scholarly journals Variation of positiveness to enhance testing of specimens during an epidemic

Author(s):  
Usama Kadri

Rapid testing of appropriate specimens from patients suspected for a disease during an epidemic, such as the current Coronavirus outbreak, is of a great importance for the disease management and control. We propose a method to enhance processing large amounts of collected samples. The method is based on mixing samples in testing tubes in a specific configuration, as opposed to testing single samples in each tube, and accounting for natural virus amounts in infected patients from variation of positiveness in test tubes. To illustrate the efficiency of the suggested method we carry out numerical tests for actual scenarios under various tests. Applying the proposed method enhances the number of tests by order of magnitudes, where all positives are identified with no false negatives, and the effective testing time can be reduced drastically even when the uncertainty in the test is relatively high.

Author(s):  
Usama Kadri

Abstract Rapid testing of appropriate specimens from patients suspected for a disease during an epidemic, such as the current Coronavirus outbreak, is of a great importance for the disease management and control. We propose a method to enhance processing large amounts of collected samples. The method is based on mixing samples in testing tubes in a specific configuration, as opposed to testing single samples in each tube, and accounting for natural virus amounts in infected patients from variation of positiveness in test tubes. To illustrate the efficiency of the suggested method we carry out numerical tests for actual scenarios under various tests. Applying the proposed method enhances the number of tests by order of magnitudes, where all positives are identified with no false negatives, and the effective testing time can be reduced drastically even when the uncertainty in the test is relatively high.


2019 ◽  
Vol 1 (2) ◽  
pp. 121
Author(s):  
Dody Nur Andriyan

Regional Regulation (Perda) which regulates public issues such as prostitution, alcoholic beverages, gambling, and the relationship between men and women turns out to be identified as a Regional Regulation with nuances of Islamic law. in Banyumas Regency there is a Regional Regulation which if used by the identification of Arfiansyah above, it can be referred to as a Regional Regulation with nuances of Islamic law. The regulation is: Banyumas District Regulation Number 15 of 2014 concerning Control, Supervision and Control of Circulation of Alcoholic Beverages and Regional Regulations of Banyumas Regency Number 16 of 2015 concerning Community Disease Management. This research has two formulations of the first problem related to the results of the content of the analysis on the Perda that are nuanced by Islamic law in Banyumas Regency. Both of the results of the analysis content on the Regional Regulations that are nuanced by Islamic law in Banyumas Regency are not contrary to Law-Invitation Number 12 of 2011? This research is a qualitative-descriptive study. The research method used is normative juridical. The main source of data is the Banyumas District Regulation Number 15 of 2014 concerning Control, Supervision and Control of Circulation of Alcoholic Beverages and Regional Regulations of Banyumas Regency Number 16 of 2015 concerning Community Disease Management. Interviews were also conducted with resource persons. Furthermore, the results of the analysis were carried out. Regional Regulation No. 15 of 2014 is actually a Regional Regulation that has a broad purpose of public interest, for the nation and state. So that the claim that Perda No 15 of 2014 as a Regional Regulation with nuances of Islamic law is not true. Regional Regulation No. 16 of 2015 is actually a Regional Regulation that has a broad purpose of public interest, for the nation and state. So that the claim that Perda No 16 of 2015 as a Regional Regulation with nuances of Islamic law is not true. Both of these Perda (Perda No 15 of 2014 and Perda No. 16 of 2015) are not in conflict with Law No. 12 of 2011 concerning the Establishment of Legislation. Both in terms of content, principles, goals, arrangements, administrative sanctions and criminal sanctions. Formally and procedurally the two Perda are in accordance with Law Number 12 of 2011


2021 ◽  
Author(s):  
José R. Serrano ◽  
Luis Miguel García-Cuevas ◽  
Vishnu Samala ◽  
Juan Antonio López-Carrillo ◽  
Holger Mai

Abstract During the last decade, increasingly advanced turbocharger models have been developed for sizing, engine matching and one-dimensional modeling. This work goes further and, instead of using these models for turbocharged engines design or analysis, it implements them in the data acquisition and control system of a turbocharger gas stand. This way, interesting new capabilities arise. The paper shows that there are important synergies between advanced turbocharger gas stand data acquisition and control systems and the modern turbocharger holistic models that have not been deeply exploited until now. They can be summarized as: on-line heat fluxes analysis, in-situ outlier testing points detection, testing time saving and using digital-twin techniques to monitor turbocharger health during testing.


2013 ◽  

The present Proceedings comprise the contributions that were presented at the 13th International Conference of the IUFRO W. Party 7.02.01 “Root and Butt Rot of Forest Trees” that was held in Italy from the 4th to the 10th of September 2011. The Conference started in Firenze than moved to FEM Research Centre, S. Michele all’Adige, Trento and continued in San Martino di Castrozza, Dolomite region. Root and Butt Rot of Forest Trees have a high biological and economic impact in forestry. The Proceedings were organized under seven headings: Genomics and Plant-Pathogen Interactions; Systematics, Taxonomy and Phylogeography; Ecology; Population Genetics; Etiology and Epidemiology; Disease Management and Control; New Reports, Diagnostics and Research on the Application of new Diagnostic Methods.


2020 ◽  
Vol 73 (12) ◽  
pp. 2651-2656
Author(s):  
Svitlana P. Yarova ◽  
Sergii O. Turchenenko ◽  
Iryna M. Tkachenko ◽  
Yuriy Yu. Yarov

The aim: Is to evaluate the effectiveness of the proposed method of constructing occlusal surfaces of orthopedic structures by monitoring the dynamics of functional indicators of occlusion and the functional condition of the masticatory muscles. Materials and methods: The object of the study was made up by 64 patients with included defects of the dentition of the 3rd class according to Kennedy. Patients were divided into two equal groups – the main group (patients were treated by using the suggested method of construction of occlusal surfaces of orthopedic structures) and control (dentition defects were replaced according to the traditional protocol). Results: The results of evaluating the effectiveness of the proposed method showed that the index of symmetry of the anterior bundles of the temporal muscles dropped by 18.5%, the index of symmetry of the masticatory muscles reduced by 22%, the torque of the mandible reduced by 32%, the index of stabilizing occlusal – by 27%, relative efforts of balance disturbance for more than 10 % regarding the left and right reduced by a factor of 4.4, the rate of opening time was 1.5 times higher than before, the rate of time of opening of the jaws – 1.8 times. Conclusions: The use of the suggested method of orthopedic treatment with temporary structures leads to probable changes in the studied functional parameters in comparison with the control group (p <0,05).


Author(s):  
Jolanta Žilinskienė ◽  
Linas Šumskas ◽  
Dalia Antinienė

The functioning of the parents&rsquo; emotional sphere is very important to a child&rsquo;s mental and physical health. This study focused on investigating the association between mothers&rsquo; emotional intelligence (EI) and paediatric type I diabetes (T1DM) disease management in their children. We hypothesized that mothers&rsquo; EI is associated with T1DM outcomes. Mothers of children with T1DM aged 6-12 years were surveyed. One hundred and thirty-four mothers, the main caregivers of their diabetic children, provided measures of EI and completed a demographic questionnaire. The primary indicator of diabetes management was haemoglobin A1c (HbA1c; the main form of glycosylated haemoglobin). EI scales and subscales were associated with glycaemic management indices. Logistic regression analysis was applied for the assessment of the association between parents&rsquo; EI and their paediatric with T1DM disease management. The analysis demonstrated a statistically significant correlation between T1DM management and mothers&rsquo; ability to understand and control own emotions, to transform their own negative emotions into positive and to control own negative emotions. Mothers&rsquo; EI scales and subscales of understanding and regulating their own emotions, subscales of transforming their own negative emotions into positive ones and controlling their own negative emotions were statistically reliable predictors of glycaemic control in children with T1DM.


Author(s):  
Indrė Čergelytė - Podgrušienė ◽  
Vida Gudžinskienė

Type 1 diabetes mellitus in children alters the rhythm and daily routines of children and parents, as there appears a need to treat and control this disease. Parents need to learn how to optimally care for the health of their children: monitor levels of blood glucose, follow a diet plan, inject insulin and organize the child’s schedule. Research object: needs and sources of information for parents of children with diabetes mellitus on the management of their child’s disease. Research aim is to reveal the needs and sources of information on the disease and its management for parents of children with diabetes mellitus. Research tasks: 1) to identify the needs of parents of children with diabetes mellitus for information on the disease management; 2) to reveal how and in what ways parents search for information on the child’s disease and its management. Research methods: theoretical – analysis, generalization and systematization of scientific literature; empirical – a semi-structured method of interview has been used for the collection of data; method of content analysis has been applied to the study of research data. There were 6 women of children with diabetes mellitus, who agreed to participate in the research. Participants of the research raise children who have diabetes mellitus up to 3 years after diagnosis; children’s age ranges from 3 to 11 years old. All women had higher education. The empirical study revealed that mothers of children with diabetes mellitus require information on the child’s disease and its control. Participants of the research mentioned that they try to obtain information from various sources: medical institutions, relatives, the Internet, social networks, etc. 


Author(s):  
Nelson Durán ◽  
Wagner J. Fávaro

Since the outbreak of SARS CoV-2 infection (Covid-19), healthcare professionals worldwide have been trying to find disease management and control alternatives to encourage immunotherapies. Immunotherapy is an efficient therapeutic option used against comparable viral contaminations such as MERS-CoV and SARS-CoV. The aim of the current study is to assess the existing knowledge associated with SARS-CoV-2 immunotherapy. Information available in published articles and their quality highlights the importance of following strict scientific rules for clinical outcomes. Thus, these studies have shown enough data to confirm that immunomodulation is the main topic investigated in research about Covid-19 therapy. Therefore, it is possible saying that immunotherapy is certainly the appropriate option against this virus.


2020 ◽  
Vol 9 (5) ◽  
pp. 1491 ◽  
Author(s):  
Jose Ceron ◽  
Elsa Lamy ◽  
Silvia Martinez-Subiela ◽  
Pia Lopez-Jornet ◽  
Fernando Capela-Silva ◽  
...  

In this report, updated information and future perspectives about the use of saliva as a sample for laboratory analysis of the Covid-19 are highlighted. Saliva can be used for the direct detection of the SARS-CoV-2 virus, the quantification of the specific immunoglobulins produced against it, and for the evaluation of the non-specific, innate immune response of the patient. Moreover, a deeper knowledge of potential changes in the saliva proteome in this disease may allow the identification of new diagnostic and prognostic biomarkers, or even help our understanding of the mechanisms associated with the disease. With the development of appropriate sample collection and processing methods and the use of adequate assays, saliva can provide useful clinical information about the disease and could be potentially included in guidelines for sample collection for the diagnosis, disease management, and control of Covid-19.


OCL ◽  
2018 ◽  
Vol 26 ◽  
pp. 2 ◽  
Author(s):  
Leire Molinero-Ruiz

The control of soilborne crop pathogens is conditioned by the limited management options due to difficult access to active infection courts and to restrictions in the use of synthetic pesticides in Europe. For most soilborne sunflower pathogens, an effective management relies on genetic resistance which is, however, hindered by new pathogen populations (new races). Special emphasis is thus put on updated monitoring and characterization of pathogens and on the enlargement of the set of tools for disease management. Concerning characterization, advances on the population structure of Verticillium dahliae affecting sunflower by means of genetic, molecular and pathogenic approaches are presented. Also in relation to increases of sunflower wilt diseases recently observed, the fungus Cadophora malorum has been identified in Russia and reported as a new pathogen of this crop. Third, new races of Plasmopara halstedii (sunflower downy mildew), have been identified in Spain and Portugal. Most of them have a high virulence, since they overcome several genes for resistance. With regard to alternatives for disease control, entomopathogenic fungi (EF) constitute a novel tool. Used for years in Integrated Pest Management strategies due to their efficacy in controlling insect pests affecting crops, new ecological roles of these fungi have recently been reported. The EF species Beauveria bassiana and Metarhizium brunneum have been assessed by their in vitro effect against V. dahliae and C. malorum by our research group. Our results suggest that antibiosis and/or competition for ecological niche are operating in some EF-pathogen interactions. In summary, pathogen characterization is essential for genetic resistance for worldwide environments of sunflower production. Moreover, the security of sunflower yield and profitability is dependent not only on effective genetic resistance, but also on additional new control options that can be included in successful strategies of sunflower disease management.


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