High-speed, multi-Z confocal microscopy for voltage imaging in densely labeled neuronal populations
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Genetically encoded voltage indicators (GEVIs) hold great promise for monitoring neuronal population activity, but GEVI imaging in dense neuronal populations remains difficult due to a lack of contrast and/or speed. To address this challenge, we developed a novel confocal microscope that allows simultaneous multiplane imaging with high-contrast at near-kHz rates. This approach enables high signal-to-noise ratio voltage imaging in densely labeled populations and minimizes optical crosstalk during concurrent optogenetic photostimulation.
2008 ◽
Vol 381-382
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pp. 73-76
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2007 ◽
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2020 ◽
Vol 64
(1-4)
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pp. 951-958
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2014 ◽
Vol 556-562
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pp. 6328-6331
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