AB0744 PSORIATIC DISEASE AND BODY COMPOSITION: A SYSTEMATIC REVIEW OF THE LITERATURE

Background:There is emerging evidence of a relationship between psoriasis and metabolic syndrome, increased prevalence of cardiovascular risk factors and adverse cardiovascular outcomes. Obesity is a risk factor for psoriatic disease itself but there has been less emphasis on body mass alterations and the distribution between separate compartments: fat-free tissue (lean body mass), extracellular water and adipose tissue. Body composition is a term used to describe the percentages of fat, bone, water and muscle in human bodies and is an emerging tool in assessment of physical fitness and metabolic health, although its role in disease is less well appreciated.Objectives:To identify whether psoriatic patients, including those with psoriatic arthritis, confer specific and recognizable body composition changes compared with the general population, and to review existing modalities for the assessment of body composition.Methods:Electronic searches of the literature were conducted in PubMed, Medline (Ovid®), Embase (Ovid®), Cochrane Central Register and Google Scholar. Titles and abstracts were reviewed by two authors independently against a set of prespecified inclusion/exclusion criteria, reference lists were examined and synthesis of the included studies was conducted.Results:Twenty-five whole-text papers met the inclusion criteria and were included in the final narrative analysis. The studies were of heterogeneous design and used a range of objective measures to assess body composition, including bioimpedance analysis (BIA), dual energy X-ray absorptiometry (DXA) and computed tomography (CT). Few studies met all the quality assessment criteria. 24 studies confirmed discrete biological and body composition changes in patients with psoriatic disease, which correlated positively with other indicators of metabolic syndrome, including waist circumference, waist-to-hip ratio, weight, BMI, plasma concentrations of LDL-cholesterol, leptin and apolipoprotein-B.Conclusion:There is an increased prevalence of metabolic, anthropometric and internal body composition derangements in psoriatic patients compared with controls, and these changes seem to be independent of obesity and the customary metabolic syndrome, including higher overall body fat, visceral fat and sarcopenia. Our study highlights the applicability of several imaging techniques in the evaluation of body composition in psoriatic patients, including some novel automated systems, and future studies should focus on validation and standardization of assessment tools both in research and clinical practice.References:[1]Balci, A., Balci, D. D., Yonden, Z., Korkmaz, I., Yenin, J. Z., Celik, E., Okumus, N. and Egilmez, E. (2010) ‘Increased amount of visceral fat in patients with psoriasis contributes to metabolic syndrome’,Dermatology,220(1), pp. 32-37.[2]Engin, B., Kutlubay, Z., Yardimci, G., Vehid, H. E., Ambarcioglu, P., Serdaroglu, S. and Tuzun, Y. (2014) ‘Evaluation of body composition parameters in patients with psoriasis’,International Journal of Dermatology,53(12), pp. 1468-1473.[3]Krajewska-Wlodarczyk, M., Owczarczyk-Saczonek, A. and Placek, W. (2017) ‘Changes in body composition and bone mineral density in postmenopausal women with psoriatic arthritis’,Reumatologia,55(5).[4]Welsh, P., Brown, R., Tindell, A., Kerrigan, S., Sattar, N., McInnes, I. and Siebert, S. ‘Effect of Phosphodiesterase 4 Inhibition with Apremilast on Cardiometabolic Outcomes in Psoriatic Arthritis – Initial Results from the Immune Metabolic Associations in Psoriatic Arthritis (IMAPA) Study’,Conference: ACR/ARP Annual Meeting, Atlanta.Disclosure of Interests:None declared

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Psoriatic disease and body composition: a systematic review of the literature

10.1101/2020.05.18.20104802 ◽

2020 ◽

Author(s):

Tim Blake ◽

Nicola J Gullick ◽

Charles E Hutchinson ◽

Thomas M Barber

Keyword(s):

Body Mass Index ◽

Body Composition ◽

Psoriatic Arthritis ◽

Body Mass ◽

Assessment Method ◽

Assessment Tools ◽

Cochrane Central Register ◽

Anthropometric Parameters ◽

Anthropometric Measures ◽

Psoriatic Disease

Background. Obesity is a leading comorbidity in psoriatic disease, including both psoriasis (Pso) and psoriatic arthritis (PsA), and is associated with adverse metabolic and cardiovascular (CV) outcomes. Anthropometric parameters, such as weight, body mass index (BMI) and waist-to-hip ratio, have been extensively reported in psoriatic disease. However, the associations of body composition and fat distribution with psoriasis have not been fully defined. Objectives. To identify whether patients with psoriatic disease, including psoriatic arthritis, have altered body composition compared with the general population, and to review existing modalities for the assessment of body composition. Methods. Electronic searches of the literature were conducted in PubMed, Medline (Ovid), Embase (Ovid), Cochrane Central Register and Google Scholar. Titles and abstracts were reviewed by two authors independently against a set of prespecified inclusion/exclusion criteria. Results. Twenty-five full text articles met the inclusion criteria and were included in the final narrative analysis. The studies were of heterogeneous design and used a range of objective measures to assess body composition, including simple anthropometric measures, bioimpedance analysis (BIA), dual energy X-ray absorptiometry (DXA) and computed tomography (CT). Few studies met all the quality assessment criteria. Conclusions. Patients with psoriatic disease reveal defined body composition changes that are independent of obesity and the customary metabolic syndrome, including higher overall body fat, visceral fat and sarcopenia. These findings emphasize that patients with psoriatic disease should be screened for abnormal adipose effects beyond their weight and body mass index (BMI). Our findings show that the last decade has seen an exciting expansion of research interest in the development and validation of new modalities for the assessment of body composition. There is no consensus on the optimal assessment method of body composition for this diverse group, hence there is a need for validation of existing modalities and standardization of assessment tools.

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Growth hormone treatment for adults with Prader-Willi syndrome: a meta-analysis

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab406 ◽

2021 ◽

Author(s):

Anna G W Rosenberg ◽

Caroline De Gouveia Buff Passone ◽

Karlijn Pellikaan ◽

Durval Damiani ◽

Aart J Van Der Lely ◽

...

Keyword(s):

Growth Hormone ◽

Body Composition ◽

Body Mass ◽

Current Knowledge ◽

Controlled Trials ◽

Cochrane Central Register ◽

Prader Willi Syndrome ◽

Mineral Density ◽

Gh Treatment ◽

Hands And Feet

Abstract Context Features of Prader-Willi syndrome (PWS) overlap with features of growth hormone (GH) deficiency, like small hands and feet, short stature, increased body fat and low muscle mass and strength. In children with PWS, GH treatment (GHt) improves physical health and cognition. GHt has become standard of care in PWS children, but in adults this is not yet the case. Objective To provide an overview of the current knowledge on GHt in PWS adults. Data source Medline, Embase and Cochrane Central Register of Controlled Trials databases. Study selection Randomized controlled trials (RCTs) and non-randomized (un)controlled trials (NRCTs) that reported data for adults with PWS, who received GHt for at least six months. Data extraction Data on body composition, body mass index (BMI), cardiovascular endpoints, bone, cognitive function, quality of life and safety were extracted. Data synthesis Nine RCTs and 20 NRCTs were included. Body composition improved during 12 months of GHt with an increase in mean (95% CI) lean body mass of 1.95 kg (0.04 – 3.87 kg), and a reduction of mean (95% CI) fat mass of -2.23% (-4.10% to -0.36%). BMI, low-density lipoprotein cholesterol levels, fasting glucose levels and bone mineral density did not change during GHt. There were no major safety issues. Conclusion GHt appears to be safe and improves body composition in adults with PWS. As poor body composition is closely linked to the observed high incidence of cardiovascular morbidity in adults with PWS, improving body composition might reduce cardiovascular complications in this vulnerable patient group.

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Body composition in professional female netball players within and between seasons: a cohort study

BMC Sports Science Medicine and Rehabilitation ◽

10.1186/s13102-021-00287-z ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Luke Hogarth ◽

Ava Farley ◽

Max McKenzie ◽

Brendan Burkett ◽

Mark McKean

Keyword(s):

Body Composition ◽

Body Mass ◽

Fat Mass ◽

Lean Mass ◽

The Body ◽

Limited Information ◽

Mineral Density ◽

Preparation Period ◽

Total Body ◽

Composition Changes

Abstract Background There is limited information on the physique attributes of female netball players from the highest playing standards and the typical body composition changes that occur with training and competition in these athletes. The purpose of this study was to examine the body composition of professional female netball players and changes that occur within and between national premier netball seasons. Methods Dual-energy X-ray absorptiometry (DXA) assessments were conducted in 20 female netball players (age = 26.5 [4.7] years, body mass = 77.3 [9.7] kg, stature = 182.7 [9.5] cm) contracted to a Suncorp Super Netball team. Total body lean mass, fat mass, bone mass and bone mineral density were derived for 127 assessments collected over three seasons. Linear mixed effects modelling was used to examine changes in body composition measures within and between seasons. Results Goal circle players were heavier (12.3 [3.5] kg, p < 0.001, g = 1.51) and taller (15.0 [2.7] cm, p < 0.001, g = 2.30) than midcourt players, and midcourt players had greater lean mass (3.1 [1.6] %, p = 0.07, g = 0.85) and less fat mass (-3.3 [1.7] %, p = 0.06, g = -0.84) than goal circle players when values were normalised to body mass. Players achieved increases in lean mass (2,191 [263] g, p < 0.01, g = 0.45) and decreases in fat mass (-835 [351] g, p = 0.09, g = -0.16) following a preseason preparation period. There were no changes in lean mass (-394 [295] g, p = 0.54, g = 0.07) or fat mass (102 [389] g, p = 0.99, g = 0.04) from the start to the end of the 14-week competition period. Conclusions Professional female netball players achieve small changes in lean mass and fat mass during preseason preparation and maintain their physique over the competitive season. The results of this study can inform practitioners on the training content necessary to promote or maintain desired body composition changes in these athletes.

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Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity

Pancreas ◽

10.1097/mpa.0000000000000771 ◽

2017 ◽

Vol 46 (3) ◽

pp. 358-365 ◽

Cited By ~ 23

Author(s):

Johan Staaf ◽

Viktor Labmayr ◽

Katharina Paulmichl ◽

Hannes Manell ◽

Jing Cen ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Mass Index ◽

Beta Cell ◽

Body Mass ◽

Visceral Fat ◽

Pediatric Obesity ◽

Beta Cell Function ◽

Cell Function ◽

Pancreatic Fat

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Body Mass and Body Composition Changes over 7 Years in a Male Professional Rugby Union Team

International Journal of Sports Medicine ◽

10.1055/a-1403-2906 ◽

2021 ◽

Author(s):

Clíodhna McHugh ◽

Karen Hind ◽

Aoife O'Halloran ◽

Daniel Davey ◽

Gareth Farrell ◽

...

Keyword(s):

Body Composition ◽

Body Mass ◽

Body Fat ◽

Lean Mass ◽

Total Mass ◽

Rugby Union ◽

Body Fat Percentage ◽

Fat Percentage ◽

Dxa Scans ◽

Composition Changes

AbstractThe purpose of this study was to investigate longitudinal body mass and body composition changes in one professional rugby union team (n=123), (i) according to position [forwards (n=58) versus backs (n=65)], analysis of players with 6 consecutive seasons of DXA scans (n=21) and, (iii) to examine differences by playing status [academy and international], over 7 years. Players [mean age: 26.8 y, body mass index: 28.9+kg.m2] received DXA scans at fourtime points within each year. A modest (but non-significant) increase in mean total mass (0.8 kg) for professional players was reflected by increased lean mass and reduced body fat mass. At all-time points, forwards had a significantly greater total mass, lean mass and body fat percentage compared to backs (p<0.05). Academy players demonstrated increased total and lean mass and decreased body fat percentage over the first 3 years of senior rugby, although this was not significant. Senior and academy international players had greater lean mass and lower body fat percentage (p<0.05) than non-international counterparts. Despite modest increases in total mass; reflected by increased lean mass and reduced fat mass, no significant changes in body mass or body composition, irrespective of playing position were apparent over 7 years.

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Metabolomics Studies in Psoriatic Disease: A Review

Metabolites ◽

10.3390/metabo11060375 ◽

2021 ◽

Vol 11 (6) ◽

pp. 375

Author(s):

John Koussiouris ◽

Nikita Looby ◽

Melanie Anderson ◽

Vathany Kulasingam ◽

Vinod Chandran

Keyword(s):

Psoriatic Arthritis ◽

Small Molecules ◽

Web Of Science ◽

Citation Index ◽

Cochrane Central Register ◽

Psoriatic Disease ◽

Ovid Medline ◽

Standardized Protocol ◽

Central Register ◽

Endogenous Metabolites

Metabolomics investigates a broad range of small molecules, allowing researchers to understand disease-related changes downstream of the genome and proteome in response to external environmental stimuli. It is an emerging technology that holds promise in identifying biomarkers and informing the practice of precision medicine. In this review, we summarize the studies that have examined endogenous metabolites in patients with psoriasis and/or psoriatic arthritis using nuclear magnetic resonance (NMR) or mass spectrometry (MS) and were published through 26 January 2021. A standardized protocol was used for extracting data from full-text articles identified by searching OVID Medline ALL, OVID Embase, OVID Cochrane Central Register of Controlled Trials and BIOSIS Citation Index in Web of Science. Thirty-two studies were identified, investigating various sample matrices and employing a wide variety of methods for each step of the metabolomics workflow. The vast majority of studies identified metabolites, mostly amino acids and lipids that may be associated with psoriasis diagnosis and activity. Further exploration is needed to identify and validate metabolomic biomarkers that can accurately and reliably predict which psoriasis patients will develop psoriatic arthritis, differentiate psoriatic arthritis patients from patients with other inflammatory arthritides and measure psoriatic arthritis activity.

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Visceral Fat and Body Composition Changes in a Female Population After RYGBP: a Two-Year Follow-Up by DXA

Obesity Surgery ◽

10.1007/s11695-014-1422-8 ◽

2014 ◽

Vol 25 (3) ◽

pp. 443-451 ◽

Cited By ~ 31

Author(s):

Alberto Bazzocchi ◽

Federico Ponti ◽

Stefano Cariani ◽

Danila Diano ◽

Luca Leuratti ◽

...

Keyword(s):

Body Composition ◽

Visceral Fat ◽

Female Population ◽

Composition Changes

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Volumetric Bone Mineral Density Measured by HR-pQCT in Patients with Psoriasis or Psoriatic Arthritis: A Systematic Review and Meta-Analysis with Trial Sequential Analysis

Healthcare ◽

10.3390/healthcare9081056 ◽

2021 ◽

Vol 9 (8) ◽

pp. 1056

Author(s):

Yu-Wen Huang ◽

Jing-Wun Lu ◽

Tai-Li Chen

Keyword(s):

Bone Mineral Density ◽

Systematic Review ◽

Psoriatic Arthritis ◽

Sequential Analysis ◽

Meta Analysis ◽

Bone Microstructure ◽

Trial Sequential Analysis ◽

Volumetric Bone Mineral Density ◽

Mineral Density ◽

Psoriatic Disease

Bone health in psoriasis and psoriatic arthritis has been emphasized in recent years. Novel imaging modalities allow investigations into volumetric bone mineral density (vBMD) and bone microstructure in psoriatic patients. However, literature regarding vBMD measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) is inconclusive. We conducted a systematic review and meta-analysis to evaluate vBMD in patients with psoriatic disease. We searched PubMed, EMBASE, Web of Science, and Cochrane Library for relevant observational studies. A random-effects meta-analysis with trial sequential analysis (TSA) was performed. The pooled mean difference (MD) and 95% confidence interval (CI) were calculated. Five studies with 780 patients were included. Patients with psoriatic disease showed a lower average vBMD than controls (MD −14.90; 95% CI −22.90 to −6.89; TSA-adjusted CI −23.77 to −6.03; I2 = 41%). Trabecular vBMD and cortical vBMD results were inconclusive because of the small sample size. Patients recruited in Asia and those whose vBMD were measured at the distal radius exhibited a lower average vBMD than controls. Further research should clarify the association of psoriasis with bone microstructure and the underlying pathophysiology.

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Whole-Food Plant-Based Lifestyle Program and Decreased Obesity: A 10-Year Follow-up

10.20944/preprints201910.0280.v1 ◽

2019 ◽

Author(s):

Boštjan Jakše ◽

Barbara Jakše ◽

Stanislav Pinter ◽

Jernej Pajek ◽

Nataša Fidler Mis

Keyword(s):

Body Composition ◽

Body Mass ◽

Body Fat ◽

Food Plant ◽

Body Fat Percentage ◽

Fat Percentage ◽

Total Body Mass ◽

Lifestyle Program ◽

Composition Changes

Failure of various weight-loss programs and long-term maintenance of favorable body composition in all kinds of people is high, since the majority go back to old dietary patterns. Many studies have documented the efficacy of a plant-based diet (PBD) for body mass management, but there are opinions that maintaining a PBD is difficult. We aimed to evaluate the long-term success of a whole-food plant-based (WFPB) lifestyle program. We investigated the differences in the obesity indices and lifestyle of 151 adults (39.6 ± SD 12.5 years), who were on our program for short (0.5–<2 years), medium (2–<5 years), or long term (5–10 years). Body-composition changes were favourable for all three groups, both genders and all participants. There were no differences in relative body-composition changes (BMI, body fat percentage and muscle mass index (MMI)) between the three groups. All participants improved their BMI (baseline mean pre-obesity BMI range (kg/m2): 26.4 ± 5.6 to normal 23.9 ± 3.8, p < 0.001), decreased body mass (–7.1 ± 8.3 kg, p < 0.001) and body fat percentage (–6.4 ± 5.6 % points, p < 0.001). 85.6% (101 out of 118) of parents of underage children (< 18 years), introduced WFPB lifestyle to their children. Those with the highest BMI at baseline lost the most of: a) BMI units, b) total body mass and c) body fat (a) (kg/m2) (–5.6 ± SD 2.9, –2.4 ± 1.8 and –0.9 ± 1.5), b) (kg) (–16.1 ± SD 8.8, –7.1 ± 5.4 and –2.5 ± 4.5) and c) (% points) (–9.5 ± SD 5.7, –6.6 ± 4.6 and –4.7 ± 5.3) for participants who had baseline BMI in obese, overweight and normal range, respectively; pbaseline vs. current < 0.001 for all). WFPB lifestyle program provides long-term lifestyle changes for reversal of obesity and is effective transferred to the next generation.

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Men and women do not have the same relation between body composition and postural sway

Journal of Morphological Sciences ◽

10.4322/jms.092715 ◽

2015 ◽

Vol 32 (02) ◽

pp. 093-097 ◽

Cited By ~ 4

Author(s):

A. Alonso ◽

L. Mochizuki ◽

N. Luna ◽

A. Canonica ◽

R. Souza ◽

...

Keyword(s):

Body Composition ◽

Body Mass ◽

Bone Mineral ◽

Postural Sway ◽

Multiple Linear Regression Model ◽

The Body ◽

Lower Limbs ◽

Quiet Standing ◽

Mineral Density ◽

Men And Women

Abstract Introduction: The aim of the present study was to evaluate the influence of body composition on the postural sway during quiet standing. Our hypothesis is that men and women do not have the same relation between body composition and postural sway during quiet standing. Materials and Methods: Participated in the study 50 men and 50 women; age range: 20-40 years old. The main outcome measures were: Body composition (bone densitometry), percentage of fat (% fat) tissue (g), fat (g), lean mass (g), bone mineral content (g) and bone mineral density (g/cm2); Anthropometry: body mass (kg), height (cm), length of the trunk-head (cm), length of lower limbs (cm). The following indices were calculated: body mass index (BMI) (kg/m2) and Postural balance test - center ofpressure displacement. Results: The correlation analysis showed low correlations between postural sway and anthropometric variables. The multiple linear regression model showed that the body composition and the anthropometry were able to explain only men's postural sway. Conclusion: The postural sway is sex type dependent. Men and women have different relations between body composition and postural sway. Only male's body composition affected the body sway.

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