scholarly journals The challenge of RNA branching prediction: a parametric analysis of multiloop initiation under thermodynamic optimization

2020 ◽  
Author(s):  
Svetlana Poznanović ◽  
Fidel Barrera-Cruz ◽  
Anna Kirkpatrick ◽  
Matthew Ielusic ◽  
Christine Heitsch
Keyword(s):  
Molecular Structure ◽  
Thermodynamic Model ◽  
Parametric Analysis ◽  
Prediction Accuracy ◽  
5S Rrna ◽  
Optimal Structure ◽  
Complete Analysis ◽  
Thermodynamic Optimization ◽  
The Cost ◽  
Insight Into

AbstractPrediction of RNA base pairings yields insight into molecular structure, and therefore function. The most common methods predict an optimal structure under the standard thermodynamic model. One component of this model is the equation which governs the cost of branching, where three or more helical “arms” radiate out from a multiloop (also known as a junction). The multiloop initiation equation has three parameters; changing those values can significantly alter the predicted structure. We give a complete analysis of the prediction accuracy, stability, and robustness for all possible parameter combinations for a diverse set of tRNA sequences, and also for 5S rRNA. We find that the accuracy can often be substantially improved on a per sequence basis. However, simultaneous improvement within families, and most especially between families, remains a challenge.

scholarly journals ALPINE: Active Link Prediction Using Network Embedding

2021 ◽  
Vol 11 (11) ◽  
pp. 5043
Author(s):  
Xi Chen ◽  
Bo Kang ◽  
Jefrey Lijffijt ◽  
Tijl De Bie
Keyword(s):  
Active Learning ◽  
Protein Interactions ◽  
Link Prediction ◽  
Prediction Accuracy ◽  
Real Data ◽  
Network Embedding ◽  
Protein Protein Interactions ◽  
Additional Information ◽  
The Cost ◽  
Active Link

Many real-world problems can be formalized as predicting links in a partially observed network. Examples include Facebook friendship suggestions, the prediction of protein–protein interactions, and the identification of hidden relationships in a crime network. Several link prediction algorithms, notably those recently introduced using network embedding, are capable of doing this by just relying on the observed part of the network. Often, whether two nodes are linked can be queried, albeit at a substantial cost (e.g., by questionnaires, wet lab experiments, or undercover work). Such additional information can improve the link prediction accuracy, but owing to the cost, the queries must be made with due consideration. Thus, we argue that an active learning approach is of great potential interest and developed ALPINE (Active Link Prediction usIng Network Embedding), a framework that identifies the most useful link status by estimating the improvement in link prediction accuracy to be gained by querying it. We proposed several query strategies for use in combination with ALPINE, inspired by the optimal experimental design and active learning literature. Experimental results on real data not only showed that ALPINE was scalable and boosted link prediction accuracy with far fewer queries, but also shed light on the relative merits of the strategies, providing actionable guidance for practitioners.

Probing pyrolysis chemistry of 1-heptene pyrolysis with insight into fuel molecular structure effects

2021 ◽  
Vol 227 ◽  
pp. 79-94
Author(s):  
Chuangchuang Cao ◽  
Wei Li ◽  
Qiang Xu ◽  
Beibei Feng ◽  
Zhandong Wang ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Insight Into

Locking down behavioural compliance: The role of emotion and emotion regulation in breaches of COVID-19 mitigation measures in Aotearoa New Zealand

2021 ◽  
pp. 135910532110299
Author(s):  
Terise Broodryk ◽  
Kealagh Robinson
Keyword(s):  
Public Health ◽  
Young Adults ◽  
New Zealand ◽  
Health Behaviours ◽  
Mitigation Measures ◽  
Aotearoa New Zealand ◽  
High Knowledge ◽  
The Cost ◽  
Insight Into

Although anxiety and worry can motivate engagement with COVID-19 preventative behaviours, people may cognitively reframe these unpleasant emotions, restoring wellbeing at the cost of public health behaviours. New Zealand young adults ( n = 278) experiencing nationwide COVID-19 lockdown reported their worry, anxiety, reappraisal and lockdown compliance. Despite high knowledge of lockdown policies, 92.5% of participants reported one or more policy breaches ( M  = 2.74, SD = 1.86). Counter to predictions, no relationships were found between anxiety or worry with reappraisal or lockdown breaches. Findings highlight the importance of targeting young adults in promoting lockdown compliance and offer further insight into the role of emotion during a pandemic.

Diplomacy Beyond History: Analytic-Violence, Producer-Centred Research, India

2021 ◽  
pp. 097492842098307
Author(s):  
Deep K. Datta-Ray
Keyword(s):  
New Method ◽  
The West ◽  
History Of ◽  
The Right ◽  
Nuclear Diplomacy ◽  
The Cost ◽  
Insight Into

The history of Indian diplomacy conceptualises diplomacy racially—as invented by the West—and restrictively—to offence. This is ‘analytic-violence’ and it explains the berating of Indians for mimicking diplomacy incorrectly or unthinkingly, and the deleting, dismissing, or denigrating, of diplomatic practices contradicting history’s conception. To relieve history from these offences, a new method is presented, ‘Producer-Centred Research’ (PCR). Initiating with abduction, an insight into a problem—in this case Indian diplomacy’s compromised historicisation—PCR solves it by converting history’s racist rationality into ‘rationalities’. The plurality renders rationality one of many, permitting PCR’s searching for rationalities not as a function of rationality but robust practices explicable in producer’s terms. Doing so is exegesis. It reveals India’s nuclear diplomacy as unique, for being organised by defence, not offence. Moreover, offence’s premise of security as exceeding opponent’s hostility renders it chimerical for such a security is, paradoxically, reliant on expanding arsenals. Additionally, doing so is a response to opponents. This fragments sovereignty and abdicates control for one is dependent on opponent’s choices. Defence, however, does not instigate opponents and so really delivers security by minimising arsenals since offence is eschewed. Doing so is not a response to opponents and so maintains sovereignty and retains control by denying others the right to offense. The cost of defence is courage, for instance, choosing to live in the shadow of nuclear annihilation. Exegesis discloses Balakot as a shift from defence to offence, so to relieve the Bharatiya Janata Party’s (BJP) leadership of having to be courageous. The intensity of the intention to discard courage is apparent in the price the BJP paid. This included equating India with Pakistan, permitting it to escalate the conflict, and so imperiling all humanity in a manner beyond history.

On a tandem queueing model with identical service times at both counters, I

1979 ◽  
Vol 11 (3) ◽  
pp. 616-643 ◽  
Author(s):  
O. J. Boxma
Keyword(s):  
Waiting Times ◽  
Sufficient Conditions ◽  
Complete Analysis ◽  
Single Server ◽  
Stationary Distributions ◽  
In Series ◽  
Queues In Series ◽  
Service Times ◽  
Necessary And Sufficient ◽  
Insight Into

This paper considers a queueing system consisting of two single-server queues in series, in which the service times of an arbitrary customer at both queues are identical. Customers arrive at the first queue according to a Poisson process.Of this model, which is of importance in modern network design, a rather complete analysis will be given. The results include necessary and sufficient conditions for stationarity of the tandem system, expressions for the joint stationary distributions of the actual waiting times at both queues and of the virtual waiting times at both queues, and explicit expressions (i.e., not in transform form) for the stationary distributions of the sojourn times and of the actual and virtual waiting times at the second queue.In Part II (pp. 644–659) these results will be used to obtain asymptotic and numerical results, which will provide more insight into the general phenomenon of tandem queueing with correlated service times at the consecutive queues.

scholarly journals Linking electronic and molecular structure: insight into aqueous chloride solvation

2013 ◽  
Vol 15 (31) ◽  
pp. 13169 ◽  
Author(s):  
Ling Ge ◽  
Leonardo Bernasconi ◽  
Patricia Hunt
Keyword(s):  
Molecular Structure ◽  
Aqueous Chloride ◽  
Insight Into

Understanding the disclosure of personal data online

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Heather J. Parker ◽  
Stephen Flowerday
Keyword(s):  
Social Media ◽  
Information Disclosure ◽  
Cost Benefit Analysis ◽  
Personal Information ◽  
Personal Data ◽  
Cost Benefit ◽  
Content Type ◽  
Privacy Violation ◽  
The Cost ◽  
Insight Into

Purpose Social media has created a new level of interconnected communication. However, the use of online platforms brings about various ways in which a user’s personal data can be put at risk. This study aims to investigate what drives the disclosure of personal information online and whether an increase in awareness of the value of personal information motivates users to safeguard their information. Design/methodology/approach Fourteen university students participated in a mixed-methods experiment, where responses to Likert-type scale items were combined with responses to interview questions to provide insight into the cost–benefit analysis users conduct when disclosing information online. Findings Overall, the findings indicate that users are able to disregard their concerns due to a resigned and apathetic attitude towards privacy. Furthermore, subjective norms enhanced by fear of missing out (FOMO) further allows users to overlook potential risks to their information in order to avoid social isolation and sanction. Alternatively, an increased awareness of the personal value of information and having experienced a previous privacy violation encourage the protection of information and limited disclosure. Originality/value This study provides insight into privacy and information disclosure on social media in South Africa. To the knowledge of the researchers, this is the first study to include a combination of the theory of planned behaviour and the privacy calculus model, together with the antecedent factors of personal valuation of information, trust in the social media provider, FOMO.

ProQuest Historical Newspapers: Leftist Newspapers and Periodicals

2021 ◽  
Vol 23 (2) ◽  
pp. 34-37
Author(s):  
Thomas J. Beck
Keyword(s):  
Twentieth Century ◽  
Price Information ◽  
Social Democrats ◽  
Search Function ◽  
Advanced Search ◽  
Definition Of ◽  
The Cost ◽  
Pdf Format ◽  
Database Content ◽  
Insight Into

ProQuest Historical Newspapers: Leftist Newspapers and Periodicals is a source for leftist publications (mostly newspapers), largely published in the twentieth century. Here, the user can access articles in PDF format from 156 national and international publications. Navigating this database and the documents therein can be easily done, but articles cannot be magnified or reduced, which may prove problematic with PDFs of old newspapers. Database content can be found through browsing or by using a basic and/or advanced search. The browse and basic search options here are understandable, but the advanced search is not self-explanatory and can possibly confuse the user. As a consequence, a new user of this database will probably benefit from instruction in its use from either the vendor or someone else familiar with this resource. However, when this search function is used properly it can produce numerous, on-point results for any query. The same is true of the basic search and browsing features, though they tend to produce larger lists of results that are less on-point than the advanced search. The vendor did not provide specific price information for this review, only indicating that pricing is determined by an institution's size and number of users. As this provides potential subscribers with very little insight into the cost of acquiring this resource, its advised that they contact ProQuest for a price quote tailored to their own institution. Its licensing agreement is the same as those used for all ProQuest databases and is average in its composition (though somewhat longer than average). The quality and quantity of content in this resource is notable, and it will certainly be of use to those looking for articles from leftist newspapers and periodicals. However, the definition of “leftist” here may be problematic for some users! Communist and Socialist publications are certainly available in this database, but those for Anarchists, Social Democrats, and other leftists are not.

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