scholarly journals Optimal evolutionary control for artificial selection on molecular phenotypes

2019 ◽  
Author(s):  
Armita Nourmohammad ◽  
Ceyhun Eksin
Keyword(s):  
Public Health ◽  
Directed Evolution ◽  
Artificial Selection ◽  
Evolutionary Trajectory ◽  
Optimal Intervention ◽  
Selection Protocol ◽  
Selection For ◽  
Molecular Phenotypes ◽  
Public Health Strategies ◽  
Evolutionary Control

Controlling an evolving population is an important task in modern molecular genetics, including in directed evolution to improve the activity of molecules and enzymes, breeding experiments in animals and in plants, and in devising public health strategies to suppress evolving pathogens. An optimal intervention to direct evolution should be designed by considering its impact over an entire stochastic evolutionary trajectory that follows. As a result, a seemingly suboptimal intervention at a given time can be globally optimal as it can open opportunities for more desirable actions in the future. Here, we propose a feedback control formalism to devise globally optimal artificial selection protocol to direct the evolution of molecular phenotypes. We show that artificial selection should be designed to counter evolutionary tradeoffs among multi-variate phenotypes to avoid undesirable outcomes in one phenotype by imposing selection on another. Control by artificial selection is challenged by our ability to predict molecular evolution. We develop an information theoretical framework and show that molecular time-scales for evolution under natural selection can inform how to monitor a population to acquire sufficient predictive information for an effective intervention with artificial selection. Our formalism opens a new avenue for devising optimal artificial selection for directed evolution of molecular functions.

scholarly journals Urbanization and greenness in HBSC survey: association with overweight and obesity in adolescents

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
V Bellisario ◽  
R Bono ◽  
G Squillacioti ◽  
M Caputo ◽  
I Gintoli ◽  
...  
Keyword(s):  
Public Health ◽  
Physical Activity ◽  
Risk Factors ◽  
Air Pollution ◽  
Population Density ◽  
Weight Status ◽  
Overweight And Obesity ◽  
Green Spaces ◽  
Children Health ◽  
Public Health Strategies

Abstract Background Childhood obesity is an important public health issue worldwide and includes different risk factors, such as environmental pollutants exposure or physical activity. Neighborhood composition and green spaces availability could contrast obesogenic lifestyles and promote healthy habits, whereas, urbanization and traffic volume exposure are inversely associated with physical activity and worsen effects on childhood health. Methods This project analyzed students involved in the HBSC survey from the Piedmont Region. Data were collected in 2018, following the protocol. All the subjects were georeferenced within buffers around schools. Green-spaces availability was measured by Normalised Difference Vegetation Index (NDVI-satellite images) while urbanization was calculated by population density, traffic intensity (satellite measurements) and air pollution concentration (sampling stations). Results Overall, the sample included 3022 subjects, with amount 50% male/female and 30% for each age group (11-13-15 years old). Concerning weight status, above 14% of the all sample is obese or overweight, with, respectively, 20% among boys and 11% among girls. Preliminary analyses showed an association between weight status and population density (rural vs urbanized areas). Currently, we are analyzing the association with greenness and the other measures of urbanization. Conclusions Our preliminary findings suggest that high urbanization levels impact health implementing weight in children. We are testing the hypothesis that greenness positively influences weight status and reduce negative effects of urbanization and air pollution. The managing of these risk factors must be deepened and corroborated by active preventive Public Health strategies for improving children health. Key messages Urbanization and greenness may influence weight status in children. Public Health strategies must be improved for children health.

scholarly journals Examining Australian’s beliefs, misconceptions and sources of information for COVID-19: a national online survey

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e043421
Author(s):  
Rae Thomas ◽  
Hannah Greenwood ◽  
Zoe A Michaleff ◽  
Eman Abukmail ◽  
Tammy C Hoffmann ◽  
...  
Keyword(s):  
Public Health ◽  
Online Survey ◽  
Health Behaviours ◽  
National Sample ◽  
Sources Of Information ◽  
Cross Sectional Survey ◽  
Commercial Television ◽  
Cross Sectional ◽  
And Gender ◽  
Public Health Strategies

ObjectivePublic cooperation to practise preventive health behaviours is essential to manage the transmission of infectious diseases such as COVID-19. We aimed to investigate beliefs about COVID-19 diagnosis, transmission and prevention that have the potential to impact the uptake of recommended public health strategies.DesignAn online cross-sectional survey.ParticipantsA national sample of 1500 Australian adults with representative quotas for age and gender provided by an online panel provider.Main outcome measureProportion of participants with correct/incorrect knowledge of COVID-19 preventive behaviours and reasons for misconceptions.ResultsOf the 1802 potential participants contacted, 289 did not qualify, 13 declined and 1500 participated in the survey (response rate 83%). Most participants correctly identified ‘washing your hands regularly with soap and water’ (92%) and ‘staying at least 1.5 m away from others’ (90%) could help prevent COVID-19. Over 40% (incorrectly) considered wearing gloves outside of the home would prevent them from contracting COVID-19. Views about face masks were divided. Only 66% of participants correctly identified that ‘regular use of antibiotics’ would not prevent COVID-19.Most participants (90%) identified ‘fever, fatigue and cough’ as indicators of COVID-19. However, 42% of participants thought that being unable to ‘hold your breath for 10 s without coughing’ was an indicator of having the virus. The most frequently reported sources of COVID-19 information were commercial television channels (56%), the Australian Broadcasting Corporation (43%) and the Australian Government COVID-19 information app (31%).ConclusionsPublic messaging about hand hygiene and physical distancing to prevent transmission appears to have been effective. However, there are clear, identified barriers for many individuals that have the potential to impede uptake or maintenance of these behaviours in the long term. We need to develop public health messages that harness these barriers to improve future cooperation. Ensuring adherence to these interventions is critical.

The burden of disease of three food-associated heavy metals in clusters in the Danish population – Towards targeted public health strategies

2021 ◽  
Vol 150 ◽  
pp. 112072
Author(s):  
Jose Alejandro Romero Herrera ◽  
Sofie Theresa Thomsen ◽  
Lea Sletting Jakobsen ◽  
Sisse Fagt ◽  
Karina Banasik ◽  
...  
Keyword(s):  
Public Health ◽  
Heavy Metals ◽  
Burden Of Disease ◽  
Danish Population ◽  
Public Health Strategies

Global Coordination of National Public Health Strategies

1990 ◽  
Vol 18 (1-2) ◽  
pp. 20-28
Author(s):  
Jonathan Mann ◽  
Marjorie Dam ◽  
Kathleen Kay
Keyword(s):  
Public Health ◽  
National Public Health ◽  
Global Coordination ◽  
Public Health Strategies

scholarly journals A Genome-Wide Scan for Evidence of Selection in a Maize Population Under Long-Term Artificial Selection for Ear Number

Genetics ◽  
2013 ◽  
Vol 196 (3) ◽  
pp. 829-840 ◽  
Author(s):  
Timothy M. Beissinger ◽  
Candice N. Hirsch ◽  
Brieanne Vaillancourt ◽  
Shweta Deshpande ◽  
Kerrie Barry ◽  
...  
Keyword(s):  
Artificial Selection ◽  
Maize Population ◽  
Genome Wide ◽  
A Genome ◽  
Selection For ◽  
Ear Number ◽  
Genome Wide Scan

Public health strategies to reduce the harmful effects of alcohol

2021 ◽  
Vol 24 (7) ◽  
pp. 7
Author(s):  
E.B. Shapovalova ◽  
E.V. Indukaeva ◽  
G.V. Artamonova
Keyword(s):  
Public Health ◽  
Public Health Strategies ◽  
Harmful Effects

The relationship between facial whorl direction and sidedness in ridden horses

2006 ◽  
Vol 35 ◽  
pp. 247-250
Author(s):  
H. Randle ◽  
E. Elworthy
Keyword(s):  
Natural Selection ◽  
Artificial Selection ◽  
Competitive Ability ◽  
Close Association ◽  
Human Behaviour ◽  
Physical Ability ◽  
Facial Hair ◽  
Selection For ◽  
The Relationship ◽  
The Brain

The influence of Natural Selection on the evolution of the horse (Equus callabus) is minimal due to its close association with humans. Instead Artificial Selection is commonly imposed through selection for features such as a ‘breed standard’ or competitive ability. It has long been considered to be useful if indicators of characteristics such as physical ability could be identified. Kidd (1902) suggested that the hair coverings of animals were closely related to their lifestyle, whether they were active or passive. In 1973 Smith and Gong concluded that hair whorl (trichloglyph) pattern and human behaviour is linked since hair patterning is determined at the same time as the brain develops in the foetus. More recently Grandin et al. (1995), Randle (1998) and Lanier et al. (2001) linked features of facial hair whorls to behaviour and production in cattle. Hair whorl features have also been related to temperament in equines (Randle et al., 2003).

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