scholarly journals Trait and state mindfulness modulate EEG microstates

2021 ◽  
Author(s):  
David Zarka ◽  
Carlos Cevallos ◽  
Pablo Ruiz ◽  
Ana Maria Cebolla ◽  
Mathieu Petieau ◽  
...  
Keyword(s):  
Lived Experience ◽  
Source Localization ◽  
Mindfulness Meditation ◽  
Anterior Cingulate ◽  
Control Group ◽  
Brain State ◽  
Cognitive Defusion ◽  
Open Monitoring ◽  
Localization Analysis ◽  
Reactive Monitoring

Here, we aimed to characterized microstate dynamics induced by open-monitoring meditation (OM), which emphasizes a non-reactive stance toward lived experience, while participants were passively exposed to auditory stimuli. We recorded EEG signals from eighteen trained meditators before, during, and after an OM, that we compared to a matched control group at rest. To characterize brain state, we used a multidimensional-based analysis including source localization EEG microstates, phenomenological reports and personality trait questionnaires. We showed that microstate A was negatively correlated with mindfulness trait and decreased in frequency after OM compared to before in meditators. Microstate B was longer and was positively correlated to non-reactivity trait after OM in the meditator group. Microstate C was less frequent and shorter at rest before OM in meditators compared to non-meditators, and decreased in frequency after OM in meditators. Further, the occurrence of microstate C was negatively correlated to non-reactivity trait of meditators. Source localization analysis revealed that the mindfulness trait effect on microstate C at rest was explained by lower activity of the salience network (identified in the anterior cingulate cortex, thalamus and insula), while the mindfulness state effect relied on a strong contribution of (anterior and posterior) cerebellum during OM. While the decreased microstate A occurrence would be related to the mitigation of phonological aspect of thinking processes, the decrease of microstate C occurrence would represent an index of the cognitive defusion enabled by non-reactive monitoring underlying mindfulness meditation, for which the cerebellum appears to play a crucial role.

scholarly journals Feasibility of using a biofeedback device in mindfulness training - a pilot randomized controlled trial

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Brenna Lin ◽  
Christopher Prickett ◽  
Steven Woltering
Keyword(s):  
College Students ◽  
Mindfulness Meditation ◽  
Controlled Trial ◽  
Scientific Evidence ◽  
Well Being ◽  
Open Science ◽  
Control Group ◽  
Test Procedures ◽  
The Usa ◽  
Biofeedback Device

Abstract Background Stress can negatively impact an individual’s health and well-being and high levels of stress are noted to exist among college students today. While traditional treatment methods are plagued with stigma and transfer problems, newly developed wearable biofeedback devices may offer unexplored possibilities. Although these products are becoming commonplace and inexpensive, scientific evidence of the effectiveness of these products is scarce and their feasibility within research contexts are relatively unexplored. Conversely, companies are not required, and possibly reluctant, to release information on the efficacy of these products against their claims. Thus, in the present pilot, we assess the feasibility of using a real-time respiratory-based biofeedback device in preparation for a larger study. Our main aims were to assess device-adherence and collaboration with the company that develops and sells the device. Method Data were collected from 39 college students who self-identified as experiencing chronic stress at a Southwestern university in the USA. Students were randomized into either a mindfulness-only control group without a biofeedback device (n = 21), or an experimental group with biofeedback device (n = 18). Both groups received mindfulness meditation training. Pre-test and post-test procedures were conducted 2 weeks apart. Further, both participant compliance and company compliance were assessed and collaboration with the company was evaluated. Results Participant device-adherence as well as the company’s collaboration necessary for a full-scale study was determined to be low. This may also have affected our results which showed a strong main effect for time for all outcome variables, suggesting all groups showed improvement in their levels of stress after the intervention period. No group by time effects were identified, however, indicating no added benefit of the biofeedback device. Conclusions Our findings suggest feasibility of future studies requires full collaboration and detailed and agreed upon data sharing procedures with the biofeedback company. The particular device under investigation added no value to the intervention outcomes and it was not feasible to continue a larger-scale study. Further, as the technology sector is innovating faster than it can validate products, we urge for open science collaborations between public and private sectors to properly develop evidence-based regulations that can withstand technological innovation while maintaining product quality, safety, and effectiveness. Trial registration NCT02837016. Registered 19 July 2016.

scholarly journals Voxel-wise meta-analysis of grey matter changes in obsessive–compulsive disorder

2009 ◽  
Vol 195 (5) ◽  
pp. 393-402 ◽  
Author(s):  
Joaquim Radua ◽  
David Mataix-Cols
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Grey Matter ◽  
Antidepressant Treatment ◽  
Meta Analysis ◽  
Anterior Cingulate ◽  
Control Group ◽  
Grey Matter Volume ◽  
Obsessive Compulsive ◽  
Caudate Nuclei ◽  
Compulsive Disorder

BackgroundSpecific cortico-striato-thalamic circuits are hypothesised to mediate the symptoms of obsessive–compulsive disorder (OCD), but structural neuroimaging studies have been inconsistent.AimsTo conduct a meta-analysis of published and unpublished voxel-based morphometry studies in OCD.MethodTwelve data-sets comprising 401 people with OCD and 376 healthy controls met inclusion criteria. A new improved voxel-based meta-analytic method, signed differential mapping (SDM), was developed to examine regions of increased and decreased grey matter volume in the OCD group v. control group.ResultsNo between-group differences were found in global grey matter volumes. People with OCD had increased regional grey matter volumes in bilateral lenticular nuclei, extending to the caudate nuclei, as well as decreased volumes in bilateral dorsal medial frontal/anterior cingulate gyri. A descriptive analysis of quartiles, a sensitivity analysis as well as analyses of subgroups further confirmed these findings. Meta-regression analyses showed that studies that included individuals with more severe OCD were significantly more likely to report increased grey matter volumes in the basal ganglia. No effect of current antidepressant treatment was observed.ConclusionsThe results support a dorsal prefrontal–striatal model of the disorder and raise the question of whether functional alterations in other brain regions commonly associated with OCD, such as the orbitofrontal cortex, may reflect secondary compensatory strategies. Whether the reported differences between participants with OCD and controls precede the onset of the symptoms and whether they are specific to OCD remains to be established.

Mindfulness Meditation Apps: An Effective Tool to Improve Mental Health Among Graduate Students in STEM Programs

2021 ◽  
Author(s):  
Kelly A. Grogan
Keyword(s):  
Graduate Students ◽  
Treatment Group ◽  
Mindfulness Meditation ◽  
Depression Scale ◽  
Well Being ◽  
Physical Symptom ◽  
Control Group ◽  
Free Access ◽  
Post Intervention ◽  
Stem Programs

Abstract This paper seeks to determine whether or not mindfulness meditation training via a simple meditation app can effectively improve well-being among graduate students enrolled in STEM programs. Graduate students were recruited from STEM programs at the University of Florida. Participants were randomly assigned into treatment and control groups. The control group simply proceeded as they normally would during an academic semester. The treatment group received free access to the Ten Percent Happier app and were asked to meditate once per day for eight weeks. Both groups completed pre-, mid-, and post-intervention surveys that included the Center for Epidemiological Depression Scale (CES-D) and the Generalized Anxiety Disorder 7-Item Scale (GAD-7). The treatment group averaged about 10 minutes of meditation per day, and the average participant meditated on about 82% of days within the intervention period. At the end of the 8-week intervention, the treatment group reported CES-D and GAD-7 scores that were about 35% and 41% lower than the control group and their physical symptom score was about 36% lower. Relative to their own starting scores, CES-D, GAD-7, and physical symptom scores decreased 35%, 50%, and 43%, respectively for the treatment group, while the control group experienced no change in scores.

scholarly journals Mindfulness meditation training in an occupational setting: Effects of a 12-weeks mindfulness-based intervention on wellbeing

Work ◽  
2021 ◽  
pp. 1-11
Author(s):  
Teresa Fazia ◽  
Francesco Bubbico ◽  
Giovanni Berzuini ◽  
Laura Dalla Tezza ◽  
Carolina Cortellini ◽  
...  
Keyword(s):  
Mindfulness Meditation ◽  
Self Regulation ◽  
Emotional Awareness ◽  
Self Report ◽  
Psychological Wellbeing ◽  
Control Group ◽  
Beneficial Effects ◽  
Self Compassion ◽  
Occupational Setting ◽  
Professional Outcomes

BACKGROUND: Mindfulness-based interventions (MBIs) are known for their beneficial effects on positive and negative psychological factors. When applied in an occupational context, MBIs might help workers to cope with stress, increase their professional outcomes and wellbeing. OBJECTIVE: In this two-groups pre-post experimental design we tested the effect of our MBI, called Integral Meditation (IM), among the employers of an Italian service company by measuring positive and negative aspects of psychological wellbeing related to mindfulness and workplace functioning through eight self-report questionnaires (CORE-OM, FFMQ, WEMWBS, MAIA, PSS, PANAS, STAI-X1, SCS). METHOD: Forty-two voluntary non-clinical employers of the company, randomly assigned to the experimental or the control group, were analyzed. The experimental group underwent our IM program, which consists of 12 weekly meditation classes given after the afternoon shift, while the control group did not receive any intervention. Data was analyzed via linear mixed models. RESULTS: Statistically significant results were obtained for FFMQ observing subscale (β= 0.49, p = 0.014), WEMWBS (β= 5.31, p = 0.02), PSS (β= –3.31, p = 0.03), the whole scale of SCS (β= 0.47, p = 0.01) and self-judgment (β= 0.68, p = 0.003) and isolation (β= –0.66, p = 0.01) SCS subscales. Statistically significant results were also found in four out of eight subscales of MAIA: emotional awareness (β= 1.26, p <  0.001), self-regulation (β= 1.28, p <  0.001), body listening (β= 1.08, p <  0.001) and trusting (β= 1.1, p <  0.001). CONCLUSION: Our intervention has demonstrated to bring beneficial effects in a mindfulness subdomain, in perceived stress, self-compassion, interoception and psychological wellbeing. Based on our results, we conclude that our intervention was effective in increasing the positive aspects of wellbeing and in reducing stress.

scholarly journals Using a Personal-Disclosure Mutual-Sharing Approach to Deliver a Team-Based Mindfulness Meditation Program to Enhance Cohesion

2021 ◽  
Vol 35 (1) ◽  
pp. 22-29
Author(s):  
Piotr A. Piasecki ◽  
Todd M. Loughead ◽  
Kyle F. Paradis ◽  
Krista J. Munroe-Chandler
Keyword(s):  
Social Cohesion ◽  
Mindfulness Meditation ◽  
Team Building ◽  
Intervention Group ◽  
Soccer Players ◽  
Control Group ◽  
Task Cohesion ◽  
Viable Approach ◽  
Building Program ◽  
Personal Disclosure

In an effort to increase perceptions of cohesion among intercollegiate soccer players, a team-based mindfulness meditation program was undertaken. This team-building program was delivered by using a personal-disclosure mutual-sharing approach. A total of 31 female intercollegiate soccer players from two teams participated. Assigned to the intervention condition was a Canadian intercollegiate team (U Sports), while the control condition was an American intercollegiate team (NCAA, Division II). The participants completed a measure of cohesion (Group Environment Questionnaire) pre- and postintervention. Controlling for the preintervention scores, the 8-week team-based mindfulness meditation program resulted in significantly higher perceptions of social cohesion for the intervention group compared with the control group at postintervention. However, there were no significant differences in task cohesion between the intervention and control groups at postintervention. Using personal disclosure, mutual sharing seems a viable approach by which to deliver a team-based mindfulness meditation program to enhance a team’s social cohesion.

scholarly journals The Influence of Mindfulness Meditation Versus CBT for Anxiety on Emotional Distress and Attitudes Towards Seeking Mental Health Treatment

2021 ◽  
Author(s):  
Daniela Aisenberg-Shafran ◽  
Liav Shturm
Keyword(s):  
Mental Health ◽  
Older Adults ◽  
Emotional Distress ◽  
Mental Health Treatment ◽  
Mindfulness Meditation ◽  
Psychological Treatment ◽  
Behavioral Therapy ◽  
Control Group ◽  
Health Treatment ◽  
Before And After

Abstract Older adults often avoid seeking psychological treatment, challenging their ability to adaptively deal with anxiety, stress and depression. The aim of the current study was to compare the effects of a mindfulness intervention vs. cognitive-behavioral-therapy (CBT) on measures of emotional distress and attitudes towards seeking mental-health treatment among older adults. Twenty-four seniors were assigned to: 1) MBIS (Mindfulness-Based Intervention for Seniors); and 2) CBT for anxiety, or to a care-as-usual control group. Attitudes towards seeking psychological treatment, levels of depression, anxiety and worry were measured before and after the interventions. Following the intervention, participants more positively addressed the possibility of utilizing psychological treatment, while no changes were observed in the control group. Interestingly, levels of worry improved only in the MBIS group, and anxiety levels only improved in the CBT group. It seems that attending cognitive group interventions are effective to their focus and positively impact attitudes towards psychological treatment.

Neurobiological findings associated with high cognitive performance in older adults: a systematic review

2018 ◽  
Vol 30 (12) ◽  
pp. 1813-1825 ◽  
Author(s):  
Wyllians Vendramini Borelli ◽  
Lucas Porcello Schilling ◽  
Graciane Radaelli ◽  
Luciana Borges Ferreira ◽  
Leonardo Pisani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Cognitive Performance ◽  
Anterior Cingulate ◽  
Control Group ◽  
High Performing ◽  
High Performers ◽  
Positron Emission ◽  
Definition Of ◽  
Molecular Brain

ABSTRACTObjectives:to perform a comprehensive literature review of studies on older adults with exceptional cognitive performance.Design:We performed a systematic review using two major databases (MEDLINE and Web of Science) from January 2002 to November 2017.Results:Quantitative analysis included nine of 4,457 studies and revealed that high-performing older adults have global preservation of the cortex, especially the anterior cingulate region, and hippocampal volumes larger than normal agers. Histological analysis of this group also exhibited decreased amyloid burden and neurofibrillary tangles compared to cognitively normal older controls. High performers that maintained memory ability after three years showed reduced amyloid positron emission tomography at baseline compared with high performers that declined. A single study on blood plasma found a set of 12 metabolites predicting memory maintenance of this group.Conclusion:Structural and molecular brain preservation of older adults with high cognitive performance may be associated with brain maintenance. The operationalized definition of high-performing older adults must be carefully addressed using appropriate age cut-off and cognitive evaluation, including memory and non-memory tests. Further studies with a longitudinal approach that include a younger control group are essential.

Altered Brain Activation in Military Personnel with One or More Traumatic Brain Injuries Following Blast

2011 ◽  
Vol 18 (1) ◽  
pp. 89-100 ◽  
Author(s):  
Randall S. Scheibel ◽  
Mary R. Newsome ◽  
Maya Troyanskaya ◽  
Xiaodi Lin ◽  
Joel L. Steinberg ◽  
...  
Keyword(s):  
Brain Injuries ◽  
Group Analysis ◽  
Negative Relationship ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Control Group ◽  
Post Traumatic Stress ◽  
Emotional Symptoms ◽  
Stimulus Response ◽  
Visual Spatial

AbstractExplosive blast is a frequent cause of traumatic brain injury (TBI) among personnel deployed to Afghanistan and Iraq. Functional magnetic resonance imaging (fMRI) with an event-related stimulus-response compatibility task was used to compare 15 subjects with mild, chronic blast-related TBI with 15 subjects who had not experienced a TBI or blast exposure during deployment. Six TBI subjects reported multiple injuries. Relative to the control group, TBI subjects had slightly slower responses during fMRI and increased somatic complaints and symptoms of post-traumatic stress disorder (PTSD) and depression. A between-group analysis indicated greater activation during stimulus-response incompatibility in TBI subjects within the anterior cingulate gyrus, medial frontal cortex, and posterior cerebral areas involved in visual and visual-spatial functions. This activation pattern was more extensive after statistically controlling for reaction time and symptoms of PTSD and depression. There was also a negative relationship between symptoms of PTSD and activation within posterior brain regions. These results provide evidence for increased task-related activation following mild, blast-related TBI and additional changes associated with emotional symptoms. Limitations of this study include no matching for combat exposure and different recruitment strategies so that the control group was largely a community-based sample, while many TBI subjects were seeking services. (JINS, 2012, 18, 89–100)

scholarly journals Effects of 12-Week Methylphenidate Treatment on Neurometabolism in Adult Patients with ADHD: The First Double-Blind Placebo-Controlled MR Spectroscopy Study

2020 ◽  
Vol 9 (8) ◽  
pp. 2601
Author(s):  
Simon Maier ◽  
Ludger Tebartz van Elst ◽  
Alexandra Philipsen ◽  
Thomas Lange ◽  
Bernd Feige ◽  
...  
Keyword(s):  
Adult Adhd ◽  
Neurodevelopmental Disorder ◽  
Synaptic Cleft ◽  
Anterior Cingulate ◽  
Cerebellar Hemisphere ◽  
Control Group ◽  
Resonance Spectroscopy ◽  
Double Blind ◽  
Neuronal Tissue ◽  
Metabolite Concentrations

Attention deficit hyperactivity disorder (ADHD) is a frequent neurodevelopmental disorder that often persists into adulthood. Methylphenidate (MPH) is the first-line treatment for ADHD; however, despite its wide usage, little is known about its neurometabolic effects. Until now, no randomized and blinded clinical trials have been conducted addressing the neurometabolic signals of MPH administration in adults with ADHD. In the current study, the authors investigated how MPH intake and group psychotherapy (GPT) influence brain neurometabolism over the course of three months. The authors hypothesized a decrease in the anterior cingulate cortex (ACC) glutamate concentration following MPH administration. This study was part of a double-blind multicenter trial (Comparison of Methylphenidate and Psychotherapy in Adult ADHD Study (COMPAS)) investigating the effects of MPH and GPT in patients with adult ADHD. Using single-voxel magnetic resonance spectroscopy (MRS) of the pregenual ACC and the left cerebellar hemisphere (CHL), we investigated the concentration of glutamate plus glutamine (Glx), N-acetyl-aspartate, creatine, total choline containing compounds, and myo-inositol in patients before and after 12 weeks of treatment. Neither MPH nor GPT significantly influenced the Glx concentration or any of the other metabolite concentrations in the ACC and CHL after 12 weeks. Therefore, contrary to the hypothesis, no change in the prefrontal Glx signal was detected after MPH treatment. Given that MRS does not differentiate between glutamate in the synaptic cleft and in neuronal tissue, MPH-induced down-regulation of glutamatergic neurotransmission in the ACC might only affect the concentration of glutamate in the synaptic cleft, while the general availability of glutamate in the respective neuronal tissue might be unaffected by MPH intake. The observed lack of any MPH-induced normalization in metabolite concentrations is less surprising, considering that the baseline sample did not significantly differ from a healthy control group. Future studies of other regions, such as the basal ganglia, and the use of novel methods, such as whole brain MRS and multimodal imaging approaches, are necessary.

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