scholarly journals NEEDS AND SOURCES OF INFORMATION ON DISEASE MANAGEMENT FOR PARENTS OF CHILDREN WITH DIABETES MELLITUS

2020 ◽  
Vol 6 ◽  
pp. 181
Author(s):  
Indrė Čergelytė - Podgrušienė ◽  
Vida Gudžinskienė
Keyword(s):  
Diabetes Mellitus ◽  
Disease Management ◽  
Scientific Literature ◽  
Sources Of Information ◽  
Daily Routines ◽  
Medical Institutions ◽  
Children And Parents ◽  
Search For Information ◽  
And Control

Type 1 diabetes mellitus in children alters the rhythm and daily routines of children and parents, as there appears a need to treat and control this disease. Parents need to learn how to optimally care for the health of their children: monitor levels of blood glucose, follow a diet plan, inject insulin and organize the child’s schedule. Research object: needs and sources of information for parents of children with diabetes mellitus on the management of their child’s disease. Research aim is to reveal the needs and sources of information on the disease and its management for parents of children with diabetes mellitus. Research tasks: 1) to identify the needs of parents of children with diabetes mellitus for information on the disease management; 2) to reveal how and in what ways parents search for information on the child’s disease and its management. Research methods: theoretical – analysis, generalization and systematization of scientific literature; empirical – a semi-structured method of interview has been used for the collection of data; method of content analysis has been applied to the study of research data. There were 6 women of children with diabetes mellitus, who agreed to participate in the research. Participants of the research raise children who have diabetes mellitus up to 3 years after diagnosis; children’s age ranges from 3 to 11 years old. All women had higher education. The empirical study revealed that mothers of children with diabetes mellitus require information on the child’s disease and its control. Participants of the research mentioned that they try to obtain information from various sources: medical institutions, relatives, the Internet, social networks, etc. 

scholarly journals Environments for the development of disease management competencies of children with diabetes mellitus: Children's experience

2020 ◽  
Vol 85 ◽  
pp. 02008
Author(s):  
Vida Gudzinskiene ◽  
Indre Cergelyte–Podgrusienei
Keyword(s):  
Diabetes Mellitus ◽  
Disease Management ◽  
Learning Environments ◽  
Family Environment ◽  
Scientific Literature ◽  
Structured Interview ◽  
Management Competencies ◽  
Interview Method ◽  
Medical Institutions

Type 1 diabetes mellitus alters the child's and their parents' life. The child must acquire necessary competencies that would help manage the disease. The child with diabetes mellitus can receive information from a variety of learning environments. Research object is – environments for the development of disease management competencies of children with diabetes mellitus. Research aim is to reveal environments for the development of disease management competencies of children with diabetes mellitus by highlighting what helps a child with diabetes to acquire disease management competencies, and the challenges occurring while acquiring those competencies. Research methods: theoretical – analysis, comparison and generalization of scientific literature; empirical – a semi-structured interview method has been used for the collection of data; method of content analysis has been applied for the study of research data. Participants of the research were children with diabetes mellitus. The empirical study revealed that environments for the development of disease management competencies of children with diabetes mellitus are the following: environment of medical institutions and the professionals working there, family environment (family members), and the environment of camps for children with diabetes mellitus, including organizers of camps and specialists and volunteers invited. The research determined challenges of developing disease management competencies of children with diabetes mellitus in various learning environments.

scholarly journals Dynamics of incidence and prevalence of type 1 diabetes mellitus in children in the Russian Federation (2001-2007)

2009 ◽  
Vol 12 (3) ◽  
pp. 23-27
Author(s):  
Tatiana Yur'evna Shiryaeva ◽  
Ekaterina Andreevna Andrianova ◽  
Yury Ivanovich Suntsov
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Far East ◽  
Secondary Source ◽  
Sources Of Information ◽  
Pediatric Endocrinology ◽  
Type 1 Dm ◽  
Epidemiological Characteristics

Aim. To study dynamics of main epidemiological characteristics (incidence and prevalence) of type 1 diabetes mellitus (DM) in children in theRussian Federation (RF) and its Federal districts (FD) in 2001-2007. Materials and methods. Analysis of main epidemiological characteristics (incidence, prevalence, mortality) of type 1 DM in children of RF has beenunderway in the Institute of Pediatric Endocrinology, ERC, since 2001 based on results of questionnaire studies. The questionnaires regularly distributedamong Health Committees of RF subjects (primary sources of information) are designed to collect data on the size, age and sex compositionof childrens populations affected by DM1 and the number of newly diagnosed cases as per the end of each reporting year. The data obtainedare compared with those stored in the State Diabetes Registry (secondary source of information). Results. Major trends in the dynamics of epidemiological characteristics of type 1 DM in children of RF are similar to those worldwide. Mean annualgrowth rate is 2,8%. The incidence of DM1 remains highest in the North-West FD (15,66 per 100 000 children) followed by Central andVolga FDs (12,82 and 10,6 respectively) where its is close to the average value FDr RF (11,01). The incidence of DM1 continues to decrease in theSouthern FD (6,61% per year) and undergoes up-and-down fluctuations in Ural and Siberian FDs. It steadily grows in the Far East FD. TheNorth-South gradient of DM1 morbidity across the territory of RF has persisted during the study period. Conclusion. Monitoring main epidemiological characteristics of type 1 diabetes mellitus in children of RF is an integral component of the organizationof medical and preventive aid to these patients that creates a basis for predicting morbidity, planning measures for its control, and improvinggeneral quality of healthcare provided to diabetic children

Therapy-related issues: endocrine system

2012 ◽  
Author(s):  
Philip Wiffen ◽  
Marc Mitchell ◽  
Melanie Snelling ◽  
Nicola Stoner
Keyword(s):  
Diabetes Mellitus ◽  
Endocrine System ◽  
Monitoring And Control ◽  
Cell Dysfunction ◽  
System P ◽  
The Uk ◽  
P Type ◽  
And Control

Diabetes mellitus 444Monitoring and control 449Thyroid disorders 450Diabetes mellitus (DM) affects approximately 4% of the UK population. In 2009, Diabetes UK reported that 2.6 million people in the UK have diabetes.Type 2 diabetes accounts for 90% of all diabetes and is a result of insulin resistance and pancreatic β-cell dysfunction. Type 1 diabetes results from an absolute insulin deficiency secondary to autoimmune dysfunction....

Generation of T Regulatory Cells in Children with Newly Diagnosed Type 1 Diabetes Mellitus

2011 ◽  
Vol 120 (02) ◽  
pp. 101-109 ◽  
Author(s):  
W. Łuczyński ◽  
N. Wawrusiewicz-Kurylonek ◽  
A. Szypowska ◽  
E. Iłendo ◽  
A. Bossowski ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
T Regulatory Cells ◽  
Mrna Level ◽  
Treg Cells ◽  
Newly Diagnosed ◽  
Regulatory Cells ◽  
Proliferation Assays ◽  
And Control

AbstractThere is increasing evidence that T-regulatory (Treg) cells could be used to prevent or cure autoimmune diseases including type 1 diabetes mellitus (T1DM). The aim of the present study was to verify the hypothesis that functional Treg cells can be generated from conventional T-cells separated from a small amount of peripheral blood of children with newly diagnosed T1DM (N=25).CD4+CD25- cells were cultured with Treg expander (CD3/CD28) and IL-2 for generating de novo Treg cells. The assessment of the expression of selected genes and proteins critical to Treg function and the proliferation assays were performed with the use of real-time RT-PCR and flow cytometry.After a 4-week stimulation with Treg expander and IL-2, the percentage of T-regulatory cells was significantly higher compared to the cells treated with medium alone (with no difference between diabetic and control children). However, we found some disturbances in the gene expression at mRNA level for molecules crucial for T-reg function. The induced Tregs from diabetic and control children were fully functional as assessed in proliferation assays.despite some disturbances at mRNA level in the critical gene expression, the suppressive properties of induced Treg cells from diabetic and control children were effective.

scholarly journals Relationship between TP53 and interleukin-6 gene variants and the risk of types 1 and 2 diabetes mellitus development in the Kermanshah province

2021 ◽  
Vol 14 (1) ◽  
pp. 37-44
Author(s):  
Lida Haghnazari ◽  
◽  
Ramin Sabzi ◽  
◽  
Keyword(s):  
Diabetes Mellitus ◽  
Tp53 Gene ◽  
Control Group ◽  
Control Groups ◽  
Codon 72 ◽  
Type 2 Dm ◽  
And Control ◽  
Type 1 Dm

Diabetes mellitus (DM) is a metabolic disorder that results from insufficient secretion or insulin resistance, or both. Insulin secretion deficiency leads to chronic hyperglycemia along with impaired metabolism of proteins, lipids, and carbohydrates. This study aimed to investigate the TP53 gene SNP (single nucleotide polymorphism) rs1042522 genotype and the interleukin-6 (IL-6) gene SNP rs1800795 genotype in DM and control groups. This study was performed on 70 patients with type 1 DM, 100 patients with type 2 DM without related complications, 66 control subjects for type 1 DM, and 95 control subjects for type 2 DM. The control groups were matched regarding age and gender and did not have a familial relationship with the patient groups. All the subjects were residents of Kermanshah, located in the western part of Iran. Polymorphisms of TP53 and IL-6 genes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Lipid profile, fasting blood glucose, and HbA1c were measured using the ELISA and immunoturbidometric methods. The frequency of genotypes (CC, CG, GG) of the TP53 gene codon 72 in type 1 DM and its control group were significantly different (P= 0.013). Likewise, the frequency of genotypes (CC, CG, GG) of the TP53 gene codon 72 was significantly different between type 2 DM and control groups (P <0.001). The frequency of genotypes (GG, GC, CC) of G174C polymorphisms in the IL-6 gene was different between type 1 DM and control group as well as between type 2 DM and its control group, but it was not statistically significant. SNP rs1042522 genotypes in the dominant form (CG + GG vs. CC) (OR= 3.880; P < 0.001) and alleles G vs. C alleles (OR= 0.384; P < 0.001) increased the risk of type 2 DM significantly. There was no significant difference between type 1 and type 2 DM groups and respected control groups regarding the frequency of the IL-6 gene SNP rs1800795 alleles. The G allele of SNP rs1042522 encoding the TP53 gene increases the risk of developing DM in the population of the Kermanshah province, Iran.

scholarly journals Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy

2009 ◽  
Vol 12 (1) ◽  
pp. 29-32 ◽  
Author(s):  
A A Afonin ◽  
M V Komkova ◽  
G A Galkina ◽  
N V Morozova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Griess Reagent ◽  
Disability Score ◽  
Peripheral Polyneuropathy ◽  
And Control

Aim. To measure endothelial factors (nitric oxide (NOx) metabolites, endothelin-1 (ET-1), and basic fibroblast growth factor (bFGF)) in children and adolescentswith diabetes mellitus (DM) during development of diabetic peripheral polyneuropathy (DPNP). Materials and methods. A total of 130 children and adolescents with diabetes mellitus were examined. Duration of DM varied from 3 months to 14 years. Thecontrol group comprised 20 children and adolescents without DM or neurologic pathology. Subjective manifestations of DPNP were assessed based on thedata of a standardized Neuropathy Symptom Score (NSS) questionnaire. Neuropathy Disability Score (NDS) questionnaire was used to monitor objectivechanges of DPNP. NOx metabolites were detected with Griess reagent (Aldrich Chemical Co, USA). Serum ET-1 and bFGF were measured using solid-phaseimmunoenzyme assay (DRG, USA) and CYTIMMINE (USA) kits respectively. Results. All children and adolescents with DM1 had lower NOx and bFGF levels than controls. ET-1 level in DM patients was 3.5 times that in controls. DMpatients with DPNP had more pronounced endothelial dysfunction than DM patients without DPNP and control subjects. Patients with hyperproduction ofNOx had DM for more than 10 years and their total NDS score was significantly higher than in two other groups. Conclusion. Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus progresses with the development of DPNP. Depletion of endothelialfunctional reserve is responsible for the unfavourable course of DPNP.

scholarly journals Pathogenesis of Type 1 Diabetes Mellitus and Rodent Experimental Models

Acta Naturae ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 24-33 ◽  
Author(s):  
I. G. Gvazava ◽  
O. S. Rogovaya ◽  
M. A. Borisov ◽  
E. A. Vorotelyak ◽  
A. V. Vasiliev
Keyword(s):  
Diabetes Mellitus ◽  
Scientific Literature ◽  
Therapeutic Agents ◽  
Experimental Models ◽  
Experimental Animal Models ◽  
Advantages And Disadvantages ◽  
Diabetes Model ◽  
Prevalence Of Diabetes Mellitus ◽  
Methods Of Treatment

The global prevalence of diabetes mellitus and its severe complications is on the rise. The study of the pathogenesis of the onset and the progression of complications related to the disease, as well as the search for new therapeutic agents and methods of treatment, remains relevant. Experimental models are extremely important in the study of diabetes. This survey contains a synthesis of the most commonly used experimental animal models described in scientific literature. The mechanisms of the streptozotocin model are also analyzed and discussed, as it is considered as the most adequate and easily reproducible diabetes model. A review of the significant advantages and disadvantages of the described models has also been conducted.

scholarly journals Unreliability of Approximate Entropy to Locate Optimal Complexity in Diabetes Mellitus via Heart Rate Variability

2020 ◽  
Vol 2 (2) ◽  
pp. 32-40
Author(s):  
David M Garner ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Statistical Significance ◽  
Approximate Entropy ◽  
Effect Sizes ◽  
Optimal Complexity ◽  
Chaotic Response ◽  
Two Measures ◽  
And Control

Introduction: Approximate Entropy (ApEn) is a widely enforced metric to evaluate the chaotic response and irregularities of RR intervals from an electrocardiogram. We applied the metric to estimate these responses in subjects with type 1 diabetes mellitus (DM1). So far, as a technique it has one key problem – the accurate choices of the tolerance (r) and embedding dimension (M). So, we attempted to overcome this drawback by applying different groupings to detect the optimum. Methods: We studied 46 subjects split into two equal groups: DM1 and control. To evaluate autonomic modulation the heart rate was measured for 30 min in a supine position without any physical, sensory, or pharmacological stimuli. For the time-series, the ApEn was applied with set values for r (0.1→0.5 in intervals of 0.1) and M (1→5 in intervals of 1) and the differences between the two groups and their effect size by two measures (Cohen’s ds and Hedges’s gs) were computed. Results: The highest value of statistical significance accomplished for the effect sizes (ES) for any of the combinations performed was -0.7137 for Cohen’s ds and -0.7015 for Hedges’s gs with M = 2 and r = 0.08. Conclusion: ApEn was able to identify the reduction in chaotic response in DM1 subjects. Still, ApEn is relatively unreliable as a mathematical marker to determine this.

scholarly journals Pengaruh Konsumsi Tempe terhadap Kadar Gula darah pada Penderita Diabetes Melitus di Kelompok Senam Ibu-Ibu di Kelurahan Talang Banjar Jambi

2020 ◽  
Vol 9 (1) ◽  
pp. 110
Author(s):  
Iin Indrawati ◽  
Maimaznah Maimaznah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Eating Habits ◽  
The Body ◽  
P Value ◽  
Control Programs ◽  
Quasi Experimental ◽  
Sugar Levels ◽  
And Control

DM management that is more effective and efficient requires prevention and control programs that are on target. There are several risk factors associated with the incidence of DM, one of which is a behavioral factor. The behavior or lifestyle in question is eating habits. The purpose of this study was to determine the effect of tempe consumption on blood sugar levels of DM sufferers in the exercise groups of women in the Talang Banjar Village, Jambi.The research method used was a quasi-experimental one group pre and post experience test. The population is group of gymnastics mothers of gymnastics mothers who suffer from diabetes mellitus, amounting to 6 people, using total sampling techniques, and analyzed using T Test.The analysis showed that there was no effect of tempe consumption with blood sugar levels with a p value (p value 0.201).Although the results of the study did not show any influence, it is likely that this was caused by several things such as the small number of samples, and it was not determined whether the N sample was a type 1 or type 2 diabetes sufferer. diabetes mellitus as a controller or helps control blood sugar levels in the body.

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