Clinical and Inflammatory Factors Influencing Constipation and Quality of Life in Cerebral Palsy

AbstractIntroductionIntestinal constipation is a clinical consequence, secondary to neuromotor disturbances, which acts on subjects with cerebral palsy (CP). The aim of this study was to investigate the factors influencing constipation and the quality of life (QOL) of CP subjects.Materials and methodsWe recruited a total of 63 subjects aging from 5-17 years with spastic CP who received physical rehabilitation. The subjects were divided into two groups including with and without constipation. Subjects were assigned into one of the 4 groups (G1-4) based on the prevalence of 1) CP and 2) Constipation. Subjects were assigned as CP with constipation (G1), CP without constipation (G2), and controls without CP with constipation (G3) and without CP and without constipation (G4). Subjects’ demographics, use of antiepileptic drugs (AEDs), motor function, caregiver priorities and child health index of life with disabilities (CPCHILD) were included. In addition to medical metadata, a subset of subjects was evaluated for oral and systemic inflammation through gingival bleeding and serum cytokine levels (TNF-α, IL-1β, IL-6, IL-8, IL-10) respectively. Statistical significance was evaluated by ANOVA One-Way (parametric data) and Kruskal Wallis (non-parametric data).ResultsA significant relationship was found between the type of medication and constipation. Subjects taking GABA and GABA+ (GABA in association with other medication) were more likely to be constipated than the other groups (P < 0.01). Additionally, quality of life was directly correlated with constipation; subjects in G1 presented the lower mean score of CPCHILD (49.0 #x00B1;13.1) compared to G2 (71.5 ± 16.7), when compared to G3 (88.9 ± 7.5), and G4 (95.5 ±5.0) (P < 0.01). Inflammation was more severe for patients in G1 (P < 0.001). There were no differences among groups regarding gender (P = 0.332) and age (P = 0.292).ConclusionsOur results suggest that constipation was mostly affected by the use of certain antiepileptic drugs, namely GABA. This showed direct detrimental effect on CP quality of life, which was influenced by inflammatory cytokines and the dosage and type of AEDs.

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Calidad de vida en adultos institucionalizados con parálisis cerebral infantil

Enfermería Global ◽

10.6018/eglobal.19.1.349901 ◽

2019 ◽

Vol 19 (1) ◽

pp. 243-262

Author(s):

Agueda Cervera Gasch ◽

Laura Martínez Traver

Keyword(s):

Quality Of Life ◽

Cerebral Palsy ◽

Developmental Disorders ◽

Physical Dependence ◽

Statistical Significance ◽

Average Score ◽

Gross Motor ◽

Calidad De Vida ◽

San Martín

Introduccion: La parálisis cerebral es considerada como un grupo de trastornos permanentes deldesarrollo que originan limitaciones en la actividad diaria. Una de las complicaciones en las personascon parálisis cerebral es la disminución de la calidad de vida.Objetivo: El objetivo de este estudio es conocer la calidad de vida de las personas adultas institucionalizadas con parálisis cerebral infantil y conocer si existen diferencias en el índice de calidad de vida en función de las características funcionales.Método: Estudio observacional descriptivo trasversal en personas adultas institucionalizas con parálisiscerebral infantil realizado en los centros APCA y ASPROPACE entre marzo y septiembre de 2017. Seadministró el cuestionario San Martín para medir la Calidad de Vida, Gross motor classification system,cuestionario Barthel, Escala CFCS para medir función motora, dependencia física, nivel decomunicación y relacionarlas con variables sociodemográficas y clínicas. La selección de lospariticipantes se llevó a cabo mediante un muestreo estratificado aleatorio. Se contó con la aprobaciónde las direcciones de los centros.Resultados: Participaron 39 personas con edad media de 32,54 años. La puntuación media global delcuestionario San Martin fue de 102,97 puntos. Las dimensiones mas afectadas fueron bienestar material, desarrollo personal e incluison social. No se obtuvo significación estadística en la puntuación global del cuestionario en función de las variables secundarias.Conclusiones: Los resultados de este estudio han demostrado que la Calidad de vida de adultos conparálisis cerebral en los sujetos estudiados es buena. Introduction: Cerebral palsy is considered a group of permanent developmental disorders that causelimitations in daily activity. One of the complications in people with cerebral palsy is the decrease inquality of life.Objective: The objective of this study is to know the quality of life for institutionalized adults withinfantile cerebral palsy and to know if there are differences in the quality of life index based on functionalcharacteristics.Method: Cross-sectional descriptive observational study in institutionalized adults with infantile cerebralpalsy performed in the APCA and ASPROPACE centers between March and September 2017. The SanMartín questionnaire was administered to measure the Quality of Life, Gross motor classificationsystem, Barthel questionnaire, Scale CFCS to measure motor function, physical dependence, level ofcommunication and relate them with sociodemographic and clinical variables. The selection of theparticipants was carried out by random stratified sampling. It was approved by the centers' addresses.Results: Participants were 39 people with an average age of 32.54 years. The overall average score ofthe San Martin questionnaire was 102.97 points. The most affected dimensions were material wellbeing,personal development and social incluison. No statistical significance was obtained in the overall score of the questionnaire based on the secondary variables.Conclusions: The results of this study have shown that the quality of life of adults with cerebral palsy inthe subjects studied is good.

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Influence of Supply with Speech Generating Devices on Health-Related Quality of Life in Children with Cerebral Palsy: A Pilot Study

Neuropediatrics ◽

10.1055/s-0034-1390518 ◽

2014 ◽

Vol 45 (S 01) ◽

Author(s):

N. Schmidt ◽

V. Mall ◽

S. Berweck ◽

I. Nehring ◽

N. Jung

Keyword(s):

Quality Of Life ◽

Cerebral Palsy ◽

Pilot Study ◽

Health Related Quality ◽

Children With Cerebral Palsy ◽

Related Quality ◽

Health Related

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Factors influencing health-related quality of life (HRQOL) in patients with implantable cardioverter defibrillator (ICD)

The JBI Database of Systematic Reviews and Implementation Reports ◽

10.11124/01938924-201008341-00019 ◽

2010 ◽

Vol 8 (Supplement) ◽

pp. 1-13

Author(s):

Florence Wong ◽

Sek Ying Chair

Keyword(s):

Quality Of Life ◽

Implantable Cardioverter Defibrillator ◽

Health Related Quality ◽

Cardioverter Defibrillator ◽

Factors Influencing ◽

Related Quality ◽

Health Related

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The influence of the Kinesio Taping on selected ultrasonography measurements, and quality of life in patients with rotator cuff lesions

Scientific Reports ◽

10.1038/s41598-020-75701-6 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Aneta Bac ◽

Magdalena Wróbel ◽

Katarzyna Ogrodzka-Ciechanowicz ◽

Edyta Michalik ◽

Anna Ścisłowska-Czarnecka

Keyword(s):

Quality Of Life ◽

Rotator Cuff ◽

Statistical Significance ◽

Control Group ◽

Subacromial Space ◽

Kinesio Taping ◽

Significant Difference ◽

Rotator Cuff Lesions ◽

Significant Change

Abstract The assessment of the six-week influence of Kinesio Taping combined with a rehabilitation on selected ultrasonography measurements, the level of disability, and the quality of life in patients with rotator cuff lesions. 60 participants were randomly assigned into a taping group (KT combined with a six-week rehabilitating protocol) and a control group (only rehabilitation protocol). In all patients the following assessments were performed twice: USG, UEFI and NHP questionnaires. In the examination of the subacromial space and the subacromial bursa in the taping group, no statistical significance was observed. A statistically significant change in the thickness of the muscles was obtained only for the thickness of the infraspinatus in the taping group. A statistically significant change was obtained in the assessment of tendinopathy only for the supraspinatus muscle in both groups. Within both groups a statistically significant difference was observed in the average UEFI and NHP scores; however, the differences in the scores obtained between the groups were not statistically significant. The use of KT with a rehabilitation program did not yield statistically significantly better results in the improvement of selected shoulder region indicators, the function of the upper limb and the quality of life.

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1525 Measurements of Quality of Life for Children with Cerebral Palsy

Archives of Disease in Childhood ◽

10.1136/archdischild-2012-302724.1525 ◽

2012 ◽

Vol 97 (Suppl 2) ◽

pp. A432-A432

Author(s):

Z. Liu

Keyword(s):

Quality Of Life ◽

Cerebral Palsy ◽

Children With Cerebral Palsy

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Analysis of Medication Adherence and Its Influencing Factors in Patients with Schizophrenia in the Chinese Institutional Environment

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094746 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4746

Author(s):

Wei Yu ◽

Jie Tong ◽

Xirong Sun ◽

Fazhan Chen ◽

Jie Zhang ◽

...

Keyword(s):

Quality Of Life ◽

Medication Adherence ◽

Activities Of Daily Living ◽

Influencing Factors ◽

Self Efficacy ◽

Daily Living ◽

Institutional Environment ◽

Factors Influencing ◽

Quality Of Life Scale

Background: Factors related to medication adherence in patients with schizophrenia have always been key to the treatment and rehabilitation of these patients. However, the treatment modes in different countries are not the same, and there is no research on the factors influencing medication adherence under different mental health service modes. Objectives: The purpose of this study was to explore medication adherence and its influencing factors in patients with schizophrenia in the Chinese institutional environment. Methods: We conducted a cross-sectional study of hospitalized persons living with schizophrenia from November 2018 to January 2019. A systematic sampling method was used to select 217 hospitalized persons living with schizophrenia. The Medication Adherence Rating Scale (MARS), Positive and Negative Syndrome Scale (PANSS), General Self-Efficacy Scale (GSES), Schizophrenia Quality of Life Scale (SQLS), and Scale of Social Skills for Psychiatric Inpatients (SSPI) were used to explore medication compliance and its influencing factors in the Chinese institutional environment. Results: The descriptive analysis and ANOVA showed that there were no significant differences in medication adherence when assessed by demographic characteristics such as sex, marital status, and education level (p > 0.05). A correlation analysis showed that there was no significant correlation between medication adherence and mental symptoms (p > 0.05) but that there was a positive correlation with self-efficacy, quality of life, and activities of daily living (p < 0.01). The linear regression analysis showed that self-efficacy, psychosocial factors, symptoms/side effects, and activities of daily living had significant effects on medication adherence (F = 30.210, p < 0.001). Conclusions: Our findings show that the self-efficacy, quality of life, and social function of patients with schizophrenia are important self-factors influencing medication adherence in the Chinese institutional environment.

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Determinants of participation and quality of life of young adults with cerebral palsy: longitudinal approach and comparison with the general population – SPARCLE 3 study protocol

BMC Neurology ◽

10.1186/s12883-021-02263-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Catherine Arnaud ◽

Carine Duffaut ◽

Jérôme Fauconnier ◽

Silke Schmidt ◽

Kate Himmelmann ◽

...

Keyword(s):

Quality Of Life ◽

Young Adults ◽

Cerebral Palsy ◽

Young People ◽

General Population ◽

Transition Period ◽

Well Being ◽

Personal Factors ◽

The Impact

Abstract Background Effective inclusion in society for young people with disabilities is increasingly seen as generating opportunities for self-development, and improving well-being. However, significant barriers remain in the vast majority of activities meaningful for young adults. Research argues that various personal (disabilities, health) and environmental (access to the resources needed, accessible environment, discrimination, lack of personal economic independence) factors contribute to limited participation. However, previous studies conducted in young people with cerebral palsy (CP) mainly investigated the transition period to adulthood, and did not fully consider the whole range of impairment severity profiles or environmental barriers. In this study, we will use the follow-up of the SPARCLE cohort and a comparison group from the general population (1) to investigate the impact of the environment on participation and quality of life of young adults with CP, (2) to determine predictors of a successful young adulthood in educational, professional, health and social fields, (3) to compare quality of life and frequency of participation in social, work and recreational activities with the general population, (4) to document on participation and quality of life in those with severe disabilities. Methods The SPARCLE3 study has a combined longitudinal and cross-sectional design. Young adults with CP aged 22 to 27 years in 6 European regions previously enrolled in the SPARCLE cohort or newly recruited will be invited to self-complete a comprehensive set of questionnaires exploring participation (daily life and discretionary activities), health-related quality of life, body function, personal factors (health, personal resources), and contextual factors (availability of needed environmental items, family environment, services provision) during home visits supervised by trained researchers. Proxy-reports or adapted questionnaires will be used for those with the most severe impairments. The recruitment of a large group from the general population (online survey) will enable to identify life areas where the discrepancies between young people with CP and their able-bodied peers are the most significant. Discussion This study will help identify to what extent disabilities and barriers in environment negatively affect participation and quality of life, and how previous valued experiences during childhood or adolescence might modulate these effects.

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