Dysregulated Translation in Autism Spectrum Disorder
Keyword(s):
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex genetic architecture and heterogeneous symptomatology. Increasing evidence indicates that dysregulated brain protein synthesis is a common pathogenic pathway involved in ASD. Understanding how genetic variants converge on a common molecular signaling pathway in neurons and brain circuits, resulting in ASD-relevant synaptic and behavioral phenotypes, is of great interest in the autism research community. This article focuses on ASD-risk genes and the molecular aspects leading to dysregulated protein synthesis.
2020 ◽
Vol 27
(40)
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pp. 6771-6786
2021 ◽
Vol 18
(13)
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pp. 6774
2021 ◽
Vol 9
(F)
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pp. 88-94
2018 ◽
Vol 1
(01)
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pp. 1-7