THE EFFECTS OF NICOTINIC ACID ON BLOOD LIPIDS IN PATIENTS WITH LOW HDL-CHOLESTEROL AND NORMAL TOTAL CHOLESTEROL LEVELS

Experimental studies have suggested that tea consumption could lower the risk of dyslipidaemia. However, epidemiological evidence is limited, especially in southern China, where oolong tea is the most widely consumed beverage. We conducted a population-based case–control study to evaluate the association between consumption of tea, especially oolong tea, and risk of dyslipidaemia in Shantou, southern China, from 2010 to 2011. Information on tea consumption, lifestyle characteristics and food consumption frequency of 1651 patients with newly diagnosed dyslipidaemia and 1390 controls was obtained using a semi-quantitative questionnaire. Anthropometric variables and serum biochemical indices were determined. Drinking more than 600 ml (2 paos) of green, oolong or black tea daily was found to be associated with the lowest odds of dyslipidaemia risk (P< 0·001) when compared with non-consumption, but only oolong tea consumption was found to be associated with low HDL-cholesterol levels. A dose–response relationship between duration of tea consumption and risk of dyslipidaemia (OR 0·10, 95 % CI 0·06, 0·16), as well as that between amount of dried tea leaves brewed and risk of dyslipidaemia (OR 0·34, 95 % CI 0·24, 0·48), was found. Moreover, consumption of oolong tea for the longest duration was found to be associated with 3·22, 11·99 and 6·69 % lower blood total cholesterol, TAG and LDL-cholesterol levels, respectively. In conclusion, the present study indicates that long-term oolong tea consumption may be associated with a lower risk of dyslipidaemia in the population of Shantou in southern China.

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Altered atherosclerotic-related gene expression signature in circulating mononuclear leukocytes from hypercholesterolemic patients with low HDL cholesterol levels

International Journal of Cardiology ◽

10.1016/j.ijcard.2014.03.042 ◽

2014 ◽

Vol 173 (2) ◽

pp. 337-338 ◽

Cited By ~ 4

Author(s):

D. de Gonzalo-Calvo ◽

V. Llorente-Cortés ◽

J. Orbe ◽

J.A. Páramo ◽

L. Badimon

Keyword(s):

Gene Expression ◽

Gene Expression Signature ◽

Hdl Cholesterol ◽

Mononuclear Leukocytes ◽

Related Gene ◽

Expression Signature ◽

Cholesterol Levels ◽

Low Hdl

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Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

New England Journal of Medicine ◽

10.1056/nejmoa1107579 ◽

2011 ◽

Vol 365 (24) ◽

pp. 2255-2267 ◽

Cited By ~ 1786

Author(s):

Keyword(s):

Statin Therapy ◽

Hdl Cholesterol ◽

Cholesterol Levels ◽

Low Hdl ◽

Intensive Statin Therapy

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Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia

British Journal Of Nutrition ◽

10.1079/bjn2001395 ◽

2001 ◽

Vol 86 (2) ◽

pp. 233-239 ◽

Cited By ~ 84

Author(s):

Robert Volpe ◽

Leena Niittynen ◽

Riitta Korpela ◽

Cesare Sirtori ◽

Antonello Bucci ◽

...

Keyword(s):

Total Cholesterol ◽

Serum Lipids ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Plant Sterols ◽

Dependent Manner ◽

Low Fat ◽

Treatment Groups ◽

Cholesterol Levels ◽

Dose Dependent

The objective of the present study was to assess the effect of consumption of a yoghurt-based drink enriched with 1–2 g plant sterols/d on serum lipids, transaminases, vitamins and hormone status in patients with primary moderate hypercholesterolaemia. Thirty patients were randomly assigned to one of two treatment groups: a low-fat low-lactose yoghurt-based drink enriched with 1 g plant sterol extracted from soyabean/dv.a low-fat low-lactose yoghurt, for a period of 4 weeks. After a 2-week wash-out period, patients were crossed over for an additional 4-week period. Second, after a 4-week wash-out period, eleven patients were treated with 2 g plant sterols/d in a second open part of the study for a period of 8 weeks. The yoghurt enriched with plant sterols significantly reduced, in a dose-dependent manner, serum total cholesterol and LDL-cholesterol levels and LDL-cholesterol:HDL-cholesterol (P<0·001), whereas no changes were observed in HDL-cholesterol and triacylglycerol levels, either in the first or the second part of the study. There were only slight, not statistically significant, differences in serum transaminase, vitamin and hormone levels. To conclude, a low-fat yoghurt-based drink moderately enriched with plant sterols may lower total cholesterol and LDL-cholesterol effectively in patients with primary moderate hypercholesterolaemia.

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Effects of Red Pitaya (Hylocereus polyrhizus) on Lipid Profile of Male White Rats (Rattus norvegicus) Receiving High Fat Diet

Folia Medica Indonesiana ◽

10.20473/fmi.v54i1.8046 ◽

2018 ◽

Vol 54 (1) ◽

pp. 16 ◽

Cited By ~ 1

Author(s):

Wiwik Werdiningsih ◽

Suhartati Suhartati

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Fruit Peel ◽

Cholesterol Levels ◽

White Rats ◽

Wistar Strain ◽

Dragon Fruit ◽

Pap Method

Red dragon fruit (Hylocereus polyrhizus) peel contains anthocyanin, fiber and vitamin C, so it can be used to improve lipid profile in dyslipidemia. The peel of the dragon fruit is not durable, so in this study we used freeze-dried dragon fruit peel. The aim of this study was to prove that the administration of the red dragon fruit peel in a dose of 0.72 g/200 g BW, 1.08 g/200 g BW, and 1.44 g/200 g BW of rat per day for 28 days may improve lipid profile in male wistar strain white rats with high-fat diet. Lipid profiles were studied by examining of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides. This was a pure experimental study using randomized post test only control group design. This study used experimental animal of 30 male wistar strain white rats which were divided into five groups. Measurements of total, LDL, and HDL cholesterol levels were done by CHOD-PAP method, while triglyceride level was measured with GPO-PAP method. Data were analyzed statistically by One Way Anova test. The results of this study indicated that giving the peel of red dragon fruit as much as 0.72 g lowered total cholesterol levels, 1.08 g lowered total and LDL cholesterol levels, and 1.44 g lowered total cholesterol, LDL cholesterol, triglyceride levels, and raised HDL cholesterol level. Red dragon fruit peel can be used alternatively to improve lipid profile in dyslipidemia.

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High-Density Lipoprotein Cholesterol (HDL-C) Levels Independently Correlates With Cardiac Arrhythmias and Atrial Fibrillation

Journal of Intensive Care Medicine ◽

10.1177/0885066618756265 ◽

2018 ◽

Vol 35 (5) ◽

pp. 438-444 ◽

Cited By ~ 2

Author(s):

Farzin Brian Boudi ◽

Nicholas Kalayeh ◽

Mohammad Reza Movahed

Keyword(s):

Acute Coronary Syndrome ◽

High Density Lipoprotein ◽

Medical Center ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

High Density ◽

St Segment Elevation ◽

Coronary Syndrome ◽

Cholesterol Levels ◽

Low Hdl

Objective: Acute coronary syndrome is frequently complicated by rhythm disturbances, yet any association between high-density lipoprotein (HDL) cholesterol levels and arrhythmias in the setting of non-ST-segment elevation myocardial infarction (non-STEMI) is uncertain. The goal of this study was to evaluate any association between HDL-cholesterol levels and arrhythmias in the setting of non-STEMI. Methods: Retrospective data from Phoenix Veterans Affair Medical Center records were utilized for our study. A total of 6881 patients were found who presented during 2000 to 2003 with non-STEMI with available fasting lipid panels collected within the first 24 hours of admission. Patients were followed for the development of rhythm disturbances up to 6 years after initial presentation, with a mean follow up of 1269 days. Results: We found that high triglycerides/HDL and low-density lipid/HDL ratios were predictive of arrhythmias. However, low HDL levels had strongest association with highest odds ratio (OR) for development of arrhythmias (for HDL <31 mg/dL, OR = 3.72, 95% confidence interval [CI] = 2.55-5.44, P < .05) in patients with diabetes and (for HDL < 31 mg/dL, OR = 3.69, 95% CI = 2.85-4.71, P < .05) in patients without diabetes. Using multivariate analysis adjusting for comorbidities, low HDL level remained independently associated with arrhythmias. Conclusions: Patients with low HDL levels during hospitalization with non-STEMI have a greater risk of developing cardiac rhythm disturbances independent of other risk factors. These data suggest a possible protective role of HDL in preventing arrhythmias in the setting of acute coronary syndrome.

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GLYCEMIC AND LIPIDEIC STATUS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1703723 ◽

2014 ◽

Vol 04 (01) ◽

pp. 009-014

Author(s):

A. Harish Rao

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Total Cholesterol ◽

Ldl Cholesterol ◽

Fasting Glucose ◽

Hdl Cholesterol ◽

Serum Levels ◽

Glucose Levels ◽

Low Hdl ◽

One Year

Abstract: Objective: to know the glycemic and lipidaemic status in patients with acute myocardial infarction, and with the secondary objective to know the effect of age, gender, diabetes, smoking, hypertension on fasting glucose and lipid levels. Methods and materials: The 74 patients admitted for acute myocardial infarction during the study period of one year were analysed for fasting glucose values and serum levels of total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides. Results: The mean serum concentrations of total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol were 233.28±45.34, 139.22±41.71, 171.43±36.53 and 27.07±36.53 respectively. Mean levels of total cholesterol, HDL cholesterol, triglycerides and fasting glucose values were not affected by age, gender, BMI, hypertension and smoking. BMI >30kg/m2 was associated with increased levels of total cholesterol(p=0.013) and LDL cholesterol(p=0.014). Also increase LDL cholesterol was seen in male gender(p=0.04). The prevalence of hypercholesterolemia, hypertriglyceridemia and low HDL cholesterol was 82.4%,77% and 78% respectively. Diabetes had no effect on lipid profile. Conclusion: our study highlighted the prevalence of dyslipidemias associated with myocardial infarction but not significant impact of fasting glucose levels.

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