scholarly journals Honeybee gut microbiota modulates host behaviors and neurological processes

2020 ◽  
Author(s):  
Zijing Zhang ◽  
Xiaohuan Mu ◽  
Qina Cao ◽  
Yao Shi ◽  
Xiaosong Hu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Behavioral Repertoire ◽  
Bacterial Phylotypes ◽  
Labor Division ◽  
Host Health ◽  
Microbe Interactions ◽  
Neurological Processes ◽  
Host Microbe Interactions ◽  
The Brain ◽  
Gut Metabolism

AbstractHoneybee is a highly social insect with a reach behavioral repertoire and is a versatile model for neurobiological research. The honeybee gut microbiota is composed of a limited number of bacterial phylotypes that play an important role in host health. However, it remains unclear whether the microbiota can shape brain profiles and behaviors. Here, we revealed that the gut microbiota is requisite for the olfactory learning and memory ability of honeybees and alters the level of neurotransmitters in the brain. Transcriptomic and proteomic analysis showed distinctive gene expression and protein signatures for gnotobiotic bees associated with different gut bacteria. Specifically, genes related to olfactory functions and labor division are most upregulated. Moreover, differentially spliced genes in the brains of colonized bees largely overlapped with the datasets for human autism. The circulating metabolome profiles identified that different gut species regulated specific module of metabolites in the host hemolymph. Most altered metabolites are involved in the amino acid and glycerophospholipid metabolism pathways for the production of neuroactive compounds. Finally, antibiotic treatment disturbed the gut community and the nursing behavior of worker bees under field conditions. The brain transcripts and gut metabolism was also greatly interfered in treated bees. Collectively, we demonstrate that the gut microbiota regulates honeybee behaviors, brain gene transcription, and the circulating metabolism. Our findings highlight the contributions of honeybee gut microbes in the neurological processes with striking parallels to those found in other animals, thus providing a promising model to understand the host-microbe interactions via the gut-brain axis.

scholarly journals Honeybee gut microbiota modulates host behaviors and neurological processes

2021 ◽  
Author(s):  
Zijing Zhang ◽  
Xiaohuan Mu ◽  
Qina Cao ◽  
Yao Shi ◽  
Xiaosong Hu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Behavioral Repertoire ◽  
Bacterial Phylotypes ◽  
Labor Division ◽  
Host Health ◽  
Microbe Interactions ◽  
Neurological Processes ◽  
Host Microbe Interactions ◽  
The Brain ◽  
Gut Metabolism

Abstract Honeybee is a highly social insect with a reach behavioral repertoire and is a versatile model for neurobiological research. The honeybee gut microbiota is composed of a limited number of bacterial phylotypes that play an important role in host health. However, it remains unclear whether the microbiota can shape brain profiles and behaviors. Here, we revealed that the gut microbiota is requisite for the olfactory learning and memory ability of honeybees and alters the level of neurotransmitters in the brain. Transcriptomic and proteomic analysis showed distinctive gene expression and protein signatures for gnotobiotic bees associated with different gut bacteria. Specifically, genes related to olfactory functions and labor division are most upregulated. Moreover, differentially spliced genes in the brains of colonized bees largely overlapped with the datasets for human autism. The circulating metabolome profiles identified that different gut species regulated specific module of metabolites in the host hemolymph. Most altered metabolites are involved in the amino acid and glycerophospholipid metabolism pathways for the production of neuroactive compounds. Finally, antibiotic treatment disturbed the gut community and the nursing behavior of worker bees under field conditions. The brain transcripts and gut metabolism was also greatly interfered in treated bees. Collectively, we demonstrate that the gut microbiota regulates honeybee behaviors, brain gene transcription, and the circulating metabolism. Our findings highlight the contributions of honeybee gut microbes in the neurological processes with striking parallels to those found in other animals, thus providing a promising model to understand the host-microbe interactions via the gut-brain axis.

Immunological Responses to Gut Bacteria

2012 ◽  
Vol 95 (1) ◽  
pp. 35-49 ◽  
Author(s):  
Julia M Green-Johnson
Keyword(s):  
Immune System ◽  
Gut Microbiota ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Host Defenses ◽  
Immunological Responses ◽  
Host Health ◽  
Microbe Interactions ◽  
Host Microbe Interactions

Abstract The integral nature of interactions between the gut microbiota and host is especially evident with respect to effects on the immune system and host defenses. Host-microbiota interactions are increasingly being revealed as complex and dynamic, with far-reaching effects on varied aspects of host health. This review focuses on adaptive and innate immune responses to the gut microbiota and the bidirectional nature of these host-microbe interactions.

Host-microbe interactions mediating antitumorigenic effects of MRX0518, a gut microbiota-derived bacterial strain, in breast, renal and lung carcinoma.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e15006-e15006 ◽  
Author(s):  
Alex Stevenson ◽  
Alessio Panzica ◽  
Amy Holt ◽  
Delphine Laute Caly ◽  
Anna Ettore ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lung Carcinoma ◽  
Bacterial Strain ◽  
Microbe Interactions ◽  
Host Microbe Interactions

scholarly journals Gut microbiota, the pharmabiotics they produce and host health

2014 ◽  
Vol 73 (4) ◽  
pp. 477-489 ◽  
Author(s):  
Elaine Patterson ◽  
John F. Cryan ◽  
Gerald F. Fitzgerald ◽  
R. Paul Ross ◽  
Timothy G. Dinan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Brain Function ◽  
Innate Immune ◽  
Aminobutyric Acid ◽  
Intestinal Lumen ◽  
Bioactive Metabolites ◽  
Bioactive Lipids ◽  
Disease States ◽  
Host Health ◽  
The Brain

A healthy gut microbiota plays many crucial functions in the host, being involved in the correct development and functioning of the immune system, assisting in the digestion of certain foods and in the production of health-beneficial bioactive metabolites or ‘pharmabiotics’. These include bioactive lipids (including SCFA and conjugated linoleic acid) antimicrobials and exopolysaccharides in addition to nutrients, including vitamins B and K. Alterations in the composition of the gut microbiota and reductions in microbial diversity are highlighted in many disease states, possibly rendering the host susceptible to infection and consequently negatively affecting innate immune function. Evidence is also emerging of microbially produced molecules with neuroactive functions that can have influences across the brain–gut axis. For example, γ-aminobutyric acid, serotonin, catecholamines and acetylcholine may modulate neural signalling within the enteric nervous system, when released in the intestinal lumen and consequently signal brain function and behaviour. Dietary supplementation with probiotics and prebiotics are the most widely used dietary adjuncts to modulate the gut microbiota. Furthermore, evidence is emerging of the interactions between administered microbes and dietary substrates, leading to the production of pharmabiotics, which may directly or indirectly positively influence human health.

scholarly journals Drosophila as a Model for Microbiota Studies of Neurodegeneration

2021 ◽  
pp. 1-12
Author(s):  
Fukiko Kitani-Morii ◽  
Robert P. Friedland ◽  
Hideki Yoshida ◽  
Toshiki Mizuno
Keyword(s):  
Gut Microbiota ◽  
Molecular Mechanisms ◽  
Environmental Changes ◽  
Fruit Fly ◽  
Endocrine Regulation ◽  
Nutrient Metabolism ◽  
Host Health ◽  
And Behavior ◽  
The Brain ◽  
Lateral Sclerosis

Accumulating evidence show that the gut microbiota is deeply involved not only in host nutrient metabolism but also in immune function, endocrine regulation, and chronic disease. In neurodegenerative conditions such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis, the gut-brain axis, the bidirectional interaction between the brain and the gut, provides new route of pathological spread and potential therapeutic targets. Although studies of gut microbiota have been conducted mainly in mice, mammalian gut microbiota is highly diverse, complex, and sensitive to environmental changes. Drosophila melanogaster, a fruit fly, has many advantages as a laboratory animal: short life cycle, numerous and genetically homogenous offspring, less ethical concerns, availability of many genetic models, and low maintenance costs. Drosophila has a simpler gut microbiota than mammals and can be made to remain sterile or to have standardized gut microbiota by simple established methods. Research on the microbiota of Drosophila has revealed new molecules that regulate the brain-gut axis, and it has been shown that dysbiosis of the fly microbiota worsens lifespan, motor function, and neurodegeneration in AD and PD models. The results shown in fly studies represents a fundamental part of the immune and proteomic process involving gut-microbiota interactions that are highly conserved. Even though the fly’s gut microbiota are not simple mimics of humans, flies are a valuable system to learn the molecular mechanisms of how the gut microbiota affect host health and behavior.

scholarly journals Adaptation of the Gut Microbiota to Modern Dietary Sugars and Sweeteners

2019 ◽  
Vol 11 (3) ◽  
pp. 616-629 ◽  
Author(s):  
Sara C Di Rienzi ◽  
Robert A Britton
Keyword(s):  
Gut Microbiota ◽  
Intestinal Tract ◽  
Western Diet ◽  
Health Concerns ◽  
Diet Cost ◽  
Microbe Interactions ◽  
Novel Approaches ◽  
Host Microbe Interactions ◽  
Genetic Profiles ◽  
Dietary Sugars

ABSTRACT The consumption of sugar has become central to the Western diet. Cost and health concerns associated with sucrose spurred the development and consumption of other sugars and sweeteners, with the average American consuming 10 times more sugar than 100 y ago. In this review, we discuss how gut microbes are affected by changes in the consumption of sugars and other sweeteners through transcriptional, abundance, and genetic adaptations. We propose that these adaptations result in microbes taking on different metabolic, ecological, and genetic profiles along the intestinal tract. We suggest novel approaches to assess the consequences of these changes on host–microbe interactions to determine the safety of novel sugars and sweeteners.

scholarly journals Gut Microbial Influences on the Mammalian Intestinal Stem Cell Niche

2017 ◽  
Vol 2017 ◽  
pp. 1-17 ◽  
Author(s):  
Bailey C. E. Peck ◽  
Michael T. Shanahan ◽  
Ajeet P. Singh ◽  
Praveen Sethupathy
Keyword(s):  
Stem Cell ◽  
Gut Microbiota ◽  
Energy Homeostasis ◽  
Environmental Changes ◽  
Intestinal Epithelial ◽  
Microbe Interactions ◽  
Host Microbe Interactions ◽  
Cell Niche ◽  
Systemic Health ◽  
Endocrine Signaling

The mammalian intestinal epithelial stem cell (IESC) niche is comprised of diverse epithelial, immune, and stromal cells, which together respond to environmental changes within the lumen and exert coordinated regulation of IESC behavior. There is growing appreciation for the role of the gut microbiota in modulating intestinal proliferation and differentiation, as well as other aspects of intestinal physiology. In this review, we evaluate the diverse roles of known niche cells in responding to gut microbiota and supporting IESCs. Furthermore, we discuss the potential mechanisms by which microbiota may exert their influence on niche cells and possibly on IESCs directly. Finally, we present an overview of the benefits and limitations of available tools to study niche-microbe interactions and provide our recommendations regarding their use and standardization. The study of host-microbe interactions in the gut is a rapidly growing field, and the IESC niche is at the forefront of host-microbe activity to control nutrient absorption, endocrine signaling, energy homeostasis, immune response, and systemic health.

scholarly journals Gut Microbiota and Iron: The Crucial Actors in Health and Disease

2018 ◽  
Vol 11 (4) ◽  
pp. 98 ◽  
Author(s):  
Bahtiyar Yilmaz ◽  
Hai Li
Keyword(s):  
Gut Microbiota ◽  
Inflammatory Diseases ◽  
Life Forms ◽  
Iron Availability ◽  
Human Beings ◽  
Human Gastrointestinal Tract ◽  
Dynamic Modulation ◽  
Microbe Interactions ◽  
Health And Disease ◽  
Host Microbe Interactions

Iron (Fe) is a highly ample metal on planet earth (~35% of the Earth’s mass) and is particularly essential for most life forms, including from bacteria to mammals. Nonetheless, iron deficiency is highly prevalent in developing countries, and oral administration of this metal is so far the most effective treatment for human beings. Notably, the excessive amount of unabsorbed iron leave unappreciated side effects at the highly interactive host–microbe interface of the human gastrointestinal tract. Recent advances in elucidating the molecular basis of interactions between iron and gut microbiota shed new light(s) on the health and pathogenesis of intestinal inflammatory diseases. We here aim to present the dynamic modulation of intestinal microbiota by iron availability, and conversely, the influence on dietary iron absorption in the gut. The central part of this review is intended to summarize our current understanding about the effects of luminal iron on host–microbe interactions in the context of human health and disease.

scholarly journals Gut Microbiota and Mucosal Immunity in the Neonate

2018 ◽  
Vol 6 (3) ◽  
pp. 56 ◽  
Author(s):  
Majda Dzidic ◽  
Alba Boix-Amorós ◽  
Marta Selma-Royo ◽  
Alex Mira ◽  
Maria Collado
Keyword(s):  
Immune System ◽  
Gut Microbiota ◽  
System Response ◽  
Delivery Mode ◽  
Complex Dynamic ◽  
Close Relationship ◽  
Gut Immunity ◽  
Microbe Interactions ◽  
Immune System Response ◽  
Host Microbe Interactions

Gut microbiota colonization is a complex, dynamic, and step-wise process that is in constant development during the first years of life. This microbial settlement occurs in parallel with the maturation of the immune system, and alterations during this period, due to environmental and host factors, are considered to be potential determinants of health-outcomes later in life. Given that host–microbe interactions are mediated by the immune system response, it is important to understand the close relationship between immunity and the microbiota during birth, lactation, and early infancy. This work summarizes the evidence to date on early gut microbiota colonization, and how it influences the maturation of the infant immune system and health during the first 1000 days of life. This review will also address the influence of perinatal antibiotic intake and the importance of delivery mode and breastfeeding for an appropriate development of gut immunity.

scholarly journals The Bee Microbiome: Impact on Bee Health and Model for Evolution and Ecology of Host-Microbe Interactions

mBio ◽  
2016 ◽  
Vol 7 (2) ◽  
Author(s):  
Philipp Engel ◽  
Waldan K. Kwong ◽  
Quinn McFrederick ◽  
Kirk E. Anderson ◽  
Seth Michael Barribeau ◽  
...  
Keyword(s):  
High Throughput Sequencing ◽  
Sequence Data ◽  
Terrestrial Ecosystem ◽  
Primary Data ◽  
Factors Affecting ◽  
Host Health ◽  
Bee Health ◽  
Microbe Interactions ◽  
Host Microbe Interactions ◽  
Global Coordination

ABSTRACT As pollinators, bees are cornerstones for terrestrial ecosystem stability and key components in agricultural productivity. All animals, including bees, are associated with a diverse community of microbes, commonly referred to as the microbiome. The bee microbiome is likely to be a crucial factor affecting host health. However, with the exception of a few pathogens, the impacts of most members of the bee microbiome on host health are poorly understood. Further, the evolutionary and ecological forces that shape and change the microbiome are unclear. Here, we discuss recent progress in our understanding of the bee microbiome, and we present challenges associated with its investigation. We conclude that global coordination of research efforts is needed to fully understand the complex and highly dynamic nature of the interplay between the bee microbiome, its host, and the environment. High-throughput sequencing technologies are ideal for exploring complex biological systems, including host-microbe interactions. To maximize their value and to improve assessment of the factors affecting bee health, sequence data should be archived, curated, and analyzed in ways that promote the synthesis of different studies. To this end, the BeeBiome consortium aims to develop an online database which would provide reference sequences, archive metadata, and host analytical resources. The goal would be to support applied and fundamental research on bees and their associated microbes and to provide a collaborative framework for sharing primary data from different research programs, thus furthering our understanding of the bee microbiome and its impact on pollinator health.

Sign in / Sign up

Export Citation Format

Share Document