scholarly journals Brain Networks Maintain a Scale-free Organization across Consciousness, Anesthesia, and Recovery

2010 ◽  
Vol 113 (5) ◽  
pp. 1081-1091 ◽  
Author(s):  
UnCheol Lee ◽  
GabJin Oh ◽  
Seunghwan Kim ◽  
GyuJung Noh ◽  
ByungMoon Choi ◽  
...  

Background Loss of consciousness is an essential feature of general anesthesia. Although alterations of neural networks during anesthesia have been identified in the spatial domain, there has been relatively little study of temporal organization. Methods Ten healthy male volunteers were anesthetized with an induction dose of propofol on two separate occasions. The duration of network connections in the brain was analyzed by multichannel electroencephalography and the minimum spanning tree method. Entropy of the connections was calculated based on Shannon entropy. The global temporal configuration of networks was investigated by constructing the cumulative distribution function of connection times in different frequency bands and different states of consciousness. Results General anesthesia was associated with a significant reduction in the number of network connections, as well as significant alterations of their duration. These changes were most prominent in the δ bandwidth and were also associated with a significant reduction in entropy of the connection matrix. Despite these and other changes, a global "scale-free" organization was consistently preserved across multiple subjects, anesthetic exposures, states of consciousness, and electroencephalogram frequencies. Conclusions Our data suggest a fundamental principle of temporal organization of network connectivity that is maintained during consciousness and anesthesia, despite local changes. These findings are consistent with a process of adaptive reconfiguration during general anesthesia.

Author(s):  
Christopher B O'Brien ◽  
Clarence E Locklear ◽  
Zachary T Glovak ◽  
Diana Zebadúa Unzaga ◽  
Helen A Baghdoyan ◽  
...  

The electroencephalogram (EEG) provides an objective, neural correlate of consciousness. Opioid receptors modulate mammalian neuronal excitability, and this fact was used to characterize how opioids administered to mice alter EEG power and states of consciousness. The present study tested the hypothesis that antinociceptive doses of fentanyl, morphine, or buprenorphine differentially alter the EEG and states of sleep and wakefulness in adult, male C57BL/6J mice. Mice were anesthetized and implanted with telemeters that enabled wireless recordings of cortical EEG and electromyogram (EMG). After surgical recovery, EEG and EMG were used to objectively score states of consciousness as wakefulness, rapid eye movement (REM) sleep, or non-REM (NREM) sleep. Measures of EEG power (dB) were quantified as delta (0.5 to 4 Hz), theta (4 to 8 Hz), alpha (8 to 13 Hz), sigma (12 to 15 Hz), beta (13 to 30 Hz), and gamma (30 to 60 Hz). Compared to saline (control), fentanyl and morphine decreased NREM sleep, morphine eliminated REM sleep, and buprenorphine eliminated NREM sleep and REM sleep. Opioids significantly and differentially disrupted the temporal organization of sleep/wake states, altered specific EEG frequency bands, and caused dissociated states of consciousness. The results are discussed relative to the fact that opioids, pain, and sleep modulate interacting states of consciousness.


2007 ◽  
Vol 17 (07) ◽  
pp. 2215-2255 ◽  
Author(s):  
LIDIA A. BRAUNSTEIN ◽  
ZHENHUA WU ◽  
YIPING CHEN ◽  
SERGEY V. BULDYREV ◽  
TOMER KALISKY ◽  
...  

We review results on the scaling of the optimal path length ℓopt in random networks with weighted links or nodes. We refer to such networks as "weighted" or "disordered" networks. The optimal path is the path with minimum sum of the weights. In strong disorder, where the maximal weight along the path dominates the sum, we find that ℓopt increases dramatically compared to the known small-world result for the minimum distance ℓ min ~ log N, where N is the number of nodes. For Erdős–Rényi (ER) networks ℓ opt ~ N1/3, while for scale free (SF) networks, with degree distribution P(k) ~ k-λ, we find that ℓopt scales as N(λ - 3)/(λ - 1) for 3 < λ < 4 and as N1/3 for λ ≥ 4. Thus, for these networks, the small-world nature is destroyed. For 2 < λ < 3 in contrary, our numerical results suggest that ℓopt scales as ln λ-1 N, representing still a small world. We also find numerically that for weak disorder ℓ opt ~ ln N for ER models as well as for SF networks. We also review the transition between the strong and weak disorder regimes in the scaling properties of ℓopt for ER and SF networks and for a general distribution of weights τ, P(τ). For a weight distribution of the form P(τ) = 1/(aτ) with (τ min < τ < τ max ) and a = ln τ max /τ min , we find that there is a crossover network size N* = N*(a) at which the transition occurs. For N ≪ N* the scaling behavior of ℓopt is in the strong disorder regime, while for N ≫ N* the scaling behavior is in the weak disorder regime. The value of N* can be determined from the expression ℓ∞(N*) = apc, where ℓ∞ is the optimal path length in the limit of strong disorder, A ≡ apc → ∞ and pc is the percolation threshold of the network. We suggest that for any P(τ) the distribution of optimal path lengths has a universal form which is controlled by the scaling parameter Z = ℓ∞/A where [Formula: see text] plays the role of the disorder strength and τc is defined by [Formula: see text]. In case P(τ) ~ 1/(aτ), the equation for A is reduced to A = apc. The relation for A is derived analytically and supported by numerical simulations for Erdős–Rényi and scale-free graphs. We also determine which form of P(τ) can lead to strong disorder A → ∞. We then study the minimum spanning tree (MST), which is the subset of links of the network connecting all nodes of the network such that it minimizes the sum of their weights. We show that the minimum spanning tree (MST) in the strong disorder limit is composed of percolation clusters, which we regard as "super-nodes", interconnected by a scale-free tree. The MST is also considered to be the skeleton of the network where the main transport occurs. We furthermore show that the MST can be partitioned into two distinct components, having significantly different transport properties, characterized by centrality — number of times a node (or link) is used by transport paths. One component the superhighways, for which the nodes (or links) with high centrality dominate, corresponds to the largest cluster at the percolation threshold (incipient infinite percolation cluster) which is a subset of the MST. The other component, roads, includes the remaining nodes, low centrality nodes dominate. We find also that the distribution of the centrality for the incipient infinite percolation cluster satisfies a power law, with an exponent smaller than that for the entire MST. We demonstrate the significance identifying the superhighways by showing that one can improve significantly the global transport by improving a very small fraction of the network, the superhighways.


2013 ◽  
Vol 119 (6) ◽  
pp. 1347-1359 ◽  
Author(s):  
Heonsoo Lee ◽  
George A. Mashour ◽  
Gyu-Jeong Noh ◽  
Seunghwan Kim ◽  
UnCheol Lee

Abstract Introduction: General anesthesia induces unconsciousness along with functional changes in brain networks. Considering the essential role of hub structures for efficient information transmission, the authors hypothesized that anesthetics have an effect on the hub structure of functional brain networks. Methods: Graph theoretical network analysis was carried out to study the network properties of 21-channel electroencephalogram data from 10 human volunteers anesthetized on two occasions. The functional brain network was defined by Phase Lag Index, a coherence measure, for three states: wakefulness, loss of consciousness induced by the anesthetic propofol, and recovery of consciousness. The hub nodes were determined by the largest centralities. The correlation between the altered hub organization and the phase relationship between electroencephalographic channels was investigated. Results: Topology rather than connection strength of functional networks correlated with states of consciousness. The average path length, clustering coefficient, and modularity significantly increased after administration of propofol, which disrupted long-range connections. In particular, the strength of hub nodes significantly decreased. The primary hub location shifted from the parietal to frontal region, in association with propofol-induced unconsciousness. The phase lead of frontal to parietal regions in the α frequency band (8–13 Hz) observed during wakefulness reversed direction after propofol and returned during recovery. Conclusions: Propofol reconfigures network hub structure in the brain and reverses the phase relationship between frontal and parietal regions. Changes in network topology are more closely associated with states of consciousness than connectivity and may be the primary mechanism for the observed loss of frontal to parietal feedback during general anesthesia.


2008 ◽  
Vol 19 (12) ◽  
pp. 1909-1918 ◽  
Author(s):  
LONG GUO ◽  
XU CAI

As well known, many real complex systems are directed and weighted ones. For understanding the topology structure of the directed China Railway Network (CRN) further, we analyze the degree properties of the directed CRN and propose a new method to measure the weight of station (i.e., the utilized efficiency of station) in CRN according to how CRN works really. Rigorous analysis of the existing CRN data shows that the CRN is an assortative network with scale-free degree distribution in space L. On the other hand, the cumulative distribution of station's relative weight, the cumulative distribution of the shortest path length between stations, and the relationship between relative weight and in-(out-)degree have been studied. Our present work provides a new perspective to define the weight of transport complex network, which will be helpful for studying the dynamics of CRN.


2019 ◽  
Author(s):  
T. Stephani ◽  
G. Waterstraat ◽  
S. Haufe ◽  
G. Curio ◽  
A. Villringer ◽  
...  

AbstractBrain responses vary considerably from moment to moment, even to identical sensory stimuli. This has been attributed to changes in instantaneous neuronal states determining the system’s excitability. Yet the spatio-temporal organization of these dynamics remains poorly understood. Here we test whether variability in stimulus-evoked activity can be interpreted within the framework of criticality, which postulates dynamics of neural systems to be tuned towards the phase transition between stability and instability as is reflected in scale-free fluctuations in spontaneous neural activity. Using a novel non-invasive approach in 33 male participants, we tracked instantaneous cortical excitability by inferring the magnitude of excitatory post-synaptic currents from the N20 component of the somatosensory evoked potential. Fluctuations of cortical excitability demonstrated long-range temporal dependencies decaying according to a power law across trials – a hallmark of systems at critical states. As these dynamics covaried with changes in pre-stimulus oscillatory activity in the alpha band (8–13 Hz), we establish a mechanistic link between ongoing and evoked activity through cortical excitability and argue that the co-emergence of common temporal power laws may indeed originate from neural networks poised close to a critical state. In contrast, no signatures of criticality were found in subcortical or peripheral nerve activity. Thus, criticality may represent a parsimonious organizing principle of variability in stimulus-related brain processes on a cortical level, possibly reflecting a delicate equilibrium between robustness and flexibility of neural responses to external stimuli.Significance StatementVariability of neural responses in primary sensory areas is puzzling, as it is detrimental to the exact mapping between stimulus features and neural activity. However, such variability can be beneficial for information processing in neural networks if it is of a specific nature, namely if dynamics are poised at a so-called critical state characterized by a scale-free spatio-temporal structure. Here, we demonstrate the existence of a link between signatures of criticality in ongoing and evoked activity through cortical excitability, which fills the long-standing gap between two major directions of research on neural variability: The impact of instantaneous brain states on stimulus processing on the one hand and the scale-free organization of spatio-temporal network dynamics of spontaneous activity on the other.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Victoria M. Bedell ◽  
Qing C. Meng ◽  
Michael A. Pack ◽  
Roderic G. Eckenhoff

Abstract The field of neuropharmacology has not yet achieved a full understanding of how the brain transitions between states of consciousness and drug-induced unconsciousness, or anesthesia. Many small molecules are used to alter human consciousness, but the repertoire of underlying molecular targets, and thereby the genes, are incompletely understood. Here we describe a robust larval zebrafish model of anesthetic action, from sedation to general anesthesia. We use loss of movement under three different conditions, spontaneous movement, electrical stimulation or a tap, as a surrogate for sedation and general anesthesia, respectively. Using these behavioral patterns, we find that larval zebrafish respond to inhalational and IV anesthetics at concentrations similar to mammals. Additionally, known sedative drugs cause loss of spontaneous larval movement but not to the tap response. This robust, highly tractable vertebrate model can be used in the detection of genes and neural substrates involved in the transition from consciousness to unconsciousness.


2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Gang-Jin Wang ◽  
Chi Xie ◽  
Peng Zhang ◽  
Feng Han ◽  
Shou Chen

Based on a time-varying copula approach and the minimum spanning tree (MST) method, we propose a time-varying correlation network-based approach to investigate dynamics of foreign exchange (FX) networks. In piratical terms, we choose the daily FX rates of 42 major currencies in the international FX market during the period of 2005–2012 as the empirical data. The empirical results show that (i) the distributions of cross-correlation coefficients (distances) in the international FX market (network) are fat-tailed and negatively skewed; (ii) financial crises during the analyzed period have a great effect on the FX network’s topology structure and lead to the US dollar becoming more centered in the MST; (iii) the topological measures of the FX network show a large fluctuation and display long-range correlations; (iv) the FX network has a long-term memory effect and presents a scale-free behavior in the most of time; and (v) a great majority of links between currencies in the international FX market survive from one time to the next, and multistep survive rates of FX networks drop sharply as the time increases.


2020 ◽  
Author(s):  
Gongchao Jing ◽  
Yufeng Zhang ◽  
Lu Liu ◽  
Zengbin Wang ◽  
Zheng Sun ◽  
...  

AbstractMicrobiomes are inherently linked by their structural similarity, yet the global features of such similarity are not clear. Here we propose as solution a search-based microbiome transition network. By traversing a composition-similarity based network of 177,022 microbiomes, we show that although the compositions are distinct by habitat, each microbiome is on-average only seven neighbors from any other microbiome on Earth, indicating the inherent homology of microbiome at the global scale. This network is scale-free, suggesting a high degree of stability and robustness in microbiome transition. By tracking the minimum spanning tree in this network, a global roadmap of microbiome dispersal was derived that tracks the potential paths of formulating and propagating microbiome diversity. Such search-based global microbiome networks, reconstructed within hours on just one computing node, provide a readily expanded reference for tracing the origin and evolution of existing or new microbiomes.


2021 ◽  
Author(s):  
Yu Rong ◽  
Panagiotis C. Theofanopoulos ◽  
Georgios C. Trichopoulos ◽  
Daniel W. Bliss

Abstract This study presents findings at Terahertz (THz) frequency band for non-contact cardiac sensing application. For the first time, cardiac pulse information is simultaneously extracted using THz waves based on the two established principles in electronics and optics. The first fundamental principle is micro-Doppler (mD) motion effect, initially introduced in coherent laser radar system 1, 2 and first experimentally demonstrated for vital sign detection 3. This motion based method, primarily using coherent phase information from the radar receiver, has been widely exploited in microwave frequency bands and has recently found popularity in millimeter waves (mmWave). The second fundamental principle is reflectance based optical measurement using infrared or visible light. The variation in the light reflection is proportional to the volumetric change of the heart, often referred as photoplethysmography (PPG). PPG has been a popular technology for pulse diagnosis. Recently it has been widely incorporated into various smart wearables for long-term monitoring, such fitness training and sleep monitoring. Herein, the concept of Terahertz-Wave-Plethysmography (TPG) is introduced, which detects blood volume changes in the upper dermis tissue layer by measuring the reflectance of THz waves, similar to the existing remote PPG (rPPG) principle 4. The TPG principle is justified by scientific deduction, electromagnetic wave (EM) simulations and carefully designed experimental demonstrations. Additionally, pulse measurements from various peripheral body parts of interest (BOI), palm, inner elbow, temple, fingertip and forehead, are demonstrated using a wideband THz sensing system developed by Terahertz Electronics Lab at Arizona State University (ASU), Tempe. Among the BOIs under test, it is found that the measurements from forehead BOI gives the best accuracy with mean heart rate (HR) estimation error 1.51 beats per minute (BPM) and stand deviation (std) 1.08 BPM. The results validate the feasibility of radar based plethysmography for direct pulse monitoring. Finally, a comparative study on pulse sensitivity in TPG and rPPG is conducted. The results indicate that the TPG contains more pulsatile from the forehead BOI than that in the rPPG signals and thus generate better heart rate (HR) estimation statistic in the form of empirical cumulative distribution function (CDF) of HR estimation error.


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