scholarly journals Sleep deprivation reduces the density of individual spine subtypes in a branch-specific fashion in CA1 neurons

2021 ◽  
Author(s):  
Youri G Bolsius ◽  
Peter Meerlo ◽  
Martien J Kas ◽  
Ted Abel ◽  
Robbert Havekes
Keyword(s):  
Sleep Deprivation ◽  
Negative Impact ◽  
Structural Plasticity ◽  
Spine Density ◽  
Ca1 Neurons ◽  
Specific Effects ◽  
Basal Dendrites ◽  
Depth Analysis ◽  
Ca1 Area ◽  
Dendritic Branches

Sleep deprivation has a negative impact on hippocampus-dependent memory, which are thought to depend on cellular plasticity. We previously found that five hours of sleep deprivation robustly decreases dendritic spine density in the CA1 area of the hippocampus in adult male mice. However, recent work by others suggests that sleep deprivation increases the density of certain spine types on specific dendritic branches. Based on these recent findings and our previous work, we conducted a more in-depth analysis of different spine types on branches 1, 2 and 5 of both apical and basal dendrites to assess whether five hours of sleep deprivation may have previously unrecognized spine-type and branch-specific effects. This analysis shows no spine-type specific changes on branch 1 and 2 of apical dendrites after sleep deprivation. In contrast, sleep deprivation decreases the number of mushroom and branched spines on branch 5. Likewise, sleep deprivation reduces thin, mushroom, and filopodia spine density on branch 5 of the basal dendrites, without affecting spines on branch 1 and 2. Our findings indicate that sleep deprivation leads to local branch-specific reduction in the density of individual spine types, and that local effects might not reflect the overall impact of sleep deprivation on CA1 structural plasticity. Moreover, our analysis underscores that focusing on a subset of dendritic branches may lead to potential misinterpretation of the overall impact of in this case sleep deprivation on structural plasticity.

Migration Patterns and Labor Market Outcomes

2018 ◽  
Author(s):  
Anda David ◽  
Mohamed Ali Marouani
Keyword(s):  
Labor Market ◽  
Negative Impact ◽  
Labor Market Outcomes ◽  
Wealth Index ◽  
Transition Matrices ◽  
Market Outcomes ◽  
Migration Patterns ◽  
Depth Analysis ◽  
Before And After ◽  
Spatial Composition

This chapter focuses on the external effects of emigration on non-migrants, and particularly on the interactions with labor market outcomes in Tunisia before and after the revolution. Using the new Tunisia Labor Market Panel Survey (TLMPS), we conduct an in-depth analysis of the structure and dynamics of migration, including the profile of migrants and their origin households, mainly in terms of skills and spatial composition. We investigate transition matrices, employment status, income for current migrants and returnees, and the evolution of remittances. Our analysis confirms the role of emigration as a safety valve for the Tunisian labor market. Moreover, origin households of migrants have a significantly higher wealth index. Our analysis also tends to confirm the effects of remittances on labor supply of non-migrants, which can have a negative impact on Tunisia’s unemployment rate when a crisis in destination countries affects the remittance rate negatively.

scholarly journals Assessment of the Sexual Violence Situation in a Regional Hospital in Guatemala: The Need for a Multidisciplinary Clinic

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S105-S105
Author(s):  
Blanca Soto ◽  
Miriam Canet ◽  
Diego Erdmenger
Keyword(s):  
Sexual Violence ◽  
Physical Violence ◽  
Negative Impact ◽  
Epidemiological Data ◽  
Depth Analysis ◽  
Significant Negative Impact ◽  
Comprehensive Health ◽  
History Of ◽  
Hepatitis B Testing

Abstract Background Sexual violence is a global health problem, in terms of age and sex, showing a significant negative impact on health. Incidence in Guatemala is among the highest of the region reaching an average of 23 cases reported daily nationally per statistics from the Ministry of Health in 2015. Methods Retrospective analysis of the database of all sexual violence cases reported from a secondary -level national hospital in Guatemala from January 2005 to September 2015 (period A) and in-depth analysis on demographic and epidemiological data along with information of the follow-up of cases between January 2012 and September 2015 (period B) was performed. Results Period A: 500 cases; female (96%; 481/500). Assault occurred between 16–20 years (34%; 163/481) 11–15 years (22.25%; 107/481), and 21–30 years (22.04%; 106/481). From all reported male cases, 73.68% (14/19) occurred under 15 years. Period B: 154/217 (70.96%) cases included; female (95.45%; 147/154), mean age: 17.87 years. Assault occurred in public spaces (57.14%; 88/154) and victim’s home (29.87%; 46/154). Almost 13% of victims reported history of previous assault, 5.84% by the same aggressor. More than one aggressor participated in 36.37% of assaults. Physical violence was associated in 57.79% of cases. Most victims (92.76%; 141/152) consulted within 72 hours of the assault. HIV, VDRL, and Hepatitis B testing performed in 100, 52, and 33.77%, respectively, were negative. Follow-up visits at 3, 6, and 12 months after the aggression were attended by 20.78% (30/154), 1.95% (3/154), and 1.95% (3/154) of victims, respectively. Psychology support was completed only in 18.18% (28/154). Emergency contraception was provided when indicated; pregnancy as result of the aggression was reported in nine cases (5.84%). Conclusion The study shows that young women were the most vulnerable group for sexual violence. There is a lack of multidisciplinary approach and follow-up. Interventions on infectious diseases screening have to be optimized to reduce the risk of ETS transmission. This evidence supports the need for a specialized clinic to ensure access to comprehensive health services for victims. Disclosures All authors: No reported disclosures.

scholarly journals Analysis of the Inner Fluid-Dynamics of Scroll Compressors and Comparison between CFD Numerical and Modelling Approaches

Energies ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 1158
Author(s):  
Giovanna Cavazzini ◽  
Francesco Giacomel ◽  
Alberto Benato ◽  
Francesco Nascimben ◽  
Guido Ardizzon
Keyword(s):  
Fluid Dynamics ◽  
Negative Impact ◽  
Heat Pumps ◽  
Average Mass ◽  
Design Procedures ◽  
Depth Analysis ◽  
Modelling Strategies ◽  
Absorbed Power ◽  
Semi Empirical ◽  
Empirical Approaches

Scroll compressors are widely adopted machines in both refrigeration systems and heat pumps. However, their efficiency is basically poor and constitutes the main bottleneck for improving the overall system performance. In fact, due to the complex machine fluid dynamics, scroll design is mainly based on theoretical and/or semi-empirical approaches. Designs strategies that do not guarantee an in-depth analysis of the machine behavior can be supplemented with a Computation Fluid Dynamics (CFD) approach. To this purpose, in the present work, the scroll compressor inner fluid dynamics is numerically analyzed in detail using two CFD software and two different modelling strategies for the axial gap. The analysis of the fluid evolution within the scroll wraps reveals unsteady phenomena developing during the suction and discharge phases, amplified by the axial clearance with negative impact on the main fluid flow (e.g., −13% of average mass flow rate for an axial gap of 30 μ) and on the scroll performance (e.g., +26% of average absorbed power for an axial gap of 30 μ). In terms of accuracy, the k-ε offers good performance on the estimation of average quantities but proves to be inadequate for capturing the complexity of the unsteady phenomena caused by the axial gap (e.g., −19% of the absorbed power in case of perfect tip seal). The need for considering specific geometric details in design procedures is highlighted, and guidelines on the choice of the most suitable numerical model are provided depending on the analysis needs.

Sleep deprivation increases cortical excitability in epilepsy: Syndrome-specific effects

Neurology ◽  
2006 ◽  
Vol 67 (6) ◽  
pp. 1018-1022 ◽  
Author(s):  
R.A.B. Badawy ◽  
J. M. Curatolo ◽  
M. Newton ◽  
S. F. Berkovic ◽  
R. A.L. Macdonell
Keyword(s):  
Sleep Deprivation ◽  
Cortical Excitability ◽  
Epilepsy Syndrome ◽  
Specific Effects

Legal and Axiological Basis for Social Reintegration of Persons Sentenced to Imprisonment and Public Participation in the Process

2021 ◽  
Vol 13 (2) ◽  
pp. 5-6
Author(s):  
Przemysław Tarwacki
Keyword(s):  
At Risk ◽  
Social Exclusion ◽  
Negative Impact ◽  
Relevant Literature ◽  
Research Centre ◽  
The European Union ◽  
Social Reintegration ◽  
The Social ◽  
Depth Analysis ◽  
Polish Society

The article discusses the problem of social reintegration of prisoners, which — despite being raised many a time in the relevant literaturę — remains to be a point of issue. In the light of a recent survey conducted by the Polish Public Opinion Research Centre (hereinafter: CBOS), former convicts are considered by the Polish society as one of the groups of people most at risk of social exclusion. In turn, a report of the Ministry of Justice of 2020, regarding convicted adults, shows that a very large number of people leaving prison return to crime as early as in the first year after being released, which, for obvious reasons, has a negative impact on the internal security of our country. These circumstances encourage one to take a fresh glance at the problem of social reintegration of convicts and to search for additional arguments in favor of extending special support to this group of people. A review of the existing legislation indicates that it allows the principle of individualisation of assistance for the sake of social readaptation of individual convicts to be applied to an unlimited extent. What is strictly limited, however, is the circle of persons who can undertake activities for the social readaptation of prisoners during their imprisonment. The exclusion from the above-mentioned circle of all persons validly convicted of intentional offences is unjustified, and with regard to those members of society who, outside the structures of non-governmental organisations, wish to engage in activities for the social readaptation of convicted persons is downright unlawful, as it is contrary to higher-order legal acts. An in-depth analysis of the law in force leads to the conclusion that argumentation for not treating this social group differently from other individuals most at risk of social exclusion can be found in the constitution itself. On the other hand, a review of lower-order legal acts leads to the observation that since our country's accession to the European Union there have appeared both new measures and additional reasons, different from those traditionally identified in the doctrine of executive criminal law, for investing in any human capital in need of support, including persons sentenced to imprisonment.

scholarly journals Comparing basal dendrite branches in human and mouse hippocampal CA1 pyramidal neurons with Bayesian networks

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Bojan Mihaljević ◽  
Pedro Larrañaga ◽  
Ruth Benavides-Piccione ◽  
Javier DeFelipe ◽  
Concha Bielza
Keyword(s):  
Bayesian Networks ◽  
Pyramidal Neurons ◽  
Graphical Representation ◽  
Data Set ◽  
Ca1 Region ◽  
Basal Dendrites ◽  
Hippocampal Ca1 ◽  
Dendritic Branches ◽  
Branch Type ◽  
Human And Mouse

Abstract Pyramidal neurons are the most common cell type in the cerebral cortex. Understanding how they differ between species is a key challenge in neuroscience. A recent study provided a unique set of human and mouse pyramidal neurons of the CA1 region of the hippocampus, and used it to compare the morphology of apical and basal dendritic branches of the two species. The study found inter-species differences in the magnitude of the morphometrics and similarities regarding their variation with respect to morphological determinants such as branch type and branch order. We use the same data set to perform additional comparisons of basal dendrites. In order to isolate the heterogeneity due to intrinsic differences between species from the heterogeneity due to differences in morphological determinants, we fit multivariate models over the morphometrics and the determinants. In particular, we use conditional linear Gaussian Bayesian networks, which provide a concise graphical representation of the independencies and correlations among the variables. We also extend the previous study by considering additional morphometrics and by formally testing whether a morphometric increases or decreases with the distance from the soma. This study introduces a multivariate methodology for inter-species comparison of morphology.

Unnecessary and disproportionate: the outcomes of remand for indigenous young people according to service providers

2016 ◽  
Vol 11 (2) ◽  
pp. 141-156
Author(s):  
Brenna Mathieson ◽  
Angela Dwyer
Keyword(s):  
Social Support ◽  
Young People ◽  
Design Methodology ◽  
Service Providers ◽  
Negative Impact ◽  
Psychological Development ◽  
Content Type ◽  
Specific Effects ◽  
Individual Service ◽  
Specific Impact

Purpose – While research often elaborates on outcomes of youth remand more broadly, the specific impact that remand has on indigenous young people can be overlooked, particularly in Australia. The paper aims to discuss these issues. Design/methodology/approach – This paper analyses interview data gathered from eight individual service providers from six community youth organisations in a city in Queensland, Australia. Findings – Participants reported the specific effects of remand for indigenous young people and their families, noting especially the negative impact on the young people’s emotional, social and psychological development. Originality/value – Results strongly suggest there is a blurring of the welfare and justice systems inherent within remand processes with indigenous young people, with remand employed so frequently that it has itself become a form of social support.

scholarly journals 493 An Examination into The Impact of Sleep Deprivation on Surgeons

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
V Antoniou ◽  
C C Booth ◽  
D Parry
Keyword(s):  
Sleep Deprivation ◽  
Health Care Professionals ◽  
Negative Impact ◽  
Sleep Habits ◽  
Deprivation Score ◽  
The United Kingdom ◽  
King's College ◽  
Lack Of Sleep ◽  
Short And Long Term ◽  
The Impact

Abstract Background Lack of sleep amongst surgeons is significant and worrying. It poses short- and long-term risks to surgeons’ health and negatively impacts patient outcomes. Previous studies have examined sleep deprivation amongst health care professionals. The aim of the present study was to examine impact in a specific population of surgical doctors. Method A questionnaire-based study completed in the anatomy department of King’s College London University. Surgical subjects spanned the United Kingdom. Subjects completed 14 questions regarding sleep habits. Data was compiled, calculating a sleep deprivation score. Results Valid responses were obtained from 66 surgical subjects of varying seniority. Mean age of subjects was 33.7 years old. 59.1% of subjects had rota commitments changing on a weekly basis. Average sleep amongst subjects amounted to 6.15 (± 1.26) hours per night. Daily sleep did not present differences dependent on seniority level (p = 0.186). 25.8% of subjects took >30 minutes to fall asleep. Our subjects woke 1.67 (± 1.21) times a night. Mean sleep deprivation score amongst our surgical population was 16.5 (± 4.26) demonstrating moderate negative impact on daily activities. 28.9% accumulated ≧20 sleep deprivation score demonstrating severe impact of sleep deprivation on life. Conclusions Our study has demonstrated reduced quantity and quality of sleep amongst our subject population. With protecting the health of both patients and surgeons in mind, we must place higher importance on improving sleep amongst surgical professionals.

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