scholarly journals Psoriatic disease and body composition: a systematic review of the literature

Author(s):  
Tim Blake ◽  
Nicola J Gullick ◽  
Charles E Hutchinson ◽  
Thomas M Barber

Background. Obesity is a leading comorbidity in psoriatic disease, including both psoriasis (Pso) and psoriatic arthritis (PsA), and is associated with adverse metabolic and cardiovascular (CV) outcomes. Anthropometric parameters, such as weight, body mass index (BMI) and waist-to-hip ratio, have been extensively reported in psoriatic disease. However, the associations of body composition and fat distribution with psoriasis have not been fully defined. Objectives. To identify whether patients with psoriatic disease, including psoriatic arthritis, have altered body composition compared with the general population, and to review existing modalities for the assessment of body composition. Methods. Electronic searches of the literature were conducted in PubMed, Medline (Ovid), Embase (Ovid), Cochrane Central Register and Google Scholar. Titles and abstracts were reviewed by two authors independently against a set of prespecified inclusion/exclusion criteria. Results. Twenty-five full text articles met the inclusion criteria and were included in the final narrative analysis. The studies were of heterogeneous design and used a range of objective measures to assess body composition, including simple anthropometric measures, bioimpedance analysis (BIA), dual energy X-ray absorptiometry (DXA) and computed tomography (CT). Few studies met all the quality assessment criteria. Conclusions. Patients with psoriatic disease reveal defined body composition changes that are independent of obesity and the customary metabolic syndrome, including higher overall body fat, visceral fat and sarcopenia. These findings emphasize that patients with psoriatic disease should be screened for abnormal adipose effects beyond their weight and body mass index (BMI). Our findings show that the last decade has seen an exciting expansion of research interest in the development and validation of new modalities for the assessment of body composition. There is no consensus on the optimal assessment method of body composition for this diverse group, hence there is a need for validation of existing modalities and standardization of assessment tools.

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1668-1668
Author(s):  
T. Blake ◽  
N. Gullick

Background:There is emerging evidence of a relationship between psoriasis and metabolic syndrome, increased prevalence of cardiovascular risk factors and adverse cardiovascular outcomes. Obesity is a risk factor for psoriatic disease itself but there has been less emphasis on body mass alterations and the distribution between separate compartments: fat-free tissue (lean body mass), extracellular water and adipose tissue. Body composition is a term used to describe the percentages of fat, bone, water and muscle in human bodies and is an emerging tool in assessment of physical fitness and metabolic health, although its role in disease is less well appreciated.Objectives:To identify whether psoriatic patients, including those with psoriatic arthritis, confer specific and recognizable body composition changes compared with the general population, and to review existing modalities for the assessment of body composition.Methods:Electronic searches of the literature were conducted in PubMed, Medline (Ovid®), Embase (Ovid®), Cochrane Central Register and Google Scholar. Titles and abstracts were reviewed by two authors independently against a set of prespecified inclusion/exclusion criteria, reference lists were examined and synthesis of the included studies was conducted.Results:Twenty-five whole-text papers met the inclusion criteria and were included in the final narrative analysis. The studies were of heterogeneous design and used a range of objective measures to assess body composition, including bioimpedance analysis (BIA), dual energy X-ray absorptiometry (DXA) and computed tomography (CT). Few studies met all the quality assessment criteria. 24 studies confirmed discrete biological and body composition changes in patients with psoriatic disease, which correlated positively with other indicators of metabolic syndrome, including waist circumference, waist-to-hip ratio, weight, BMI, plasma concentrations of LDL-cholesterol, leptin and apolipoprotein-B.Conclusion:There is an increased prevalence of metabolic, anthropometric and internal body composition derangements in psoriatic patients compared with controls, and these changes seem to be independent of obesity and the customary metabolic syndrome, including higher overall body fat, visceral fat and sarcopenia. Our study highlights the applicability of several imaging techniques in the evaluation of body composition in psoriatic patients, including some novel automated systems, and future studies should focus on validation and standardization of assessment tools both in research and clinical practice.References:[1]Balci, A., Balci, D. D., Yonden, Z., Korkmaz, I., Yenin, J. Z., Celik, E., Okumus, N. and Egilmez, E. (2010) ‘Increased amount of visceral fat in patients with psoriasis contributes to metabolic syndrome’,Dermatology,220(1), pp. 32-37.[2]Engin, B., Kutlubay, Z., Yardimci, G., Vehid, H. E., Ambarcioglu, P., Serdaroglu, S. and Tuzun, Y. (2014) ‘Evaluation of body composition parameters in patients with psoriasis’,International Journal of Dermatology,53(12), pp. 1468-1473.[3]Krajewska-Wlodarczyk, M., Owczarczyk-Saczonek, A. and Placek, W. (2017) ‘Changes in body composition and bone mineral density in postmenopausal women with psoriatic arthritis’,Reumatologia,55(5).[4]Welsh, P., Brown, R., Tindell, A., Kerrigan, S., Sattar, N., McInnes, I. and Siebert, S. ‘Effect of Phosphodiesterase 4 Inhibition with Apremilast on Cardiometabolic Outcomes in Psoriatic Arthritis – Initial Results from the Immune Metabolic Associations in Psoriatic Arthritis (IMAPA) Study’,Conference: ACR/ARP Annual Meeting, Atlanta.Disclosure of Interests:None declared


2021 ◽  
Vol 10 (17) ◽  
pp. 3911
Author(s):  
Peter Francis Raguindin ◽  
Alessandro Bertolo ◽  
Ramona Maria Zeh ◽  
Gion Fränkl ◽  
Oche Adam Itodo ◽  
...  

The level of injury is linked with biochemical alterations and limitations in physical activity among individuals with spinal cord injury (SCI), which are crucial determinants of body composition. We searched five electronic databases from inception until 22 July 2021. The pooled effect estimates were computed using random-effects models, and heterogeneity was calculated using I2 statistics and the chi-squared test. Study quality was assessed using the Newcastle–Ottawa Scale. We pooled 40 studies comprising 4872 individuals with SCI (3991 males, 825 females, and 56 sex-unknown) in addition to chronic SCI (median injury duration 12.3 y, IQR 8.03–14.8). Individuals with tetraplegia had a higher fat percentage (weighted mean difference (WMD) 1.9%, 95% CI 0.6, 3.1) and lower lean mass (WMD −3.0 kg, 95% CI −5.9, −0.2) compared to those with paraplegia. Those with tetraplegia also had higher indicators of central adiposity (WMD, visceral adipose tissue area 0.24 dm2 95% CI 0.05, 0.43 and volume 1.05 L 95% CI 0.14, 1.95), whereas body mass index was lower in individuals with tetraplegia than paraplegia (WMD −0.9 kg/mg2, 95% CI −1.4, −0.5). Sex, age, and injury characteristics were observed to be sources of heterogeneity. Thus, individuals with tetraplegia have higher fat composition compared to paraplegia. Anthropometric measures, such as body mass index, may be inaccurate in describing adiposity in SCI individuals.


Author(s):  
Stevo POPOVIC ◽  
Boris BANJEVIC ◽  
Bojan MASANOVIC ◽  
Dusko BJELICA

Background: The body composition and physical fitness of members of the army is always a relevant topic for research, since the level of defense and security of people and material goods in a specific territory in many ways depends on the level of ability of the army. However, members of the armed forces are a heterogeneous group, typified by different abilities, characteristics, but also everyday needs, and the trend of changing body composition and reducing physical fitness is a current issue that has not bypassed this population either. Therefore, this study aimed to determine possible differences in body composition indicators that could appear between members of the Army of Montenegro of different military specialties. Methods: The sample of respondents included 240 Montenegrin male soldiers (32.5yr±9.5), who were measured at the sports dispensaries within the barracks of Montenegrin Army around the country in the spring of 2020, was classified into eight numerically equal subsamples according to their military specialty. The sample of variables included five anthropometric measures, which were necessary to calculate two derived body composition indicators: Body Mass Index (BMI) and Body Fat Percentage (FAT %). Using the one-way ANOVA and Post Hoc test with Taki’s model, the variables were analyzed. Results: It was determined that the body composition of Montenegrin soldiers shows a certain peculiarity compared to other national military corps, while there are differences in body composition indicators between members of the Montenegrin Army of different military specialties. Conclusion: This fact dramatically strengthens the issues of Montenegrin distinctive regarding body composition, both in general terms and in terms of distinctive within specific professional vocations.  


Author(s):  
Lakshmi Devi Chauhan ◽  
Sudhir Kumar Pani

Despite numerous global sensible corrective attempts to provide nutrition, undernutrition (Kaarshya) remains one of the most pressing issues. The bulk of the population in underdeveloped nations is undernourished. It is one of the main causes of death and morbidity in both children                  and adults. One of the eight components of primary health care in the worldwide campaign                           for health for all is the promotion of appropriate diet. A person who is malnourished is prone                                     to a slew of problems. It is a condition in which the body's fat and muscles are depleted. This is why it is critical to treat it to restore the body's normalcy. With its unique approach to lifestyle management and medication therapy, Ayurveda, with its holistic perspective, can aid with this disease. Swasthavritta (Community Medicine) has a part in Kaarshya management. Ashwagandhadi avaleha acts as an excellent nutritional treatment to alleviate the symptoms                      of Kaarshya in youngsters. As a result, Ayurvedic therapy for Kaarshya was arranged. After                                 one month of treatment, the patient gained 1.5 kg of weight, and the next month, i.e., the                               follow-up period, the patient exhibited substantial improvement in weight growth. Other anthropometric measures improved as a result of the therapy. The assessment was carried out over two months. Aim: To study the effect of Ashwagandhadi avaleha on BMI and weight in karshya. Materials and Methods: This is a single case study on underweight female. Ashwagandhadi avaleha was given for two months. Anthropometric parameters such as weight, body mass index (BMI), hip circumference (HC) and mid-arm circumference (MAC) and subjective parameters were assessed before and after 2 months. Result: Significantly increased in weight i.e. 2Kg was observed after two months. Conclusion: Regular intake of Ashwagandhadi avaleha significantly increases weight and body mass index in Karshya.


2017 ◽  
Vol 26 (9) ◽  
pp. 941-950 ◽  
Author(s):  
Uba Backonja ◽  
Mary L. Hediger ◽  
Zhen Chen ◽  
Diane R. Lauver ◽  
Liping Sun ◽  
...  

1970 ◽  
Vol 25 (1) ◽  
pp. 9-13
Author(s):  
S Jahan ◽  
TR Das ◽  
KB Biswas

Background and Aims: Cord blood leptin may reflect the leptinemic status of a newborn at birth more accurately than the leptin values of blood collected from other sites. The present study was undertaken to determine the relationship of cord serum leptin concentration at birth with neonatal and maternal anthropometric parameters. Materials and Methods: Blood was taken from the umbilical cord of the babies at delivery. Maternal anthropometric measurements were recorded at admission for delivery. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between cord serum leptin concentration and anthropometric parameters of the baby and the mother. Both Serum leptin and serum C-peptide levels were measured by chemiluminescence-based ELISA method. Results: The leptin concentration (ng/ml, mean±SD) in cord blood was 39.13±14.44. Cord leptin levels correlated with birth weight (r=0.673, p<0.0001), ponderal index (r=0.732, p<0.0001) but it did not correlate with maternal body mass index, gestational age (r=0.135, p=0.349) at delivery or cord serum C-peptide concentration (r=-0.049, p=0.735) or placental weight (r=0.203, p=0.157). Conclusion: There are associations between cord leptin concentration at delivery and birth weight, ponderal index (PI) of the babies but not body mass index (BMI) of the mothers. High leptin levels of the baby could represent an important feedback modulator of substrate supply and subsequently for adipose tissue status during late gestation. (J Bangladesh Coll Phys Surg 2007; 25 : 9-13)


2013 ◽  
Vol 32 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Emina Čolak ◽  
Dragana Pap ◽  
Nada Majkić-Singh ◽  
Ivana Obradović

Summary Background: It has been reported that obesity is associated with metabolic syndrome, insulin resistance, cardiovascular risk but also with nonalcoholic fatty liver disease (NAFLD). The prevalence of obesity in children and adolescents is increasing rapidly all over the world. The aim of this study was to analyze the value of liver enzymes: AST, ALT and γGT in a group of obese students in order to establish their correlation to anthropometric parameters such as: BMI (body mass index), WC (waist circumference), HC (hip circumference), and WHR (waist-to-hip ratio) compared to non-obese students who comprised the control group (CG). Methods: In this study, 238 students from the University of Novi Sad of both sexes (126 men and 112 women) with a mean age of 22.32 ± 1.85 years were included. According to the body mass index (BMI) lower and higher than 25 kg/m2 and waist circumference (WC) lower and higher than 94 cm (80 cm for females) the whole group of 238 students was divided into 2 subgroups: the obese group at increased risk for CVD (Group 1) and the group at lower risk for CVD (Group 2). AST, ALT and γGT activities were determined in fasting blood samples. Results: Statistical processing data revealed significantly higher values of AST, ALT and γGT in the group of students with BMI>25 kg/m2, WC>94 cm for males and WC>80 cm for females, HC>108 cm for males and HC>111 cm for females, and WHR>0.90 for males and WHR>0.80 for females (P<0.001). Significant association was established between anthropometric parameters and liver enzyme levels (P<0.0001). Conclusions: Obese students with higher BMI, WC, HC and WHR values have higher liver enzyme activites and a higher chance to develop NAFLD in the future.


2020 ◽  
pp. 1-26
Author(s):  
Jéssica Cumpian Silva ◽  
Ana Elisa Madalena Rinaldi ◽  
Francisco de Assis Guedes Vasconcelos ◽  
Maria Alice Altenburg Assis ◽  
Camila Medeiros Mazzeti ◽  
...  

ABSTRACT Objective: Our study aimed to describe body phenotypes (BP) estimated by multivariate analysis and their association with body mass. Design: Body phenotypes were defined based on demographic variables, anthropometric data (body mass, height, skinfolds and circumferences), body composition (phase angle measured by bioelectrical impedance analysis), biochemical parameters (triglycerides, glucose, total cholesterol ratio/Low Density Lipoproteins (LDL), haemoglobin and sexual maturation (pubic hair and breasts or gonads). Analysis of variance (ANOVA) was performed to verify the differences between skin colour and the stages of pubertal development, body phenotypes, body composition, anthropometric, and biochemical variables. Setting: Cities of São Paulo-SP, Piracicaba-SP and Florianópolis-SC from Brazil and the United States. Participants: 9269 adolescents aged between 10 to 15 years old. Results: The composition of BP was similar in all surveys, which are: BP1 was composed by skinfolds, body mass and circumferences variables; BP2 by pubic hair, breast in girls or gonad in boys, height and age; BP3 by cholesterol, triglycerides and glucose; and BP4 by phase angle, haemoglobin and glucose (negative loading). There was a strong correlation (r = 0.9, p <0.001) between BP1 and body mass index. Conclusion: We highlighted independence observed between biochemical parameters, anthropometry, body composition and sexual maturation. BP may support the calculation of scores for diagnosis of obesity based on anthropometric variables and overcome ambiguity in the isolated use of body mass index.


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