Good News: Research and Medicinal Chemists Making a Difference

ReAction! ◽  
2009 ◽  
Author(s):  
Mark A. Griep ◽  
Marjorie L. Mikasen

Stories of people doing their jobs well, treating each other with respect, and trying to make the world a better place are all examples of “good news.” Such stories don’t generate many website hits, nor do they bring people into the theaters. Instead, it seems readers and movie viewers would rather have the double pleasure of learning about bad behavior and its comeuppance. Five movies in this chapter overcome this problem; they are based on true stories. The advantage of such stories is the sympathy viewers feel as they appreciate the adversities the chemist has overcome to make their celebrated findings. For instance, in the documentary Me & Isaac Newton, which explores the motivations of seven scientists, pharmaceutical chemist Gertrude Elion is warm and charming as she describes why she decided to become a chemist. When she later describes her struggles to enter graduate school and then get a job as a chemist, the viewer is struck by her matter-of-fact, water-under-the-bridge tone. This all happened before she understood there was a climate of active discrimination against women that had nothing to do with their drive or abilities. Still later, she says the ultimate reward for all her work comes when someone thanks her for having developed the drug that cured a loved one. The disadvantage of using true stories is the need to create dramatic tension. The important moments in people’s lives rarely coincide with obvious indications that “this is the moment when everything fell into place,” whereas a movie’s linear narrative has to make that point clear to the audience. Another problem for moviemakers is that most people just aren’t very curious about the origins of everyday things. This is a challenge because very few chemicals cause the imagination to soar (unless you are a chemist), which may explain why all five movies based on true stories are about medicinal chemistry, which can be seen as the external evidence of the chemist’s desire to do good things for other people. Fictional movie chemists are less likely to develop medicines. Like the chemistry professors in chapter 8, they tend to develop chemical products for more selfish reasons.


2019 ◽  
Vol 26 (23) ◽  
pp. 4403-4434 ◽  
Author(s):  
Susimaire Pedersoli Mantoani ◽  
Peterson de Andrade ◽  
Talita Perez Cantuaria Chierrito ◽  
Andreza Silva Figueredo ◽  
Ivone Carvalho

Neglected Diseases (NDs) affect million of people, especially the poorest population around the world. Several efforts to an effective treatment have proved insufficient at the moment. In this context, triazole derivatives have shown great relevance in medicinal chemistry due to a wide range of biological activities. This review aims to describe some of the most relevant and recent research focused on 1,2,3- and 1,2,4-triazolebased molecules targeting four expressive NDs: Chagas disease, Malaria, Tuberculosis and Leishmaniasis.



Author(s):  
Aneta Ejsmont

Building own business is a long-term and laborious process. A person who leads a startup tries to start with building own business by taking first steps toward financial independence. Analyzing conditions in Poland, on average every second startup sells its services abroad, admittedly it is good news, although half of them do not export at all. Half of the startups which export their services and goods generates more than 50% of their revenues outside Poland. Very interesting is the fact that 60% of exporters have conducted their foreign sale since the moment of establishing their business. On which markets do they sell their services? It turns out that the most popular are markets in the European Union (54%), including the United Kingdom 14% and Germany 9%. Only about 25% of Polish startups exports their products and services to the United States. Taking the United States into consideration, in 2008 the USA lost their leading position in the number of startups which are newly created and achieving success in business. Currently in terms of the number of new startups the USA is on a quite distant place after Denmark, Finland, Sweden, Hungary, New Zealand, Israel or Italy. In short, more companies were closed than created, so it was, as a matter of fact, like in Poland. Therefore, the condition to improve the development of startups both from Poland and other countries all the world is to increase cooperation and coopetition.



1992 ◽  
Vol 45 (2) ◽  
pp. 209-222
Author(s):  
Scott W. Gustafson

From the moment Jesus was hung on the cross, Christians have been compelled to address the fact of evil within God's creation. For the most part we have made the mistake of addressing this reality by logical means. It is not that there are no logical solutions to the apparent contradiction between the fact of evil and an omnipotent and benevolent God. The difficulty is far more fundamental. Logical solutions or answers do not address the fact of sin, evil and suffering in the world. At best, they are innocuous. At worst, they are destructive. For example, a pastor presiding at a funeral may well have an answer or two to the inevitable question raised by the grieving, 'Why did Jack have to die so young?' She might say that the wages of sin are death, and she might even speculate thatjack died young because he was such an accomplished sinner. Moreover, it is at least conceivable that our pastor could be correct in herjudgment!!! Nevertheless, those gathered would be right to be angry if the pastor said such a thing because her answer did not address the issue. Indeed, no answer can. The people gathered do not need answers. They already have biological, psychological and even theological answers. The people longfor presence instead. To be sure, they long for the presence of their departed loved one, but they require the presence of friends, relatives and God. The theodicy issue is addressed by such presence. The theodicy issue does not simply pose a question to be answered. It creates a context in which ministry may happen.



Author(s):  
Peggy D. Bennett

Sometimes we become so focused on the turmoil, we forget to see the charm that surrounds us. Consumed by our to- do lists and home obligations, we forget to look, listen, and feel. Plenty of obstacles can devitalize teachers. And sometimes we can get in the habit of stewing in our malaise. So we must be intentional about looking for and absorbing the charming sights, sounds, and feelings that surround us. Like vitamins for the soul, moments of charm can boost and revive. The simplest things can bring us back to the roots and bounty of our lives: The giggle of a child. The good- natured sparring of teenagers. The fearlessly perched raven watching traffic from a stop sign. The pattern of a spiderweb and the brilliance of the spider that wove it. The easy laughter of friends. The look of wonder when a student “gets it.” The beauty of young musicians as they personify music. The brisk gait of an elderly neighbor. The pure joy of singing with abandon. The first sip of your morn­ing coffee. The scent of a book. The frenzied cheers of parents at a sporting event. The embracing hug of a loved one. The luxury of living without pain. The buzz of energy when school begins and ends. The allure of these charming moments can be smothered by our intense focus on work and troubles. Yes, these simple moments of charm are always there for us . . . when we notice them. We can inhale their whimsy and encourage ourselves to smile, laugh, and be glad for the moment. Seeing, hearing, and appreciating simple things returns the aesthetic to our anesthetic worlds. When we look for and feel those moments of charm, we can be grateful. Those moments remind us we are alive in the world.



2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Japkaran Saroya
Keyword(s):  

This poem touches on a perfect moment where the world stands still and you take everything in. This precious moment is one that is taken for granted and one that we don't recognize or even care for in the moment and watch as it passes us by. It also touches on the loss of a loved one and letting go and the bliss that comes with it.



2007 ◽  
Vol 4 ◽  
pp. 21-37
Author(s):  
Kristupas Sabolius

Kitybės klausimas dažniausiai kyla iš ego santykio su kitais arba su pasauliu. Šiame straipsnyje daroma prielaida, kad įsivaizdavimo funkcija ištirpdo subjektą ir jame pačiame atveria intersubjektyvią perspektyvą. Šiuo tikslu sugretinami Sartre’o, Husserlio bei Merleau-Ponty įsivaizdavimo funkcijos tyrimai, kuriuose išryškėja vaizdo kaip iš ego centro išslystančios ribos statusas, ir Holivudo filmo „Kovos klubas“ siužetas. Viename iš šios juostos epizodų pasirodantis pingvinas žymi egologinės schizmos akimirką ir tampa fantazijos apsireiškimu ir įsikūnijimu.Išgryninus žaidybinį, savarankišką ir multiformišką charakterį, galime konstantuoti, kad įsivaizdavimas, jei kalbėtume Kanto terminais, yra ne papildanti tarpinė funkcija, bet transcendentalinio subjekto genezėje atlieka paradoksalų „svetimos vidujybės“ arba „vidinės svetimybės“ vaidmenį. Vaizduotė yra katalizatoriaus, kuris, likdamas šalia, įgalina transcendentalinių formų išsikristalizavimą.Pagrindiniai žodžiai: vaizduotė, įsivaizdavimas, fantazija, ego, kitybė, sąmonė.PENGUIN AND PROTEUSImagination as Otherness in meKristupas Sabolius SummaryThe question of Otherness is usually taken into account while discussing the Ego’s relation with Others as well as with the World. This article is based on the premises that the function of phantasy melts the subjectivity, revealing the perspective of intersubjectivity within it. On this purpose Sartre’s, Husserl’s and Merleau-Ponty’s researches on the function of imagination, which elucidate the image as the boundary slipping from the centre of Ego, are compared to the story of Hollywood’ movie „Fight Club“. The penguin, which appears in one of the episodes, registers the moment of egological schism, thus becoming the revelation and incarnation of phantasy. While the playful, autonomous and multiform character of imaginary is cleared out, we can ascertain, speaking in Kantian terms, that it has not a complementary or intermediary function, but, in the genesis of transcendental subject, plays the paradoxical role of „allien innerness“ or „inner alienity“. Thought remaining always beside, imagination is a catalyzer which enables crystallization of transcendental forms.Keywords: imagination, imaginary, phantasy, ego, otherness, consciousness.



2009 ◽  
Vol 2009 (1) ◽  
pp. 61-78
Author(s):  
Petr Kouba

This article examines the limits of Heidegger’s ontological description of emotionality from the period of Sein und Zeit and Die Grundbegriffe der Metaphysik along the lines outlined by Lévinas in his early work De l’existence à l’existant. On the basis of the Lévinassian concept of “il y a”, we attempt to map the sphere of the impersonal existence situated out of the structured context of the world. However the worldless facticity without individuality marks the limits of the phenomenological approach to human existence and its emotionality, it also opens a new view on the beginning and ending of the individual existence. The whole structure of the individual existence in its contingency and finitude appears here in a new light, which applies also to the temporal conditions of existence. Yet, this is not to say that Heidegger should be simply replaced by Lévinas. As shows an examination of the work of art, to which brings us our reading of Moravia’s literary exposition of boredom (the phenomenon closely examined in Die Grundbegriffe der Metaphysik), the view on the work of art that is entirely based on the anonymous and worldless facticity of il y a must be extended and complemented by the moment in which a new world and a new individual structure of experience are being born. To comprehend the dynamism of the work of art in its fullness, it is necessary to see it not only as an ending of the world and the correlative intentional structure of the individual existence, but also as their new beginning.



2017 ◽  
Vol 2017 (1) ◽  
pp. 39-54
Author(s):  
Jörg Zimmer

In classical philosophy of time, present time mainly has been considered in its fleetingness: it is transition, in the Platonic meaning of the sudden or in the Aristotelian sense of discreet moment and isolated intensity that escapes possible perception. Through the idea of subjective constitution of time, Husserl’s phenomenology tries to spread the moment. He transcends the idea of linear and empty time in modern philosophy. Phenomenological description of time experience analyses the filled character of the moment that can be detained in the performance of consciousness. As a consequence of the temporality of consciousness, he nevertheless remains in the temporal conception of presence. The phenomenology of Merleau-Ponty, however, is able to grasp the spacial meaning of presence. In his perspective of a phenomenology of perception, presence can be understood as a space surrounding the body, as a field of present things given in perception. Merleau-Ponty recovers the ancient sense of ‘praesentia’ as a fundamental concept of being in the world.



Screen Bodies ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 111-128
Author(s):  
Lara Bochmann ◽  
Erin Hampson

This article is a theoretical, audiovisual, and personal exploration of being a trans and non-binary person and the challenges this position produces at the moment of entering the outside world. Getting ready to enter public space is a seemingly mundane everyday task. However, in the context of a world that continuously fails or refuses to recognize trans and non-binary people, the literal act of stepping outside can mean to move from a figurative state of self-determination to one of imposition. We produced a short film project called Step Out to delve into issues of vulnerability and recognition that surface throughout experiences of crossing the threshold into public space. It explores the acts performed as preparation to face the world, and invokes the emotions this can conquer in trans and non-binary people. Breathing is the leading metaphor in the film, indicating existence and resistance simultaneously. The article concludes with a discussion of affective states and considers them, along with failed recognition, through the lens of Lauren Berlant’s concept of “cruel optimism.”



Designs ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 8
Author(s):  
Pyrrhon Amathes ◽  
Paul Christodoulides

Photography can be used for pleasure and art but can also be used in many disciplines of science, because it captures the details of the moment and can serve as a proving tool due to the information it preserves. During the period of the Apollo program (1969 to 1972), the National Aeronautics and Space Administration (NASA) successfully landed humans on the Moon and showed hundreds of photos to the world presenting the travel and landings. This paper uses computer simulations and geometry to examine the authenticity of one such photo, namely Apollo 17 photo GPN-2000-00113. In addition, a novel approach is employed by creating an experimental scene to illustrate details and provide measurements. The crucial factors on which the geometrical analysis relies are locked in the photograph and are: (a) the apparent position of the Earth relative to the illustrated flag and (b) the point to which the shadow of the astronaut taking the photo reaches, in relation to the flagpole. The analysis and experimental data show geometrical and time mismatches, proving that the photo is a composite.



Sign in / Sign up

Export Citation Format

Share Document