scholarly journals Effects of crossover interference on genomic recombination landscape

2020 ◽  
Author(s):  
Mikko Kivikoski ◽  
Pasi Rastas ◽  
Ari L&oumlytynoja ◽  
Juha Meril&auml
Keyword(s):  
Sex Differences ◽  
Genetic Variability ◽  
Gasterosteus Aculeatus ◽  
Chromosome Length ◽  
Linkage Maps ◽  
Response To Selection ◽  
Pungitius Pungitius ◽  
Crossover Interference ◽  
Genomic Recombination ◽  
The Relationship

Crossovers in meiosis increase genetic variability in gamete pool by breaking existing and creating new haplotypes, resulting in novel combinations of alleles. Frequencies of crossovers are known to differ between sexes in many species, but possible sex differences in localization of crossovers have seldom been studied in detail. Here, we address several long-standing questions regarding frequency and distribution of crossovers, with aid of in-depth analyses of ultra-dense sex-specific linkage maps of nine-spined (Pungitius pungitius) and three-spined (Gasterosteus aculeatus) sticklebacks. We observe that males have typically one crossover per chromosome, independently of the chromosome length, whereas in females the number of crossovers increases with the chromosome length, being typically more than two. We show that these differences largely explain more uniform crossover distribution of females and the fact that females have crossovers closer to the centromere. Furthermore, highly constrained crossover localization reveals that the relationship between linkage and genetic distance varies inside the chromosome. Our analyses show that recombination rate is highly heritable in females (h^2=0.56-0.65), and thus, able to evolve in response to selection. Similar results for the two species that diverged 26 million years ago suggest that our findings are general, at least in the context of stickleback fishes.

The Relationship of Compliance with Coping Strategies and Self-Esteem

2003 ◽  
Vol 19 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Gisli H. Gudjonsson ◽  
Jon Fridrik Sigurdsson
Keyword(s):  
Sex Differences ◽  
Coping Strategies ◽  
Multiple Regression ◽  
Sex Difference ◽  
Test Scores ◽  
Self Esteem ◽  
Stressful Situation ◽  
Men And Women ◽  
Relationship Of ◽  
The Relationship

Summary: The Gudjonsson Compliance Scale (GCS), the COPE Scale, and the Rosenberg Self-Esteem Scale were administered to 212 men and 212 women. Multiple regression of the test scores showed that low self-esteem and denial coping were the best predictors of compliance in both men and women. Significant sex differences emerged on all three scales, with women having lower self-esteem than men, being more compliant, and using different coping strategies when confronted with a stressful situation. The sex difference in compliance was mediated by differences in self-esteem between men and women.

165 Sex differences in the relationship between self-reported sleep quality and frailty in South Florida older adult outpatients

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A67-A67
Author(s):  
Sonya Kaur ◽  
Katalina McInerney ◽  
Mitchell Slugh ◽  
Annelly Bure ◽  
Marina Sarno ◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Sleep Quality ◽  
Grip Strength ◽  
Brain Research ◽  
Functional Independence ◽  
South Florida ◽  
Left Hand ◽  
Depression Status ◽  
The Relationship

Abstract Introduction Frailty, a multidimensional construct of decreased reserve is an important predictor of functional independence and quality of life in older adults. There is a growing body of evidence highlighting reduced sleep efficiency and sleep duration predicts frailty in older adults. However, the sex differences in these relationships have been understudied. Methods 253 participants (163) ranging in age from 50-92 years (mean= 67.59 years, S.D.= 9.22 years), underwent frailty assessment and completed the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS). Statistical moderation was assessed using nonparametric bootstrapping. All models statistically controlled for age, education and depression status. Results Higher scores on the PSQI predicted higher levels of fatigue (β=1.87, 95% CI= 0.48-3.27) and higher grip strength with the left hand (β= 0.81, 95% CI= 0.85-1.53). These relationships were significantly moderated by sex (β=-0.77, p=0.05 & β=-0.52, p=0.01). Specifically, high scores on the PSQI predicted more fatigue stronger grip strength in men (β=1.11, 95% CI=0.41-1.81) and weaker grip strength in women (β=-0.25, 95% CI=-0.51--0.02). There was no association between scores on the ESS and any of the frailty measures. Conclusion The relationships between PSQI scores and measures of fatigue and grip strength were statistically moderated by sex. These differences are not explained by sex differences in overall sleep quality or baseline frailty. This is consistent with the literature emphasizing sex differences in the effects of risk/lifestyle factors. It is possible that the relationship between sleep quality and frailty is altered by additional hormonal factors and warrant further investigation. Support (if any) This research was supported by the Evelyn F. McKnight Brain Research Foundation

scholarly journals Elucidating the Relationship Between Insomnia, Sex, and Cardiovascular Disease

2020 ◽  
Vol 4 ◽  
pp. 247028972098001
Author(s):  
Rebecca Leeds ◽  
Ari Shechter ◽  
Carmela Alcantara ◽  
Brooke Aggarwal ◽  
John Usseglio ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Sex Differences ◽  
Cardiovascular Health ◽  
Future Research ◽  
Sex And Gender ◽  
Men And Women ◽  
Sex Research ◽  
And Gender ◽  
The Relationship ◽  
Cvd Mortality

Sex differences in cardiovascular disease (CVD) mortality have been attributed to differences in pathophysiology between men and women and to disparities in CVD management that disproportionately affect women compared to men. Similarly, there has been investigation of differences in the prevalence and presentation of insomnia attributable to sex. Few studies have examined how sex and insomnia interact to influence CVD outcomes, however. In this review, we summarize the literature on sex-specific differences in the prevalence and presentation of insomnia as well as existing research regarding the relationship between insomnia and CVD outcomes as it pertains to sex. Research to date indicate that women are more likely to have insomnia than men, and there appear to be differential associations in the relation between insomnia and CVD by sex. We posit potential mechanisms of the relationship between sex, insomnia and CVD, discuss gaps in the existing literature, and provide commentary on future research needed in this area. Unraveling the complex relations between sex, insomnia, and CVD may help to explain sex-specific differences in CVD, and identify sex-specific strategies for promotion of cardiovascular health. Throughout this review, terms “men” and “women” are used as they are in the source literature, which does not differentiate between sex and gender. The implications of this are also discussed.

scholarly journals BREED AND SEX EFFECTS ON THE RELATIONSHIP BETWEEN WEIGHT AND FATNESS IN LACOMBE AND YORKSHIRE SWINE AND THEIR RECIPROCAL CROSSES

1965 ◽  
Vol 45 (1) ◽  
pp. 33-36
Author(s):  
G. W. Rahnefeld
Keyword(s):  
Body Weight ◽  
Sex Differences ◽  
Regression Coefficients ◽  
Average Depth ◽  
Constant Weight ◽  
Reciprocal Crosses ◽  
Sex Effects ◽  
Female Mating ◽  
The Mean ◽  
The Relationship

The relationship between thickness of fat measured at the shoulder, last rib, and loin of live pigs and market weight (86.2 to 95.2 kg) was studied in 1596 pigs from the Lacombe and Yorkshire breeds and their reciprocal crosses. No significant breed or sex differences were found in the proportion of fat at the three sites. Breed and sex differences were evident in the average depth of fat. The regression coefficients for the mean of three fat measurements on market weight were.016 ±.003,.019 ±.007, and.017 ±.004 for Lacombe males, barrows, and females respectively;.039 ±.002,.036 ±.005, and.041 ±.001 for Yorkshire males, barrows and females respectively;.027 ±.005 and.029 ±.004 for barrows and females from the Lacombe male × Yorkshire female mating; and.023 ±.007 and.021 ±.009 for barrows and females from the Yorkshire male × Lacombe female mating. Comparisons between animals measured at a relatively constant weight should be made after the fat measurement is adjusted for variations in body weight. The results of this study indicate that separate corrections should be applied for each breed. Separate corrections for sexes within breeds do not appear warranted.

Parasites of Freshwater and Anadromous Fishes from Matamek River System, Quebec

1974 ◽  
Vol 31 (6) ◽  
pp. 1135-1139 ◽  
Author(s):  
George Hanek ◽  
Kalman Molnar
Keyword(s):  
Salmo Salar ◽  
Gasterosteus Aculeatus ◽  
Salvelinus Fontinalis ◽  
River System ◽  
Anguilla Rostrata ◽  
Osmerus Mordax ◽  
Pungitius Pungitius ◽  
Apeltes Quadracus ◽  
Catostomus Catostomus

In 224 fish of nine species from Matamek River system 38 genera of parasites were recovered (12 Protozoa, 3 Monogenea, 6 Digenea, 6 Cestoda, 6 Nematoda, 2 Acanthocephala, 3 Copepoda). Six genera of parasites were noted in Salmo salar, Salvelinus fontinalis harbored 17 genera, S. alpinus 5 genera, Osmerus mordax 4 genera, Anguilla rostrata 9 genera, Catostomus catostomus 8 genera, Apeltes quadracus 1 genus, Gasterosteus aculeatus 12 genera, and Pungitius pungitius 9 genera.

Self-Report Depression Scales in the Elderly: The Relationship between the CES-D and ZUNG

1989 ◽  
Vol 18 (4) ◽  
pp. 325-338 ◽  
Author(s):  
Bruce R. Deforge ◽  
Jeffery Sobal
Keyword(s):  
Mental Health ◽  
Sex Differences ◽  
Mental Health Problems ◽  
Psychological Symptoms ◽  
Somatic Symptoms ◽  
The Elderly ◽  
Self Report ◽  
Common Mental Health Problems ◽  
Depression Scales ◽  
The Relationship

Depression is one of the most common mental health problems in the elderly, but there is little consensus about the best way to assess depression in the aged. The relationship between the CES-D and the ZUNG self-report depression scales was investigated in seventy-eight elderly people with osteoarthritis (mean age 71). The correlation between the scales was r = .69, with the CES-D classifying 15 percent of the participants as depressed, as compared to 6 percent by the ZUNG. Psychological symptoms had the strongest relationship with overall depression scores on both scales. No sex differences were found on psychological items on either scale, but females reported more somatic symptoms on the ZUNG. People over age seventy-four reported more psychological symptoms than their younger counterparts.

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