common cause of blood stream infections and pneumonia. The ability of S. aureus to develop resistance to all classes of antimicrobials, in particular the �-lactams, has become a major global problem. In the pre-antibiotic era, the mortality rate for severe staphylococcal sepsis was as high as 90%. In a recent meta-analysis of nine studies of S. aureus bacteraemia in the antibiotic era, although the mean mortality rate due to methicillin-susceptible S. aureus (MSSA) was 12% (ranging from 0 to 38%), for methicillin-resistant S. aureus (MRSA) the mean was 29% (ranging from 8 to 50%). Whilst estimates vary, the mortality associated with MRSA is on average twice that with MSSA.

scholarly journals Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study

2019 ◽  
Vol 40 (39) ◽  
pp. 3237-3244 ◽  
Author(s):  
Lauge Østergaard ◽  
Niels Eske Bruun ◽  
Marianne Voldstedlund ◽  
Magnus Arpi ◽  
Christian Østergaard Andersen ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Infective Endocarditis ◽  
Enterococcus Faecalis ◽  
Blood Stream ◽  
Blood Cultures ◽  
Trend Test ◽  
Coagulase Negative Staphylococci ◽  
Blood Stream Infections ◽  
Nationwide Study ◽  
Male Patients

Abstract Aims Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSIs). Previous studies have been conducted on selected patient cohorts, yet unselected data are sparse. We aimed to investigate the prevalence of IE in BSIs with bacteria typically associated with IE. Methods and results By crosslinking nationwide registries from 2010 to 2017, we identified patients with BSIs typically associated with IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and coagulase negative staphylococci (CoNS) and examined the concurrent IE prevalence. A trend test was used to examine temporal changes in the prevalence of IE. In total 69 021, distributed with 15 350, 16 726, 19 251, and 17 694 BSIs were identified in the periods of 2010–2011, 2012–2013, 2014–2015, and 2016–2017, respectively. Patients with E. faecalis had the highest prevalence of IE (16.7%) followed by S. aureus (10.1%), Streptococcus spp. (7.3%), and CoNS (1.6%). Throughout the study period, the prevalence of IE among patients with E. faecalis and Streptococcus spp. increased significantly (P = 0.0005 and P = 0.03, respectively). Male patients had a higher prevalence of IE for E. faecalis, Streptococcus spp., and CoNS compared with females. A significant increase in the prevalence of IE was seen for E. faecalis, Streptococcus spp., and CoNS with increasing age. Conclusion For E. faecalis BSI, 1 in 6 had IE, for S. aureus BSI 1 in 10 had IE, and for Streptococcus spp. 1 in 14 had IE. Our results suggest that screening for IE seems reasonable in patients with E. faecalis BSI, S. aureus BSI, or Streptococcus spp. BSI.

Sign in / Sign up

Export Citation Format

Share Document