For the Joy of the Working

Margaret Mead ◽  
2020 ◽  
pp. 189-210
Author(s):  
Elesha J. Coffman
Keyword(s):  
End Of Life ◽  
Cancer Diagnosis ◽  
Women's Movement ◽  
Full Range ◽  
Medical Science ◽  
Nuclear Safety ◽  
Faith Healer ◽  
Earth Day ◽  
First Time

Mead stayed extraordinarily busy to the end of life, engaged with such issues as nuclear safety, Earth Day, and the women’s movement. When a cancer diagnosis threatened her forward momentum, she denied it, preferring the ministrations of a faith healer over the recommendations of medical science. This choice dismayed her closest friends, but it was not entirely a departure from a life marked by curiosity about the full range of human experiences, even those that could not be explained by science. After her death, she was widely mourned and celebrated. She was, at her request, buried at the same church where she had been baptized and married for the first time. She is recognized by some fellow Episcopalians as a saint.

Fouling Is the Beginning: Upcycling Biopolymer-Fouled Substrates for Fabricating High-Permeance Thin-Film Composite Polyamide Membranes

2020 ◽  
Author(s):  
Ruobin Dai ◽  
Hongyi Han ◽  
Tianlin Wang ◽  
Jiayi Li ◽  
Chuyang Y. Tang ◽  
...  
Keyword(s):  
Thin Film ◽  
High Pressure ◽  
End Of Life ◽  
Water Purification ◽  
Low Pressure ◽  
Polymeric Membranes ◽  
Membrane Recycling ◽  
Film Composite ◽  
Thin Film Composite ◽  
First Time

Commercial polymeric membranes are generally recognized to have low sustainability as membranes need to be replaced and abandoned after reaching the end of their life. At present, only techniques for downcycling end-of-life high-pressure membranes are available. For the first time, this study paves the way for upcycling fouled/end-of-life low-pressure membranes to fabricate new high-pressure membranes for water purification, forming a closed eco-loop of membrane recycling with significantly improved sustainability.

scholarly journals A METHODOLOGY TO SUPPORT COMPANIES IN THE FIRST STEPS TOWARDS DE-MANUFACTURING

2021 ◽  
Vol 1 ◽  
pp. 131-140
Author(s):  
Federica Cappelletti ◽  
Marta Rossi ◽  
Michele Germani ◽  
Mohammad Shadman Hanif
Keyword(s):  
Environmental Impact ◽  
End Of Life ◽  
Design Stage ◽  
Life Strategies ◽  
Disassembly Sequence ◽  
The Status ◽  
The Cost ◽  
Technical Solutions ◽  
First Time ◽  
Complex Activities

AbstractDe-manufacturing and re-manufacturing are fundamental technical solutions to efficiently recover value from post-use products. Disassembly in one of the most complex activities in de-manufacturing because i) the more manual it is the higher is its cost, ii) disassembly times are variable due to uncertainty of conditions of products reaching their EoL, and iii) because it is necessary to know which components to disassemble to balance the cost of disassembly. The paper proposes a methodology that finds ways of applications: it can be applied at the design stage to detect space for product design improvements, and it also represents a baseline from organizations approaching de-manufacturing for the first time. The methodology consists of four main steps, in which firstly targets components are identified, according to their environmental impact; secondly their disassembly sequence is qualitatively evaluated, and successively it is quantitatively determined via disassembly times, predicting also the status of the component at their End of Life. The aim of the methodology is reached at the fourth phase when alternative, eco-friendlier End of Life strategies are proposed, verified, and chosen.

scholarly journals Cyclopropenium Nanoparticles and Gene Transfection in Cells

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 768
Author(s):  
Noam Y. Steinman ◽  
Luis M. Campos ◽  
Yakai Feng ◽  
Abraham J. Domb ◽  
Hossein Hosseinkhani
Keyword(s):  
Viral Vectors ◽  
Gene Transfection ◽  
Medical Science ◽  
Genetic Material ◽  
Mouse Fibroblast ◽  
Ethylene Imine ◽  
Efficient Gene ◽  
Poly Ethylene ◽  
First Time

Non-viral vectors for the transfection of genetic material are at the frontier of medical science. In this article, we introduce for the first time, cyclopropenium-containing nanoparticles as a cationic carrier for gene transfection, as an alternative to the common quaternary ammonium transfection agents. Cyclopropenium-based cationic nanoparticles were prepared by crosslinking poly(ethylene imine) (PEI) with tetrachlorocyclopropene. These nanoparticles were electrostatically complexed with plasmid DNA into nanoparticles (~50 nm). Their cellular uptake into F929 mouse fibroblast cells, and their eventual expression in vitro have been described. Transfection is enhanced relative to PEI with minimal toxicity. These cyclopropenium nanoparticles possess efficient gene transfection capabilities with minimal cytotoxicity, which makes them novel and promising candidates for gene therapy.

scholarly journals AVATAR Therapy for Distressing Voices: A Comprehensive Account of Therapeutic Targets

2020 ◽  
Vol 46 (5) ◽  
pp. 1038-1044 ◽  
Author(s):  
Thomas Ward ◽  
Mar Rus-Calafell ◽  
Zeyana Ramadhan ◽  
Olga Soumelidou ◽  
Miriam Fornells-Ambrojo ◽  
...  
Keyword(s):  
Side Effects ◽  
Future Development ◽  
Full Range ◽  
Therapeutic Targets ◽  
Digital Representation ◽  
Face To Face ◽  
Comprehensive Account ◽  
First Time ◽  
Therapy Delivery ◽  
Complete Account

Abstract AVATAR therapy represents an effective new way of working with distressing voices based on face-to-face dialogue between the person and a digital representation (avatar) of their persecutory voice. To date, there has been no complete account of AVATAR therapy delivery. This article presents, for the first time, the full range of therapeutic targets along with information on acceptability and potential side effects. Interest in the approach is growing rapidly and this report acts as a necessary touchstone for future development.

scholarly journals Newly onset: sudden & severe headache in a patient who overused analgesic

2015 ◽  
Vol 14 (4) ◽  
pp. 399-401 ◽  
Author(s):  
Khairi Che Mat ◽  
Rohayah Husain ◽  
Nasir Mohamad
Keyword(s):  
Medical Science ◽  
Severe Headache ◽  
Increased Intracranial Pressure ◽  
Provisional Diagnosis ◽  
Early Management ◽  
Progressive Development ◽  
Acute Headache ◽  
First Time ◽  
Space Occupying Lesion ◽  
New Onset

This case report presented a rare cause of severe headache in a patient who developed episodes of acute severe headache for the first time. The earliest accurate provisional diagnosis is crucial for a new onset severe headache in adult. A good history taking and high index of suspicious are remained the most important clinical component in managing severe first time headache in adult. The differential diagnosis of subarachnoid hemorrhage, space-occupying lesion with increased intracranial pressure, acute intoxication, meningo-encephalitis and others must be ruled out as these conditions are benefited in early management. In this patient, progressive development of headache is masked by severe intense headache, which later will be described as acute headache. The causes of newly onset severe intense headache will be discussed in the discussion.Bangladesh Journal of Medical Science Vol.14(4) 2015 p.399-401

The Chalice of Repose Project’s Music-Thanatology History and Praxis

2017 ◽  
Vol 9 (2) ◽  
pp. 128 ◽  
Author(s):  
Therese Schroeder-Sheker
Keyword(s):  
Palliative Care ◽  
End Of Life ◽  
Full Range ◽  
Narrative Medicine ◽  
Cost Effective ◽  
Arts And Sciences ◽  
Letting Go ◽  
The Usa ◽  
Field Notes ◽  
Effective Pain Relief

 Abstract The palliative medical modality of music-thanatology as developed by the author and pioneered at the Chalice of Repose Project is an evidence-based practice-vocation-profession, and maintains a singular focus and orientation: the physical and spiritual care of the dying with prescriptive music.  Music-thanatology palliative care is delivered in every psychosocial setting and serves every patient constituency, pediatric to geriatric.  The music-thanatology delivery of prescriptive music occurs live, at the bedside; is responsive to the patient’s unique, dynamic medical and interior conditions, and features quiet reception rather than clinician-patient interaction. This historical report provides a condensed overview of forty-four years of music-thanatology development, history and clinical practice. This includes a description of the historical and current curricula, excerpts from clinical field notes and an example of a spiritual practice that can sensitively orient musician-clinicians toward the existential patient experience. The bibliographical resources cited reflect the methodologies of a variety of scholarly disciplines in the biomedical and nursing arts and sciences and a full range of the humanities, all of which are integrated into music-thanatology education, formation and praxis. Recent population studies [1] report that there are currently over 46 million Americans aged 65 and older, and this number is expected to double by 2060. Life expectancy has generally increased and with it the need for excellent end-of-life palliative care programs. A full array of dedicated and competent practitioners skilled in a variety of end-of-life arts and sciences has never been so greatly needed in the USA. When interventional modalities have been exhausted, music-thanatology offers effective pain relief and meaningful, effective, cost-effective supportive care options during the final days and hours of life.  Keywords: Music-thanatology, palliative care, prescriptive music, narrative medicine, spirituality, transitus, monastic medicine, contemplative practice, letting go.    

The Need for Schools of Psychiatry

1920 ◽  
Vol 66 (272) ◽  
pp. 10-23
Author(s):  
C. Hubert Bond
Keyword(s):  
Public Health ◽  
Mental Disorder ◽  
Annual Report ◽  
Medical Profession ◽  
Medical Science ◽  
Medical Schools ◽  
Public Institutions ◽  
Extended Form ◽  
First Time ◽  
Important Branch

In their fourth Annual Report, published in 1918, the Board of Control drew attention—not for the first time, but in more extended form than hitherto—to deficiencies in the arrangements, as at present organised, for the treatment of persons suffering from mental disorder, especially in its incipient and early stages; to the insufficiency of attention paid at medical schools to this important branch of medical science with its consequent ill-effects both to patients and to the medical profession; and to the absence of any special qualification in psychiatry, as a requirement for the higher medical posts in public institutions for the insane, such as is demanded in public health of medical officers of health of areas of above a stated size.

Characteristics of patients (pts) receiving end of life treatment (EOLT) at an NCI-Designated Cancer Center.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e18245-e18245
Author(s):  
Kevin Do ◽  
Sarmad Sadeghi ◽  
Peggy Matsuura ◽  
Gwendoyn Lynch ◽  
Afsaneh Barzi
Keyword(s):  
End Of Life ◽  
Cancer Diagnosis ◽  
Expert Panel ◽  
Renal Cell Carcinoma Patient ◽  
Cancer Center ◽  
P Value ◽  
Cancer Subtype ◽  
Chi Squared ◽  
To Receive ◽  
End Of Life Treatment

e18245 Background: End of life treatment is identified as a high cost low return intervention and is under evaluation as a quality measure for providers. A 2012 ASCO expert panel acknowledged it as the most wasteful practice in oncology. However, characteristics of pts who receive EOLT is poorly described and so interventions to assist providers avoid such treatments are limited. Methods: We identified 299 pts with cancer diagnosis from 2008-2012 and confirmed deceased using our cancer registry. Pts charts were reviewed for last cancer-specific treatments, either chemotherapy (CTX) or radiation therapy (XRT). Characteristics of pts who received treatment within the last 90, 30, and 14 days of life was described. We compared the characteristics of those who received treatment with in the last 14 days of life (here defined as EOLT) to the rest of the population. Chi-squared tests were used to compare between groups. Results: 292 pts (98%) received CTX or XRT within the last 90 days of life, 167 (56%) received treatment within the last 30 days, and 78 (26%) within the last 14 days of life. The main modality of EOLT was CTX (99%). By cancer subtype, up to 50% of gastric and renal cell carcinoma patient received treatment in the last 14 days of life. Older pts, those on clinical trials, and those with longer period of time between diagnosis and death, were less likely to receive EOLT. There is a trend for receipt of EOLT for female pts and those younger than 65 years (p-value 0.059) Conclusions: Our data establishes that more than 25% of deceased pts received treatment in the last 14 days of life. Certain characteristics may influence providers to be aggressive and to deliver care when it is futile. Research to risk stratify pts who are good candidates for treatment is necessary and can improve the value of care delivered to these subjects.

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