scholarly journals The York Gospels: a one thousand year biological palimpsest

2017 ◽  
Author(s):  
Matthew D. Teasdale ◽  
Sarah Fiddyment ◽  
Jiří Vnouček ◽  
Valeria Mattiangeli ◽  
Camilla Speller ◽  
...  
Keyword(s):  
Sampling Technique ◽  
Cost Effective ◽  
Biological Data ◽  
Biological Information ◽  
Non Invasive ◽  
The Reformation ◽  
Small Collection ◽  
History Of ◽  
First Time ◽  
Selection Of

AbstractMedieval manuscripts, carefully curated and conserved, represent not only an irreplaceable documentary record but also a remarkable reservoir of biological information. Palaeographic and codicological investigation can often locate and date these documents with remarkable precision. The York Gospels (York Minster Ms. Add. 1) is one such codex, one of only a small collection of pre-conquest Gospel books to have survived the Reformation. By extending the non-invasive triboelectric (eraser-based) sampling technique eZooMS, to include the analysis of DNA we report a cost effective and simple-to-use biomolecular sampling technique. We apply this combined methodology to document for the first time a rich palimpsest of biological information contained within the York Gospels, which has accumulated over the 1,000 year lifespan of this cherished object that remains an active participant in the life of York Minster. This biological data provides insights into the decisions made in the selection of materials, the construction of the codex and the use history of the object.

scholarly journals The York Gospels: a 1000-year biological palimpsest

2017 ◽  
Vol 4 (10) ◽  
pp. 170988 ◽  
Author(s):  
Matthew D. Teasdale ◽  
Sarah Fiddyment ◽  
Jiří Vnouček ◽  
Valeria Mattiangeli ◽  
Camilla Speller ◽  
...  
Keyword(s):  
Sampling Technique ◽  
Cost Effective ◽  
Biological Data ◽  
Biological Information ◽  
Non Invasive ◽  
The Reformation ◽  
Small Collection ◽  
History Of ◽  
First Time ◽  
Selection Of

Medieval manuscripts, carefully curated and conserved, represent not only an irreplaceable documentary record but also a remarkable reservoir of biological information. Palaeographic and codicological investigation can often locate and date these documents with remarkable precision. The York Gospels (York Minster Ms. Add. 1) is one such codex, one of only a small collection of pre-conquest Gospel books to have survived the Reformation. By extending the non-invasive triboelectric (eraser-based) sampling technique eZooMS, to include the analysis of DNA, we report a cost-effective and simple-to-use biomolecular sampling technique for parchment. We apply this combined methodology to document for the first time a rich palimpsest of biological information contained within the York Gospels, which has accumulated over the 1000-year lifespan of this cherished object that remains an active participant in the life of York Minster. These biological data provide insights into the decisions made in the selection of materials, the construction of the codex and the use history of the object.

Live birth following the first mutation specific pre-implantation genetic diagnosis for haemophilia A

2006 ◽  
Vol 95 (02) ◽  
pp. 373-379 ◽  
Author(s):  
Edward Tuddenham ◽  
Cathy Turner ◽  
Ben Lavender ◽  
Stuart Lavery ◽  
Katerina Michaelides
Keyword(s):  
Live Birth ◽  
Genetic Diagnosis ◽  
Proteinase K ◽  
Amplification Efficiency ◽  
Haemophilia A ◽  
Singleton Pregnancy ◽  
Single Nucleotide ◽  
History Of ◽  
First Time ◽  
Selection Of

SummaryHaemophilia A is an X-linked, recessive, inherited bleeding disorder which affects 1 in 5000 males born worldwide. It is caused by mutations in the FactorVIII (F8) gene on chromosome Xq28. We describe for the first time two mutation specific, single cell protocols for pre-implantation genetic diagnosis (PGD) of haemophilia A that enable the selection of both male and female unaffected embryos. This approach offers an alternative to sexing, frequently used for X-linked disorders, that results in the discarding of all male embryos including the 50% that would have been normal. Two families witha history of severe haemophilia A requested carrier diagnosis and subsequently proceeded to PGD. The mutation in family1 isa single nucleotide substitution c. 5953C>T, R1966X in exon 18 and in family 2, c. 5122C>T, R1689C in exon 14 of the F8 gene. Amplification efficiency was compared between distilled water and SDS/proteinase K cell lysis (98.0%, 96/98 and 80%, 112/140 respectively) using 238 single lymphocytes. Blastomeres from spare IVF cleavage-stage embryos donated for research showed amplification efficiencies of 83.3% (45/54) for the R1966X and 92.9% (13/14) for the R1689C mutations. The rate of allele dropout (ADO) on heterozygous lymphocytes was 1.1% (1/93) for R1966X and 5.94% (6/101) for R1689C mutations. A single PGD treatment cycle for family1 resulted in two embryos for transfer but these failed to implant. However, with family 2, two embryos were transferred to the uterus on day 4 resulting in a successful singleton pregnancy and subsequent live birth of a normal non-carrier female.

scholarly journals On Eminescu’s philosophy of history: towards an English anthology of relevant texts

2020 ◽  
Vol 3 (1) ◽  
pp. 241-258
Author(s):  
Catalin Pavel
Keyword(s):  
Nineteenth Century ◽  
Philosophy Of History ◽  
Complex Interplay ◽  
History Of ◽  
Academic Philosophy ◽  
Per Se ◽  
First Time ◽  
Selection Of ◽  
Historical Thought

The present paper aims to offer Anglophone researchers a selection of translated quotes from Mihai Eminescu’s non-literary oeuvre, relevant to the philosophy of history of the most complex Romanian author of the nineteenth century. It should thus become possible to reconsider Eminescu’s position within the concert of European philosophers of history. The fragments gathered here stem mainly from his activity as a cultural and political journalist, throughout which he voiced, albeit unsystematically, his views on history. Although he did not ultimately articulate an academic philosophy of history per se, these fragments, now available in English for the first time, may give valuable insights into Eminescu’s conception of history. Above all else, they meaningfully complement whatever can be gleaned from Eminescu’s already translated poetry or literary prose. Hopefully the fragments presented here will aid scholars in establishing more precisely what Eminescu’s views on history owe to Schopenhauer’s metaphysics and what to the proper philosophy of history he could find in Hegel. This is a double allegiance scholars have also recognized in Maiorescu’s work. By the same token, it would further be important to chart Eminescu’s ambivalence towards Hegel, an ambivalence also visible in the works of Romanian philosopher Vasile Conta. Finally, the fragments below may help to bring to the fore the complex interplay between Hegelian theodicy and Kantian teleology in Eminescu’s historical thought.

Roman History

2015 ◽  
Vol 62 (2) ◽  
pp. 237-241
Author(s):  
Lucy Grig
Keyword(s):  
Literary Tradition ◽  
Roman History ◽  
Ancient History ◽  
Clear Case ◽  
Classical Studies ◽  
History Of ◽  
Lively Debate ◽  
First Time ◽  
Selection Of ◽  
Future Reference

Let's start at the very beginning: that is, at the beginning of the history of Rome. This latest volume of the Oxford Readings in Classical Studies makes a clear case for the virtue of reprinting old articles even in an age of supposedly wide digital availability. An obvious virtue here is the fact this collection includes no fewer than seven articles that have been translated into English for the first time. In making this collection, the editors hope to show the continuing lively debate on the nature of the ancient historiographical tradition. Rather than taking a particular editorial line, the collection includes scholars with differing views as to the reliability of this tradition when it comes to early Roman history. That being said, it is not surprising that scholarship that aims wholeheartedly to uphold the historicity of the traditional accounts is definitely outnumbered by studies demonstrating instead the construction of historiographical tradition(s). Nonetheless, Andrea Carandini begins the collection by arguing once more for the congruence of the archaeological evidence and the literary tradition. The articles that follow vary somewhat in approach and in degrees of scepticism – for instance, Fausto Zevi admits a historical core to stories about Demoratus and the Tarquins, whereas Michael Crawford is forthright in his rejection of historicity in the earliest list of Roman colonies. The editors have taken the helpful decision to focus rather more on ‘stories’ than individual authors and this certainly helps shape a thought-provoking collection that can be read with profit rather than just put on the shelf for future reference. In particular, the editors’ suggestion that this volume could profitably be given to students in place of a single ‘authoritative’ version of the history of early Rome, so that they can see that there are indeed different ways of ‘doing’ ancient history, is persuasive. Finally, any selection of papers is, of course, subjective but an article focusing rather more particularly on non-literary historical traditions might have rounded out the picture more fully.

Popular Disturbance and the Fall of Thomas Cromwell and the Reformers, 1539–1540

1981 ◽  
Vol 24 (2) ◽  
pp. 257-278 ◽  
Author(s):  
Susan Brigden
Keyword(s):  
Religious History ◽  
Social Disorder ◽  
The People ◽  
The Reformation ◽  
History Of ◽  
Religious Radicalism ◽  
First Time ◽  
High Politics

On 28 July 1540 Thomas Cromwell went to execution, and two days later Robert Barnes, Thomas Garret and William Jerome, leading protestant preachers and the minister's protégés, were burned at the stake.1 These reformers were sacrificed to implicate Cromwell in apostasy, but their deaths were more than judicial murder; they died for making a reality of the conservatives’ old fears that religious radicalism would engender social disorder. With the coming of the Reformation issues of faith for the first time deeply divided the people, and the rift went beyond the schism between orthodox and reformed alone. Many who witnessed the confusion thought that ‘the devyll reyneth over us nowe’ and believed that ‘alle thys devysyon comyth through that ffalse knave that heretyke Doctor Barnys and such other heretiks as he ys’.2 The faction struggles in court and council which dominated the last years of Henry VIII's reign produced the shifting policies of reaction or toleration towards reform, but while political intrigue determined the incidence of persecution and decided the victims the events of 1540 were to reveal that Protestantism was spreading independently, thwarting the restoration of Catholic orthodoxy, whatever the policy of government. The religious history of London was inextricably linked with the feuds of contending factions at court in the confused months of the spring and summer of 1540, not least because many of the protagonists and persecuted were Londoners themselves. The tensions witnessed in the capital between orthodox and reformed, and popular disturbance there, underlay all the machinations in high politics and influenced the outcome.

scholarly journals First description of two immune escape indian B.1.1.420 and B.1.617.1 SARS-CoV2 variants in France

2021 ◽  
Author(s):  
Vincent Garcia ◽  
Veronique Vig ◽  
Laurent Peillard ◽  
Alaa Ramdani ◽  
Sofiane Mohamed ◽  
...  
Keyword(s):  
Immune Escape ◽  
Close Monitoring ◽  
Infected People ◽  
Gene Coding ◽  
Fast Spreading ◽  
History Of ◽  
Travel Abroad ◽  
First Time ◽  
Induced Immunity ◽  
Selection Of

Following the outbreak of the SARS-CoV2 virus worldwide in 2019, the rapid widespread overtime of variants suggests today an undergoing positive selection of variants which could potentially provide advantageous genetic property of the virus. Numerous variants have already been described across different countries including N501Y, E484K or L452R mutations on gene coding to spike protein. Most recently, 2 new Indian variants with N440K and E484Q and L452R mutations associated with impaired antibody response and immune reactions were identified in India. The potential consequences of emerging variants are increased transmissibility, increased pathogenicity and the ability to escape natural or vaccine-induced immunity. We described for the first time in France both variants: the N440K immune escape variant within a new strain detected in France in a couple of patients who did not have any history of travel abroad and the new E484Q and L452R Indian variant from a patient travelling from Indian to Marseille to embark on a ship as a crew member. Such study of the circulating viral strains and their variants within the increasing number of infected people worldwide will provide further insights into the viral dissemination. Hence, real time close monitoring variant could help the scientific community to prevent fast-spreading and raise alarms towards potentially harmful variants.

scholarly journals Analisis Preeklampsia Ibu Hamil pada Masa Pandemi Covid-19 di Puskesmas Sepatan Kabupaten Tangerang Tahun 2021

2021 ◽  
Vol 10 (2) ◽  
pp. 375
Author(s):  
Yenny Aulya ◽  
Vivi Silawati ◽  
Wulan Safitri
Keyword(s):  
Nutritional Status ◽  
Pregnant Women ◽  
Health Center ◽  
Significant Relationship ◽  
Multiple Pregnancy ◽  
Sampling Technique ◽  
Cross Sectional ◽  
History Of Disease ◽  
History Of ◽  
First Time

Medical record data at the Sepatan Health Center in 2019 showed that the incidence of preeclampsia from 735 deliveries was obtained as many as 93 people (12.65%) pregnant women who underwent examinations in the January-December 2020 period, and increased to 116 people (13.25%) from 875. childbirth, and in January 2021 there were 35 preeclampsia of pregnant women and 81 preeclampsia of pregnant women, out of 875 deliveries. Analyzing factors associated with preeclampsia of pregnant women during the Covid-19 pandemic at the Sepatan Public Health Center, Tangerang Regency in 2021. Methods This type of research is an analytical survey research, with a cross sectional approach. This population is all pregnant women who experience preeclampsia in January 2021 as many as 35 respondents, using a total sampling technique of 35 respondent’s pregnant women with preeclampsia. The results showed that five variables were statistically proven to have a significant relationship with the incidence of preeclampsia, namely age (p = 0.010 <0.05), parity (p = 0.021 <0.05), history of disease (p = 0.004 <0, 05) multiple pregnancy (p = 0.026 <0.05) and nutritional status (p = 0.007 <0.05). There is a significant relationship between age, parity, history of disease, multiple pregnancies and nutritional status on the incidence of preeclampsia of pregnant women at the Puskesmas Sepatan, Tangerang District in 2021.  For midwives to be more observant in examining preeclampsia, especially age (<20 years or> 35 years), mothers who are pregnant for the first time, have a history of disease, pregnancy with multiple fetuses and nutritional status who are overweight in pregnant women

Enhancing Flow Field Measurements Through Adaptive Multi-Dimensional Data Sampling

2005 ◽  
Author(s):  
Arnoud R. C. Franken ◽  
Paul C. Ivey
Keyword(s):  
Flow Field ◽  
High Speed ◽  
Sampling Technique ◽  
Field Measurements ◽  
Cost Effective ◽  
Pressure Probe ◽  
Data Sets ◽  
Data Sampling ◽  
Essential Information ◽  
Selection Of

A way to gain insights into the flow field conditions in turbomachinery is by carrying out a series of point measurements in a cross-section of the flow, for example, with a miniature multi-hole pressure probe. A problem commonly encountered in situations like these is the selection of a suitable measurement grid layout and density for obtaining all essential information in a cost-effective and timely manner. In order to achieve the latter, a novel adaptive multi-dimensional data sampling technique has been developed at Cranfield University. This paper describes the underlying principles of this technique, the algorithms utilized, and the results obtained during its successful application to data sets of two different flow fields in a high-speed research compressor.

scholarly journals Whose Gaze? Stories Told between Kabul, Herat and Berlin

2020 ◽  
Vol 11 (1) ◽  
pp. 61-77
Author(s):  
Sandra Schäfer
Keyword(s):  
Women Filmmakers ◽  
Film Festival ◽  
History Of ◽  
Women's Cinema ◽  
Gender And Society ◽  
First Time ◽  
Selection Of

This visual essay focuses on contemporary women’s cinema in Afghanistan, which started in 2001, when, for the first time, women made films in Afghanistan. They narrate stories from their perspectives, and choose different filmic means, characters and genres to tell their stories. With a selection of film stills and photographs, this visual essay introduces the work of these women filmmakers. The images are accompanied by text that describes the contents and the making of their films. Text includes quotations from filmmakers reflecting on their practice. The directors whose work I present are, among others, Roya Sadat, Saba Sahar, Diana Saqeb and Aiqela Rezaie. As some of the filmmakers also work as actresses, I draw an arc into the changeful history of Afghan cinema and the role women played as actresses in these films. The essay highlights the period between 2002 and 2009, when I worked in Kabul making my film Passing the Rainbow and co-organising the film festival SPLICE IN on Gender and Society.

Opera Evangelica: A Lost Collection of Christian Apocrypha

2021 ◽  
Vol 67 (3) ◽  
pp. 356-387
Author(s):  
Tony Burke ◽  
Gregory Peter Fewster
Keyword(s):  
Eighteenth Century ◽  
English Language ◽  
Rare Book ◽  
Cambridge University ◽  
University Of Toronto ◽  
History Of ◽  
The University ◽  
First Time ◽  
Material Form ◽  
Selection Of

Within the holdings of the Thomas Fisher Rare Book Library at the University of Toronto there is a curious, rarely examined handwritten book entitled Opera Evangelica, containing translations of several apocryphal works in English. It opens with a lengthy Preface that provides an antiquarian account of Christian apocrypha along with a justification for translating the texts. Unfortunately, the book's title page gives little indication of its authorship or date of composition, apart from an oblique reference to the translator as ‘I. B.’ But citations in the Preface to contemporary scholarship place the volume around the turn of the eighteenth century, predating the first published English-language compendium of Christian apocrypha in print by Jeremiah Jones (1726). A second copy of the book has been found in the Cambridge University Library, though its selection of texts and material form diverges from the Toronto volume in some notable respects. This article presents Opera Evangelica to a modern audience for the first time. It examines various aspects of the work: the material features and history of the two manuscripts; the editions of apocryphal texts that lie behind its translations; the views expressed on Christian apocrypha by its mysterious author; and its place within manuscript publication and English scholarship around the turn of the eighteenth century. Scholars of Christian apocrypha delight in finding ‘lost gospels’ but in Opera Evangelica we have something truly unique: a long-lost collection of Christian apocrypha.

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