Diet, blood cholesterol levels, and coronary heart disease

1993 ◽  
Vol 4 (10) ◽  
pp. 871-882 ◽  
Author(s):  
Neil J. Stone
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Blood Cholesterol ◽  
Cholesterol Levels

Treatment with Simvastatin and Low-dose Aspirin Depresses Thrombin Generation in Patients with Coronary Heart Disease and Borderline-high Cholesterol Levels

2001 ◽  
Vol 85 (02) ◽  
pp. 221-225 ◽  
Author(s):  
Anetta Undas ◽  
Robert Undas ◽  
Jan Brożek ◽  
Andrzej Szczeklik ◽  
Jacek Musiał
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Thrombin Generation ◽  
Low Dose ◽  
Ex Vivo ◽  
Blood Cholesterol ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Dose Aspirin ◽  
Low Dose Aspirin

SummaryAspirin and statins are beneficial in coronary heart disease across a broad range of cholesterol levels. We assessed the effects of low-dose aspirin (75 mg daily) on thrombin generation in patients with coronary heart disease and average blood cholesterol levels. We also investigated whether in patients with borderline-high cholesterol level who have been already taking aspirin, additional treatment with simvastatin would affect thrombin generation.Seven-day treatment with low-dose aspirin decreased thrombin generation ex vivo only in patients with total cholesterol 5.2 mmol/L. In patients with higher cholesterol levels aspirin had no effect. In these patients, already taking low-dose aspirin, additional three-month simvastatin treatment resulted in a reduction of thrombin generation. This demonstrates that low-dose aspirin depresses thrombin generation only in subjects with desirable blood cholesterol levels, while in others, with borderline-high cholesterol, thrombin formation is being reduced following the addition of simvastatin.

scholarly journals Cholesterol Screening in Children and Family History of Coronary Heart Disease.

Circulation ◽  
2001 ◽  
Vol 103 (suppl_1) ◽  
pp. 1369-1369
Author(s):  
Viktorina N Muratova ◽  
Syed S Islam ◽  
Emily C Spangler ◽  
Ellen W Demerath ◽  
William A Neal
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Lipid Profile ◽  
School Children ◽  
Preventive Health Care ◽  
Blood Cholesterol ◽  
Cholesterol Screening ◽  
Cholesterol Levels ◽  
History Of

P94 Background: Selective blood cholesterol screening of children based upon National Cholesterol Education Program (NCEP) guidelines of family history of premature cardiovascular disease (CVD) or parental hypercholesterolemia is inadequate in a population with high prevalence of coronary heart disease (CHD), low levels of cholesterol screening, low socio-economic status (SES) and diminished access to preventive health care. We hypothesize that universal cholesterol screening of pre-pubertal school children may be effective in identifying children and their parents with abnormal lipid levels in this high risk rural population. Fifth grade school children from seven rural Appalachian counties participated in a school based cholesterol screening program. Data on family history of premature CHD, anthropometric and blood pressure measurements, tobacco smoke exposure, dietary history and physical activity levels were collected at the time of screening. Seven hundred and nine 5 th grade students ( mean age 10.8 years) participated in the program. One hundred seventy four (24.5%) were considered presumptively dyslipidemic after non-fasting finger- stick (FS) cholesterol screening. Thirty six percent of these dyslipidemic children had a fasting lipid profile done. Dyslipidemia was confirmed in 37(59%) of these children. FS cholesterol levels were significantly correlated with fasting TC (r=0.80 p < 0.0001). Among confirmed dyslipidemic children, family history was not a good predictor of dyslipidemia (sensitivity 21.6%). Seventy nine parents of dyslipidemic children participated in fasting lipid profile assessment. Fifty two parents (67%) were dyslipidemic, most of them (79%) did not have a family history of premature CHD or hypercholesterolemia. FS cholesterol levels were also correlated with fasting TC of fathers (r=0.46 p=0.01), and mothers (r=0.32 p=0.02). Conclusion: Significant correlation exists between non-fasting FS cholesterol levels of children and subsequent fasting lipid profile of children and their parents. Family history has low sensitivity in predicting children with elevated serum cholesterol concentrations.

scholarly journals Faktor resiko kadar kolesterol darah pada pasien rawat jalan penderita jantung koroner di RSUD Meuraxa

2018 ◽  
Vol 3 (2) ◽  
pp. 132
Author(s):  
Nunung Sri Mulyani ◽  
Agus Hendra Al Rahmad ◽  
Raudatul Jannah
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Nutritional Status ◽  
Total Cholesterol ◽  
Significant Relationship ◽  
Coffee Consumption ◽  
Case Control ◽  
Blood Cholesterol ◽  
Chi Square ◽  
Cholesterol Levels

Coronary heart disease generally occurs due to an increase in irregular cholesterol levels. Blood cholesterol is influenced by several factors, including genetic, gender, diet, obesity, and excessive coffee drinking. This study aims to determine the factors that influence blood cholesterol levels in outpatients with coronary heart disease at Meuraxa Regional Hospital. This study is a descriptive-analytical Case Control design, conducted in patients with coronary heart disease as many as 45 cases and 45 controls in May 2017 Data analysis using Chi-Square test. Diet data was collected using food recall, genetic data, sex collected by interview using questionnaires, nutritional status data collected through body mass index (BMI) measurements and cholesterol data collected through blood tests. Bivariate analysis showed a significant relationship between coffee consumption and total cholesterol levels with OR 2.768 (p = 0.033). There was no significant relationship between coffee consumption with HDL, LDL, and triglycerides (0.292; 0.088; 0.125). There was no significant correlation between genetic, gender, diet and nutritional status with levels of total cholesterol, LDL, HDL, and Triglycerides.T here is a significant relationship between coffee consumption and total cholesterol levels in patients with coronary heart disease, so it is necessary to limit coffee consumption for people with coronary heart disease.Penyakit jantung koroner umumnya terjadi karena peningkatan kadar kolesterol yang tidak teratur. Kolesterol darah dipengaruhi oleh beberapa faktor, diantaranya genetik, jenis kelamin, pola makan, obesitas, serta minum kopi yang berlebihan. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi kadar kolesterol darah pada pasien rawat jalan penderita jantung koroner di RSUD Meuraxa. Penelitian deskriptif analitik berdesain Case Control, yang dilakukan pada  pasien penderita jantung koroner sebanyak 45 kasus dan 45 kontrol pada bulan Mei 2017. Analisis data menggunakan uji Chi-Square. Data pola makan dikumpulkan dengan menggunakan food recall, data genetik, jenis kelamin dikumpulkan dengan wawancara menggunakan kuisioner, data status gizi dikumpulkan melalui pengukuran indeks massa tubuh (IMT) dan data kolesterol dikumpulkan melalui pemeriksaan darah. Analisis bivariat  menunjukkan ada hubunganyang signifika konsumsi kopi dengan kadar kolesterol total dengan OR 2,768 (p= 0,033). Tidak ada hubungan yang signifikan konsumsi kopi dengan HDL, LDL dan trigliserida (0,292; 0,088; 0,125). Tidak ada hubungan yang signifikan genetik, jenis kelamin, pola makan dan status gizi dengan kadar kolesterol total, LDL, HDL dan Trgliserida. Ada hubungan yang signifikan konsumsi kopi dengan kadar kolesterol total pada penderita jantung koroner sehingga perlu kiranya pembatasan konsumsi kopi bagi penderita jantung koroner.

CHILDHOOD DIET AND CORONARY HEART DISEASE

PEDIATRICS ◽  
1972 ◽  
Vol 49 (2) ◽  
pp. 305-307
Author(s):  
L. J. Filler ◽  
Lewis A. Barness ◽  
Richard B. Goldbloom ◽  
James C. Haworth ◽  
Malcolm A. Holliday ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Dietary Intervention ◽  
Dietary Habits ◽  
Dietary Cholesterol ◽  
Later Life ◽  
Blood Cholesterol ◽  
Cholesterol Levels ◽  
Childhood Diet ◽  
Special Circumstances

A subcommittee of the Inter-Society Commission for Heart Disease Resources recently recommended an immediate, nationwide change in dietary habits to reduce the risk of coronary heart disease in later life.1 Specifically, the Commission urges that people eat less than 300 mg of cholesterol each day, that the total calories from fat be less than 35% of the diet, and that the fat calories essentially be divided equally among saturated, monounsaturated, and polyunsaturated sources. (A commentary on these recommendations appears in this issue of Pediatrics.2) The Committee on Nutrition, realizing that pediatricians will increasingly be asked about diets for children to reduce the risk of heart disease in later life, has evaluated the Commission's report for its application to pediatric practice. The Committee stresses that such dietary intervention is, at present, experimental and recommends against dietary changes for all children. Dietary intervention may be warranted in special circumstances, but not before 1 year of age. Reasons for these recommendations will be given in this report. The evidence relating dietary cholesterol to coronary heart disease is summarized as follows: 1. Some inborn or acquired diseases with hypercholesterolemia are associated with premature atherosclerosis. 2. Serum cholesterol levels are higher than usual in persons with coronary heart disease. 3. Persons with high cholesterol levels in prospective studies developed coronary heart disease more often than those with normal levels. 4. The mortality rate from coronary heart disease in different countries varies in relation to the average blood cholesterol values (or dietary fat intake). 5. Experimentally induced hypercholesterolemia in animals is associated with atherosclerotic deposits.

Pediatric Preventive Cardiology: Atherosclerosis and Coronary Heart Disease

1988 ◽  
Vol 9 (10) ◽  
pp. 303-314
Author(s):  
William B. Strong ◽  
Barbara A. Dennison
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cholesterol Level ◽  
Disease Risk ◽  
Diet Therapy ◽  
Blood Cholesterol ◽  
Elevated Blood ◽  
Blood Cholesterol Level ◽  
Preventive Cardiology ◽  
Cholesterol Levels

Pediatric preventive cardiology has as one of its goals, the reduction in incidence and severity of cardiovascular disease in adults by the promotion of prudent life-styles in children and adolescents. Few would find fault with this goal, yet the "best" approach and strategy to reduce atherosclerosis and coronary heart disease has been the source of controversy.1-4 The recently published National Institutes of Health Consensus Conference Statement on lowering blood cholesterol to prevent heart disease has summarized the literature relating blood cholesterol and heart disease.5 The strategies recommended include: (1) dietary changes to reduce total dietary fat, saturated fat, and dietary cholesterol consumption in everyone older than 2 years of age, (2) universal blood cholesterol screening for all adults older than 18 years of age, (3) more intensive diet therapy for those with a blood cholesterol level ≥75th percentile, (4) possible addition of drug therapy for individuals whose blood cholesterol levels remain ≥75th percentile despite diet therapy, and (5) in individuals with elevated blood cholesterol levels, emphasis on management of other coronary heart disease risk factors: hypertension, cigarette smoking, diabetes and physical inactivity. The European Atherosclerosis Society has also recently advocated screening the population to find those at high risk (eg, those with an elevated blood cholesterol level in conjunction with population strategies to improve nutrition, eradicate smoking, control hypertension, and promote suitable physical activity.6

Risk Factors for Coronary Artery Disease in Children: Recognition, Evaluation, and Therapy

1980 ◽  
Vol 2 (5) ◽  
pp. 131-138
Author(s):  
C. J. Glueck ◽  
M. J. Mellies ◽  
R. C. Tsang ◽  
J. A. Morrison
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Eating Habits ◽  
Plasma Cholesterol ◽  
Saturated Fat ◽  
Cholesterol Levels ◽  
Chd Risk ◽  
Artery Disease ◽  
Atherosclerosis Prevention

PEDIATRIC GENESIS OF ATHEROSCLEROSIS Atherosclerosis results from a variety of pathophysiologic disturbances, some currently recognized, and many undoubtedly not yet recognized, which in aggregate are identified as risk factors. Genetic and environmental influences conjointly affect the incidence and the severity of these risk factors and, thus, coronary heart disease (CHD) risk. Prophylaxis should be designed to prevent or retard the development of arterial plaques. This suggests that diagnostic and preventive efforts should begin in childhood. Eating habits are also probably established in childhood, allowing their early modification. The atherosclerotic plaque appears to have its genesis in childhood. The data from wartime autopsies confirm the presence of mature atherosclerotic lesions by the end of the second decade and emphasize the importance of primary atherosclerosis prevention beginning in the first and second decades. While there are clearly genetic factors in CHD, variation in rates in differing geographic areas appears less likely to be related to genetic than to environmental differences. Marked differences in plasma cholesterol levels are found in children in different geographic areas, generally paralleling pediatric cholesterol and saturated fat intake and the incidence of adult coronary heart disease. The relationships of elevated total plasma cholesterol levels to the incidence of coronary heart disease are clearly established in adults.

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