scholarly journals A Real World Evaluation of the safety and immunogenicity of the Covishield vaccine, ChAdOx1 nCoV- 19 Corona Virus Vaccine (Recombinant) in Health Care Workers (HCW) in National Capital Region (NCR) of India: A preliminary report

2021 ◽  
Author(s):  
Sushia Kataria ◽  
Pooja Sharma ◽  
Vikas Deswal ◽  
Kuldeep Kumar ◽  
Manish Kumar Singh ◽  
...  
Keyword(s):  
Health Care ◽  
Adverse Events ◽  
Virus Vaccine ◽  
Health Care Workers ◽  
Real World ◽  
Vaccine Recombinant ◽  
Serious Adverse Events ◽  
Corona Virus ◽  
Care Workers ◽  
History Of

Background: The SARS-CoV-2 pandemic has severely impacted health systems, economic and social progress globally in 2020. The rollout of vaccines in several parts of the world is being hailed as a solution to the crisis. With newer and more virulent serotypes on the horizon and limited vaccine available, evaluation of safety and immunogenicity is critical for rationalization of vaccine use in public health. Objective To evaluate real world safety, and, immunogenicity of the Covishield vaccine, ChAdOx1 nCoV- 19 Corona Virus Vaccine (Recombinant) in Health Care Workers (HCW) during the national vaccine roll out in the NCR, New Delhi. The safety is evaluated through Adverse Events and Serious Adverse Events reported though enhanced pharmacovigilance protocols, and, the immunogenicity by quantitative determination of anti-S1 and anti-S2 specific IgG antibodies to SARS-CoV-2 in serum samples collected before the receipt of the vaccine and 14 days after dose 1, using the fully automated LIAISON SARS-CoV-2 S1/S2 IgG test using the chemiluminescence immunoassay (CLIA) Results: In the two weeks after immunization with the Covishield vaccine {ChAdOx1 nCoV- 19 Corona Virus Vaccine (Recombinant)}, none of the 1638 evaluated participants reported any serious adverse events (ie require hospitalization or emergency room visit). Solicited adverse events reported via daily diary cards included pain (62.7%) and soreness (24.1%) at injection site as most common, whereas fever (48.4%), headache (43.4%), myalgia (38.4%), fatigue (33.4%), joint pain (27.0%) and nausea (16.0%) were most common solicited systemic adverse events on day 1. Majority of local and systemic adverse events were seen in first 2 days post vaccination and thereafter they resolved. Lesser reactogenicity was observed in subjects with age >50 years. No major difference was observed in adverse events when subjects were stratified based on history of COVID 19 disease or baseline seropositivity. In our study serostatus improved from 48.2% positive at baseline to 79.0% positive 2 weeks following first dose of vaccination. After first dose of vaccination overall higher percentage (98.2%) of seropositivity rates were observed in those with past history of COVID 19 disease Conclusion: The Covishield vaccine {ChAdOx1 nCoV- 19 Corona Virus Vaccine (Recombinant)}, was safe and reported mild self limiting adverse events over 2-4 days and had an good early (within 2 weeks) seroresponse .This holds the promise of far reaching impact on vaccine availability for a larger population and thereby providing a widespread coverage.

Stepping up detection, response, preparedness and readiness measures for “COVID-19”- A Pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1042-1047
Author(s):  
Khushbu Balsara ◽  
Deepankar Shukla
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Clinical History ◽  
Frontline Workers ◽  
Diagnostic Assays ◽  
Care Workers ◽  
Short Period ◽  
History Of ◽  
Detection Response ◽  
Care Worker

In a very short period of time, “COVID-19” has seized the consciousness globally by making remarkable changes in our day to day living and has superintended as a public health emergency globally. It has high radar of transmission, affecting an individual at work to frontline workers. The measures and planning for a response plays a key role from drawing up an emergency committee and this follows an equation which broadly deals with epidemiological to clinical history of the patient, management steps from isolation, screening, diagnostic assays for identification and treatment. The application of an organized plan with secure structure aids in better performance, increases efficacy of management and saves time. Also saves time for a health care worker to g through routine levels of channels of administration if already a familiar way of operation is known for such situations. Thus, planning and developing a ‘blueprint of approach’ towards management of patient while facing such situation is a must. This review provides an insight to the measures for detection, response and preparedness of the hospital and health care workers should largely be inclusive of; also highlights the measures to be taken at every step after coming in contact with a positive case of “COVID-19”.

Corona Virus (COVID-19) Awareness Assessment - A Survey Study Amongst the Indian Population

2020 ◽  
Author(s):  
Gabriela Fernandes
Keyword(s):  
Health Care ◽  
Social Media ◽  
Health Care Workers ◽  
Indian Population ◽  
Age Groups ◽  
Survey Study ◽  
Social Distancing ◽  
Corona Virus ◽  
Care Workers ◽  
Amount Of Knowledge

Aim: The aim of this survey study was to assess the level of awareness amongst Indian population regarding the COVID-19. Method: A survey was conducted amongst 745 individuals to assess their level of awareness regarding COVID-19 and steps to be taken for its prevention. Result: The results revealed that a considerable percentage of individuals learned about the pandemic through social media and news and were aware of the mode of spread of the virus and also steps to be taken to prevent it from spreading. But considerable percentage of people was also not fully aware regarding the age groups this virus will be affecting. Conclusion: Upon understanding the percentage of people not aware about the age groups this virus will be affecting, keeping in mind good amount of knowledge amongst individuals about maintaining hygiene and social distancing, this survey would help the health care workers to create awareness regarding the effect of this virus on different age groups to help prevent carelessness amongst youth in following the regime.

scholarly journals Perceptions on Diet and Dietary Modifications during Postpartum Period Aiming at Attenuating Progression of GDM to DM: A Qualitative Study of Mothers and Health Care Workers

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Thamudi D. Sundarapperuma ◽  
Champa J. Wijesinghe ◽  
Priyadarshika Hettiarachchi ◽  
Sudharshani Wasalathanthri
Keyword(s):  
Diabetes Mellitus ◽  
Health Care ◽  
Health Care Workers ◽  
Postpartum Period ◽  
Food Habits ◽  
Later Life ◽  
Dietary Recommendations ◽  
Financial Barriers ◽  
Care Workers ◽  
History Of

Background. Gestational diabetes mellitus (GDM) is a global concern. GDM mothers have a 7-fold relative risk of developing type 2 diabetes mellitus (T2DM) in their later life. User-friendly and culturally acceptable dietary interventions can minimize this risk. Therefore, this study aims at exploring the perceptions of GDM mothers and health care workers regarding factors that influence postpartum dietary practices aimed at attenuating the trajectory from GDM to DM. Methods. The study was conducted in selected MOH areas in three districts of Sri Lanka. Six focus group discussions were conducted with thirty mothers with a history of GDM and six in-depth interviews with six health care workers. The phenomenon of interest was to obtain inputs of two stakeholder groups on healthy food habits of GDM mothers during the postpartum period. Framework analysis was used to analyse the data. Data were coded using the analytical framework, abstracted from transcripts, and summarized verbatim in Microsoft Excel in a matrix comprised of one row per participant and one column per code. Finally, the matrix was reviewed intensely and themes were generated. Results. Overall, seven themes emerged from both cases: (1) myths and traditions specific to the postpartum period, (2) lack of motivation, (3) time pressure, (4) financial barriers, (5) negligence of mothers and families, (6) lack of awareness regarding GDM and its postpartum dietary recommendations, and (7) cultural barriers. Conclusions. This study provides an insight into the existing knowledge, common practices, and attitudes regarding food habits among postpartum mothers with a history of GDM. Since the postpartum period is unique, identifying barriers is crucial when introducing dietary modification protocols in order to prevent or attenuate the progression of GDM to T2DM in these mothers. The knowledge gained will be used to introduce feasible, scientifically sound, and culturally acceptable postpartum dietary recommendations for GDM mothers.

Health-Care Workers’ Perception of Patients’ Suicide Intention and Factors Leading to It: A Qualitative Study

2018 ◽  
Vol 82 (2) ◽  
pp. 323-345 ◽  
Author(s):  
Lei-Hum Wee ◽  
Norhayati Ibrahim ◽  
Suzaily Wahab ◽  
Uma Visvalingam ◽  
Seen Heng Yeoh ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Interpretative Phenomenological Analysis ◽  
Cognitive Status ◽  
Risk Minimization ◽  
Negative Attitudes ◽  
Face To Face ◽  
Care Workers ◽  
History Of ◽  
Suicidal Patients

This study explored health-care workers’ perception of patients’ suicide intention and their understanding of factors leading to particular interpretations. Semistructured face-to-face in-depth interviews were conducted with 32 health-care workers from a general hospital in Klang Valley, Malaysia. Interview data were transcribed verbatim and analyzed using the interpretative phenomenological analysis. The health-care workers were found to have four types of perceptions: to end life, not to end life, ambivalence about intention, and an evolving understanding of intention. Factors leading to their perceptions of patients’ suicide intention were patient demographics, health status, severity of ideation/attempt, suicide method, history of treatment, moral character, communication of suicide intention, affective/cognitive status, availability of social support, and health-care workers’ limited knowledge of patients’ condition/situation. Insufficient knowledge and negative attitudes toward suicidal patients led to risk minimization and empathic failure, although most health-care workers used the correct parameters in determining suicide intention.

scholarly journals COVID-19 infection outbreak among health care workers: perspective from a low-middle income country

2020 ◽  
Vol 90 (3) ◽  
Author(s):  
Nishanth Dev ◽  
Vijay Kumar ◽  
Jhuma Sankar
Keyword(s):  
Health Care ◽  
Severe Acute Respiratory Syndrome ◽  
Health Care Workers ◽  
Middle Income Country ◽  
Income Country ◽  
Middle Income ◽  
Corona Virus ◽  
Care Workers ◽  
Global Threat

To the Editor, The new pandemic COVID -19 caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a global threat. So far, more than 11 million infections and more than five hundred thousand deaths have been reported worldwide. In India the number of cases as of 5th July, 2020 is 6,73,165 with 19,268 deaths. Health care workers (HCWs) have been the backbone of this pandemic since the very beginning...

scholarly journals A cross-sectional study on mental health among health care workers during the outbreak of Corona Virus Disease 2019

2020 ◽  
Vol 51 ◽  
pp. 102111 ◽  
Author(s):  
Wenpeng Cai ◽  
Bin Lian ◽  
Xiangrui Song ◽  
Tianya Hou ◽  
Guanghui Deng ◽  
...  
Keyword(s):  
Mental Health ◽  
Health Care ◽  
Health Care Workers ◽  
Virus Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Corona Virus ◽  
Care Workers

scholarly journals Seroprevalence of SARS-CoV-2 (COVID-19) among Health Care Workers in Three Health Facilities of Yaounde, Center Region of Cameroon

2021 ◽  
Vol 3 (6) ◽  
pp. 89-94
Author(s):  
Philippe Salomon Nguwoh ◽  
Akenji Blaise Mboringong ◽  
Joseph Fokam ◽  
Christian Ngounouh Taheu ◽  
Ibrahima Halilou ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Clinical Signs ◽  
Rapid Test ◽  
Cross Sectional Study ◽  
Health Facilities ◽  
Cross Sectional ◽  
Face To Face ◽  
Care Workers ◽  
History Of

Introduction: Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first appeared in December 2019 in Wuhan, China and has subsequently become a worldwide pandemic. During the pandemic, health care workers (HCWs) were very exposed to COVID-19 infected patients. The aim of this study was to determine seroprevalence of SARS-CoV-2 (COVID-19) among HCWs in three health facilities of Yaounde. Methods: A cross-sectional study involving 368 HCWs was conducted from January 18th to February 13th, 2021, in three health facilities located in city of Yaounde. Data of study participants were collected by face-to-face interviews using standard questionnaire. Blood samples were collected in labelled dry tubes and analyzed using Rapid Diagnostic Test (RDT) cassettes (Abbott PanbioTMCOVID-19 IgG/IgM Rapid Test Device). The data collected was analyzed using Epi info version 7. Any value of p <0.05 was considered statistically significant. Results: The average age was 30.25 (SD±10.43) years old, range from 21 to 72 years old. Overall, the positivity rates of IgM, IgG and IgM+IgG were 6.79% (n=25), 17.93% (n=66) and 1.09% (n=4) respectively. Multivariate analysis showed that, the rate of IgM positivity was highest in laboratory personnel (χ2= 7.99, p=0.3) and IgG (χ2= 8.50, p=0.29), IgM+IgG (χ2= 1.92, p=0.26) respectively in pharmacy and clinical personnel. The clinical signs such as fever (˃38°C) or history of fever was statistically significant with IgM (χ2=11.71, p= 0.0006) while, sore throat was statistically significant associated with IgM (χ2= 14.3, p= 0.0008) and IgG (χ2= 6.33, p= 0.04). Conclusion: The results of this study reveal a high seroprevalence of circulation of the virus in hospital milieu in Yaounde suggesting the continuation of the COVID-19 « Track-Test-Treat » system to break the chain of transmission.

scholarly journals A description of the influenza vaccination program for health care workers in Vietnam

2020 ◽  
Author(s):  
Nga Ha ◽  
Thoa Thi Minh Nguyen ◽  
Tung Xuan Nguyen ◽  
Phu Dac Tran ◽  
Hang Minh Nguyen ◽  
...  
Keyword(s):  
Health Care ◽  
Adverse Events ◽  
Influenza Vaccination ◽  
Health Care Workers ◽  
Cold Chain ◽  
The North ◽  
Technical Requirements ◽  
Care Workers ◽  
Distributed Communication ◽  
Referral Hospitals

Abstract Background: In 2017, the Vietnam Ministry of Health conducted a demonstration project to introduce seasonal influenza vaccination to health care workers. A total of 11,000 doses of influenza vaccine, single-dose prefilled syringes, were provided free to HCWs at 29 selected hospitals, clinics, and research institutes in four provinces: Hanoi, Khanh Hoa, Dak Lak and Ho Chi Minh City. Methods: Before the campaign, a workshop was organized to discuss an implementation plan including technical requirements, cold chain, uptake reporting, and surveillance for adverse events following immunization. All sites distributed communication materials and encouraged their staff to register for vaccination. Following immunization sessions, sites sent reports on uptake and adverse events following immunization. Left-over vaccine was transferred to other sites to maximize vaccine use. Results: The average uptake was 57% for all health care workers, with 11 sites achieving 90% and above. These 11 sites were small with less than 500 staff, including 5 primary hospitals, 3 preventive medicine units, and 2 referral hospitals. Among the six biggest sites with over 1,000 staff, four sites had the lowest uptake (14%-47%). Most of the high-uptake sites were from the central to the south; only one site, a referral hospital, was from the north. After redistribution of left-over vaccine, only 130 vaccine doses (1.2%) were not used and destroyed. Based on factors that affected uptake, including registration levels, differing communication strategies, availability of vaccination, and commitment by health facility leaders, we recommended ways to increase health care worker coverage; recommendations to improve reporting adverse events following immunization were also made.Conclusions: The project demonstrated that it was feasible to conduct influenza vaccination campaigns among health care workers in Vietnam. Improvements in promotion of registration, more intense pre-planning, especially at larger facilities, and wider, more consistent availability of communication materials will result in increased efficiency and coverage in this program’s future expansion.

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