373 Historical Use of Substances for Insomnia Impacts Current Beliefs about Hypnotic Medications

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A148-A149
Author(s):  
Jessica Dietch ◽  
Norah Simpson ◽  
Joshua Tutek ◽  
Isabelle Tully ◽  
Elizabeth Rangel ◽  
...  
Keyword(s):  
Prescription Medication ◽  
Stepped Care ◽  
Future Research ◽  
Prescription Medications ◽  
Over The Counter ◽  
Multiple Treatment ◽  
History Of ◽  
Study Participants ◽  
Beliefs About Medications ◽  
The Impact

Abstract Introduction The purpose of the current study was to examine the relationship between current beliefs about hypnotic medications and historical use of prescription hypnotic medications or non-prescription substances for sleep (i.e., over the counter [OTC] medications, alcohol, and cannabis). Methods Participants were 142 middle age and older adults with insomnia (M age = 62.9 [SD = 8.1]; 71.1% female) enrolled in the RCT of the Effectiveness of Stepped-Care Sleep Therapy In General Practice (RESTING) study. Participants reported on history of substances they have tried for insomnia and completed the Beliefs about Medications Questionnaire-Specific with two subscales assessing beliefs about 1) the necessity for hypnotics, and 2) concerns about potential adverse consequences of hypnotics. Participants were grouped based on whether they had used no substances for sleep (No Subs, 11.6%), only prescription medications (Rx Only, 9.5%), only non-prescription substances (NonRx Only, 26.6%), or both prescription and non-prescription substances (Both, 52.3%). Results Sixty-one percent of the sample had used prescription medication for sleep and 79% had used non-prescription substances (74% OTC medication, 23% alcohol, 34% cannabis). The greater number of historical substances endorsed, the stronger the beliefs about necessity of hypnotics, F(1,140)=23.3, p<.001, but not about concerns. Substance groups differed significantly on necessity beliefs, F(3,1)=10.68, p<.001; post-hocs revealed the Both group had stronger beliefs than the No and NonRx Only groups. Substance groups also differed significantly on the concerns subscale, F(3,1)=6.68, p<.001; post-hocs revealed the NonRx Only group had stronger harm beliefs than the other three groups. Conclusion The majority of the sample had used both prescription and non-prescription substances to treat insomnia. Historical use of substances for treating insomnia was associated with current beliefs about hypnotics. Individuals who had used both prescription and non-prescription substances for sleep in the past had stronger beliefs about needing hypnotics to sleep at present, which may reflect a pattern of multiple treatment failures. Individuals who had only tried non-prescription substances for sleep may have specifically sought alternative substances due to concerns about using hypnotics. Future research should seek to understand the impact of treatment history on engagement in and benefit from non-medication-based treatment for insomnia. Support (if any) 1R01AG057500; 2T32MH019938-26A1

scholarly journals How the Lifestyle Leaders View and Manage Medications

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 611-612
Author(s):  
Taylor Patskanick ◽  
Julie Miller
Keyword(s):  
Side Effects ◽  
Medication Management ◽  
Healthcare Providers ◽  
Prescription Medication ◽  
The Internet ◽  
Prescription Medications ◽  
Over The Counter ◽  
Attitudes And Behaviors ◽  
The Past ◽  
Drug Companies

Abstract Medication management is an ongoing consideration for adults ages 85 and older, their caregivers, and healthcare providers. When asked about their attitudes and behaviors regarding medication management, over 73% of the Lifestyle Leaders reported taking 3+ prescription medications daily and managing their own medication regimes. 61.9% of participants had taken over-the-counter, non-prescription medication for pain over the past five years. When asked why some participants didn’t currently take prescription medications to manage pain, the most frequently-reported responses were: “I don’t feel that my pain warrants a prescription medication,” (19%, n=8), “I don’t want to deal with the side effects,” and “I don’t trust drug companies,” (9.5%, n=4, respectively). The Lifestyle Leaders reported they would be most likely to go to the internet (over their local pharmacist) to ask for advice about their medication(s). Meanwhile, 39% of Lifestyle Leaders would trust a robot to manage their medication(s) for them.

RYR1-related rhabdomyolysis: a spectrum of hypermetabolic states due to ryanodine receptor dysfunction

2021 ◽  
Vol 27 ◽  
Author(s):  
Nick Kruijt ◽  
Luuk Van den Bersselaar ◽  
Marc Snoeck ◽  
Kees Kramers ◽  
Sheila Riazi ◽  
...  
Keyword(s):  
Genetic Susceptibility ◽  
Ryanodine Receptor ◽  
Illicit Drugs ◽  
Positive Family History ◽  
Prescription Medication ◽  
Future Research ◽  
Wide Range ◽  
Recurrent Rhabdomyolysis ◽  
History Of ◽  
Medical Disciplines

: Variants in the ryanodine receptor-1 gene (RYR1) have been associated with a wide range of neuromuscular conditions, including various congenital myopathies and malignant hyperthermia (MH). More recently, a number of RYR1 variants, mostly MH-associated, have been demonstrated to contribute to rhabdomyolysis events not directly related to anesthesia in otherwise healthy individuals. This review focuses on RYR1-related rhabdomyolysis, in the context of several clinical presentations (i.e., exertional rhabdomyolysis, exertional heat illnesses and MH), and conditions involving a similar hypermetabolic state, in which RYR1 variants may be present (i.e., neuroleptic malignant syndrome and serotonin syndrome). The variety of triggers that can evoke rhabdomyolysis, on their own or in combination, as well as the number of potentially associated complications, illustrates that this is a condition relevant to several medical disciplines. External triggers include but are not limited to strenuous physical exercise, especially if unaccustomed or performed under challenging environmental conditions (e.g., high ambient temperature or humidity), alcohol/illicit drugs, prescription medication (in particular statins, other anti-lipid agents, antipsychotics and antidepressants) infection, or heat. Amongst all patients presenting with rhabdomyolysis, a genetic susceptibility is present in a proportion, with RYR1 being one of the most common genetic causes. Clinical clues for a genetic susceptibility include recurrent rhabdomyolysis, creatine kinase (CK) levels above 50 times the upper limit of normal, hyperCKemia lasting for 8 weeks or longer, drug/medication doses insufficient to explain the rhabdomyolysis event, and a positive family history. For the treatment or prevention of RYR1-related rhabdomyolysis, the RYR1 antagonist dantrolene can be administered, both in the acute phase, or prophylactically in patients with a history of muscle cramps and/or recurrent rhabdomyolysis events. Aside from dantrolene, several other drugs are being investigated for their potential therapeutic use in RYR1-related disorders. These findings offer further therapeutic perspectives for humans, suggesting an important area for future research.

Sharing Prescription Medication Among Teenage Girls: Potential Danger to Unplanned/Undiagnosed Pregnancies

PEDIATRICS ◽  
2003 ◽  
Vol 111 (Supplement_1) ◽  
pp. 1167-1170 ◽  
Author(s):  
Katherine Lyon Daniel ◽  
Margaret A. Honein ◽  
Cynthia A. Moore
Keyword(s):  
Children And Adolescents ◽  
Mail Survey ◽  
Basic Research ◽  
Prescription Medication ◽  
Prescription Medications ◽  
Health Issues ◽  
Teenage Girls ◽  
History Of ◽  
Special Concern ◽  
Media Preferences

Objective. The objective of this study was to determine how often children and adolescents share prescription medications and, because of teratogenic concerns, assess specific reasons why girls might engage in medication-sharing behaviors. Methods. Data were collected as part of Youthstyles, a mail survey of children and adolescents 9 through 18 years of age (764 girls and 804 boys) about health issues, attitudinal variables, and media preferences. Information collected by the survey included the respondent’s history of borrowing or sharing prescription medications, the frequency with which sharing occurred, the reasons why medications might be borrowed or shared, and who influences their decisions to borrow or share medication. Results. A total of 20.1% of girls and 13.4% of boys reported ever borrowing or sharing medications. Of the girls surveyed, 15.7% reported borrowing prescription medications from others, and 14.5% reported sharing their prescription medication with someone else. The reported likelihood of sharing increased with age. Medication sharing or borrowing was not a “one time only” emergency use for many: 7.3% of girls 15 through 18 years of age had shared medications >3 times. Reasons that girls gave for why they would share medications included having a prescription for the same medicine (40.2%), getting the medication from a family member (33.4%), having the same problem as the person who had the medication (29%), or wanting something strong for pimples or oily skin (10.5%). Conclusions. Medication sharing is relatively common among children and adolescents and is more common among girls than boys. An adolescent who receives a medication via sharing does not receive the appropriate information about its actions and possible negative interactions with other medications or any other associated risks. Sharing potentially teratogenic drugs is of special concern. Many barriers exist to communicating the risk about teratogenic drugs to women and girls, particularly if they are not planning a pregnancy or are unaware that they are already pregnant. These findings suggest the need for basic research on issues related to the dangers of medication sharing and teratogenic risks, as well as the development of successful approaches to communicate these risks.

scholarly journals The Efficacy of Ethnic Stacking: Military Defection during Uprisings in Africa

2019 ◽  
Vol 5 (4) ◽  
pp. 695-702 ◽  
Author(s):  
Julien Morency-Laflamme ◽  
Theodore McLauchlin
Keyword(s):  
Large Scale ◽  
Armed Forces ◽  
Future Research ◽  
Group Loyalty ◽  
Limited Support ◽  
History Of ◽  
Group Members ◽  
Using Data ◽  
The Cost ◽  
The Impact

Abstract Does ethnic stacking in the armed forces help prevent military defection? Recent research, particularly in Africa and the Middle East, suggests so; by favoring in-groups, regimes can keep in-group soldiers loyal. In-group loyalty comes at the cost of antagonizing members of out-groups, but many regimes gladly run that risk. In this research note, we provide the first large-scale evidence on the impact of ethnic stacking on the incidence of military defection during uprisings from below, using data on fifty-seven popular uprisings in Africa since formal independence. We find clear evidence for the downside: ethnic stacking is associated with more frequent defection if out-group members are still dominant in the armed forces. We find more limited support for the hypothesized payoff. Ethnic stacking may reduce the risk of defection, but only in regimes without a recent history of coup attempts. Future research should therefore trace the solidification of ethnic stacking over time.

scholarly journals Impact of Beef and Beef Product Intake on Cognition in Children and Young Adults: A Systematic Review

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1797
Author(s):  
Ruopeng An ◽  
Sharon M Nickols-Richardson ◽  
Naiman Khan ◽  
Jianxiu Liu ◽  
Ruidong Liu ◽  
...  
Keyword(s):  
Young Adults ◽  
Cognitive Abilities ◽  
Primary Source ◽  
Bibliographic Databases ◽  
Future Research ◽  
Republic Of The Congo ◽  
Children And Young Adults ◽  
Study Participants ◽  
Feeding Control ◽  
The Impact

(1) Background: Undernutrition and micronutrient deficiency have been consistently linked to cognitive impairment among children and young adults. As a primary source of dietary animal protein, beef consumption holds the potential to improve diet quality and positively influence cognitive function. This study systematically reviewed evidence linking beef intake to cognition among children and young adults. (2) Methods: A literature search was conducted in seven electronic bibliographic databases for studies assessing the impact of beef consumption on cognition. (3) Results: We identified eight studies reporting results from five unique interventions. Two interventions were conducted in Kenya, two in the U.S. and one in four countries including Guatemala, Pakistan, Democratic Republic of the Congo and Zambia. Only one intervention employed a non-feeding control arm and found beef consumption to improve cognitive abilities compared to the control. However, the other interventions comparing beef consumption to other food types found no consistent result. (4) Conclusions: Evidence pertaining to the impact of beef consumption on cognition remains limited due to the small and heterogeneous set of studies. Future research should adopt a population representative sample and longer follow-up period, employ a non-feeding control arm and comprehensively measure nutrient intakes among study participants.

Winning and Losing in Federal Sector Dispute Resolution

1994 ◽  
Vol 23 (2) ◽  
pp. 301-319 ◽  
Author(s):  
Charles G. Smith
Keyword(s):  
Dispute Resolution ◽  
Federal Agencies ◽  
Background Information ◽  
Future Research ◽  
Federal Sector ◽  
Final Offer ◽  
Labor Agreement ◽  
History Of ◽  
The Impact ◽  
Do So

This paper examines the binding decisions of the Federal Service Impasses Panel. (Panel) The Panel has the authority to mediate and ultimately decide the terms of a labor agreement should the federal agencies and labor unions be unable to do so bilaterally. This paper presents descriptive data on who wins and who loses with the Federal Service Impasses Panel. Background information on the history of dispute resolution machinery in the federal government is outlined. The data was collected from a content analysis of 307 of 311 binding cases decided by the Panel from 1/79 through 7/87. The paper chronicles the types of procedures used by the Panel, the nature of issues at impasse and who wins. Also, the number and types of arguments used by the parties in support of their respective positions with the Panel are examined. A number of conclusions are drawn from the analysis. (1) The Panel uses a number of different types of dispute machinery including conventional and final offer procedures. (2) Management won almost sixty percent of all issues brought before the Panel (3) Labor and management tend to use a variety of different arguments to support their positions. (4) Neither labor nor management appeared very interested in the impact of their proposals on the general public. Future research may wish to investigate the specific reasons for management success.

Genealogy and Governmentality

2008 ◽  
Vol 2 (3) ◽  
pp. 363-396 ◽  
Author(s):  
Thomas Biebricher
Keyword(s):  
Final Section ◽  
Historical Narrative ◽  
Future Research ◽  
Historical Contingency ◽  
Measuring Device ◽  
Future Research Agenda ◽  
History Of ◽  
Governmentality Studies ◽  
The Impact

AbstractThe essay aims at an assessment of whether and to what extent the history of governmentality can be considered to be a genealogy. To this effect a generic account of core tenets of Foucauldian genealogy is developed. The three core tenets highlighted are (1) a radically contingent view of history that is (2) expressed in a distinct style and (3) highlights the impact of power on this history. After a brief discussion of the concept of governmentality and a descriptive summary of its history, this generic account is used as a measuring device to be applied to the history of governmentality. While both, the concept of governmentality and also its history retain certain links to genealogical precepts, my overall conclusion is that particularly the history of governmentality (and not necessarily Foucault's more programmatic statements about it) departs from these precepts in significant ways. Not only is there a notable difference in style that cannot be accounted for entirely by the fact that this history is produced in the medium of lectures. Aside from a rather abstract consideration of the importance of societal struggles, revolts and other forms of resistance, there is also little reference to the role of these phenomena in the concrete dynamics of governmental shifts that are depicted in the historical narrative. Finally, in contrast to the historical contingency espoused by genealogy and the programmatic statements about governmentality, the actual history of the latter can be plausibly, albeit unsympathetically, read in a rather teleological fashion according to which the transformations of governmentality amount to the unfolding of an initially implicit notion of governing that is subsequently realised in ever more consistent ways. In the final section of the essay I turn towards the field of governmentality studies, arguing that some of the more problematic tendencies in this research tradition can be traced back to Foucault's own account. In particular, the monolithic conceptualisation of governmentality and the implicit presentism of an excessive focus on Neoliberalism found in many of the studies in governmentality can be linked back to problems in Foucault's own history of governmenality. The paper concludes with suggestions for a future research agenda for the governmentality studies that point beyond Foucault's own account and its respective limitations.

scholarly journals A Medication Synchronization Program and Blood Pressure Levels in a Community Pharmacy: Protocol (Preprint)

2018 ◽  
Author(s):  
Anthony Pattin ◽  
Rebekah L Panak ◽  
Rebecca Hunold ◽  
Abagail Kirwen ◽  
Samantha R Minnich ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Health Outcomes ◽  
Cardiovascular Complications ◽  
Care Group ◽  
Prescription Medications ◽  
Improve Medication Adherence ◽  
Antihypertensive Medications ◽  
History Of ◽  
The Impact

BACKGROUND The lack of adherence to prescribed antihypertensive medication occurs in 50% of patients and leads to poor health outcomes and increased medical costs. Consistent use of antihypertensive medications among patients with hypertension is essential to the reduction of short- and long-term cardiovascular complications. Strategies to improve medication adherence include syncing prescription medications in the pharmacy, which allow patients to retrieve chronically prescribed medications in one visit. The adoption of medication synchronization has been shown to improve adherence to medications; however, there is a lack of data showing if the intervention reduces blood pressure and improves long-term health outcomes. OBJECTIVE This study aims to determine the association between participation in an appointment-based medication synchronization service and blood pressure levels among patients on antihypertensive medications. METHODS This longitudinal prospective cohort study will observe changes in blood pressure among individuals in a medication synchronization program and those in a usual care group. Patients on at least two antihypertensive medications and four total medications have been recruited to participate in the study. All participants will be required to have at least a 6-month history of filling prescriptions at the pharmacy prior to enrollment in the study. Based on an estimated standard deviation of 14 mmHg, a sample size of 70 participants provides approximately 80% power with a two-sided .05 significance to detect a difference of 9 mmHg blood pressure between the two cohorts. RESULTS As of the publication of this paper, patients are completing final blood pressure visits at the pharmacy and medication data are being collected from the pharmacy. Once patients complete all blood pressure visits, data analysis will begin. CONCLUSIONS This study will link medication synchronization and changes in blood pressure levels among individuals with hypertension. This study will provide preliminary data for a randomized clinical trial that will assess the impact of medication synchronization on blood pressure. INTERNATIONAL REGISTERED REPOR DERR1-10.2196/12527

The Impact of Changing Norms on Creativity in Psychological Science

2018 ◽  
Vol 13 (4) ◽  
pp. 466-472 ◽  
Author(s):  
Jonathan Wai ◽  
Diane F. Halpern
Keyword(s):  
Policy Change ◽  
Open Science ◽  
Academic Science ◽  
Future Research ◽  
Scientific Advance ◽  
Psychological Science ◽  
History Of ◽  
New Policies ◽  
The Impact

The open science or credibility revolution has divided psychologists on whether and how the “policy” change of preregistration and similar requirements will affect the quality and creativity of future research. We provide a brief history of how norms have rapidly changed and how news and social media are beginning to “disrupt” academic science. We note a variety of benefits, including more confidence in research findings, but there are possible costs as well, including a reduction in the number of studies conducted because of an increased workload required by new policies. We begin to craft a study to evaluate the short- and long-term impacts of these changing norms on creativity in psychological science, run into some possible roadblocks, and hope others will build on this idea. This policy change can be evaluated in the short term but will ultimately need to be evaluated decades from now. Long-term evaluations are rare, yet this is the ultimate measure of creative scientific advance. Our conclusion supports the goals and procedures for creating a more open science.

Irritability, disruptive mood, and ADHD

2018 ◽  
Author(s):  
Melissa Mulraney ◽  
Argyris Stringaris ◽  
Eric Taylor
Keyword(s):  
Future Research ◽  
Children With Adhd ◽  
Disruptive Mood Dysregulation Disorder ◽  
History Of ◽  
Practical Guidance ◽  
The Impact ◽  
Mood Dysregulation

The chapter ‘Irritability, disruptive mood, and ADHD’ provides an overview of what is known about irritability and disruptive mood dysregulation disorder (DMDD) in children with ADHD. It provides practical guidance for the assessment and management of severe irritability in children with ADHD. The chapter begins by discussing the importance of irritability as a construct, the history of DMDD, and how to measure irritability. It then reviews the literature regarding irritability and mood dysregulation in ADHD and discusses reasons for the overlap between irritability and ADHD. The chapter also reviews what is known about the impact of treatments on irritability in children with ADHD before concluding with suggestions for future research.

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