scholarly journals Will Vaccine-derived Protective Immunity Curtail COVID-19 Variants in the US?

2021 ◽  
Author(s):  
Marina Mancuso ◽  
Steffen Eikenberry ◽  
Abba Gumel
Keyword(s):  
Vaccine Coverage ◽  
Protective Efficacy ◽  
Wild Strain ◽  
The United States ◽  
Cross Protection ◽  
Mortality Data ◽  
High Coverage ◽  
New Variant ◽  
The Us ◽  
The Impact

Multiple effective vaccines are currently being deployed to combat the COVID-19 pandemic (caused by SARS-COV-2), and are viewed as the major factor in marked reductions in disease burden in regions around the world with moderate to high coverage of these vaccines. The effectiveness of COVID-19 vaccination programs is, however, significantly threatened by the emergence of new SARS-COV-2 variants that, in addition to being more transmissible and potentially more virulent than the wild (resident) strain, may at least partially evade existing vaccines. A new two-strain (one resident, the other wild) and two-group (vaccinated or otherwise) mechanistic mathematical model is designed and used to assess the impact of the vaccine-induced cross-protective efficacy on the spread the COVID-19 pandemic in the United States. Analysis of the model, which is fitted using COVID-19 mortality data for the US, shows that vaccine-induced herd immunity can be achieved if 61% of the American population is fully vaccinated with the Pfizer or Moderna vaccines. Parameter sensitivity analysis suggests three main factors that significantly affect the COVID-19 burden in the US, namely (a) daily vaccination rate, (b) the level of cross-protection the vaccines offer against the variant, and (c) the relative infectiousness of the dominant variant relative to the wild strain. This study further suggests that a new variant can cause a significant disease surge in the US if (i) the vaccine coverage against the wild strain is low (roughly < 50%), (ii) the variant is much more transmissible (e.g., twice more transmissible) than the wild-type strain, or (iii) the level of cross-protection offered by the vaccine is relatively low (e.g., less than 70%). A new variant will not cause such surge in the US if it is only moderately more transmissible (e.g., 1:56 more transmissible) than the wild strain, at least 66% of the population of the US is fully vaccinated, and the three vaccines being deployed in the US (Pfizer, Moderna, and Johnson & Johnson) offer a moderate level of cross-protection against the variant.

scholarly journals Epidemiological Differences in the Impact of COVID-19 Vaccination in the United States and China

Vaccines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 223 ◽  
Author(s):  
Monia Makhoul ◽  
Hiam Chemaitelly ◽  
Houssein H. Ayoub ◽  
Shaheen Seedat ◽  
Laith J. Abu-Raddad
Keyword(s):  
United States ◽  
Vaccine Coverage ◽  
Scale Up ◽  
The United States ◽  
The Us ◽  
High Incidence ◽  
Vaccine Impact ◽  
Infection Disease ◽  
The Impact ◽  
Actual Vaccine

This study forecasts Coronavirus Disease 2019 (COVID-19) vaccination impact in two countries at different epidemic phases, the United States (US) and China. We assessed the impact of both a vaccine that prevents infection (VES of 95%) and a vaccine that prevents only disease (VEP of 95%) through mathematical modeling. For VES of 95% and gradual easing of restrictions, vaccination in the US reduced the peak incidence of infection, disease, and death by >55% and cumulative incidence by >32% and in China by >77% and >65%, respectively. Nearly three vaccinations were needed to avert one infection in the US, but only one was needed in China. For VEP of 95%, vaccination benefits were half those for VES of 95%. In both countries, impact of vaccination was substantially enhanced with rapid scale-up, vaccine coverage >50%, and slower or no easing of restrictions, particularly in the US. COVID-19 vaccination can flatten, delay, and/or prevent future epidemic waves. However, vaccine impact is destined to be heterogeneous across countries because of an underlying “epidemiologic inequity” that reduces benefits for countries already at high incidence, such as the US. Despite 95% efficacy, actual vaccine impact could be meager in such countries if vaccine scale-up is slow, acceptance is poor, or restrictions are eased prematurely.

scholarly journals Epidemiological differences in the impact of COVID-19 vaccination in the United States and China

2021 ◽  
Author(s):  
Monia Makhoul ◽  
Hiam Chemaitelly ◽  
Houssein H. Ayoub ◽  
Shaheen Seedat ◽  
Laith J Abu-Raddad
Keyword(s):  
United States ◽  
Vaccine Coverage ◽  
Scale Up ◽  
The United States ◽  
The Us ◽  
High Incidence ◽  
Vaccine Impact ◽  
Infection Disease ◽  
The Impact ◽  
Actual Vaccine

Background: The objective of this study was to forecast the impact of COVID-19 vaccination in the United States (US) and China, two countries at different epidemic phases. Methods: A mathematical model describing SARS-CoV-2 transmission and disease progression was used to investigate vaccine impact. Impact was assessed both for a vaccine that prevents infection (VEs = 95%) and a vaccine that prevents only disease (VEp = 95%). Results: For VEs = 95% and gradual easing of restrictions, vaccination in the US reduced the peak incidence of infection, disease, and death by >55% and cumulative incidence by >32%, and in China by >77% and >65%, respectively. Nearly three vaccinations were needed to avert one infection in the US, but only one was needed in China. For VEp = 95%, benefits of vaccination were half those for VEs = 95%. In both countries, the impact of vaccination was substantially enhanced with rapid scale-up, vaccine coverage >50%, and slower or no easing of restrictions, particularly in the US. Conclusions: COVID-19 vaccination can flatten, delay, and/or prevent future epidemic waves. However, vaccine impact is destined to be heterogeneous across countries because of an underlying epidemiologic inequity that reduces benefits for countries already at high incidence, such as the US. Despite 95% efficacy, actual vaccine impact could be meager in such countries, if vaccine scale-up is slow, acceptance of the vaccine is poor, or restrictions are eased prematurely.

The Impact of Monetary and Fiscal Policies on the Stock Market in the United States (U.S); Evidence from Linear ARDL Framework

2020 ◽  
Vol 11 (1) ◽  
pp. 132-132
Author(s):  
Aref Emamian
Keyword(s):  
United States ◽  
Stock Market ◽  
The United States ◽  
Real Effective Exchange Rate ◽  
Annual Data ◽  
Fiscal Policies ◽  
Long Run ◽  
The Us ◽  
Short Run ◽  
The Impact

This study examines the impact of monetary and fiscal policies on the stock market in the United States (US), were used. By employing the method of Autoregressive Distributed Lags (ARDL) developed by Pesaran et al. (2001). Annual data from the Federal Reserve, World Bank, and International Monetary Fund, from 1986 to 2017 pertaining to the American economy, the results show that both policies play a significant role in the stock market. We find a significant positive effect of real Gross Domestic Product and the interest rate on the US stock market in the long run and significant negative relationship effect of Consumer Price Index (CPI) and broad money on the US stock market both in the short run and long run. On the other hand, this study only could support the significant positive impact of tax revenue and significant negative impact of real effective exchange rate on the US stock market in the short run while in the long run are insignificant. Keywords: ARDL, monetary policy, fiscal policy, stock market, United States

scholarly journals Spring Freeze Damage of Pecan Bloom: A Review

Horticulturae ◽  
2020 ◽  
Vol 6 (4) ◽  
pp. 82
Author(s):  
Amandeep Kaur ◽  
Louise Ferguson ◽  
Niels Maness ◽  
Becky Carroll ◽  
William Reid ◽  
...  
Keyword(s):  
Tree Height ◽  
The United States ◽  
Reproductive Organs ◽  
Tree Age ◽  
The Us ◽  
Nut Production ◽  
Freeze Damage ◽  
Terminal Buds ◽  
And Function ◽  
The Impact

Pecan is native to the United States. The US is the world’s largest pecan producer with an average yearly production of 250 to 300 million pounds; 80 percent of the world’s supply. Georgia, New Mexico, Texas, Arizona, Oklahoma, California, Louisiana, and Florida are the major US pecan producing states. Pecan trees frequently suffer from spring freeze at bud break and bloom as the buds are quite sensitive to freeze damage. This leads to poor flower and nut production. This review focuses on the impact of spring freeze during bud differentiation and flower development. Spring freeze kills the primary terminal buds, the pecan tree has a second chance for growth and flowering through secondary buds. Unfortunately, secondary buds have less bloom potential than primary buds and nut yield is reduced. Spring freeze damage depends on severity of the freeze, bud growth stage, cultivar type and tree age, tree height and tree vigor. This review discusses the impact of temperature on structure and function of male and female reproductive organs. It also summarizes carbohydrate relations as another factor that may play an important role in spring growth and transition of primary and secondary buds to flowers.

scholarly journals Mining Google and Apple mobility data: temporal anatomy for COVID-19 social distancing

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Corentin Cot ◽  
Giacomo Cacciapaglia ◽  
Francesco Sannino
Keyword(s):  
Infection Rate ◽  
The United States ◽  
Strong Decrease ◽  
Social Distancing ◽  
Mobility Data ◽  
Actual Measure ◽  
The Us ◽  
The Impact ◽  
Political Decisions ◽  
Mobility Reduction

AbstractWe employ the Google and Apple mobility data to identify, quantify and classify different degrees of social distancing and characterise their imprint on the first wave of the COVID-19 pandemic in Europe and in the United States. We identify the period of enacted social distancing via Google and Apple data, independently from the political decisions. Our analysis allows us to classify different shades of social distancing measures for the first wave of the pandemic. We observe a strong decrease in the infection rate occurring two to five weeks after the onset of mobility reduction. A universal time scale emerges, after which social distancing shows its impact. We further provide an actual measure of the impact of social distancing for each region, showing that the effect amounts to a reduction by 20–40% in the infection rate in Europe and 30–70% in the US.

scholarly journals Outcomes for Children and Adolescents With Cancer: Challenges for the Twenty-First Century

2010 ◽  
Vol 28 (15) ◽  
pp. 2625-2634 ◽  
Author(s):  
Malcolm A. Smith ◽  
Nita L. Seibel ◽  
Sean F. Altekruse ◽  
Lynn A.G. Ries ◽  
Danielle L. Melbert ◽  
...  
Keyword(s):  
United States ◽  
Childhood Cancer ◽  
Cancer Mortality ◽  
Lymphoblastic Leukemia ◽  
The United States ◽  
Mortality Rates ◽  
Mortality Data ◽  
Childhood Cancers ◽  
Essential Information ◽  
The Impact

Purpose This report provides an overview of current childhood cancer statistics to facilitate analysis of the impact of past research discoveries on outcome and provide essential information for prioritizing future research directions. Methods Incidence and survival data for childhood cancers came from the Surveillance, Epidemiology, and End Results 9 (SEER 9) registries, and mortality data were based on deaths in the United States that were reported by states to the Centers for Disease Control and Prevention by underlying cause. Results Childhood cancer incidence rates increased significantly from 1975 through 2006, with increasing rates for acute lymphoblastic leukemia being most notable. Childhood cancer mortality rates declined by more than 50% between 1975 and 2006. For leukemias and lymphomas, significantly decreasing mortality rates were observed throughout the 32-year period, though the rate of decline slowed somewhat after 1998. For remaining childhood cancers, significantly decreasing mortality rates were observed from 1975 to 1996, with stable rates from 1996 through 2006. Increased survival rates were observed for all categories of childhood cancers studied, with the extent and temporal pace of the increases varying by diagnosis. Conclusion When 1975 age-specific death rates for children are used as a baseline, approximately 38,000 childhood malignant cancer deaths were averted in the United States from 1975 through 2006 as a result of more effective treatments identified and applied during this period. Continued success in reducing childhood cancer mortality will require new treatment paradigms building on an increased understanding of the molecular processes that promote growth and survival of specific childhood cancers.

GPTs and growth: evidence on the technological adoption of electrical and electronic technologies in the 1920s

2020 ◽  
Author(s):  
Sergio Petralia
Keyword(s):  
The United States ◽  
General Purpose ◽  
Geographical Information ◽  
General Purpose Technologies ◽  
Technological Adoption ◽  
Transformative Potential ◽  
The Us ◽  
The Impact ◽  
Electronic Technologies ◽  
Patenting Activity

Abstract The pervasive diffusion of electricity-related technologies at the beginning of the twentieth century has been studied extensively to understand the transformative potential of general purpose technologies (GPTs). Most of what we know, however, has been investigated in relation to the diffusion of their use. This article provides evidence on the county-level economic impact of the technological adoption of electrical and electronic (E&E) technologies in the 1920s in the United States (US). It focuses on measuring the impact of a GPT on technological adopters, i.e., those who are able to develop, transform, and complement it. It is shown that places with patenting activity in E&E technologies grew faster and paid higher wages than others between 1920 and 1930. This analysis required constructing a novel database identifying detailed geographical information for historical patent documents in the US since 1836, as well as developing a text-mining algorithm to identify E&E patents based on patent descriptions.

scholarly journals The Impact of the US Financial Crisis on How Students Pay for College

2015 ◽  
Author(s):  
Arthur M. Hauptman
Keyword(s):  
The United States ◽  
Public Institutions ◽  
Federal Financial Aid ◽  
For Profit ◽  
American Students ◽  
The Us ◽  
Home Values ◽  
The Impact ◽  
Private Loan ◽  
Us Financial Crisis

The 2008 failure of major financial institutions in the United States may have dramatic ramifications on American students and whether/where they attend college. Several sources of funding may be at risk, including potential decreases in federal financial aid, the tightening of private loan availability, lowered home values impinging on equity-based lending, and stock market losses in college-fund savings. Public institutions, whose tuition is much lower than private or for-profit institutions, may see an increase in enrollment.

History and Current Trends in the Electronic Cigarette Retail Marketplace in the United States: 2010–2016

2018 ◽  
Vol 22 (5) ◽  
pp. 843-847 ◽  
Author(s):  
Jennifer Cantrell ◽  
Jidong Huang ◽  
Marisa Greenberg ◽  
Jeffrey Willett ◽  
Elizabeth Hair ◽  
...  
Keyword(s):  
Tobacco Industry ◽  
The United States ◽  
Retail Market ◽  
Current Trends ◽  
Published Evidence ◽  
The Us ◽  
Industry Response ◽  
Market Trends ◽  
The Impact ◽  
Over Time

Abstract Introduction The US market for electronic nicotine delivery systems (ENDS) has grown rapidly in the last decade. There is limited published evidence examining changes in the ENDS marketplace prior to the US Food and Drug Administration’s (FDA) deeming rule in 2016. This study describes US ENDS retail market trends from 2010 to 2016. Methods National data were obtained from Nielsen retail scanners for five product types: (1) disposables, (2) rechargeables, (3) cartridge replacements, (4) e-liquid bottle refills, and (5) specialty vapor products. We examined dollar sales, volume, price, brand, and flavor. Results Adjusted national sales increased from $11.6 million in 2010 to $751.2 million in 2016. The annual rate of sales growth rapidly increased before slowing through 2015. The rate of growth spiked in 2016. Market share for menthol products and other assorted flavors increased from 20% in 2010 to 52.1% by 2016. NJOY’s early market dominance shifted as tobacco industry brands entered the market and eventually captured 87.8% of share by 2016. Rechargeables and accompanying products comprised an increased proportion of total volume sold over time while disposable volume declined. Specialty vapor products appeared at retail in 2015. Conclusions Findings show strong early growth in the ENDS retail market followed by considerable slowing over time, despite a slight uptick in 2016. Trends reflect shifts to flavored products, newer generation “open-system” devices, lower prices, and tobacco industry brands. This study provides a baseline against which to compare the impact of FDA’s 2016 deeming rule and future actions on the ENDS marketplace. Implications This study uses market scanner data from US retail outlets to describe trends in the ENDS retail market from 2010 to 2016, providing a baseline against which to compare the impact of FDA’s 2016 deeming rule and future actions on the ENDS marketplace. Understanding historical market trends is valuable in assessing how future regulatory efforts and advances in ENDS technology may impact industry response and consumer uptake and use.

scholarly journals The Convergence of Military Conduct and Policing in Israeli-Controlled Territories

2020 ◽  
Vol 35 (2) ◽  
pp. 1-8
Author(s):  
Nir Gazit ◽  
Keyword(s):  
United States ◽  
Police Officer ◽  
The United States ◽  
Police Brutality ◽  
Media Attention ◽  
Military Forces ◽  
The Us ◽  
The Military ◽  
The Impact

The murder of George Floyd by a police officer in the United States in May 2020 and the subsequent turmoil, as well as the violence against migrants on the US-Mexican border, have drawn major public and media attention to the phenomenon of police brutality (see, e.g., Levin 2020; Misra 2018; Taub 2020), which is often labeled as ‘militarization of police’. At the same time, in recent years military forces have been increasingly involved in policing missions in civilian environments, both domestically (see, e.g., Kanno-Youngs 2020; Schrader 2020; Shinkman 2020) and abroad. The convergence of military conduct and policing raises intriguing questions regarding the impact of these tendencies on the military and the police, as well as on their legitimacy.

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