scholarly journals Effects of Ethanol Extract of Gastrodia elata Blume on High‐Fructose induced Metabolic syndrome

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Min Chul Kho ◽  
Yoon Jung Lee ◽  
You Mee Ahn ◽  
Yoon Hee Choi ◽  
A Young Kim ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Ethanol Extract ◽  
Gastrodia Elata ◽  
Gastrodia Elata Blume ◽  
High Fructose

scholarly journals Gastrodia elataAmeliorates High-Fructose Diet-Induced Lipid Metabolism and Endothelial Dysfunction

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Min Chul Kho ◽  
Yun Jung Lee ◽  
Jeong Dan Cha ◽  
Kyung Min Choi ◽  
Dae Gill Kang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Endothelial Dysfunction ◽  
Glucose Tolerance ◽  
Ethanol Extract ◽  
Oral Glucose ◽  
Gastrodia Elata ◽  
High Fructose ◽  
Amp Activated Protein Kinase ◽  
Endothelial Nitric Oxide

Overconsumption of fructose results in dyslipidemia, hypertension, and impaired glucose tolerance, which have documented correlation with metabolic syndrome.Gastrodia elata, a widely used traditional herbal medicine, was reported with anti-inflammatory and antidiabetes activities. Thus, this study examined whether ethanol extract ofGastrodia elataBlume (EGB) attenuate lipid metabolism and endothelial dysfunction in a high-fructose (HF) diet animal model. Rats were fed the 65% HF diet with/without EGB 100 mg/kg/day for 8 weeks. Treatment with EGB significantly suppressed the increments of epididymal fat weight, blood pressure, plasma triglyceride, total cholesterol levels, and oral glucose tolerance, respectively. In addition, EGB markedly prevented increase of adipocyte size and hepatic accumulation of triglycerides. EGB ameliorated endothelial dysfunction by downregulation of endothelin-1 (ET-1) and adhesion molecules in the aorta. Moreover, EGB significantly recovered the impairment of vasorelaxation to acetylcholine and levels of endothelial nitric oxide synthase (eNOS) expression and induced markedly upregulation of phosphorylation AMP-activated protein kinase (AMPK)αin the liver, muscle, and fat. These results indicate that EGB ameliorates dyslipidemia, hypertension, and insulin resistance as well as impaired vascular endothelial function in HF diet rats. Taken together, EGB may be a beneficial therapeutic approach for metabolic syndrome.

scholarly journals Malus toringoides (Rehd.) Hughes Improves Metabolic Syndrome and Liver Injury in High-Fructose-Induced Mice

2020 ◽  
Author(s):  
Xiang Hua Quan ◽  
Qie Guo ◽  
Xiang-Peng Li ◽  
Yu Liang ◽  
Meng-Na Cui ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Liver Injury ◽  
Glucose Tolerance ◽  
Lipid Accumulation ◽  
Liver Lipid ◽  
Ethanol Extract ◽  
Edible Plant ◽  
Apo B ◽  
High Fructose

Abstract Background: Malus toringoides (Rehd.) Hughes, as a traditional medicinal and edible plant used in Tibet, China, is used to treat hypertension, hyperlipemia and liver diseases. This present study was designed to investigate the effects of ethanol extract of M. toringoides (EMT) on metabolic syndrome (MS) and liver injury in high-fructose-induced mice. Methods: The C57BL/6J male mice were divided into five groups (n=8). Con group was drunk with standard water, Fru group and the other three with 30% high-fructose water for 8 weeks. EMT (195 mg/kg, 390 mg/kg, 780 mg/kg) was administered to each of high fructose groups simultaneously. Glucose tolerance tests (GTT) were performed. Blood samples were collected from eyeball. The mice were euthanized. Liver and epididymal fat were weighed. The palmitic acid (PA)-induced HepG2 cells were used to evaluate the protective effect of EMT on liver lipid accumulation. Results: The administration of EMT is helpful to maintain near normal body weight, blood glucose, insulin, organ index, glucose tolerance, and serum levels of TC, TG, LDL-C, HDL-C, Apo-B, and Apo-A1 (P < 0.05 or P < 0.01). EMT treatment significantly improved liver injury by the down-regulation of liver lipid accumulation, oxidative stress and inflammatory mediators in high-fructose-induced mice (P < 0.05 or P < 0.01). In vitro, EMT (25 µg/mL-200 µg/mL) significantly decreased lipid droplet accumulation and TG content in PA-induced HepG2 (P < 0.05 or P < 0.01).Conclusion: EMT can obviously improve high fructose-induced MS in mice. In vitro, EMT can inhibit PA-induced lipid accumulation in HepG2 cells.which may emphasizes the use of M. toringoides supplementation in everyday life of over-weighted persons and opens perspectives for clinical trials.

scholarly journals Recent Developments in Rodent Models of High-Fructose Diet-Induced Metabolic Syndrome: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2497
Author(s):  
Alvin Man Lung Chan ◽  
Angela Min Hwei Ng ◽  
Mohd Heikal Mohd Yunus ◽  
Ruszymah Bt Hj Idrus ◽  
Jia Xian Law ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Animal Studies ◽  
18Th Century ◽  
Disease Model ◽  
Hepatic Function ◽  
Chronic Illnesses ◽  
Paradigm Shifts ◽  
Response Factors ◽  
High Fructose ◽  
Recent Developments

Metabolic syndrome (MetS) is the physiological clustering of hypertension, hyperglycemia, hyperinsulinemia, dyslipidemia, and insulin resistance. The MetS-related chronic illnesses encompass obesity, the cardiovascular system, renal operation, hepatic function, oncology, and mortality. To perform pre-clinical research, it is imperative that these symptoms be successfully induced and optimized in lower taxonomy. Therefore, novel and future applications for a disease model, if proven valid, can be extrapolated to humans. MetS model establishment is evaluated based on the significance of selected test parameters, paradigm shifts from new discoveries, and the accessibility of the latest technology or advanced methodologies. Ultimately, the outcome of animal studies should be advantageous for human clinical trials and solidify their position in advanced medicine for clinicians to treat and adapt to serious or specific medical situations. Rodents (Rattus norvegicus and Mus musculus) have been ideal models for mammalian studies since the 18th century and have been mapped extensively. This review compiles and compares studies published in the past five years between the multitude of rodent comparative models. The response factors, niche parameters, and replicability of diet protocols are also compiled and analyzed to offer insight into MetS-related disease-specific modelling.

The analysis of surface saccharide profiles through fluorescein-labelled lectins in a rat pancreatic tissue with established metabolic syndrome model

2018 ◽  
Vol 44 (1) ◽  
pp. 98-104
Author(s):  
Yosun Mater ◽  
Sule Beyhan-Ozdas
Keyword(s):  
Metabolic Syndrome ◽  
Metabolic Diseases ◽  
Pancreatic Tissue ◽  
Control Group ◽  
High Fructose Diet ◽  
Tissue Sections ◽  
Membrane Surfaces ◽  
High Fructose ◽  
A Cell ◽  
And Control

Abstract“Glycans”, which are generally referred as oligosaccharides and polysaccharides, are structures that are present on all cellular surfaces with proteins and lipids being attached to their basic chain structures. Many studies in the field of glycobiology have identified the various and complicated biological roles of these glycans which make them perfect molecules to use in labelling and selecting body cells specifically. This study aims at analyzing the modifications in saccharide units of glycans on a cell membrane surfaces of the pancreatic tissue of rats to which normal and metabolic syndrome (MetS) are established. To this end, a MetS model was created through a high fructose diet in Spraque Dawley breed of rats and the pancreatic tissue sections of the group with MetS and control group animals were evaluated comparatively. The targeted saccharide units were examined with Fluorescent Microscope by using two different Fluorescein (FITC) labelled lectins, namely Maackia amurensis-1 lectin [FITC-(MAL-I)] and the Wheat Germ Agglutinin (FITC-WGA). It was observed that FITC-MAL-1-labelled Galβ4GlcNAc units did not change much due to high- fructose diet. On the other hand, more GlcNAc, Neu5Ac and β-GlcNAc units which are labelled with FITC-WGA lectin increase in numbers in pancreatic sections of high fructose diet, compared to control group. Thus, a rapid and specific labelling method, which can identify surface saccharide sequences specifically, was developed. The method can be used in early diagnosis and/or treatment for metabolic diseases.

Protective effect of thymoquinone against high-fructose diet-induced metabolic syndrome in rats

2014 ◽  
Vol 54 (7) ◽  
pp. 1117-1127 ◽  
Author(s):  
Pankaj Prabhakar ◽  
K. H. Reeta ◽  
S. K. Maulik ◽  
A. K. Dinda ◽  
Y. K. Gupta
Keyword(s):  
Metabolic Syndrome ◽  
Protective Effect ◽  
High Fructose Diet ◽  
High Fructose
Sign in / Sign up

Export Citation Format

Share Document