scholarly journals Enthesis strength, toughness and stiffness: an image-based model comparing tendon insertions with varying bony attachment geometries

2021 ◽  
Vol 18 (185) ◽  
Author(s):  
Mikhail Golman ◽  
Victor Birman ◽  
Stavros Thomopoulos ◽  
Guy M. Genin
Keyword(s):  
Dissimilar Materials ◽  
Bone Geometry ◽  
The Body ◽  
Bone Architecture ◽  
Joint Stability ◽  
Simultaneous Imaging ◽  
Force Transfer ◽  
Bony Ridge ◽  
Strength And Stiffness ◽  
Insight Into

Tendons of the body differ dramatically in their function, mechanics and range of motion, but all connect to bone via an enthesis. Effective force transfer at the enthesis enables joint stability and mobility, with strength and stiffness arising from a fibrous architecture. However, how enthesis toughness arises across tendons with diverse loading orientations remains unclear. To study this, we performed simultaneous imaging of the bone and tendon in entheses that represent the range of tendon-to-bone insertions and extended a mathematical model to account for variations in insertion and bone geometry. We tested the hypothesis that toughness, across a range of tendon entheses, could be explained by differences observed in interactions between fibre architecture and bone architecture. In the model, toughness arose from fibre reorientation, recruitment and rupture, mediated by interactions between fibres at the enthesis and the bony ridge abutting it. When applied to tendons sometimes characterized as either energy-storing or positional, the model predicted that entheses of the former prioritize toughness over strength, while those of the latter prioritize consistent stiffness across loading directions. Results provide insight into techniques for surgical repair of tendon-to-bone attachments, and more broadly into mechanisms for the attachment of highly dissimilar materials.

Basic Concepts and Definitions of Allergology

2019 ◽  
Author(s):  
Zoran Vrucinic
Keyword(s):  
Immune Reaction ◽  
The Body ◽  
The Other ◽  
Specific Response ◽  
Other Hand ◽  
Medical Vocabulary ◽  
The Future ◽  
Basic Concepts ◽  
Basic Insight ◽  
Insight Into

The future of medicine belongs to immunology and alergology. I tried to not be too wide in description, but on the other hand to mention the most important concepts of alergology to make access to these diseases more understandable, logical and more useful for our patients, that without complex pathophysiology and mechanism of immune reaction,we gain some basic insight into immunological principles. The name allergy to medicine was introduced by Pirquet in 1906, and is of Greek origin (allos-other + ergon-act; different reaction), essentially representing the reaction of an organism to a substance that has already been in contact with it, and manifested as a specific response thatmanifests as either a heightened reaction, a hypersensitivity, or as a reduced reaction immunity. Synonyms for hypersensitivity are: altered reactivity, reaction, hypersensitivity. The word sensitization comes from the Latin (sensibilitas, atis, f.), which means sensibility,sensitivity, and has retained that meaning in medical vocabulary, while in immunology and allergology this term implies the creation of hypersensitivity to an antigen. Antigen comes from the Greek words, anti-anti + genos-genus, the opposite, anti-substance substance that causes the body to produce antibodies.

Force in Nature

2020 ◽  
pp. 146-160
Author(s):  
David Carus
Keyword(s):  
Natural Science ◽  
The Body ◽  
The Core ◽  
Thing In Itself ◽  
The Will ◽  
Insight Into

This chapter explores Schopenhauer’s concept of force, which lies at the root of his philosophy. It is force in nature and thus in natural science that is inexplicable and grabs Schopenhauer’s attention. To answer the question of what this inexplicable term is at the root of all causation, Schopenhauer looks to the will within us. Through will, he maintains that we gain immediate insight into forces in nature and hence into the thing in itself at the core of everything and all things. Will is thus Schopenhauer’s attempt to answer the question of the essence of appearance. Yet will, as it turns out, cannot be known immediately as it is subject to time, and the acts of will, which we experience within us, do not correlate immediately with the actions of the body (as Schopenhauer had originally postulated). Hence, the acts of will do not lead to an explanation of force, which is at the root of causation in nature. Schopenhauer sets out to explain what is at the root of all appearances, derived from the question of an original cause, or as Schopenhauer states “the cause of causation,” but cannot determine this essence other than by stating that it is will; a will, however, that cannot be immediately known.

scholarly journals Minimally Invasive Autopsy Practice in COVID-19 Cases: Biosafety and Findings

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 412
Author(s):  
Natalia Rakislova ◽  
Lorena Marimon ◽  
Mamudo R. Ismail ◽  
Carla Carrilho ◽  
Fabiola Fernandes ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Cause Of Death ◽  
Diffuse Alveolar Damage ◽  
The Body ◽  
Protective Equipment ◽  
Safe Alternative ◽  
Minimally Invasive Autopsy ◽  
Postmortem Studies ◽  
Death Investigation ◽  
Insight Into

Postmortem studies are crucial for providing insight into emergent diseases. However, a complete autopsy is frequently not feasible in highly transmissible diseases due to biohazard challenges. Minimally invasive autopsy (MIA) is a needle-based approach aimed at collecting samples of key organs without opening the body, which may be a valid alternative in these cases. We aimed to: a) provide biosafety guidelines for conducting MIAs in COVID-19 cases, b) compare the performance of MIA versus complete autopsy, and c) evaluate the safety of the procedure. Between October and December 2020, MIAs were conducted in six deceased patients with PCR-confirmed COVID-19, in a basic autopsy room, with reinforced personal protective equipment. Samples from the lungs and key organs were successfully obtained in all cases. A complete autopsy was performed on the same body immediately after the MIA. The diagnoses of the MIA matched those of the complete autopsy. In four patients, COVID-19 was the main cause of death, being responsible for the different stages of diffuse alveolar damage. No COVID-19 infection was detected in the personnel performing the MIAs or complete autopsies. In conclusion, MIA might be a feasible, adequate and safe alternative for cause of death investigation in COVID-19 cases.

Tourism, environment and hotel management: an innovative perspective to address modern trends in contemporary tourism management

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Chunhui Huo ◽  
Javaria Hameed ◽  
Muhammad Waqas Sadiq ◽  
Gadah Albasher ◽  
Wedad Alqahtani
Keyword(s):  
Brand Image ◽  
Interactional Justice ◽  
Tourism Industry ◽  
The Body ◽  
Hotel Management ◽  
Content Type ◽  
Service Value ◽  
Study Results ◽  
Customer's Loyalty ◽  
Insight Into

PurposeThis paper aims to provide a valid insight into consumers' minds while considering word of mouth (WOM), brand image and uniqueness as independent variables while considering the tourism industry as the primary stakeholder.Design/methodology/approachThe study adopts qualitative research methods and data collected from 1,033 respondents using convenience sampling methodology. The data are collected from different tourists spots in China and Pakistan. The PROCESS macro was utilized in this study using SPSS version 25.0 to inspect the impacts by using Model 4 and the conditional effects indirectly by utilizing Model 14.FindingsCustomer's intimacy, search for novel and unexplored destinations highlight WOM interactions and perceived service value. Service value, interactional justice and professional attitude of hotel management mediated all the given relationships significantly. The brand image does not mediate any significant associations. Perceived service value and brand image predict customer's loyalty, and WOM is the direct measure of their intentions, and these variables are market trend indicators. A tourist's response toward different destinations is described in this study with comparative analysis of Chinese and Pakistani tourists. The study results showed a significantly positive relationship between hotel management professional behavior, customer's loyalty, customer's intimacy and WOM.Research limitations/implicationsThe recruited population might not be represented as the broader and larger visitor population, resulting in restricting establishing tactics. Moreover, this study's results provide significant insight into a tourism industry, hence providing a chance to manage customer loyalty better.Social, managerial and theoretical implicationsThis study contributes significantly to the body of knowledge and provides remarkable insight from the managerial perspective. Interactional justice results in significant value for hotel management directors and top management, front desk staff and operatives and front level employees and managers. Consumer sensitivity of fairness in interpersonal dealings calls for behavioral changes in frontline employees, especially those directly dealing with hotel visitors. Hotel staff and management should formulate a system to deal with the demands and needs of visitors. It should describe the rights and obligations of visitors and ensure that each customer is treated equally and with respect. Customers should be motivated to read the survey questionnaires kept in their rooms and offer their views on the services provided. This strategy might increase the customers' sense of empowerment and leading to notions of fairness in individual encounters.Originality/valueThis study provides an insight into the customer's minds while considering essential variables that include WOM, brand image, perceived service value and uniqueness.

A Welcome Conversation: Toward a New Historiography of Intellectual Property

2018 ◽  
Vol 43 (03) ◽  
pp. 1113-1129
Author(s):  
Kali Murray
Keyword(s):  
Intellectual Property ◽  
Legal History ◽  
Social Practices ◽  
The Body ◽  
Property Law ◽  
Legal Concept ◽  
Narrative Structures ◽  
History Of ◽  
The Relationship ◽  
Insight Into

This essay considers what tools should be used to study the legal history of intellectual property. I identify three historiographical strategies: narration, contest, and formation. Narration identifies the diverse “narrative structures” that shape the field of intellectual property history. Contest highlights how the inherent instability of intellectual property as a legal concept prompts recurrent debates over its meaning. Formation recognizes how intellectual property historians can offer insight into broader legal history debates over how to consider the relationship between informal social practices and formalized legal mechanisms. I consider Kara W. Swanson's Banking on the Body: The Market in Blood, Milk and Sperm in Modern America (2014) in light of these historiographical strategies and conclude that Swanson's book guides us to a new conversation in the legal history of intellectual property law.

Vibrational Analysis of Human Femur Bone

2018 ◽  
Author(s):  
Reza Sadeghi ◽  
Firooz Bakhtiari-Nejad ◽  
Taha Goudarzi
Keyword(s):  
Natural Frequencies ◽  
Vibrational Analysis ◽  
Bone Geometry ◽  
The Body ◽  
Mode Shapes ◽  
Pelvic Bone ◽  
Cross Sectional ◽  
Femur Bone ◽  
Bone Structures ◽  
Elderly Falls

Femur bone is the longest and largest bone in the human skeleton. This bone connects the pelvic bone to the knee and carries most of the body weight. The static behavior of femur bone has been a center of investigation for many years while little attention has been given to its dynamic and vibrational behavior, which is of great importance in sports activities, car crashes and elderly falls. Investigation of natural frequencies and mode shapes of bone structures are important to understand the dynamic and vibrating behaviors. Vibrational analysis of femoral bones is presented using finite element method. In the analysis, the bone was modeled with isotropic and orthotropic mechanical properties. The effect of surrounding bone muscles has also been accounted for as a viscoelastic medium embedding the femur bone. Natural frequencies extracted considering the effects of age aggravated by weakening the elastic modulus and density loss. The effects of real complex bone geometry on natural frequencies are studied and are compared with a simple circular cross-sectional model.

scholarly journals У каждого своя Сибирь. Два женских рассказа о депортации калмыков

2020 ◽  
Vol 12 (4) ◽  
pp. 778-800
Author(s):  
Elza-Bair M. Guchinova ◽  
Keyword(s):  
High School ◽  
Textual Analysis ◽  
Adaptation Strategies ◽  
The Body ◽  
Indigenous Populations ◽  
Young Generation ◽  
Inner Life ◽  
Life Choices ◽  
History Of ◽  
Insight Into

Introduction. The proposed publication consists of an introduction, texts of two biographical interviews and comments thereon. Both the conversations took place in Elista (2004, 2017) as part of the research project ‘Everyone Has One’s Own Siberia’ dedicated to the important period in the history of Kalmykia though not yet sufficiently explored by anthropologists and sociologists — the deportation of Kalmyks to Siberia (1943–1956) and related memories. Goals. The project seeks to show the daily survival practices of Kalmyks in Siberia. In the spontaneous biographical interviews focusing on the years of Kalmyk deportation, not only the facts cited are important — of which we would otherwise stay unaware but from the oral narratives — but also the introduced stories of inner life: feelings and thoughts of growing girls. Methods. The paper involves the use of textual analysis and the method of text deconstruction. Results. The transcribed texts show survival and adaptation strategies employed by the young generation of ‘special settlers’ in places of forced residence. For many Kalmyks of that generation, high school was a ‘glass ceiling’, a limitation in life choices. In the narrative of R. Ts. Azydova, we face a today unthinkable social package for KUTV students with children — this illustrates how the korenization policy for indigenous populations in the USSR worked, and provides insight into daily practices of pre-war Elista. The story of T. S. Kachanova especially clearly manifests the ‘language of trauma’, first of all, through the memory of the body, vocabulary of death and displays of laughter. The texts of the interviews shall be interesting to all researchers of Kalmyk deportation and the memory of that period.

scholarly journals TALKING PARTS, TALKING BACK: FLESHING OUT LINGUISTIC CITIZENSHIP

2020 ◽  
Vol 59 (3) ◽  
pp. 1636-1658
Author(s):  
Christopher Stroud ◽  
Quentin Williams ◽  
Ndimphiwe Bontiya ◽  
Janine Harry ◽  
Koki Kapa ◽  
...  
Keyword(s):  
South Africa ◽  
The Body ◽  
Men And Women ◽  
Linguistic Citizenship ◽  
Insight Into

ABSTRACT One of the greatest challenges of our times is that of lack of voice for abused bodies. These are the bodies of children and men and women who have inherited the brutalities of colonialism, plantation servitude and slavery and now re-live these miseries in the belly of a rampant global neoliberal and patriarchal capitalism. They are the racialized, sexualized, genderized and godless bodies that first took form in coloniality-modernity in conjunction with the emergence of MAN, the White, rational, disembodied male as HUMAN. They retain their shape today through technologies of vulnerability, with which the manufactured lack of voice works in dynamic synergy. This is particularly the case for South Africa, with its tender histories and distraught presents, raw emotion and sore vulnerabilities of racialized and neoliberal patriarchy. In this paper, we suggest that vulnerability, beyond its potentially devastating effect on souls and livelihoods, may also be a productive site for the articulation of alternative, and habitually silenced voices. In this regard, we explore how a focus on acts of Linguistic Citizenship may orientate thinking on voice and agency to different sites of the body, as well as allow insight into the complex technologies and practices of vulnerability.

scholarly journals Zingerone Ameliorates Hepatotoxicity

2020 ◽  
Vol 11 (1) ◽  
pp. 280-284 ◽  
Author(s):  
Julietpoornamathy J ◽  
Parameswari C.S.
Keyword(s):  
The Body ◽  
Control Group ◽  
Medical Sciences ◽  
Toxic Compounds ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Insight Into ◽  
Group 1

In medical sciences, toxicity is an area wherein extensive studies have been carried to improve the diseases as well as to prevent. So, there is a high requirement for novel and improved alternative therapeutic strategies to manage diseases. The liver is the largest gland in the body, which executes several important mechanisms; it stores minerals and vitamins and releases them in periods of need. The main aim of this study was to give a closer insight into potent non- toxic compounds that is capable of modifying the responses. Animals were divided into five equal groups viz control (Group 1), administered with food and water ad libitum, (Group 2) administered with olive oil, (Group 3) administered with zingerone, (Group 4) administered with concanavalin A, (Group 5) administered with cyclosporine A followed by zingerone. Our results revealed significant changes in liver marker enzymes and liver histology of zingerone treated rats when compared to control rats.  A corollary, zingerone has no toxic effect on hepatocytes and was found to be safe at a dose of 10mg/kg b wt and also ameliorates hepatotoxicity.

scholarly journals Perception of visual-tactile asynchrony, bodily perceptual aberrations, and bodily illusions in schizophrenia

2020 ◽  
Author(s):  
Regine Zopf
Keyword(s):  
The Body ◽  
Detection Sensitivity ◽  
Body Ownership ◽  
Body Perception ◽  
Rubber Hand ◽  
Bodily Experiences ◽  
Asynchrony Detection ◽  
Body Perceptions ◽  
Proprioceptive Drift ◽  
Insight Into

Body perception can be dramatically altered in individuals with schizophrenia resulting in experiences of undefined bodily boundaries, loss of body ownership, and size changes for parts of the body. These individuals may also be more susceptible to the rubber hand illusion (RHI: an illusion of body perception that can also be induced in neurotypical populations), but the findings are mixed. Furthermore, the perception of timing information about multisensory stimuli, which is thought to be fundamental for body perception, has been reported to be altered in schizophrenia. We tested here whether altered perception of the temporal relationship between visual and tactile signals in schizophrenia can predict self-reported perceptual aberrations and RHI susceptibility (indexed by both illusion self-ratings and a more objective proprioceptive-drift measure). We found that the sensitivity to detect temporal asynchronies is reduced in schizophrenia and this predicts bodily perceptual symptoms. In contrast, we found no evidence for a direct relationship between asynchrony detection sensitivity and RHI susceptibility. Instead, our findings suggest that experiencing more bodily perceptual symptoms increases the likelihood of endorsing unusual bodily experiences, resulting in higher RHI self-ratings but not higher proprioceptive-drift scores. Overall, our findings provide evidence for both direct and indirect links between temporal and body perception and thus new insight into the mechanisms that may underlie unusual body perceptions in schizophrenia.

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