scholarly journals Exploring the genetic overlap of suicide-related behaviors and substance use disorders

2021 ◽  
Author(s):  
Sarah Mary Carlton Colbert ◽  
Alexander S Hatoum ◽  
Andrey Shabalin ◽  
Hilary Coon ◽  
Elliot Nelson ◽  
...  
Keyword(s):  
Substance Use ◽  
Suicide Attempt ◽  
Substance Use Disorders ◽  
Structural Equation Models ◽  
Genetic Relationships ◽  
Risk Tolerance ◽  
General Level ◽  
Genome Wide Association Studies ◽  
Suicide Death ◽  
Genetic Overlap

Background: Suicide-related behaviors are heterogeneous and transdiagnostic, and may demonstrate varying levels of genetic overlap with different substance use disorders (SUDs). Methods: We used linkage disequilibrium score regression and genomic structural equation models to examine the genetic relationships between several SUDs and suicide-related behaviors. Our analyses incorporated summary statistics from the largest genome-wide association studies (GWAS) of problematic alcohol use (PAU), the Fagerstrom Test for Nicotine Dependence (FTND), cannabis use disorder (CUD), and opioid use disorder (OUD; Ns ranging from 46,213-435,563) and GWAS of ever self-harmed, suicide attempt, and suicide death (Ns ranging from 18,223-117,733). We also accounted for genetic liability to depression (N=500,199) and risk tolerance (N=315,894). Results: Ever self-harmed correlated most strongly with CUD (rg=0.60) and suicide death correlated most strongly with OUD (rg=0.53). Suicide attempt correlated similarly with all SUDs. Simultaneously correlating a common SUD factor with each specific suicide indicator while controlling for depression and risk tolerance revealed significant, positive genetic correlations between all SUDs and suicide-related behaviors (rg=0.26-0.46). Discussion: Our findings suggest that genetic and behavioral contributions to suicide death may somewhat differ from non-lethal suicide-related behaviors. Additionally, we identify a general level of genetic overlap between SUDs and suicide-related behaviors which is independent of depression and risk tolerance.

scholarly journals Substance use disorder and risk of suicidal ideation, suicide attempt and suicide death: a meta-analysis

2015 ◽  
Vol 38 (3) ◽  
pp. e282-e291 ◽  
Author(s):  
Jalal Poorolajal ◽  
Tahereh Haghtalab ◽  
Mehran Farhadi ◽  
Nahid Darvishi
Keyword(s):  
Substance Use ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Substance Use Disorder ◽  
Meta Analysis ◽  
Suicide Death

scholarly journals A Study to Assess the Suicidal Behaviour among the Psychiatric Patients in a Tertiary Care Teaching Hospital, Guntur

2016 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr Vaddadi. Venkata kiran ◽  
Dr. Neeli Uma Jyothi ◽  
Mounica. Bollu
Keyword(s):  
Substance Use ◽  
Suicide Attempt ◽  
Psychiatric Disorders ◽  
Substance Use Disorders ◽  
Suicidal Behaviour ◽  
Psychiatric Patients ◽  
Tertiary Care ◽  
Wide Range ◽  
Self Harm ◽  
Commit Suicide

Suicide attempt is a deliberate act of self harm with at least some intent of die that does not result in death. Such act has a wide range of medical seriousness. Individuals with psychiatric disorders are far more likely to commit suicide than the others. People who are psychologically disabled are often commit suicide from years of pain, frustration and depression. Spiritually they may perceive themselves as hopelessly damaged and lose all sense of purpose and meaning of life. Suicide is not a diagnosis or a disorder. it is a behaviour. Suicide is a worldwide, national, local and familial problem. 90% of people who kill themselves suffer from a diagnosable and preventable problem such as depression co-occurring mental and substance use disorders are common and potent combination among those who die by suicide.

scholarly journals Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

2019 ◽  
Author(s):  
Hang Zhou ◽  
Julia M. Sealock ◽  
Sandra Sanchez-Roige ◽  
Toni-Kim Clarke ◽  
Daniel Levey ◽  
...  
Keyword(s):  
Substance Use ◽  
Alcohol Use ◽  
Genetic Relationships ◽  
Meta Analysis ◽  
European Ancestry ◽  
Polygenic Risk Score ◽  
Genome Wide Association Studies ◽  
Problematic Alcohol ◽  
Risk Variants ◽  
Problematic Alcohol Use

AbstractProblematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although genome-wide association studies (GWASs) have identified PAU risk genes, the genetic architecture of this trait is not fully understood. We conducted a proxy-phenotype meta-analysis of PAU combining alcohol use disorder and problematic drinking in 435,563 European-ancestry individuals. We identified 29 independent risk variants, 19 of them novel. PAU was genetically correlated with 138 phenotypes, including substance use and psychiatric traits. Phenome-wide polygenic risk score analysis in an independent biobank sample (BioVU, n=67,589) confirmed the genetic correlations between PAU and substance use and psychiatric disorders. Genetic heritability of PAU was enriched in brain and in genomic conserved and regulatory regions. Mendelian randomization suggested causal effects on liability to PAU of substance use, psychiatric status, risk-taking behavior, and cognitive performance. In summary, this large PAU meta-analysis identified novel risk loci and revealed genetic relationships with numerous other outcomes.

Over-the-Counter Drugs and Other Substances Used in Attempted Suicide Presented to Emergency Departments in Montreal, Canada

Crisis ◽  
2019 ◽  
Vol 40 (3) ◽  
pp. 166-175 ◽  
Author(s):  
Alexandre Mikhail ◽  
Omaid Tanoli ◽  
Gilles Légaré ◽  
Pierre-André Dubé ◽  
Youssef Habel ◽  
...  
Keyword(s):  
Substance Use ◽  
Suicide Attempt ◽  
Substance Use Disorders ◽  
Prescription Drugs ◽  
Suicide Attempts ◽  
Patient Characteristics ◽  
Cross Sectional ◽  
Over The Counter ◽  
Otc Drugs ◽  
Do So

Abstract. Background: Over-the-counter (OTC) analgesics are frequently used in suicide attempts. Accessibility, toxicity, and unsupervised acquisition of large amounts may be facilitators. Aims: To identify patient characteristics associated with OTC drug use as a suicide attempt method among adults. Method: A cross-sectional study was conducted using chart review of all individuals who presented to the emergency department (ED) of two adult general hospitals following a suicide attempt during 2009–2010 in Montreal, Canada. Results: Among the 369 suicide attempters identified, 181 used overdosing, 47% of whom used OTC drugs. In logistic regression, women and those with medical comorbidity were more likely to use overdosing, while those with substance use disorders were less likely to do so. Among those who overdosed, women were more likely to use OTC drugs, while those who were Caucasian, had children, comorbidities, diagnoses with substance use disorders, and made attempts in the Fall were less likely to do so. Substances most frequently used were: acetaminophen among OTC drugs (30%); antidepressants (37%), anxiolytics (30%), opioids (10%), and anticonvulsants (9%) among prescription drugs; and cocaine (10%) among recreational drugs. Limitations: Reasons for the suicide method choice were not available. Conclusion: OTC drugs, in particular acetaminophen, are frequently used in suicide attempts. Accessibility to these drugs may be an important contributor.

scholarly journals Childhood exposure to a parental suicide attempt and risk for substance use disorders

2015 ◽  
Vol 46 ◽  
pp. 70-76 ◽  
Author(s):  
Kimberly H. McManama O'Brien ◽  
Christopher P. Salas-Wright ◽  
Michael G. Vaughn ◽  
Mary LeCloux
Keyword(s):  
Substance Use ◽  
Suicide Attempt ◽  
Substance Use Disorders ◽  
Childhood Exposure ◽  
Parental Suicide

scholarly journals Genetic variation in personality traits explains genetic overlap between borderline personality features and substance use disorders

Addiction ◽  
2014 ◽  
Vol 109 (12) ◽  
pp. 2118-2127 ◽  
Author(s):  
Lauren R. Few ◽  
Julia D. Grant ◽  
Timothy J. Trull ◽  
Dixie J. Statham ◽  
Nicholas G. Martin ◽  
...  
Keyword(s):  
Substance Use ◽  
Genetic Variation ◽  
Personality Traits ◽  
Substance Use Disorders ◽  
Borderline Personality ◽  
Genetic Overlap ◽  
Personality Features ◽  
Borderline Personality Features

scholarly journals Genome-wide Association Study of Creativity Reveals Genetic Overlap With Psychiatric Disorders, Risk Tolerance, and Risky Behaviors

2020 ◽  
Vol 46 (5) ◽  
pp. 1317-1326 ◽  
Author(s):  
Huijuan Li ◽  
Chuyi Zhang ◽  
Xin Cai ◽  
Lu Wang ◽  
Fang Luo ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Genetic Basis ◽  
Risky Behaviors ◽  
Risk Tolerance ◽  
Genome Wide Association ◽  
Polygenic Risk Score ◽  
Genome Wide Association Studies ◽  
Polygenic Risk ◽  
Genome Wide ◽  
Genetic Overlap

Abstract Creativity represents one of the most important and partially heritable human characteristics, yet little is known about its genetic basis. Epidemiological studies reveal associations between creativity and psychiatric disorders as well as multiple personality and behavioral traits. To test whether creativity and these disorders or traits share genetic basis, we performed genome-wide association studies (GWAS) followed by polygenic risk score (PRS) analyses. Two cohorts of Han Chinese subjects (4,834 individuals in total) aged 18–45 were recruited for creativity measurement using typical performance test. After exclusion of the outliers with significantly deviated creativity scores and low-quality genotyping results, 4,664 participants were proceeded for GWAS. We conducted PRS analyses using both the classical pruning and thresholding (P+T) method and the LDpred method. The extent of polygenic risk was estimated through linear regression adjusting for the top 3 genotyping principal components. R2 was used as a measurement of the explained variance. PRS analyses demonstrated significantly positive genetic overlap, respectively, between creativity with schizophrenia ((P+T) method: R2(max) ~ .196%, P = .00245; LDpred method: R2(max) ~ .226%, P = .00114), depression ((P+T) method: R2(max) ~ .178%, P = .00389; LDpred method: R2(max) ~ .093%, P = .03675), general risk tolerance ((P+T) method: R2(max) ~ .177%, P = .00399; LDpred method: R2(max) ~ .305%, P = .00016), and risky behaviors ((P+T) method: R2(max) ~ .187%, P = .00307; LDpred method: R2(max) ~ .155%, P = .00715). Our results suggest that human creativity is probably a polygenic trait affected by numerous variations with tiny effects. Genetic variations that predispose to psychiatric disorders and risky behaviors may underlie part of the genetic basis of creativity, confirming the epidemiological associations between creativity and these traits.

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