scholarly journals Antibody response in individuals affected with Sars-Cov-2 infection: temporal trends and qualitative and quantitative differences in symptomatic and asymptomatic subjects. A Cross Sectional Analysis. Ab-Covid Study

2021 ◽  
Author(s):  
Iosief Abraha ◽  
Antonella Germani ◽  
Erica Pasquarelli ◽  
Sofia Pascolini ◽  
Rossana Antonietti ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Temporal Trends ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Cross Sectional ◽  
Entire Cohort ◽  
One Year ◽  
Asymptomatic Subjects

Objectives To describe clinical characteristics and treatment used in subjects who had Sars-Cov-2 infection during the first pandemic and to assess the correlation between serological titers and clinical characteristics; to evaluate the persistence of anti-Sars-Cov-2 titers over a follow-up of 12. Design Cross-sectional study. Setting Residents in Azienda USL Umbria 2. Participants Consecutive subjects aged 15 to 75 who from February, 2020, to March 2021 were discharged with the diagnosis of Sars-Cov-2 from the hospitals of the AUSL Umbria 2, or resulted positive to a PCR test for Sars-Cov-2 infection with or without symptoms. Participants were classified according to clinical findings. SARS-CoV-2 serologic testing for antibodies targeting the Nucleocapside and Spike proteins were determined. Results Of 184 eligible subjects, 149 were available for evaluation: 17 were classified as Oligo/asymptomatic, 107 as Symptomatic (with no hospital admission), 25 as Hospital. While fever resulted common to all the groups, headache or musculoskeletal pain was common to symptomatic participants whereas cough and dyspnea was present in all the hospital admitted. Participants with significant signs and symptoms were more likely to use antibiotics, hydroxychloroquine, heparin and steroids. Compared to Oligo/asymptomatic participants, Symptomatic and Hospital admitted participants had higher levels of anti-S titers at every follow-up (median titer at 12 month follow-up: 29 vs 94 vs 116 respectively; P < 0.001). At 12 months follow-up, anti-S titers persisted above the threshold for at least 12 months in all Hospital admitted participants, in 90% of the Symptomatic participants and 83% in the oligo/asymptomatic participants; in 30% of participants the titer raised significantly probably due to reinfection. Anti-N antibody titer tended to decrease over time and in 62% of the entire cohort resulted negative. None of the participants reported clinical reinfection with Sars-Cov-2 virus. Conclusion - Anti-S and anti-N antibody titers correlates well with disease severity. While anti-N decline overtime, anti-S antibodies persist for at least one year and most probably provide protection from reinfection.

scholarly journals Incidência de Interações Medicamentosas e Avaliação Clínica nos Pacientes de um Hospital Público Brasileiro

2020 ◽  
Vol 24 (3) ◽  
pp. 202-210
Author(s):  
Fabiana Cristina Furquim ◽  
Cristina Eunice Okuyama ◽  
Sandro Rostelato-Ferreira ◽  
Carla Leticia Rivero-Wendt ◽  
Helder Oliveira ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Positive Association ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Documentary Evidence ◽  
Potential Ddis ◽  
Cross Sectional ◽  
De Se ◽  
Clinical Interactions

Interações droga-droga (IDDs) são responsáveis por problemas terapêuticos e as principais causas de reações adversas a medicamentos que levam a hospitalização. O objetivo do trabalho foi analisar a incidência de IDDs em pacientes admitidos em hospital público no Brasil, em 2015. Em um estudo transversal, 351pacientes foram selecionados com IDDs utilizando-se o banco de dados da Micromedex®, e as interações foram classificadas de acordo com a severidade e documentação. Os potenciais IDDs foram avaliados durante o acompanhamento farmacoterapêutico diário por anamnese farmacêutica e a análise dos exames laboratoriais foi realizada. Um total de 2.937 potenciais IDDs foram identificados e 28,42% deles tinham sinais e sintomas clínicos confirmados em 87 pacientes (29%). Entre os pacientes que apresentaram interações, 62,07% tinham mais que 60 anos. Neste grupo de idade, 61,27% de todos os sinais e sintomas clínicos observados foram também identificados, demonstrando uma associação positiva entre interações clínicas e idade. Além disso, uma correlação positiva entre o número de drogas prescritas e a ocorrência de sinais clínicos também foram observados. Muitos IDDs observados foram de severidade moderada e estavam relacionados a alterações das pressões arteriais e níveis glicêmicos. Este estudo demonstrou que IDDs estão diretamente relacionados a idade e número de drogas prescritas. E a grande frequência de IDDs com documentação fraca alertam para a necessidade de se analisar esse tipo de interação. Sendo assim, este estudo mostrou que potenciais IDDs e sinais e sintomas clínicos significantes em pacientes só reforçam a necessidade de se apoiar a farmácia clínica.   Palavras-chave: Interação Droga-Droga (IDD). Pacientes Internados. Farmacoterapia, Poli Farmácia. Sinais e Sintomas.   Abstract Drug-drug interactions (DDIs) are responsible for therapeutic problems and the main causes of adverse drug reactions that require hospitalization. The aim of this study was to analyze the incidence of DDIs in patients admitted in a Public Hospital in Brazil, in 2015. In a cross-sectional study, DDIs were screened in 351 patients, using Micromedex® database, that classify interactions according to severity and documentary evidence. Potential DDIs were assessed at the daily pharmacotherapeutic follow-up through pharmaceutical anamnesis and analysis of laboratory tests were performed. A total of 2,937 potential DDIs were identified and 28.42% of these had confirmed signs and symptoms clinical in 87 patients (29%). Among the patients that presented interactions, 62.07% were older than 60 years. In this age group, 61.27% of all signs and symptoms clinical observed in the study were also identified, demonstrating a positive association between the occurrence of clinical interactions and age. In addition, a positive correlation between the number of drugs prescribed and the occurrence of signs clinicals was also observed. Most DDIs observed were of moderate severity and were related to imbalance of blood pressure and glycemic levels. This study demonstrated that DDIs are directly related to the age and number of drugs prescribed. And the greater frequency of DDIs with fair documentary evidence alerts to the need to consider all the possible interactions. Thereafter, this study showed that potential DDIs and sign and clinical symptoms  are significant in patients and reinforce the need to support Clinical Pharmacy.   Keywords: Drug-Drug Interaction (DDI). Inpatients. Pharmacotherapy. Poly Pharmacy. Sign and Symptom.    

Mosaic Neurofibromatosis Type 1 in Children: A Single-Institution Experience

2017 ◽  
Vol 21 (5) ◽  
pp. 379-382 ◽  
Author(s):  
Irene Lara-Corrales ◽  
Mitra Moazzami ◽  
Maria Teresa García-Romero ◽  
Elena Pope ◽  
Patricia Parkin ◽  
...  
Keyword(s):  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Loss Of Function ◽  
Cross Sectional ◽  
Uncommon Presentation ◽  
Sick Children

Background: Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder caused by loss-of-function mutation in the NF1 gene. Segmental or mosaic NF1 (MNF) is an uncommon presentation of the NF1 result of postzygotic mutations that present with subtle localised clinical findings. Objectives: Our study’s objectives were to describe the clinical characteristics of children with MNF. Methods: We conducted a cross-sectional study of children diagnosed with MNF at the Hospital for Sick Children in Toronto, Canada, from January 1992 to September 2012. Data were abstracted from health records and analysed using a standardised data collection form approved by our hospital Research Ethics Board. Results: We identified 60 patients with MNF; 32 of 60 (53.3%) were female. Mean ± SD age at first assessment was 10.6 ± 4.6 years. The most common initial physical manifestation in 39 of 60 (65.0%) patients was localised pigmentary changes only, followed by plexiform neurofibromas only in 10 of 60 (16.7%) and neurofibromas only in 9 of 60 (15.0%). Unilateral findings were seen in 46 of 60 (76.7%) patients. Most common associations identified included learning disabilities (7/60; 12%) and bony abnormalities (6/60; 10.0%). Conclusions: MNF is an underrecognised condition with potential implications for patients. Children mostly present with pigmentary anomalies only. Most patients do not develop associated findings or complications before adulthood, but long-term follow-up will help determine outcomes and possible associations. Recognition and confirmation of the diagnosis is important to provide follow-up and genetic counselling to patients.

scholarly journals Regional Differences in Epidemiological and Clinical Characteristics, Treatment, and Clinical Outcomes of COVID-19 in Wuhan and Remote Areas of Hubei Province

2021 ◽  
Vol 8 ◽  
Author(s):  
Honggang Ren ◽  
Xingyi Guo ◽  
Antonio Palazón-Bru ◽  
Pengcheng Yang ◽  
Nan Huo ◽  
...  
Keyword(s):  
Regional Differences ◽  
Case Fatality Rate ◽  
Clinical Characteristics ◽  
Case Fatality ◽  
Cross Sectional Study ◽  
Hubei Province ◽  
Fatality Rate ◽  
Cross Sectional ◽  
Suburban Areas

Background: The Coronavirus disease 2019 (COVID-19) pandemic has been a major threat to global health. Regional differences in epidemiological and clinical characteristics, treatment and outcomes of patients have not yet been investigated. This study was conducted to investigate these differences amongCOVID-19 patients in Hubei Province, China.Methods: This retrospective cross-sectional study analyzed data on 289 COVID-19 patients from designated hospitals in three regions:Urban (Wuhan Union West Hospital), Suburban areas of Wuhan (Hannan Hospital) and Enshi city, between February 8 and 20, 2020. The final date of follow-up was December 14th, 2020. The outcomes were case fatality rate and epidemiological and clinical data.Results: Urban Wuhan experienced a significantly higher case fatality rate (21.5%) than suburban Wuhan (5.23%) and rural area of Enshi (3.51%). Urban Wuhan had a higher proportion of patients on mechanical ventilation (24.05%) than suburban Wuhan (0%) and rural Enshi (3.57%). Treatment with glucocorticoids was equivalent in urban and suburban Wuhan (46.84 and 45.75%, respectively) and higher than Enshi (25.00%). Urban Wuhan had a higher proportion of patients with abnormal tests including liver function and serum electrolytes and a higher rate of pneumonia (p &lt; 0.01 for all). Urban Wuhan also had a higher incidence of respiratory failure, heart disease, liver disease and shock, compared with the other two regions (all p &lt; 0.05).Conclusions: Our findings revealed that there are regional differences in COVID-19. These findings provide novel insights into the distribution of appropriate resources for the prevention, control and treatment of COVID-19 for the global community.

scholarly journals Frequency of signs and symptoms in children with foreign body aspiration: A retrospective study in Iran

2021 ◽  
Vol 12 (1) ◽  
pp. 350-356
Author(s):  
Gholam-Ali Dashti Khavidaki ◽  
Reza Gharibi
Keyword(s):  
Foreign Body ◽  
Respiratory Distress ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Foreign Body Aspiration ◽  
Respiratory Sounds ◽  
Common Symptom ◽  
Protective Mechanisms ◽  
Cross Sectional

Foreign body aspiration is still one of the most important diagnostic and therapeutic items for physicians. The mortality rate and prevalence of diseases caused by foreign bodies are higher in children due to the relatively narrow airway and immature protective mechanisms. Considering the high prevalence of foreign body aspiration in children, as well as the possible complications, we decided to investigate the frequency distribution of signs and symptoms in children with foreign body aspiration. This retrospective cross-sectional study was performed on the files of 50 children with foreign body aspiration who referred to Khatam Al-Anbia Hospital in Zahedan, Iran from 2016 to 2018. The files were entered into the study by the census method, based on inclusion and exclusion criteria. Finally, demographic factors (age and sex), as well as the type of aspirated object, signs, and symptoms, were examined. The files of 50 children with a foreign body aspiration were reviewed. Among the patients, 27 (54%) were boys and 23 (46%) were girls. The highest frequency was between 1 and 2 years, with 36%. The most common symptom in these patients was cough and respiratory distress with a frequency of 72% and the most common clinical findings were unilateral wheezing with 50% and decreased unilateral respiratory sounds with 18%. Also, the most common types of foreign objects were nuts with a frequency of 44% and supari with 38%. Also, unilateral wheezing had a significant relationship with the type of aspirated foreign body (P = 0.01). Children between the ages of one and two years are more likely to have foreign body aspiration, and in children with symptoms of cough and respiratory distress, as well as clinical findings of unilateral wheezing and decreased unilateral respiratory sounds, foreign body aspiration should be suspected.

scholarly journals Revisiting the Urge to Operate: One-year Neurophysiological Follow-up in Severe CTS

2020 ◽  
Vol 6 (1) ◽  
pp. 21-28
Author(s):  
Alireza Ashraf ◽  
◽  
Zahra Hooshanginezhad ◽  
Attiyeh Vasaghi ◽  
Nima Derakhshan ◽  
...  
Keyword(s):  
Hand Function ◽  
Symptom Relief ◽  
Sensory Nerve ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Sensory Nerve Action ◽  
One Year ◽  
The One ◽  
Low Amplitude

Background and Aim: Several approaches have been proposed for the treatment of Carpal Tunnel Syndrome (CTS) based on its severity. The aim of this study is to determine the optimal management for severe CTS. Methods and Materials/Patients: This cross-sectional study was conducted for 22 months from August 2017 to June 2019 in a referral rehabilitation clinic in southern Iran. A total of 117 hands diagnosed with severe CTS were included in 78 patients according to Electrodiagnostic Study (EDX) reports (considering Sensory Proximal Latency (SPL) >3.6 msec, Sensory Distal Latency (SDL) >5.3 msec, Sensory Nerve Conduction Velocity (SNCV) <30 m/sec, Distal Motor Latency (DML) >6.5 msec as being severe) who refused to undergo surgery. Boston questionnaire was filled out and conventional EDX was carried out at the first and the 1-year follow-up visits. Results: In patients with a detectable Sensory Nerve Action Potential (SNAP), motor amplitude (P<0.002) and latency (P<0.01), SPL (P<0.003) and SNCV (P<0.006), and Boston parameters improved significantly in the one-year follow-up visit compared with the results at the first visit. However, improvement in patients with absent or low amplitude SNAP at the first visit was only observed in proximal sensory latency (P<0.005) and amplitude (P<0.003). Conclusion: There is a considerable chance for non-surgical improvement of patients with severe CTS in terms of symptom relief, hand function, and EDX parameters in those with detectable SNAP at the first visit; however, patients with undetectable SNAP have little, if any, the chance for improvement with conservative measures.

scholarly journals Recurrence Rate and Risk Factors for the Recurrence of Ovarian Endometriosis after Laparoscopic Ovarian Cystectomy

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Sornsittipong Wacharachawana ◽  
Paweena Phaliwong ◽  
Sinart Prommas ◽  
Buppa Smanchat ◽  
Kornkarn Bhamarapravatana ◽  
...  
Keyword(s):  
Risk Factors ◽  
Medical Treatment ◽  
Recurrence Rate ◽  
Cross Sectional Study ◽  
Ovarian Endometriosis ◽  
Cross Sectional ◽  
Ovarian Cystectomy ◽  
Laparoscopic Cystectomy ◽  
One Year

The aim of this study was to identify the recurrence rate and risk factors for the recurrence of ovarian endometriosis (OE) after laparoscopic cystectomy. This was a retrospective cross-sectional study. Subjects were OE cases who underwent laparoscopic ovarian cystectomy at Bhumibol Adulyadej Hospital (BAH). The period of this study was from January 2008 to December 2017. Ovarian histopathology and at least one-year follow-up after surgery were the prerequisite requirements. A total of 106 OE cases were included in the study. Subjects were classified into recurrence and nonrecurrence groups. It comprised of 24 and 82 cases, respectively. The mean age of the participant was 32.4 years old. The demographic characters of both groups were comparable. The recurrence rate after laparoscopic OE surgery in the present study was 22.6% (24/106). The average largest diameter of OE in the present study was 54.5 mm. Postoperative medical treatment (OR 3.15, 95% CI 1.14-8.74, p = 0.02 ) and postoperative pregnancy (OR 2.86, 95% CI 1.03-7.93, p = 0.04 ) were associated factors for recurrence decrement. The recurrence rate of OE after laparoscopic cystectomy was 22.6%. Postoperative medical treatment and postoperative pregnancy were a significant factor that lowered OE recurrence.

scholarly journals Barodontalgia among Aircrew of Bangladesh Air Force

2020 ◽  
Vol 15 (2) ◽  
pp. 186-188
Author(s):  
Md Masudur Rahman ◽  
Mizanur Rahman Khan ◽  
Mohammad Ahmed Ahsan ◽  
Mohammad Khairul Alam ◽  
Md Abdul Wahab
Keyword(s):  
Air Force ◽  
Atmospheric Pressure ◽  
Cross Sectional Study ◽  
Moderate Pain ◽  
Sectional Study ◽  
Cross Sectional ◽  
One Year ◽  
Pressure Changes ◽  
Study Participants

subjected to atmospheric pressure changes and have an influence on flights. Barodontalgia is caused whenever the pulp is exposed to differential pressure gradient. Objective:  To see the barodontalgia among aircrew of Bangladesh Air Force. Methodology: A cross-sectional study was carried out in Dental wing medical squadron BAF base Basher Dhaka. The study participants were recruited during one year among all the pilots and crewmembers attending departments specializing in medical follow-up at the study period from the Bangladesh Air Force. Results: Among the 50 barodontalgia group, most 39(78%) of the respondents were found technical and military flying whereas 50 without barodontalgia group 38(76%) specifically in military flying. In barodontalgia, 62% respondents were found in moderate pain (4-6), 26% in mild pain (1-3) and 32% in severe pain (7-10). In barodontalgia, 50% respondents were descent of barodontalgia, 52% were altitude where barodontalgia was reported to appear during the flight was <4000 meters and 70% were flight speed was 500-1000 km/h. Most of the respondents were found specifically in commercial flights in patients with barodontalgia. Majority pain intensity was found moderately in barodontalgia JAFMC Bangladesh. Vol 15, No 2 (December) 2019: 186-188

scholarly journals Prevalence and Clinical Characteristics of Psoriatic Arthritis in Japan

2015 ◽  
Vol 42 (8) ◽  
pp. 1439-1442 ◽  
Author(s):  
Yuri Ohara ◽  
Mitsumasa Kishimoto ◽  
Naoho Takizawa ◽  
Kazuki Yoshida ◽  
Masato Okada ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Clinical Characteristics ◽  
Tertiary Care ◽  
Age At Onset ◽  
Japanese Patients ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Cross Sectional ◽  
Western Countries ◽  
Tertiary Care Centers

Objective.To investigate the prevalence of psoriatic arthritis (PsA) in Japanese patients with psoriasis.Methods.A multicenter, noninterventional, retrospective cross-sectional study was conducted at 3 tertiary care centers in Japan. PsA was diagnosed by rheumatologists based on clinical findings. Prevalence of PsA, clinical characteristics, comorbidities, and treatment patterns were examined.Results.PsA was identified in 431 of 3021 patients with psoriasis, with a mean prevalence of 14.3% (range, 8.8–20.4%). No large differences between these results and previous reports from Western countries were observed in arthritis distribution, skin disease type, or treatment selection.Conclusion.The prevalence of PsA in patients with psoriasis in Japan approaches 20% in some areas, similar to that observed in Western countries, and is higher than previously reported in Asia. Clinical features including age, sex, age at onset, and manifestation patterns were also similar to those reported in the West.

scholarly journals Response of People with Type 1 Diabetes for Follow Up

2019 ◽  
Vol 1 (1) ◽  
pp. 30-32
Author(s):  
Sarfraz Ahmad Khan ◽  
Faiza Kamal ◽  
Rozina Arshad ◽  
Bilal Bin Younis ◽  
Rashid Ahmed
Keyword(s):  
Type 1 Diabetes ◽  
Cross Sectional Study ◽  
Childhood And Adolescence ◽  
Cross Sectional ◽  
Global Epidemic ◽  
Type1 Diabetes ◽  
Type 1Diabetes ◽  
One Year

Diabetes is becoming a global epidemic. Type1 diabetes (T1DM) accounts for 3-5% of all the diabetics. As T1DMis diagnosed in childhood and adolescence, it is associated with more complications because of longer life span ofindividuals with this condition. The main objective of the study was to find out attitudes of people with type 1diabetes especially with regards to their follow up. A cross-sectional study was planned and a total of 97 people withtype 1 diabetes were included for a period of one year. To analyze the data SPSS 20.0 version was used. Resultsshowed that out of 97 people, 48 (49.5%) were male and 49 (50.5%) were female. The mean age of total type 1diabetics were 17.03±6.54 years. Mean glycated hemoglobin (HbA1c) was 10.59±3.09. The results revealed that45% of people showed positive attitude and 55% showed negative behavior towards follow-up. It was concludedthat overall follow up of people with type 1 diabetes was poor. It was observed that they wanted a complete cure andthis contribute to missed follow up.

Sign in / Sign up

Export Citation Format

Share Document