scholarly journals Comparative analysis of primer-probe sets for the laboratory confirmation of SARS-CoV-2

2020 ◽  
Author(s):  
Yu Jin Jung ◽  
Gun-Soo Park ◽  
Jun Hye Moon ◽  
Keunbon Ku ◽  
Seung-Hwa Beak ◽  
...  
Keyword(s):  
Hong Kong ◽  
Comparative Analysis ◽  
Severe Acute Respiratory Syndrome ◽  
Early Diagnosis ◽  
Human Infection ◽  
World Health ◽  
N Gene ◽  
Laboratory Confirmation ◽  
Orf1 Gene ◽  
Health Organization

AbstractCoronavirus disease 2019 (COVID-19) is newly emerging human infectious diseases, which is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, also previously known as 2019-nCoV). Within two months of the outbreak, more than 80,000 cases of COVID-19 have been confirmed worldwide. Since the human to human transmission occurred easily and the human infection is rapidly increasing, the sensitive and early diagnosis is essential to prevent the global outbreak. Recently, World Health Organization (WHO) announced various primer and probe sets for SARS-CoV-2 previously developed in China, Germany, Hong Kong, Japan, Thailand, and USA. In this study, we compared the ability to detect SARS-CoV-2 RNA among the seven primer-probe sets for N gene and the three primer-probe sets for Orf1 gene. The result of the comparative analysis represented that the ‘2019-nCoV_N2, N3’ of USA and the ‘ORF1ab’ of China are the most sensitive primer-probe sets for N and Orf1 genes, respectively. Therefore, the appropriate combination from ORF1ab (China), 2019-nCoV_N2, N3 (USA), and NIID_2019-nCOV_N (Japan) sets should be selected for the sensitive and reliable laboratory confirmation of SARS-CoV-2.

scholarly journals Epigenetic Mechanisms Underlying COVID-19 Pathogenesis

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1142
Author(s):  
Syuzo Kaneko ◽  
Ken Takasawa ◽  
Ken Asada ◽  
Norio Shinkai ◽  
Amina Bolatkan ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Methylation Status ◽  
Therapeutic Strategies ◽  
Human Infection ◽  
World Health ◽  
Epigenetic Mechanisms ◽  
Angiotensin I ◽  
Angiotensin I Converting Enzyme ◽  
Health Organization ◽  
Molecular Framework

In 2019, a novel severe acute respiratory syndrome called coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was reported and was declared a pandemic by the World Health Organization (WHO) in March 2020. With the advancing development of COVID-19 vaccines and their administration globally, it is expected that COVID-19 will converge in the future; however, the situation remains unpredictable because of a series of reports regarding SARS-CoV-2 variants. Currently, there are still few specific effective treatments for COVID-19, as many unanswered questions remain regarding the pathogenic mechanism of COVID-19. Continued elucidation of COVID-19 pathogenic mechanisms is a matter of global importance. In this regard, recent reports have suggested that epigenetics plays an important role; for instance, the expression of angiotensin I converting enzyme 2 (ACE2) receptor, an important factor in human infection with SARS-CoV-2, is epigenetically regulated; further, DNA methylation status is reported to be unique to patients with COVID-19. In this review, we focus on epigenetic mechanisms to provide a new molecular framework for elucidating the pathogenesis of SARS-CoV-2 infection in humans and of COVID-19, along with the possibility of new diagnostic and therapeutic strategies.

scholarly journals Criteria for removing WHO travel warnings in relation to SARS - outcome of discussions between Hong Kong and World Health Organization

2003 ◽  
Vol 7 (19) ◽  
Author(s):  
Keyword(s):  
Hong Kong ◽  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
World Health ◽  
The World ◽  
Health Organization

During a videoconference between Geneva and Hong Kong on 6 May, the World Health Organization (WHO) thanked the Hong Kong Secretary for Health, Welfare and Food for Hong Kong's continuing efforts at containing severe acute respiratory syndrome (SARS). WHO thanked the Health Secretary in particular for allowing a Malaysian ship to enter the port recently with suspected SARS cases on board.

Multisystem Inflammatory Syndrome in Infant with Negative SARS-CoV-2 RT-PCR and Antibodies

2021 ◽  
pp. 35-39
Author(s):  
Hanna Sahhar ◽  
Karly Derwitz ◽  
Erica Rubin
Keyword(s):  
Polymerase Chain Reaction ◽  
Severe Acute Respiratory Syndrome ◽  
Early Diagnosis ◽  
World Health ◽  
Rt Pcr ◽  
Chain Reaction ◽  
The World ◽  
Polymerase Chain ◽  
Health Organization ◽  
Inflammatory Syndrome

Since the declaration of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in March 2020 by the World Health Organization (WHO), there has been an emergence of a new syndrome termed multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. MIS-C is defined by the presence of fever, systemic inflammation and multiorgan dysfunction in association with SARS-CoV-2 infection or COVID-19 exposure. Knowledge of this syndrome’s presentation and pathophysiology is constantly evolving as more cases are reported in the literature. This case identifies a 3-month-old patient who tested negative for SARS-CoV-2 antigen, reverse transcriptase polymerase chain reaction (RT-PCR) and antibodies but qualified for MIS-C diagnosis. To the best of our knowledge and through extensive research at the time of diagnosing and reporting this condition to the healthcare authorities, we report the youngest pediatric patient with MIS-C diagnosis. We document this case to contribute to further understanding the variable manifestations of MIS-C and the importance of early diagnosis and treatment with intravenous immunoglobulin (IVIG).

scholarly journals Severe Acute Respiratory Syndrome: international update

2003 ◽  
Vol 7 (14) ◽  
Author(s):  
P Horby ◽  
A Nicoll
Keyword(s):  
Hong Kong ◽  
Severe Acute Respiratory Syndrome ◽  
Case Fatality ◽  
Guangdong Province ◽  
World Health ◽  
The United Kingdom ◽  
Current Transmission ◽  
The World ◽  
Health Organization ◽  
Local Transmission

As of 2 April 2003, 2223 cases of Severe Acute Respiratory Syndrome (SARS) and 78 deaths have been reported to the World Health Organization (WHO), a case fatality rate of 3.5% (http://www.who.int/csr/sarscountry/2003_04_02/en/). This is an increase of four to fivefold in the global totals in the last seven days (http://www.who.int/csr/sarscountry/2003_03_25/en/) with the greatest proportionate and absolute increases being in China (Hong Kong and Guangdong Province), and to a much lesser extent in Canada. There has been little absolute rise in other country totals. Eighteen countries have now reported cases but in most of these no transmission seems to have occurred. Local transmission has occurred in Hanoi (Vietnam), Singapore, Toronto (Canada), Taiwan, and the following parts of China: Guangdong Province; Beijing; Shanxi; and the special administrative region of Hong Kong. In the United Kingdom three probable SARS cases have been reported; all have now recovered. Indeed, the only areas where WHO feels there is evidence consistent with current transmission are Hong Kong and Guangdong (http://www.who.int/csr/sarsarchive/2003_02_02b/en/), and the WHO has issued advice to international travellers not to travel to or through either area.

The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 748-752
Author(s):  
Swapnali Khabade ◽  
Bharat Rathi ◽  
Renu Rathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthy Person ◽  
World Health ◽  
Physical And Mental Health ◽  
Leading Role ◽  
Global Pandemic ◽  
The People ◽  
The World ◽  
Health Organization ◽  
The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

COVID-19: A comparative study of SARS, MERS and COVID-19

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Chandra Mohan ◽  
Vinod Kumar
Keyword(s):  
Public Health ◽  
Comparative Analysis ◽  
Central China ◽  
World Health ◽  
Unknown Aetiology ◽  
Economic Sectors ◽  
Past Life ◽  
Current Article ◽  
Disease Spreading ◽  
Health Organization

: World Health Organization (WHO) office in China received the information of pneumonia cases of unknown aetiology from Wuhan, central China on 31st December 2019, subsequently this disease spreading in china and rest of world. Till the March 2020 end, more than 2 lakhs confirmed cases with more than 70000 deaths were reported worldwide, very soon researchers identified it as novel beta Corona virus (virus SARS-CoV-2) and its infection coined as COVID-19. Health ministries of various countries and WHO together fighting to this health emergency, which not only affects public health, but also started affecting various economic sectors as well. The main aim of the current article is to explore the various pandemic situations (SARS, MERS) in past, life cycle of COVID-19, diagnosis procedures, prevention and comparative analysis of COVID-19 with other epidemic situations.

scholarly journals Optimizing COVID-19 testing capabilities and clinical management using pathology informatics

JAMIA Open ◽  
2020 ◽  
Author(s):  
Srikar Chamala ◽  
Sherri Flax ◽  
Petr Starostik ◽  
Kartikeya Cherabuddi ◽  
Nicole M Iovine ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Management ◽  
World Health ◽  
University Of Florida ◽  
Pathology Informatics ◽  
Large Numbers ◽  
The World ◽  
Health Organization ◽  
The University ◽  
Reporting Data

Abstract Coronavirus disease 2019, first reported in China in late 2019, has quickly spread across the world. The outbreak was declared a pandemic by the World Health Organization on March 11, 2020. Here, we describe our initial efforts at the University of Florida Health for processing of large numbers of tests, streamlining data collection, and reporting data for optimizing testing capabilities and superior clinical management. Specifically, we discuss clinical and pathology informatics workflows and informatics instruments which we designed to meet the unique challenges of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. We hope these results benefit institutions preparing to implement SARS-CoV-2 testing.

scholarly journals SARS-CoV-2-Cholesterol Interaction: A Lot of Food for Thought

Pathogens ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 32
Author(s):  
Giovanni Di Guardo
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
World Health ◽  
The World ◽  
Global Catastrophe ◽  
Health Organization

With over 80 million cases, and 1,800,000 deaths reported at the end of 2020 by the World Health Organization, the “CoronaVirus Disease-2019” (CoViD-19) pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), should be viewed as a global catastrophe [...]

Impact OF Covid-19 on Several Industries in Context with the Dialysis Industry

2021 ◽  
Vol 8 (2) ◽  
pp. 01-03
Author(s):  
Ashish Gujrathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
World Health ◽  
Healthcare Sector ◽  
Growth Opportunities ◽  
Wuhan City ◽  
First Case ◽  
The World ◽  
New Challenges ◽  
Health Organization

Coronavirus (COVID-19) was recognized in late December in Hubei province of Wuhan city in China. This highly contagious disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is transmitted from humans to humans. After the first case in Wuhan, the disease rapidly spread to other parts of the globe. On March 11, 2020, the World Health Organization (WHO) made an assessment that COVID-19 can be characterized as a pandemic. Thus, social-distancing became an important measure to stop the spread of this disease. Various countries across the world adopted nationwide lockdowns. This led to a completely new scenario for the world, where every business in each industry faced new challenges and witnessed new opportunities. Similarly, the medical personal protective industry, a vital part of the healthcare sector, also witnessed new growth opportunities.

OBESITY IN SARS-COV-2 INFECTION: LITERATURE REVIEW

2021 ◽  
pp. 19-23
Author(s):  
Donizete Tavares Da Silva ◽  
Priscila De Sousa Barros Lima ◽  
Renato Sampaio Mello Neto ◽  
Gustavo Magalhães Valente ◽  
Débora Dias Cabral ◽  
...  
Keyword(s):  
Public Health ◽  
Acute Respiratory Distress Syndrome ◽  
Gastrointestinal Tract ◽  
Severe Acute Respiratory Syndrome ◽  
Distress Syndrome ◽  
Circulatory System ◽  
World Health ◽  
Global Public Health ◽  
The World ◽  
Health Organization

In March 2020, the World Health Organization (1) declared COVID-19 as a pandemic and a threat to global public health (2). The virus mainly affects the lungs and can cause acute respiratory distress syndrome (ARDS). In addition, coronavirus 2 severe acute respiratory syndrome (SARSCOV2) also has devastating effects on other important organs, including the circulatory system, brain, gastrointestinal tract, kidneys and liver

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