scholarly journals Respective contribution of conventional risk factors and antihypertensive treatment to stable angina pectoris and acute coronary syndrome as the first presentation of coronary heart disease: the PRIME Study

2009 ◽  
Vol 16 (5) ◽  
pp. 550-555 ◽  
Author(s):  
Florence Canoui-Poitrine ◽  
Gerald Luc ◽  
Irène Juhan-Vague ◽  
Pierre-Emmanuel Morange ◽  
Dominique Arveiler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Angina Pectoris ◽  
Antihypertensive Treatment ◽  
Stable Angina Pectoris ◽  
Coronary Syndrome ◽  
Respective Contribution ◽  
Conventional Risk Factors

scholarly journals Difference in risk factors between acute coronary syndrome and stable angina pectoris in the Japanese: Smoking as a crucial risk factor of acute coronary syndrome

2010 ◽  
Vol 55 (3) ◽  
pp. 345-353 ◽  
Author(s):  
Hidenori Yagi ◽  
Kimiaki Komukai ◽  
Koichi Hashimoto ◽  
Makoto Kawai ◽  
Takayuki Ogawa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Risk Factor ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Stable Angina Pectoris ◽  
Coronary Syndrome

The condition of the production of cytokines, soluble co-stimulatory molecules, intracellular signaling pathways and nitric oxide in patients with coronary heart disease on the background of low-intensity microwave therapy

2016 ◽  
Vol 10 (1) ◽  
pp. 0-0 ◽  
Author(s):  
Аржников ◽  
V. Arzhnikov ◽  
Логаткина ◽  
A. Logatkina ◽  
Бондарь ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Angina Pectoris ◽  
Microwave Radiation ◽  
Interstitial Fluid ◽  
Radiation Frequency ◽  
Coronary Syndrome ◽  
Low Intensity ◽  
Caspase 1

The concentration of cytokines of the family IL-10 (IL-10, IL-22, IL-24), interferon-gamma, soluble forms of co-stimulatory molecules CD28, CD80, CD152, as well as NO was investigated in patients with coronary heart disease in interstitial fluid. In addition, the level of caspase-1, inducible and endothelial forms of NO synthasis (eNOS, iNOS), protein kinase AKT1 and AMPK and the total antioxidant activity from the cell culture supernantat were evaluatedin the agranulocytic patients. In the current study (in vitro) the impact on production of these mediators of low-intensity microwave radiation frequency of 1000 MHz, generated by an apparatus of low-intensity physiotherapy "Aquaton" was evaluated. Material of this study was whole venous blood of patients with angina pectoris and acute coronary syndrome. The analysis of the results revealed a reduced level of NO, IL-24, as well as increased production of IL-10, IL-22 and the concentration of soluble forms of CD28, CD80, CD152 in patients with coronary artery disease in the interstitial fluid in comparison with practically healthy persons. At a single irradiation of cell cultures whole blood by low-intensity microwave radiation frequency of 1000 MHz in patients with angina pectoris and acute coronary syndrome there were an increasing of NO production by 20,6 and 25,5‰, IL-24 by 18,6 and 33,6‰, and a reduction in intracellular caspase-1 by 32,5 and 25,8‰, as well as increasing of the levels of IL-10 by 3,5 and 3,1‰, IL-22 by 28,7 and 26,5‰ and reduction of the levels of CD28 by 3,6 and 3,9‰, CD80 6,8 and 5,7‰, CD152 by 9,4 and 11,3‰, respectively. In addition, in terms of irradiation there is an increase in interstitial fluid levels of antioxidants by 37,1 and 49,2‰.

scholarly journals Risk Factors for Acute Coronary Syndrome in Upper Gastrointestinal Bleeding Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Tianyu Chi ◽  
Quchuan Zhao ◽  
Peili Wang
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Heart Disease ◽  
Gastrointestinal Bleeding ◽  
Upper Gastrointestinal Bleeding ◽  
Coronary Syndrome ◽  
Upper Gastrointestinal

Background. Upper gastrointestinal bleeding (UGIB) is a common critical disease with a certain fatality rate. Acute coronary syndrome (ACS), another critical ill condition, is a regular occurrence in the UGIB. We identified risk factors for ACS in UGIB. Methods. 676 patients diagnosed with UGIB were enrolled retrospectively. We assessed the occurrence of ACS in UGIB patients and identified the risk factors for ACS by logistic regression analysis and random forest analysis. Results. After propensity score matching (PSM), the ACS group ( n = 69 ) and non-ACS group ( n = 276 ) were analyzed. Logistic regression analysis showed that syncope ( P = 0.001 ), coronary heart disease history ( P = 0.001 ), Glasgow Blatchford score ( P ≤ 0.001 ), Rockall risk score ( P = 0.004 ), red blood cell distribution width (RDW) ( P ≤ 0.001 ), total bilirubin (TBil) ( P = 0.046 ), fibrinogen ( P ≤ 0.001 ), and hemoglobin ( P = 0.001 ) had important roles in ACS patients. With Mean Decrease Gini (MDG) sequencing, fibrinogen, RDW, and hemoglobin were ranked the top three risk factors associated with ACS. In ROC analysis, fibrinogen ( AUC = 0.841 , 95% CI: 0.779-0.903) and RDW ( AUC = 0.826 , 95% CI: 0.769-0.883) obtained good discrimination performance. According to sensitivity > 80 %, the pAUC of fibrinogen and RDW were 0.077 and 0.101, respectively, and there was no significant difference ( P = 0.326 ). However, according to specificity > 80 %, the pAUC of fibrinogen was higher than that of RDW (0.126 vs. 0.088, P = 0.018 ). Conclusion. Fibrinogen and RDW were important risk factors for ACS in UGIB. Additionally, combination with coronary heart disease, syncope, hemoglobin, and TBil played important roles in the occurrence of ACS. Meanwhile, it was also noted that Rockall score and Glasgow Blatchford score should be performed to predict the risk.

Coronary heart disease: issues of pathogenesis, diagnosis, treatment and medical and labor expertise

2021 ◽  
Vol 3 ◽  
Author(s):  
D.Yu. Gamayunov ◽  
◽  
V.A. Khaptanova ◽  
N.M. Balabina ◽  
A.N. Kalyagin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Lifestyle Modification ◽  
Diagnostic Methods ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Stable Angina Pectoris

This article provides a review of the literature on coronary heart disease, namely stable angina pectoris – one of the forms of chronic coronary heart disease. The role of CHD in mortality and disability of the population is considered. The literature review describes the etiology, risk factors, classification, pathogenetic nature of the disease, diagnostic methods, and also addresses issues of treatment and medical and labor expertise that are relevant today. The importance of subjective and objective methods of examination along with highly informative laboratory and instrumental methods currently being introduced is noted. A fundamental step towards eliminating risk factors is lifestyle modification. Of particular relevance is the issue of drug treatment of stable angina pectoris, the main purpose of which is to reduce the symptoms of angina pectoris and prevent cardiovascular complications. The article presents data from clinical studies examining the effectiveness of modern antianginal, antithrombotic, lipid-lowering therapy. The data on the possibility of using the valsartan and sacubitril complex in order to reduce the risk of hospitalization and death in the presence of symptomatic CHF (LVEF ≤ 35%) are presented.

scholarly journals Acute Coronary Syndrome in an Intensive Care Unit of a Tertiary Referral Centre in Central Nepal: The Spectrum and Coronary Risk Factors.

2013 ◽  
Vol 52 (190) ◽  
Author(s):  
Mani Prasad Gautam ◽  
Guruprasad Sogunuru ◽  
Gangapatnam Subramanyam ◽  
Lekhjung Thapa ◽  
Raju Paudel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Intensive Care Unit ◽  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Intensive Care ◽  
Heart Disease ◽  
St Elevation Myocardial Infarction ◽  
Coronary Syndrome ◽  
St Elevation

Introduction: Acute coronary syndrome is the major leading cause for coronary care unit admission. Its spectrum comprises a variety of disorders including unstable angina, non ST elevation and ST elevation myocardial infarction.Methods: An observational study was designed to study the spectrum of acute coronary syndrome and associated coronary heart disease risk factors in subjects admitted in intensive care unit from August 2009 to September 2010. Details including coronary risk factors and the categories and outcomes of acute coronary syndrome were analyzed.Results: A total of 57 subjects were included in the study. The majority (63.1%) were males. The mean age was 64.54±13.8 years.  Five (8.8%) patients were ≤45 years and 29 (50.88%) patients were ≥65 years. Majority of the patients were smokers (50.87%). The other major coronary heart disease risk factors were diabetes (43.85%), hypertension (36.87%), dyslipidemia (26.32%) and previous history of coronary heart disease (31.58%). Coronary heart disease figured prominently in the family history as well (26.32%). ST elevation myocardial infarction was the major category (42.11%) followed by non-ST elevation myocardial infarction and unstable angina (31.58% and 26.32% respectively). Myocardial infarction complicated with cardiogenic shock had very high mortality (83.33%).  Conclusions: The ST elevation myocardial infarction was the major clinical form of acute coronary syndrome admitted in intensive care unit. Prevention should be targeted on modifiable risk factors such as the management of risk factors. In addition, the improvement in cardiology service with the establishment of CCU and cathlab might alter the mortality and morbidity in ACS management.Keywords: acute coronary syndrome; coronary risk factors; intensive care unit.

scholarly journals Risk factors for coronary heart disease and the development of acute coronary syndrome in patients with normal lipid metabolism

2016 ◽  
Vol 0 (2(64)) ◽  
pp. 95-98
Author(s):  
Л. В. Хіміон ◽  
О. Б. Ященко ◽  
В. В. Ватага ◽  
О. Г. Дубчак
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Lipid Metabolism ◽  
Coronary Syndrome

scholarly journals Prevalence of conventional risk factors in patients with coronary heart disease

Medicina ◽  
2009 ◽  
Vol 45 (2) ◽  
pp. 140 ◽  
Author(s):  
Egidija Rinkūnienė ◽  
Žaneta Petrulionienė ◽  
Aleksandras Laucevičius ◽  
Ernesta Ringailaitė ◽  
Agnė Laučytė
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
University Hospital ◽  
Stable Angina Pectoris ◽  
Younger Patients ◽  
Statistical Studies ◽  
Vilnius University ◽  
Conventional Risk Factors

Extensive clinical and statistical studies have identified risk factors that increase the incidence of coronary heart disease. It is commonly suggested that more than 50% of patients with coronary heart disease lack any of the conventional risk factors. Objective. To determine the prevalence of four conventional risk factors among patients with coronary heart disease. Material and methods. We analyzed data of 606 patients with coronary heart disease (myocardial infarction, unstable and stable angina pectoris) hospitalized in the Clinics of Santariškės, Vilnius University Hospital, in 1997–2005. Results. Among patients with coronary heart disease, at least one of four conventional risk factors was present in 98% of patients. Hypertension was present in 47.7% of patients, diabetes – in 12.9%, dyslipidemia – 90.1%, and smoking – in 24.1% of patients. In younger patients (<55 years), only 2.3% of patients lacked any of four conventional risk factors. Two-thirds (66.5%) of younger patients with coronary heart disease had two and more risk factors. Conclusions. Considering the fact that patients with coronary heart disease often lack conventional risk factors, currently more attention is given to nontraditional risk factors as well as genetic causes of coronary heart disease. Nevertheless, the present study revealed that 98% of patients with coronary heart disease had at least one of four conventional risk factors. Among younger patients (younger than 55 years), conventional risk factors are identified very frequently. Thus, it can be concluded that in order to reduce the epidemic of coronary heart disease, much greater emphasis should be given to identify and to improve prevention of four conventional risk factors as well as the lifestyle of the patient.

scholarly journals Risk factors for coronary heart disease and family medicine: What can be done?

2021 ◽  
Vol 52 (4) ◽  
pp. 258-265
Author(s):  
Dalibor Mihajlović ◽  
Biljana Mihajlović ◽  
Nevena Todorović ◽  
Žana Maksimović
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Angina Pectoris ◽  
Blood Cholesterol ◽  
Individual Risk ◽  
Coronary Syndrome ◽  
Number Of Patients

Background / Aim: More people die each year due to cardiovascular diseases (CVDs) than from any other cause. The most common cause of ischaemic heart diseases (IHD) is atherosclerosis of the coronary arteries. Risk factors for the development of coronary heart disease (CHD) can be preventable and non-preventable. The aim of the study was to determine the frequency of individual risk factors in patients with CHD. Methods: Retrospective analysis included patients with diagnoses of stable angina pectoris (AP), unstable angina pectoris and myocardial infarction - acute coronary syndrome (ACS) and ischaemic cardiomyopathy (iCMP). The prevalence of the following risk factors for IHD was analysed: hypertension, diabetes, obesity, cholesterol, smoking, family history, age and sex. Data were taken from the Register of Patients with Chronic Diseases and Risk Factors and electronic patient records. Results: Of the total number of respondents older than 18, 4.95 % had CHD. Of the 178 patients with IHD, 70 (39.3 %) patients had AP, 60 (33.7 %) patients had ACS and 48 (27.0 %) patients had iCMP. Positive family history had 63.5 % of patients, 72 % were older than 66, 24.1 % were smokers and 74.2 % of patients had elevated blood cholesterol levels. Diabetes mellitus affected 29.2 % of patients, hypertension 88.8 %, and BMI ≥ 25 kg/m2 had 70.8 % of patients. Of the total number of patients with ACS, 68.3 % were men, while higher percentage of women suffered from AP (62.9 %) (p = 0.002). In the age below 65, CHD was more common in men (p = 0.007). Cholesterol was elevated more often in patients with AP than iCMP (p = 0.001). Patients with ACS were more likely to have diabetes mellitus compared to patients with AP and iCMP (p = 0.010). Conclusion: The prevalence of preventable risk factors is alarmingly high. Of particular importance is the timely detection and treatment of risk factors by family physicians and strengthening the personal responsibility of each individual in choosing their lifestyle and active involvement in the therapeutic process.

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