scholarly journals On the presence of hæm-agglutinin and hæmolysins in the blood obtained from infectious and non-infectious diseases in man. (Third report.)

The further investigations on this subject which form the basis of this paper have been mainly directed towards phagocytosis and the specific hæmagglutinins and hæmolysins present in the blood of apparently healthy people and those suffering from acute and chronic infections. To these we may possibly add a note on the susceptibility of the red blood corpuscles in various diseases to water containing graduated percentages of sodium chloride. Normal Blood It is stated in a paper published in the ‘Proceedings of the Royal Society’ by one of us (L. S. D.), that while auto-agglutination of the red blood corpuscles does not occur, iso-agglutination is met with in a certain proporation of cases. The Samples of blood used in these experiments is met in a certain proportion of cases. The samples of blood used in these experiments have been obtained from workers in these laboratories and other apparently in the best of health. The technique was similar to that referred to in the preliminary report.

Circulation ◽  
1960 ◽  
Vol 21 (2) ◽  
pp. 204-213 ◽  
Author(s):  
F. A. L. MATHEWSON ◽  
G. S. VARNAM

1901 ◽  
Vol 67 (435-441) ◽  
pp. 370-385 ◽  

This expedition was one of those organised by the Joint Permanent Eclipse Committee of the Royal Society and the Royal Astronomical Society, funds being provided from a grant made by the Government Grant Committee. The following were the principal objects which I had in view in arranging the expedition:— To obtain a long series of photographs of the chromosphere and flash spectrum, including regions of the sun’s surface in mid-latitudes, and near one of the poles.


The following preliminary report deals briefly with the observations made during my residence in Montserrat from 24 March to 24 July, 1936, and with the main conclusions to be drawn from them. The Royal Society Expedition is greatly indebted to the representatives of His Majesty’s Government, to His Excellency Sir Gordon Lethem, Governor of the Leeward Islands, and to the Commissioner and Acting Commissioners of Montserrat for much kindness and assistance. We are also indebted for the most generous and liberal assistance rendered to the expedition by officials, representatives of organizations, and private individuals in ways too numerous to be described in detail. The members of the Expedition had the fullest support from the Government and the citizens of the island.


Author(s):  
Rashida Ferrand

Infectious diseases remain the leading cause of death in adolescents despite the improvements in public health that have occurred in the past decades. While mortality rates from infections are slowly declining in this age group, an exception is HIV, with HIV-related deaths having tripled in the last decade. As with other infections, the risk of acquiring HIV is partly explained by the biological and physical environment. However, the biological changes and the social and behavioural context of adolescence play an important role in determining risk. Notably, infections can result in long-term complications and consequent disability. While effective methods to prevent and treat many common infections do exist, the major challenges are to make these accessible to adolescents, an age-group that is often neglected by health programmes. In addition, adherence to treatment for chronic infections such as HIV, remains a major barrier to ensuring successful outcomes.


1883 ◽  
Vol 36 (228-231) ◽  
pp. 443-446

A preliminary report by Mr. Lockyer, written before the reduction of the observations given in the present paper was complete, was read to the Royal Society on December 15, 1881, and printed in the Proceedings (vol. 33, p. 154). In the present paper the author describes the plan of the observations and of their discussion, and presents some general conclusions. When observations of spot spectra were commenced in 1869, the original idea was to observe the behaviour of every line widened or brightened in the spectra of each spot.


1989 ◽  
Vol 26 (6) ◽  
pp. 462-472 ◽  
Author(s):  
H. Bielefeldt Ohmann ◽  
M. Campos ◽  
M. Snider ◽  
N. Rapin ◽  
T. Beskorwayne ◽  
...  

Cachectin/tumor necrosis factor-alpha (TNF), a protein produced by macrophages upon stimulation, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in chronic infectious diseases. In order to study further the potential role of TNF in infectious diseases, a homologous system was employed in which recombinant Escherichia coli (E. coli) derived bovine TNF (rBoTNF) was injected in cattle, either as a single bolus or in a repetitive treatment-regime. No clinical signs were observed, although changes occurred in hematologic and immunologic parameters when less than 0.5 mg of TNF/100 kg body weight was administered twice daily for 18 days. Prolonged treatment with 0.05–0.5 mg/100 kg induced histologic but no gross changes in the kidneys and liver. When doses were increased above 0.5 mg/100 kg, depression, anorexia, cachexia, and diarrhea appeared rapidly. Pathologic changes were apparent in various tissues including liver, kidneys, and lymphoid organs; body fat depots were depleted. Most of these changes appeared to be reversible; return to normal tissue-morphology occurred within 3 weeks of withdrawal of rBoTNF. The clinical and pathologic changes induced by prolonged rBoTNF administration resembled those observed in some chronic parasitic and viral infections of cattle in which macrophage-activation characteristically occur. Our finding may be relevant to the elucidation of the pathogenesis of these and other chronic infections.


We have made this attempt to describe and interpret the endocranial cast of Sinanthropus in deference to the wishes of Professor Davidson Black.* When he submitted to the Royal Society his preliminary report (Black, 1933, a ), he explained to us that he did not regard it as a disadvantage that his paper was incomplete, because it opened the way for those who had opportunities for comparing the cast with those of other human fossils and actual brains of primitive men and apes, to undertake the necessary work of comparison and interpretation, and we willingly undertake this duty. Each of us has independently studied the actual fossil skull in the Union Medical College at Peiping and examined the beautiful cast made by Professor Davidson Black from the actual fossils, and we should like to express our gratitude to him for these opportunities and many other kindnesses which he showed us. In studying the endocranial cast obtained from the Piltdown skull one of us (G.E.S.), years ago, was impressed by the extraordinary resemblance presented by the form of the brain in this extinct member of the human family to that of the primitive brain of a modern human being, a Sudanese negress (Elliot Smith, 1927, figs. 40 and 41). The other (J.L.S.) was impressed by the remarkable likeness to the endocranial cast of Sinanthropus of the brain of the Bushwoman, described in 1865 by Professor John Marshall. The recognition of these facts adds particular importance to the consideration that both the authors of this communication have served an apprenticeship to the task by examining large series of primitive brains, aboriginal Australians (J.L.S.) and Sudanese negroes (G.E.S.), and have devoted some attention to the comparison of the brains of the anthropoid apes and primitive men. In attempting to interpret the significance of the endocranial cast of Sinanthropus special attention must obviously be paid to comparison with the casts of Pithecanthropus and Eoanthropus . The comparison with the brains of the larger apes is also important, throwing light as it does upon the characters one ought to expect to find in extremely primitive human brains. In attempting to convey some real conception of the nature of the form of the brain we have resorted to the use of series of contours, figs. 10-14, so that the reader at a glance can obtain a graphic expression of the distinctive peculiarities of form. * The misfortune of his premature death deprives us of the pleasure of presenting this memoir to him.


1877 ◽  
Vol 25 (171-178) ◽  
pp. 177-230 ◽  

On this occasion I propose to adopt the same course that was taken in presenting to the Royal Society the Preliminary Report of the scientific exploration of the deep sea in H. M. Surveying-vessel ‘Porcupine’ in the years 1869 and 1870, in both of which expeditions I took a part. Narrative. 1. The Government having, at the instance of the Society and other scientific bodies, determined to equip and send out last year two ships (the ‘Alert’ and ‘Discovery’) on a North-Polar Expedition, and with these vessels the ‘Valorous’ frigate as a store-ship to accompany them as far as Disco in Davis Strait, it was considered desirable to make the last-named vessel available for sounding and dredging on her return voyage. Accordingly the following correspondence with the Admiralty took place, and will serve to explain the circumstances under which the scientific results now about to be noticed were obtained.


The expedition to which this report refers was one of those organised by the Joint Permanent Eclipse Committee of the Royal Society and the Royal Astronomical Society; it was supported by a grant made by the Government Grant Committee. Guelma was chosen for the site of the observations, as being an inland station between Sfax, which was selected for an expedition from the Royal Observatory, Greenwich, and Philippeville, which it was at first expected Sir Norman Lockyer would occupy. Guelma is 58 kilometres from Bona, 65 kilometres from Philippeville, 55 kilometres from the nearest coast of the Mediterranean Sea; it lies at a height of about 1200 feet above sea-level on the south side of the Valley of the Seybouze, amongst hills which range in height from about 3100 feet at 13 kilometres to the north, to about 4700 feet at 11 kilometres on the south, where lies the celebrated mountain, Mahouna, “the sleeping lady,” so called from the resemblance of its silhouette to the form of a woman. (For the position of the observing hut, see p. 59.)


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