scholarly journals The role of oxidative stress in postcopulatory selection

2020 ◽  
Vol 375 (1813) ◽  
pp. 20200065
Author(s):  
Christopher R. Friesen ◽  
Daniel W. A. Noble ◽  
Mats Olsson
Keyword(s):  
Oxidative Stress ◽  
Sexual Selection ◽  
Life History Theory ◽  
Primary Source ◽  
Research Area ◽  
Good Genes ◽  
Atp Production ◽  
Left Behind ◽  
Trade Offs ◽  
Postcopulatory Selection

Two decades ago, von Schantz et al . (von Schantz T, Bensch S, Grahn M, Hasselquist D, Wittzell H. 1999 Good genes, oxidative stress and condition-dependent sexual signals. Proc. R. Soc. B 266, 1–12. ( doi:10.1098/rspb.1999.0597 )) united oxidative stress (OS) biology with sexual selection and life-history theory. This set the scene for analysis of how evolutionary trade-offs may be mediated by the increase in reactive molecules resulting from metabolic processes at reproduction. Despite 30 years of research on OS effects on infertility in humans, one research area that has been left behind in this integration of evolution and OS biology is postcopulatory sexual selection—this integration is long overdue. We review the basic mechanisms in OS biology, why mitochondria are the primary source of ROS and ATP production during oxidative metabolism, and why sperm, and its performance, is uniquely susceptible to OS. We also review how postcopulatory processes select for antioxidation in seminal fluids to counter OS and the implications of the net outcome of these processes on sperm damage, sperm storage, and female and oocyte manipulation of sperm metabolism and repair of DNA to enhance offspring fitness. This article is part of the theme issue ‘Fifty years of sperm competition’.

scholarly journals Elevated oxidative damage is correlated with reduced fitness in interpopulation hybrids of a marine copepod

2013 ◽  
Vol 280 (1767) ◽  
pp. 20131521 ◽  
Author(s):  
Felipe S. Barreto ◽  
Ronald S. Burton
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Life History Evolution ◽  
Functional Ecology ◽  
Hybrid Fitness ◽  
Atp Production ◽  
Marine Copepod ◽  
Trade Offs ◽  
Oxidative Phosphorylation Pathway ◽  
Mtdna Evolution

Aerobic energy production occurs via the oxidative phosphorylation pathway (OXPHOS), which is critically dependent on interactions between the 13 mitochondrial DNA (mtDNA)-encoded and approximately 70 nuclear-encoded protein subunits. Disruptive mutations in any component of OXPHOS can result in impaired ATP production and exacerbated oxidative stress; in mammalian systems, such mutations are associated with ageing as well as numerous diseases. Recent studies have suggested that oxidative stress plays a role in fitness trade-offs in life-history evolution and functional ecology. Here, we show that outcrossing between populations with divergent mtDNA can exacerbate cellular oxidative stress in hybrid offspring. In the copepod Tigriopus californicus , we found that hybrids that showed evidence of fitness breakdown (low fecundity) also exhibited elevated levels of oxidative damage to DNA, whereas those with no clear breakdown did not show significantly elevated damage. The extent of oxidative stress in hybrids appears to be dependent on the degree of genetic divergence between their respective parental populations, but this pattern requires further testing using multiple crosses at different levels of divergence. Given previous evidence in T. californicus that hybridization disrupts nuclear/mitochondrial interactions and reduces hybrid fitness, our results suggest that such negative intergenomic epistasis may also increase the production of damaging cellular oxidants; consequently, mtDNA evolution may play a significant role in generating postzygotic isolating barriers among diverging populations.

Are parental care trade-offs in shorebirds driven by parental investment or sexual selection?

2009 ◽  
Vol 22 (4) ◽  
pp. 672-682 ◽  
Author(s):  
V. A. OLSON ◽  
T. J. WEBB ◽  
R. P. FRECKLETON ◽  
T. SZÉKELY
Keyword(s):  
Sexual Selection ◽  
Parental Care ◽  
Parental Investment ◽  
Trade Offs

Post-Copulatory Sexual Selection

2021 ◽  
Author(s):  
Patricia L.R. Brennan ◽  
Dara N. Orbach
Keyword(s):  
Sexual Selection ◽  
Sperm Competition ◽  
Female Choice ◽  
Reproductive Tract ◽  
Seminal Fluid ◽  
Fertilization Success ◽  
Female Reproductive Tract ◽  
Cryptic Female Choice ◽  
Trade Offs ◽  
Morphological Criteria

The field of post-copulatory sexual selection investigates how female and male adaptations have evolved to influence the fertilization of eggs while optimizing fitness during and after copulation, when females mate with multiple males. When females are polyandrous (one female mates with multiple males), they may optimize their mating rate and control the outcome of mating interactions to acquire direct and indirect benefits. Polyandry may also favor the evolution of male traits that offer an advantage in post-copulatory male-male sperm competition. Sperm competition occurs when the sperm, seminal fluid, and/or genitalia of one male directly impacts the outcome of fertilization success of a rival male. When a female mates with multiple males, she may use information from a number of traits to choose who will sire her offspring. This cryptic female choice (CFC) to bias paternity can be based on behavioral, physiological, and morphological criteria (e.g., copulatory courtship, volume and/or composition of seminal fluid, shape of grasping appendages). Because male fitness interests are rarely perfectly aligned with female fitness interests, sexual conflict over mating and fertilization commonly occur during copulatory and post-copulatory interactions. Post-copulatory interactions inherently involve close associations between female and male reproductive characteristics, which in many species potentially include sperm storage and sperm movement inside the female reproductive tract, and highlight the intricate coevolution between the sexes. This coevolution is also common in genital morphology. The great diversity of genitalia among species is attributed to sexual selection. The evolution of genital attributes that allow females to maintain reproductive autonomy over paternity via cryptic female choice or that prevent male manipulation and sexual control via sexually antagonistic coevolution have been well documented. Additionally, cases where genitalia evolve through intrasexual competition are well known. Another important area of study in post-copulatory sexual selection is the examination of trade-offs between investments in pre-copulatory and post-copulatory traits, since organisms have limited energetic resources to allocate to reproduction, and securing both mating and fertilization is essential for reproductive success.

Abstract P309: Particulate Matter Increases Oxidative Stress And Shortens The Action Potential In IPS-derived Cardiomyocytes

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
Mariana Argenziano ◽  
jiajia yang ◽  
Mariana Burgos Angulo ◽  
Thomas V McDonald
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Action Potential ◽  
Cardiac Electrophysiology ◽  
Structural Changes ◽  
Hospital Admissions ◽  
Induced Pluripotent Stem Cell ◽  
Toxic Substances ◽  
Direct Role ◽  
Atp Production

Introduction: Air particulate matter (PM) represents one of the most critical environmental issues worldwide, causing more than 3 million deaths a year. In the US, hospital admissions due to heart failure (HF) increase by 0.8% for every 10 μg/m3 elevation in PM. However, the biological mechanisms behind the effects of PM on cardiovascular disease (CVD) remain poorly defined. Recent studies showed that PM 2.5 can translocate into the circulation, causing cumulative toxicity. With air pollution increasing due to human activity and the growing prevalence of HF, there is a critical need to understand PM's contributions to CVD to develop preventive treatments and novel therapeutic approaches. Hypothesis: We hypothesize that PM can exert its toxic effect by increasing oxidative stress and apoptosis and affecting cardiac electrophysiology. Methods: Three independent induced pluripotent stem cell lines (IPSC) were differentiated into cardiomyocytes (iCMs) and cultured for 30 days before treatment with 100 μg/ml of PM 2.5 for 48h. Experiments including immunostaining, qPCR, RNAseq and Multielectrode Array (MEA) were performed in control (CT) and PM-treated iCMs (PM). Results: Treatment with PM increased ROS and decreased ATP production (CT 9.9±1.2pmol vs PM 6.6±0.8pmol, p<0.01, n=20). Immunostaining showed mitochondrial fragmentation and increased expression of cleaved caspase3 without structural changes. Moreover, PM caused upregulation of the apoptotic markers P53 , PARP1 and CASP3, oxidative stress markers CYP1A1, CYP1B1 and MT2A, and cardiac markers CACNA1C together with downregulation of GJA1 . RNAseq analysis showed upregulation of Gene Ontology terms related to detoxification, response to toxic substances and oxidative stress. Upregulated KEGG pathways included oxidative phosphorylation, hypertrophic cardiomyopathy and dilated cardiomyopathy. MEA experiments revealed a decrease in the spike amplitude and conduction velocity, along with shortening of the action potential (APD90: CT 577±20ms vs. PM 489±16ms, p<0.05, n=20) and increased beat period irregularity (CT 3.2±0.7% vs. PM 13.1±1.6%, p<0.001, n=20). These electrophysiological changes were reversed by treatment with the antioxidant N-acetylcysteine. Conclusions: We conclude that PM plays a direct role in the development of CVD, causing an increase in oxidative stress and affecting the electrophysiology of the heart. Further functional studies in iCMs from HF patients will provide evidence of the effects of these changes on the phenotype of the disease.

The costs of reproduction in tree swallows (Tachycineta bicolor)

1991 ◽  
Vol 69 (10) ◽  
pp. 2540-2547 ◽  
Author(s):  
Nathaniel T. Wheelwright ◽  
Joanna Leary ◽  
Caragh Fitzgerald
Keyword(s):  
Life History ◽  
Clutch Size ◽  
Brood Size ◽  
Life History Theory ◽  
Tachycineta Bicolor ◽  
Laying Date ◽  
Tree Swallows ◽  
Costs Of Reproduction ◽  
Return Rates ◽  
Trade Offs

We investigated the effect of brood size on nestling growth and survival, parental survival, and future fecundity in tree swallows (Tachycineta bicolor) over a 4-year period (1987–1990) in an effort to understand whether reproductive trade-offs limit clutch size in birds. In addition to examining naturally varying brood sizes in a population on Kent Island, New Brunswick, Canada, we experimentally modified brood sizes, increasing or decreasing the reproductive burdens of females by two offspring. Unlike previous studies, broods of the same females were enlarged or reduced in up to 3 successive years in a search for evidence of cumulative costs of reproduction that might go undetected by a single brood manipulation. Neither observation nor experiment supported the existence of a trade-off between offspring quality and quantity, in contrast with the predictions of life-history theory. Nestling wing length, mass, and tarsus length were unrelated to brood size. Although differences between means were in the direction predicted, few differences were statistically significant, despite large sample sizes. Nestlings from small broods were no more likely to return as breeding adults than nestlings from large broods, but return rates of both groups were very low. Parental return rates were also independent of brood size, and there was no evidence of a negative effect of brood size on future fecundity (laying date, clutch size). Reproductive success, nestling size, and survival did not differ between treatments for females whose broods were manipulated in successive years. Within the range of brood sizes observed in this study, the life-history costs of feeding one or two additional nestlings in tree swallows appear to be slight and cannot explain observed clutch sizes. Costs not measured in this study, such as the production of eggs or postfledging parental care, may be more important in limiting clutch size in birds.

scholarly journals Phytochemicals from the Cocoa Shell Modulate Mitochondrial Function, Lipid and Glucose Metabolism in Hepatocytes via Activation of FGF21/ERK, AKT, and mTOR Pathways

Antioxidants ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 136
Author(s):  
Miguel Rebollo-Hernanz ◽  
Yolanda Aguilera ◽  
Maria A. Martin-Cabrejas ◽  
Elvira Gonzalez de Gonzalez de Mejia
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Function ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Fatty Acid Synthase ◽  
Cell Model ◽  
Fibroblast Growth Factor 21 ◽  
Alcoholic Fatty Liver ◽  
Atp Production ◽  
Cocoa Shell

The cocoa shell is a by-product that may be revalorized as a source of bioactive compounds to prevent chronic cardiometabolic diseases. This study aimed to investigate the phytochemicals from the cocoa shell as targeted compounds for activating fibroblast growth factor 21 (FGF21) signaling and regulating non-alcoholic fatty liver disease (NAFLD)-related biomarkers linked to oxidative stress, mitochondrial function, and metabolism in hepatocytes. HepG2 cells treated with palmitic acid (PA, 500 µmol L−1) were used in an NAFLD cell model. Phytochemicals from the cocoa shell (50 µmol L−1) and an aqueous extract (CAE, 100 µg mL−1) enhanced ERK1/2 phosphorylation (1.7- to 3.3-fold) and FGF21 release (1.4- to 3.4-fold) via PPARα activation. Oxidative stress markers were reduced though Nrf-2 regulation. Mitochondrial function (mitochondrial respiration and ATP production) was protected by the PGC-1α pathway modulation. Cocoa shell phytochemicals reduced lipid accumulation (53–115%) and fatty acid synthase activity (59–93%) and prompted CPT-1 activity. Glucose uptake and glucokinase activity were enhanced, whereas glucose production and phosphoenolpyruvate carboxykinase activity were diminished. The increase in the phosphorylation of the insulin receptor, AKT, AMPKα, mTOR, and ERK1/2 conduced to the regulation of hepatic mitochondrial function and energy metabolism. For the first time, the cocoa shell phytochemicals are proved to modulate FGF21 signaling. Results demonstrate the in vitro preventive effect of the phytochemicals from the cocoa shell on NAFLD.

scholarly journals Groundwater vulnerability assessment and mapping in shallow groundwater

2021 ◽  
Vol 926 (1) ◽  
pp. 012047
Author(s):  
K Aribowo ◽  
W Wilopo ◽  
D H Barianto
Keyword(s):  
Land Use Planning ◽  
Unsaturated Zone ◽  
Shallow Groundwater ◽  
Primary Source ◽  
Groundwater Vulnerability ◽  
Research Area ◽  
A Value ◽  
Groundwater Vulnerability Assessment ◽  
Vulnerability Map ◽  
Very High

Abstract The increasing population density can contaminate groundwater. So far, groundwater is still the primary source to fulfill clean water and drinking water in Muntilan, Salam, and Ngluwar Sub-District. Studies on groundwater vulnerability are essential to minimize the contamination risks as a piece of basic information for land use planning. This research aims to assess groundwater vulnerability in Muntilan, Salam, and Ngluwar Sub-District. The simple vertical vulnerability (SVV) method with GIS was selected to develop a groundwater vulnerability map. The parameters of this method consist of the type of soil/rock, the thickness of the water-unsaturated zone, and the recharge value. The results show that the research area can be divided into three vulnerability classes: very low, moderate, and high groundwater vulnerability. Very low groundwater vulnerability has a value of more than 70 with very high protection effectiveness. The class is distributed in Muntilan and Salam Sub-Districts. Moderate groundwater vulnerability has a value less than 35 to 65 with moderate protection effectiveness, and high groundwater vulnerability has a value ranging from 24 to 35 with low protection effectiveness. Both of the class is evenly distributed in Muntilan, Ngluwar and Salam Sub-Districts.

scholarly journals Sexual selection studies: a NESCent catalyst meeting

2015 ◽  
Author(s):  
Joan Roughgarden ◽  
Elizabeth Adkins-Regan ◽  
Erol Akçay ◽  
Jeremy Chase Crawford ◽  
Raghavendra Gadagkar ◽  
...  
Keyword(s):  
Sexual Selection ◽  
Behavioral Theory ◽  
Good Genes ◽  
Ethical Dimension ◽  
Dependent Process ◽  
Deep Disagreement ◽  
Fecundity Selection ◽  
The Status ◽  
Definition Of ◽  
Political Economic

A catalyst meeting on sexual selection studies was held in July 2013 at the facilities of the National Evolutionary Synthesis Center (NESCent) in Durham, NC. This article by a subcommittee of the participants foregrounds some of the topics discussed at the meeting. Topics mentioned here include the relevance of heritability estimates to assessing the presence of sexual selection, whether sexual selection is distinct from natural selection, and the utility of distinguishing sexual selection from fecundity selection. A possible definition of sexual selection is offered based on a distinction between sexual selection as a frequency-dependent process and fecundity selection as a density-dependent process. Another topic highlighted is a deep disagreement among participants in the reality of good-genes, sexy-sons, and run-away processes. Finally, the status of conflict in political-economic theory is contrasted with the status accorded to conflict in evolutionary behavioral theory, and the professional responsibility of sexual-selection workers to consider the ethical dimension of their research is underscored.

scholarly journals Temperature as a modulator of sexual selection

2018 ◽  
Author(s):  
Roberto García-Roa ◽  
Francisco Garcia-Gonzalez ◽  
Daniel W.A. Noble ◽  
Pau Carazo
Keyword(s):  
Global Warming ◽  
Sexual Selection ◽  
Thermal Environment ◽  
Abiotic Factors ◽  
Meta Analysis ◽  
Population Viability ◽  
Order Effects ◽  
Secondary Sexual Traits ◽  
Trade Offs ◽  
Wide Range

A central question in ecology and evolution is to understand why sexual selection varies so much in strength across taxa, and it has long been known that ecological factors are crucial to this respect. Temperature is a particularly critical abiotic ecological factor that can drastically modulate a wide range of physiological, morphological and behavioural traits, impacting individuals and populations at a global taxonomic scale. Furthermore, temperature exhibits substantial temporal variation (e.g. daily, seasonally and inter-seasonally), and hence for most species in the wild sexual selection will regularly unfold in a dynamic thermal environment. Unfortunately, studies have so far almost completely neglected the role of temperature as a modulator of sexual selection. Here, we outline the main pathways via which temperature can affect the intensity and form (i.e. mechanisms) of sexual selection, via: a) direct effects on secondary sexual traits and preferences (i.e. trait variance, opportunity for selection and trait-fitness covariance), and b) indirect effects on key mating parameters, sex-specific reproductive costs/benefits, trade-offs, demography and correlated abiotic factors. Building upon this framework, we show that, by focusing exclusively on the first order effects that environmental temperature has on traits linked with individual fitness and population viability, current global warming studies may be ignoring important eco-evolutionary feedbacks mediated by sexual selection. Finally, we tested the general prediction that temperature modulates sexual selection by conducting a meta-analysis of available studies experimentally manipulating temperature and reporting effects on the variance of male/female reproductive success and/or traits under sexual selection. Our results show a clear association between temperature and sexual selection measures in both sexes. In short, we suggest that studying the feedback between temperature and sexual selection processes can be vital to better understand variation in the strength of sexual selection in nature, and its consequences for population viability in response to environmental change (e.g. global warming).

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