Calcium Pyrophosphate Crystal Deposition in a Cohort of 57 Patients with Gitelman Syndrome

Rheumatology ◽  
2021 ◽  
Author(s):  
Emile Chotard ◽  
Anne Blanchard ◽  
Agnès Ostertag ◽  
Augustin Latourte ◽  
Gilles Gailly ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Serum Magnesium ◽  
Calcium Pyrophosphate ◽  
Magnesium Level ◽  
Gitelman Syndrome ◽  
Control Group ◽  
Serum Magnesium Level ◽  
Crystal Deposition ◽  
Salt Wasting ◽  
Factors Associated

Abstract Objective Gitelman syndrome (GS) is the most frequent salt-wasting genetic tubulopathy and a source of hypokalaemia and hypomagnesemia. Chondrocalcinosis (CC) is a frequent feature of GS. The aim of our study was to determine the prevalence, distribution patterns, clinical phenotypes and risk factors of CC in GS. Methods This prospective study of a cohort of 57 patients with GS included a systematic screening for CC by peripheral joint radiography, cervical spine computerized tomography (CT) and joint ultrasonography. The prevalence of cervical C1-C2 CC by CT was compared between 33 GS patients and sex- and age-matched controls. Clinical and biochemical features were analysed to identify factors associated with CC. Results Mean age of patients was 46.5 ± 12.4 years, 66.7% were women, and 93.0% carried SLC12A3 mutations. Mean serum magnesium level was 0.60 ± 0.30 mmol/l. CC was observed in 79% of patients, with the highest prevalence at the cervical spine (81.8%) followed by the knee (52.6%), wrist (50.9%), ankle (38.6%), temporomandibular joint (36.4%), shoulder (33.3%), hip (22.8%), elbow (14.0%) and sclero-choroid (12.1%). Prevalence of CC at the C1-C2 level was higher in the GS cohort than control group (72.7% vs 9.1%) (adjusted odds ratio 21.0, 95% CI 2.8–156.1, p= 0.003). Independent factors associated with CC were low serum magnesium level and age. Conclusion GS was associated with widespread CC, favoured by aging and hypomagnesemia. The C1-C2 level was the most affected site. Follow-up of this unique cohort will help understanding the clinical consequences of CC, especially the precise characterization of pyrophosphate arthropathy.

scholarly journals Serum Magnesium Level in Gestational Diabetes Mellitus in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 9 (2) ◽  
pp. 59-62
Author(s):  
FA Mishu ◽  
MA Muttalib ◽  
S Naher ◽  
R Tabassum ◽  
R Ahmed ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Control Group ◽  
Care Hospital ◽  
Serum Magnesium Level ◽  
Third Trimester ◽  
Group I

Gestational diabetes mellitus (GDM) is characterized by glucose intolerance during pregnancy. GDM is associated with an increased incidence of congenital abnormalities usually aggravated by maternal magnesium deficiency. Magnesium is one of the essential trace elements for normal embryogenesis and foetal growth and its deficiency increases mortality and morbidity rate of mothers, embryos and neonates. The present study was undertaken to evaluate the association of serum magnesium with GDM in second and third trimester of pregnancy. This case-control study was conducted in Mymensingh Medical College Hospital during the period from July 2013 to June 2014 to evaluate the association of serum magnesium with GDM in Bangladeshi women. A total of 172 subjects were recruited in this study; among them eighty six women with GDM were selected as case (Group-I) and eighty six healthy pregnant women were taken as control (Group- II). The cases again were subdivided as Group Ia and Ib at second and third trimester respectively. Controls also were subdivided as Group IIa and IIb at second and third trimester respectively. Student's unpaired 't' test was used to compare the data between groups. For analytical purpose 95% confidence limit (p<0.05) was taken as level of significance. Serum magnesium level was significantly decreased in cases compared to that of controls. It was significantly lowered (p<0.001) in cases Gr-Ia (1.3884±0.255 mg/dl) than controls Gr-IIa (1.6651±0.304 mg/dl) at second trimester. The result was also significantly (p<0.001) lowered when compared between cases Gr-Ib (0.9349±0.145 mg/dl) and controls Gr-IIb (1.6674±0.308 mg/dl) at third trimester. The study shows that serum magnesium level is decreased in pregnancy with GDM. So estimation of serum magnesium level may be done in every GDM cases to reduce the incidence of magnesium related complications by timely intervention.Bangladesh J Med Biochem 2016; 9(2): 59-62

scholarly journals Serum magnesium level in acute exacerbation of the chronic obstructive pulmonary disease

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2231-2235
Author(s):  
Nitin N Jadhav ◽  
Patange Aparna ◽  
Patil Shilpa ◽  
Pardesi A T
Keyword(s):  
Acute Exacerbation ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Stage Ii ◽  
Control Group ◽  
Chronic Obstructive ◽  
Copd Exacerbation ◽  
Serum Magnesium Level ◽  
Copd Patients ◽  
Number Of Patients

In this hospital based Case Control study, the patient population consisted of 100 patients of COPD admitted as an acute exacerbation, maximum number of patients of acute exacerbation 45% was in the age of 61-70 years, mean age was 66.44 ± 8.19 years. 74 patients were males, 71% of COPD patients were chronic smokers, 45 (45%) patients were in stage II, and 72% of patients of COPD exacerbation had hypomagnesaemia. In the control group, 99% of patients had normomagnesaemia. The incidence of hypomagnesaemia was 78% with acute exacerbation. The correlation of serum magnesium levels in exacerbation patients moreover, serum magnesium level stable COPD patients was significantly important. There was a significant correlation between hypomagnesaemia and GOLD staging in stage II and stage III, with a non-significant correlation between hypomagnesaemia and stage I and stage IV. The study concludes that COPD exacerbation is associated with hypomagnesaemia. Further studies are needed to find out the correlation between the staging of COPD and serum magnesium levels, and the effect of magnesium therapy in COPD exacerbation patients with hypomagnesaemia. Also, further studies are needed to find out possible aetiology of hypomagnesaemia in COPD exacerbation.

scholarly journals SERUM MAGNESIUM LEVEL

2010 ◽  
Vol 17 (02) ◽  
pp. 279-285
Author(s):  
SADIA ZAFAR ◽  
HINA AYESHA ◽  
ASGHAR BUTT ◽  
Bushra Abdul Malik
Keyword(s):  
Serum Albumin Level ◽  
Serum Magnesium ◽  
Simple Random Sampling ◽  
Albumin Level ◽  
Magnesium Level ◽  
Healthy Children ◽  
Persistent Diarrhea ◽  
Serum Magnesium Level ◽  
Cross Sectional ◽  
Study Setting

Objectives: To evaluate serum magnesium level in children with 3rd degree malnutrition and to compare these values with healthy children. Study Design: Cross sectional comparative study. Setting and Duration: Pediatric Department of Allied Hospital Faisalabad from Oct. 2003 to Nov. 2004. Subjects: Cases: 60 children of age six month to five year having weight < 60% of that for age. Control: 60 healthy children of age six month to five year having weight > 80% of that for age. Methods: Both cases & controls were selected from indoor & outdoor through simple random sampling. Detailed history & examination was done and S/Mg level were measured by atomic absorption spectrophotometer. Data was analyzed with the help of SPSS by applying T test and was presented by frequency tables. Results: The cases showed decreased S/Mg level (1.11+/- 0.24 mg/dl) as compared to controls (2.01+/- 0.78mg/dl).S/Mg levels were also decreased in cases with height < 80 % of that for age (0.98+/-0.5mg/dl) as compared to controls having height > 90 % of that for age. S/Mg levels were markedly low in cases who had low albumin level (0.98+/- 0.05 mg/dl) and those children who presented with persistent diarrhea (0.96+/-0.12mg/dl) Conclusion: S/Mg levels were decreased in children with PEM as compared to those with age and sex matched control. This decrease in S/Mglevels was marked in those cases who had decrease serum albumin level and persistent diarrhea.

scholarly journals Association between Serum Magnesium Level with Acute Coronary Syndrome (ACS) in Diabetes Mellitus (DM) Patients

2019 ◽  
Vol 2 (2) ◽  
pp. 96
Author(s):  
Ratih Wulansari ◽  
Soebagijo Adi Soelistijo ◽  
Achmad Lefi
Keyword(s):  
Diabetes Mellitus ◽  
Acute Coronary Syndrome ◽  
Plaque Rupture ◽  
Serum Magnesium ◽  
Demographic Data ◽  
Cardiovascular Complications ◽  
Magnesium Level ◽  
Serum Magnesium Level ◽  
Coronary Syndrome ◽  
Normally Distributed

Introduction: Until now, cardiovascular complications are still the highest cause of death and disability in DM patients. Hypomagnesemia in DM accelerate atherosclerosis and can cause instability and plaque rupture which can lead to acute coronary syndrome.Methods: Design of this study was observational analytic using a "case control" study involved 76 samples of DM patients, consisting of 38 samples with SKA (+) and 38 samples with SKA (-). Subjects of this study were all DM patients in the period July-December 2018 in the Emergency Room (ER) and Outpatient Installation of Endocrine at the RSUD Dr. Soetomo Surabaya, which fulfills the criteria for inclusion and exclusion. Demographic data and clinical characteristics are presented descriptively. If data is normally distributed then an unpaired t test is carried out and if the data is not normally, distributed with Mann Whitney test is performed. The statistical test was stated to be significant if p <0.05. The association between hypomagnesemia and the incidence of ACS a multivariate logistic regression test was performed, the risk number was in the form of odds ratios (OR). Results: This study involved 76 subjects with diabetes mellitus with SKA and non SKA 38 subjects. The mean serum magnesium level in the ACS group was lower than non ACS (1.9 mg / dL vs. 2.1 mg / dL), hypomagnesemia cut-off of <2.08 mg / dL. In this study hypomagnesemia as a risk factor for the incidence of ACS in DM patients with OR 2.8 (CI 1.1-7.6; p = 0.039).Conclusion: Magnesium levels in the ACS group were lower than the non ACS group. Hypomagnesemia Increase The Incidence of Acute Coronary Syndrome in Diabetes Mellitus Patients.

ASSOCIATION OF SERUM MAGNESIUM LEVEL WITH RESISTANT HYPERLIPIDEMIA IN DIABETIC AND HYPERTENSIVE PATIENTS

2021 ◽  
pp. 33-35
Author(s):  
Manish Kumar ◽  
Syed Yousuf Faisal ◽  
Sudhir Chandra Jha ◽  
Debarshi Jana
Keyword(s):  
Serum Magnesium ◽  
Cross Sectional Study ◽  
Magnesium Level ◽  
Lipid Lowering ◽  
Diabetic Patients ◽  
Serum Magnesium Level ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Present Cross Sectional Study ◽  
Lipid Lowering Agents

Introduction: Both diabetes mellitus and hypertension are aspects of metabolic syndrome. Objectives: The aim of this study was to determine the relationship between serum magnesium level with resistant hyperlipidemia in a group of diabetic and hypertensive patients. Patients And Methods: The present cross- sectional study was carried out on 90 hypertensive and diabetic patients in Medicine Department of DMCH, Laheriasarai, Bihar, (45 hypertensive and 45 diabetic patients). Included patients had high triglyceride levels despite 8 weeks of treatment with lipid-lowering agents. Results: There was an inverse signicant relationship between serum magnesium and triglyceride levels in diabetic patients (P=0.002, r=-0.458), however, this correlation was not signicant in hypertensive patients (P=0.754, r=0.048). Conclusion: This study showed, serum magnesium may affect triglycerides levels in diabetic patients, however, our nding requires further investigation with larger population

Sign in / Sign up

Export Citation Format

Share Document