scholarly journals Polygenic Scores for Cognitive Abilities and their Association with Different Aspects of General Intelligence – a Deep Phenotyping Approach

2020 ◽  
Author(s):  
Erhan Genç ◽  
Caroline Schlüter ◽  
Christoph Fraenz ◽  
Larissa Arning ◽  
Huu Phuc Nguyen ◽  
...  

AbstractIntelligence is a highly polygenic trait and GWAS have identified thousands of DNA variants contributing with small effects. Polygenic scores (PGS) can aggregate those effects for trait prediction in independent samples. As large-scale light-phenotyping GWAS operationalized intelligence as performance in rather superficial tests, the question arises which intelligence facets are actually captured. We used deep-phenotyping to investigate the molecular determinantes of individual differences in cognitive ability. We therefore studied the association between PGS of educational attainment (EA-PGS) and intelligence (IQ-PGS) with a wide range of intelligence facets in a sample of 320 healthy adults. EA-PGS and IQ-PGS had the highest incremental R2s for general (3.25%; 1.78%), verbal (2.55%; 2.39%) and numerical intelligence (2.79%; 1.54%) and the weakest for non-verbal intelligence (0.50%; 0.19%) and short-term memory (0.34%; 0.22%). These results indicate that PGS derived from light-phenotyping GWAS do not reflect different facets of intelligence equally well, and thus should not be interpreted as genetic indicators of intelligence per se. The findings refine our understanding of how PGS are related to other traits or life outcomes.

2020 ◽  
Vol 12 (1) ◽  
pp. 349 ◽  
Author(s):  
Alessandro Crivellari ◽  
Euro Beinat

The increasing availability of trajectory recordings has led to the mining of a massive amount of historical track data, allowing for a better understanding of travel behaviors by revealing meaningful motion patterns. In the context of human mobility analysis, the problem of motion prediction assumes a central role and is beneficial for a wide range of applications, including for touristic purposes, such as personalized services or targeted recommendations, and sustainability studies related to crowd management and resource redistribution. This paper tackles a particular case of the trajectory prediction problem, focusing on large-scale mobility traces of short-term foreign tourists. These sparse trajectories, short and non-repetitive, lack spatial and temporal regularity, making prediction analysis based on individual historical motion data unreliable. To face this issue, we hereby propose a deep learning-based approach, taking into account the collective mobility of tourists over the territory. The underlying semantics of motion patterns are captured by means of a long short-term memory (LSTM) neural network model trained on pre-processed location sequences, aiming to predict the next visited place in the trajectory. We tested the methodology on a real-world big dataset, demonstrating its higher feasibility with respect to traditional approaches.


2019 ◽  
Author(s):  
Manuel Bohn ◽  
Vanessa Schmitt ◽  
Alejandro Sanchez-Amaro ◽  
Stefanie Keupp ◽  
Lydia Hopper ◽  
...  

Inferring the evolutionary history of cognitive abilities requires large and diverse samples. However, such samples are often beyond the reach of individual researchers or institutions, and studies are often limited to small numbers of species. Consequently, methodological and site-specific-differences across studies can limit comparisons between species. Here we introduce the ManyPrimates project, which addresses these challenges by providing a large-scale collaborative framework for comparative studies in primate cognition. To demonstrate the viability of the project we conducted a case study of short-term memory. In this initial study, we were able to include 176 individuals from 12 primate species housed at 11 sites across Africa, Asia, North America and Europe. All subjects were tested in a delayed-response task using consistent methodology across sites. Individuals could access food rewards by remembering the position of the hidden reward after a 0, 15, or 30-second delay. Overall, individuals performed better with shorter delays, as predicted by previous studies. Phylogenetic analysis revealed a strong phylogenetic signal for short-term memory. Although, with only 12 species, the validity of this analysis is limited, our initial results demonstrate the feasibility of a large, collaborative open-science project. We present the ManyPrimates project as an exciting opportunity to address open questions in primate cognition and behaviour with large, diverse datasets.


2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Sungmin O. ◽  
Rene Orth

AbstractWhile soil moisture information is essential for a wide range of hydrologic and climate applications, spatially-continuous soil moisture data is only available from satellite observations or model simulations. Here we present a global, long-term dataset of soil moisture derived through machine learning trained with in-situ measurements, SoMo.ml. We train a Long Short-Term Memory (LSTM) model to extrapolate daily soil moisture dynamics in space and in time, based on in-situ data collected from more than 1,000 stations across the globe. SoMo.ml provides multi-layer soil moisture data (0–10 cm, 10–30 cm, and 30–50 cm) at 0.25° spatial and daily temporal resolution over the period 2000–2019. The performance of the resulting dataset is evaluated through cross validation and inter-comparison with existing soil moisture datasets. SoMo.ml performs especially well in terms of temporal dynamics, making it particularly useful for applications requiring time-varying soil moisture, such as anomaly detection and memory analyses. SoMo.ml complements the existing suite of modelled and satellite-based datasets given its distinct derivation, to support large-scale hydrological, meteorological, and ecological analyses.


Electronics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 534
Author(s):  
Huogen Wang

The paper proposes an effective continuous gesture recognition method, which includes two modules: segmentation and recognition. In the segmentation module, the video frames are divided into gesture frames and transitional frames by using the information of hand motion and appearance, and continuous gesture sequences are segmented into isolated sequences. In the recognition module, our method exploits the spatiotemporal information embedded in RGB and depth sequences. For the RGB modality, our method adopts Convolutional Long Short-Term Memory Networks to learn long-term spatiotemporal features from short-term spatiotemporal features obtained from a 3D convolutional neural network. For the depth modality, our method converts a sequence into Dynamic Images and Motion Dynamic Images through weighted rank pooling and feed them into Convolutional Neural Networks, respectively. Our method has been evaluated on both ChaLearn LAP Large-scale Continuous Gesture Dataset and Montalbano Gesture Dataset and achieved state-of-the-art performance.


2014 ◽  
Vol 26 (7) ◽  
pp. 1377-1389 ◽  
Author(s):  
Bo-Cheng Kuo ◽  
Mark G. Stokes ◽  
Alexandra M. Murray ◽  
Anna Christina Nobre

In the current study, we tested whether representations in visual STM (VSTM) can be biased via top–down attentional modulation of visual activity in retinotopically specific locations. We manipulated attention using retrospective cues presented during the retention interval of a VSTM task. Retrospective cues triggered activity in a large-scale network implicated in attentional control and led to retinotopically specific modulation of activity in early visual areas V1–V4. Importantly, shifts of attention during VSTM maintenance were associated with changes in functional connectivity between pFC and retinotopic regions within V4. Our findings provide new insights into top–down control mechanisms that modulate VSTM representations for flexible and goal-directed maintenance of the most relevant memoranda.


2020 ◽  
Author(s):  
Doretta Caramaschi ◽  
Alexander Neumann ◽  
Andres Cardenas ◽  
Gwen Tindula ◽  
Silvia Alemany ◽  
...  

ABSTRACTCognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts (N=2196-3798) within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall, verbal and non-verbal cognitive scores. The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that cord blood DNA methylation at single CpGs can predict cognitive skills and further studies are needed to confirm regional differences.


2019 ◽  
Vol 9 (14) ◽  
pp. 2861 ◽  
Author(s):  
Alessandro Crivellari ◽  
Euro Beinat

The interest in human mobility analysis has increased with the rapid growth of positioning technology and motion tracking, leading to a variety of studies based on trajectory recordings. Mapping the routes that people commonly perform was revealed to be very useful for location-based service applications, where individual mobility behaviors can potentially disclose meaningful information about each customer and be fruitfully used for personalized recommendation systems. This paper tackles a novel trajectory labeling problem related to the context of user profiling in “smart” tourism, inferring the nationality of individual users on the basis of their motion trajectories. In particular, we use large-scale motion traces of short-term foreign visitors as a way of detecting the nationality of individuals. This task is not trivial, relying on the hypothesis that foreign tourists of different nationalities may not only visit different locations, but also move in a different way between the same locations. The problem is defined as a multinomial classification with a few tens of classes (nationalities) and sparse location-based trajectory data. We hereby propose a machine learning-based methodology, consisting of a long short-term memory (LSTM) neural network trained on vector representations of locations, in order to capture the underlying semantics of user mobility patterns. Experiments conducted on a real-world big dataset demonstrate that our method achieves considerably higher performances than baseline and traditional approaches.


Complexity ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-13 ◽  
Author(s):  
Junmin Fang ◽  
Dechun Huang ◽  
Jingrong Xu

With the improvement of citizens’ risk perception ability and environmental protection awareness, social conflicts caused by environmental problems in large-scale construction projects are becoming more and more frequent. Traditional social risk prevention management has some defects in obtaining risk data, such as limited coverage, poor availability, and insufficient timeliness, which makes it impossible to realize effective early warning of social risks in the era of big data. This paper focuses on the three environments of diversification of stakeholders, risk media, and big data era. The evolution characteristics of the social risk of environmental damage of large-scale construction projects are analyzed from the four stages of incubation, outbreak, mitigation, and regression in essence. On this basis, a social risk early warning model is constructed, and the multicenter network governance mode of social risk of environmental damage in large-scale construction projects and practical social risk prevention strategies in different stages are put forward. Experiments show that the long short-term memory neural network model is effective and feasible for predicting the social risk trend of environmental damage of large-scale construction projects. Compared with other classical models, the long short-term memory model has the advantages of strong processing capability and high early warning accuracy for time-sensitive data and will have broad application prospects in the field of risk control research. By using the network governance framework and long short-term memory model, this paper studies the environmental mass events of large-scale construction projects on the risk early warning method, providing reference for the government to effectively prevent and control social risk of environmental damage of large-scale construction project in China.


2020 ◽  
Author(s):  
Frederik Kratzert ◽  
Daniel Klotz ◽  
Günter Klambauer ◽  
Grey Nearing ◽  
Sepp Hochreiter

<p>Simulation accuracy among traditional hydrological models usually degrades significantly when going from single basin to regional scale. Hydrological models perform best when calibrated for specific basins, and do worse when a regional calibration scheme is used. </p><p>One reason for this is that these models do not (have to) learn hydrological processes from data. Rather, they have a predefined model structure and only a handful of parameters adapt to specific basins. This often yields less-than-optimal parameter values when the loss is not determined by a single basin, but by many through regional calibration.</p><p>The opposite is true for data driven approaches where models tend to get better with more and diverse training data. We examine whether this holds true when modeling rainfall-runoff processes with deep learning, or if, like their process-based counterparts, data-driven hydrological models degrade when going from basin to regional scale.</p><p>Recently, Kratzert et al. (2018) showed that the Long Short-Term Memory network (LSTM), a special type of recurrent neural network, achieves comparable performance to the SAC-SMA at basin scale. In follow up work Kratzert et al. (2019a) trained a single LSTM for hundreds of basins in the continental US, which outperformed a set of hydrological models significantly, even compared to basin-calibrated hydrological models. On average, a single LSTM is even better in out-of-sample predictions (ungauged) compared to the SAC-SMA in-sample (gauged) or US National Water Model (Kratzert et al. 2019b).</p><p>LSTM-based approaches usually involve tuning a large number of hyperparameters, such as the number of neurons, number of layers, and learning rate, that are critical for the predictive performance. Therefore, large-scale hyperparameter search has to be performed to obtain a proficient LSTM network.  </p><p>However, in the abovementioned studies, hyperparameter optimization was not conducted at large scale and e.g. in Kratzert et al. (2018) the same network hyperparameters were used in all basins, instead of tuning hyperparameters for each basin separately. It is yet unclear whether LSTMs follow the same trend of traditional hydrological models to degrade performance from basin to regional scale. </p><p>In the current study, we performed a computational expensive, basin-specific hyperparameter search to explore how site-specific LSTMs differ in performance compared to regionally calibrated LSTMs. We compared our results to the mHM and VIC models, once calibrated per-basin and once using an MPR regionalization scheme. These benchmark models were calibrated individual research groups, to eliminate bias in our study. We analyse whether differences in basin-specific vs regional model performance can be linked to basin attributes or data set characteristics.</p><p>References:</p><p>Kratzert, F., Klotz, D., Brenner, C., Schulz, K., and Herrnegger, M.: Rainfall–runoff modelling using Long Short-Term Memory (LSTM) networks, Hydrol. Earth Syst. Sci., 22, 6005–6022, https://doi.org/10.5194/hess-22-6005-2018, 2018. </p><p>Kratzert, F., Klotz, D., Shalev, G., Klambauer, G., Hochreiter, S., and Nearing, G.: Towards learning universal, regional, and local hydrological behaviors via machine learning applied to large-sample datasets, Hydrol. Earth Syst. Sci., 23, 5089–5110, https://doi.org/10.5194/hess-23-5089-2019, 2019a. </p><p>Kratzert, F., Klotz, D., Herrnegger, M., Sampson, A. K., Hochreiter, S., & Nearing, G. S.: Toward improved predictions in ungauged basins: Exploiting the power of machine learning. Water Resources Research, 55. https://doi.org/10.1029/2019WR026065, 2019b.</p>


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