scholarly journals Characterizing the Behavioral and Neuroendocrine Features of Susceptibility and Resilience to Social Stress

2021 ◽  
Author(s):  
Dalia Murra ◽  
Kathryn L Hilde ◽  
Anne Fitzpatrick ◽  
Pamela M Maras ◽  
Stanley J. Watson ◽  
...  
Keyword(s):  
Social Stress ◽  
Escape Behavior ◽  
Social Defeat ◽  
Social Avoidance ◽  
Social Events ◽  
The Social ◽  
Wide Range ◽  
Subsequent Behavior ◽  
And Coping ◽  
Social Stressor

Evaluating and coping with stressful social events as they unfold is a critical strategy in overcoming them without long-lasting detrimental effects. Individuals display a wide range of responses to stress, which can manifest in a variety of outcomes for the brain as well as subsequent behavior. Chronic Social Defeat Stress (CSDS) in mice has been widely used to model individual variation following a social stressor. Following a course of repeated intermittent psychological and physical stress, mice diverge into separate populations of social reactivity: resilient (socially interactive) and susceptible (socially avoidant) animals. A rich body of work reveals distinct neurobiological and behavioral consequences of this experience that map onto the resilient and susceptible groups. However, the range of factors that emerge over the course of defeat have not been fully described. Therefore, in the current study, we focused on characterizing behavioral, physiological, and neuroendocrine profiles of mice in three separate phases: before, during, and following CSDS. We found that following CSDS, traditional read-outs of anxiety-like and depression-like behaviors do not map on to the resilient and susceptible groups. By contrast, behavioral coping strategies used during the initial social stress encounter better predict which mice will eventually become resilient or susceptible. In particular, mice that will emerge as susceptible display greater escape behavior on Day 1 of social defeat than those that will emerge as resilient, indicating early differences in coping mechanisms used between the two groups. We further show that the social avoidance phenotype in susceptible mice is specific to the aggressor strain and does not generalize to conspecifics or other strains, indicating that there may be features of threat discrimination that are specific to the susceptible mice. Our findings suggest that there are costs and benefits to both the resilient and susceptible outcomes, reflected in their ability to cope and adapt to the social stressor.

scholarly journals Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Katherine A. Partrick ◽  
Anna M. Rosenhauer ◽  
Jérémie Auger ◽  
Amanda R. Arnold ◽  
Nicole M. Ronczkowski ◽  
...  
Keyword(s):  
Social Stress ◽  
Bifidobacterium Longum ◽  
Social Defeat ◽  
Lactobacillus Helveticus ◽  
Rrna Gene ◽  
Social Avoidance ◽  
Social Defeat Stress ◽  
Microbial Structure ◽  
Microbial Composition ◽  
Anti Inflammatory

AbstractSocial stress exacerbates anxious and depressive behaviors in humans. Similarly, anxiety- and depressive-like behaviors are triggered by social stress in a variety of non-human animals. Here, we tested whether oral administration of the putative anxiolytic probiotic strains Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces the striking increase in anxiety-like behavior and changes in gut microbiota observed following social defeat stress in Syrian hamsters. We administered the probiotic at two different doses for 21 days, and 16S rRNA gene amplicon sequencing revealed a shift in microbial structure following probiotic administration at both doses, independently of stress. Probiotic administration at either dose increased anti-inflammatory cytokines IL-4, IL-5, and IL-10 compared to placebo. Surprisingly, probiotic administration at the low dose, equivalent to the one used in humans, significantly increased social avoidance and decreased social interaction. This behavioral change was associated with a reduction in microbial richness in this group. Together, these results demonstrate that probiotic administration alters gut microbial composition and may promote an anti-inflammatory profile but that these changes may not promote reductions in behavioral responses to social stress.

Stress and Coping Theory Across the Adult Lifespan

2018 ◽  
Author(s):  
Agus Surachman ◽  
David M. Almeida
Keyword(s):  
Adult Development ◽  
Social Stress ◽  
Stress And Coping ◽  
Social Psychological ◽  
Adult Lifespan ◽  
Biological Stress ◽  
Theoretical Perspectives ◽  
The Social ◽  
Coping Theory ◽  
And Coping

Stress is a broad and complex phenomenon characterized by environmental demands, internal psychological processes, and physical outcomes. The study of stress is multifaceted and commonly divided into three theoretical perspectives: social, psychological, and biological. The social stress perspective emphasizes how stressful life experiences are embedded into social structures and hierarchies. The psychological stress perspective highlights internal processes that occur during stressful situations, such as individual appraisals of the threat and harm of the stressors and of the ways of coping with such stressors. Finally, the biological stress perspective focuses on the acute and long-term physiological changes that result from stressors and their associated psychological appraisals. Stress and coping are inherently intertwined with adult development.

scholarly journals Role of CRF receptor 1 antagonism in the bed nucleus of the stria terminalis of male rats after intermittent social defeat stress

2019 ◽  
Author(s):  
Mailton Vasconcelos ◽  
Dirson J. Stein ◽  
Matheus Gallas-Lopes ◽  
Luane Landau ◽  
Luiza Behrens ◽  
...  
Keyword(s):  
Social Behavior ◽  
Social Stress ◽  
Social Behaviors ◽  
Social Defeat ◽  
Corticotropin Releasing Factor ◽  
Male Rats ◽  
Stria Terminalis ◽  
Social Avoidance ◽  
Bed Nucleus ◽  
Sweet Solution

AbstractWe recently demonstrated that the experience of brief episodes of social defeat caused impairments in social behaviors. Moreover, we provided evidence that the antagonism of corticotropin-releasing factor binding protein (CRFBP) in the bed nucleus of the stria terminalis (BNST) restored social approach in stressed animals. This study aimed to test the relation between corticotropin-releasing factor receptor type 1 (CRFR1) located in the BNST and the establishment of social stress-disrupted behaviors in rats submitted to social defeat in the resident-intruder paradigm. Animals were tested for sweet solution preference, subjected to the elevated-plus maze (EPM), and to the social interaction three-chamber test. Social behavior was tested after BNST drug infusions. The drug used in this study was a CRF receptor 1 antagonist, CP376395 (CP), administered in two doses: 50 ng/0.20 μL/side, and 500 ng/0.20 μL/side. Saline solution was used as vehicle and administered 0.20 μL/side. Socially stressed animals (n = 11) did not differ compared to control animals (n = 11) in the EPM. Stressed animals displayed impaired social behavior, represented by a decrease in time spent in the interaction zone. The lower dose (CP 50 ng/0.20 μL/side) administered intra-BNST restored social behaviors in stressed animals. On the other hand, the higher dose of the CRFR1 antagonist (CP 500 ng/0.20 μL/side) induced social avoidance in rats without a history of agonistic confrontations. These findings implicate BNST CRFR1 signaling in the modulation of social behaviors in rats given the choice to explore an unfamiliar conspecific.

scholarly journals Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress

2020 ◽  
Vol 11 ◽  
Author(s):  
Nobuhiko Ebisutani ◽  
Hirokazu Fukui ◽  
Heihachiro Nishimura ◽  
Takashi Nakanishi ◽  
Kenki Morimoto ◽  
...  
Keyword(s):  
Social Interaction ◽  
Epithelial Cells ◽  
Psychological Stress ◽  
Functional Gastrointestinal Disorders ◽  
Social Defeat ◽  
Sodium Concentration ◽  
Social Avoidance ◽  
Social Defeat Stress ◽  
The Social ◽  
Lovo Cells

Psychological stress is deeply involved in the pathophysiology of not only mental illness but also functional gastrointestinal disorders. In the present study, we examined the relationship between psychological stress and abnormality of stool properties, focusing on the alteration of plasma glucocorticoid and guanylin (GN)/uroguanylin (UGN) expression in the colon. A murine model of chronic social defeat stress (CSDS) was established by exposing a C57BL/6N intruder mouse to a CD-1 aggressor mouse for 3–5 min. Thereafter the mice were kept in the same cage but separated by a divider for the remainder of the day. This procedure was repeated for 10 consecutive days, and then a social interaction test was performed to evaluate social avoidance. Fresh fecal and blood samples were collected for stool property analysis and measurement of the plasma glucocorticoid level by ELISA. The expression of GN, UGN, and guanylate cyclase 2C in the colonic tissues was examined by real-time RT-PCR and immunohistochemistry. Moreover, Lovo cells were stimulated with dexamethasone, and the expression of GN/UGN mRNA was examined. In the CSDS group, the time spent in the social interaction zone was significantly shorter when the CD-1 aggressor mouse was present than when it was absent. The social interaction ratio was also significantly lower in the CSDS group relative to the controls. The mean Bristol scale score was significantly lower in the CSDS group, but the fecal sodium concentration did not differ between CSDS mice and controls. The level of plasma corticosterone was significantly higher in the CSDS group than in the controls immediately after the 10th day of CSDS. The expression of both GN and UGN was significantly decreased in the CSDS mice. GN was expressed in all colonic epithelial cells, and UGN was expressed in ovoid or pyramidal epithelial cells in the colonic mucosa. The expression of both GN and UGN was significantly decreased in the CSDS mice relative to controls. The expression of both GN and UGN was significantly suppressed in Lovo cells upon stimulation with dexamethasone. Psychological stress-induced glucocorticoid may suppress colonic GN/UGN expression, resulting in a change in stool properties leading to constipation.

scholarly journals Stress-induced sleep-like inactivity modulates stress susceptibility in mice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Midori Nagai ◽  
Hirotaka Nagai ◽  
Chisato Numa ◽  
Tomoyuki Furuyashiki
Keyword(s):  
Sleep Deprivation ◽  
Social Stress ◽  
Social Interest ◽  
Social Behaviors ◽  
Social Defeat ◽  
Brain Regions ◽  
Social Characteristics ◽  
Social Avoidance ◽  
Social Defeat Stress ◽  
Positive Valence

AbstractSevere environmental and social stress induces dysregulation of sleep along with mood and cognitive disturbances. However, the role and mechanism of this sleep dysregulation remain elusive. Here we evaluated sleep-like inactivity measured by voluntary movements and its relationship to social behaviors in mice without or with social defeat stress as well as the stressed mice with subsequent sleep deprivation. Social defeat stress immediately induced sleep-like inactivity with decreased body temperature. In the social interaction test, the control mice showed high social interest and its correlation with social sniffing intensity, the latter of which indicates positive valence of social sniffing. After the stress, these social characteristics were maintained in stress-resilient mice, but disrupted in stress-susceptible mice, leading to social avoidance. Sleep deprivation after the stress decreased social sniffing intensity along with reduced social interest, but enhanced the exploratory activity with the positive valence of social sniffing. We also found by c-Fos immunohistochemistry that the stress activated sleep-related brain regions, the dorsomedial hypothalamus and ventrolateral periaqueductal gray. Collectively, these findings show that stress activates sleep-related brain regions and induces sleep-like inactivity, contributing to multiple roles of stress-induced sleep for social behaviors.

Cognitive strategies in coping with expedition stress

1993 ◽  
Vol 7 (4) ◽  
pp. 255-266 ◽  
Author(s):  
Fraser N. Watts ◽  
Shernaaz M. Webster ◽  
Colin J. Morley ◽  
John Cohen
Keyword(s):  
Social Stress ◽  
Cognitive Strategies ◽  
Stress And Coping ◽  
Personality Change ◽  
Self Report ◽  
Future Research ◽  
Stressful Situation ◽  
Coping With Stress ◽  
The Social ◽  
And Coping

Expeditions provide a valuable opportunity for studying processes of coping with a stressful situation. An expedition to India organized by the British Schools Exploring Society has already been reported as being accompanied by positive changes on self‐report personality scales. This paper is concerned with detailed cognitive coping measures completed throughout the 6 weeks of the expedition. It needs to be noted that the results relate to young adults and to those who provided detailed coping information; the generalizability of the result is a matter for future research. The expedition presented a mixture of physical and social stresses. Men enjoyed the physical experience more than women, but women enjoyed the social experience more than men. There was generally greater reliance on personal resources than on social support in coping with stress. This was particularly true for men in coping with physical stress and women in coping with social stress. In general, the physical stresses had been better anticipated than the social ones. Positive reformulations were much more widely used as coping strategies than avoidance/resignation strategies, especially so for physical stresses. However, use of avoidance/resignation strategies was the better predictor of outcome, with those who used them being least likely to show positive personality change as a result of the expedition. The results are related to current research on stress and coping.

Implications of the gut microbiota in vulnerability to the social avoidance effects of chronic social defeat in male mice

2017 ◽  
Vol 66 ◽  
pp. 45-55 ◽  
Author(s):  
Joanna Kasia Szyszkowicz ◽  
Alex Wong ◽  
Hymie Anisman ◽  
Zul Merali ◽  
Marie-Claude Audet
Keyword(s):  
Gut Microbiota ◽  
Social Defeat ◽  
Social Avoidance ◽  
Male Mice ◽  
The Social

scholarly journals Lavandula angustifolia Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2694 ◽  
Author(s):  
Lucia Caputo ◽  
Marina Reguilon ◽  
José Mińarro ◽  
Vincenzo De Feo ◽  
Marta Rodriguez-Arias
Keyword(s):  
Social Interaction ◽  
Essential Oil ◽  
Social Stress ◽  
Anxiolytic Effect ◽  
Social Defeat ◽  
Mental Illnesses ◽  
Acute Administration ◽  
Social Avoidance ◽  
Lavandula Angustifolia

Many vegetable extracts, essential oils, and their main constituents are active on the Central Nervous System (CNS). In fact, they have been used as sedatives, hypnotics, or tranquilizers for their activity in treating CNS disorders. In this research, we studied the possible activities of Lavandula angustifolia (LA) essential oil and of its main constituent, linalool, as anti-stress compounds on anxiety and social interaction and their in vitro effects on proteins (pERK and PKA) involved in the transmission of the signal. An acute intraperitoneal injection of linalool (100 mg/kg) and of LA essential oil (200 mg/kg) reduced motor activity without any anxiolytic effect, but significantly increased social interaction. Stressed mice, after being exposed to a social defeat encounter, showed heightened anxiety and social avoidance. Acute administration of LA essential oil blocked stress-induced anxiety, while linalool showed no effects. However, both compounds were capable of reversing social aversion, acting as antidepressant agents. Our results showed that linalool inhibits pERK and PKA expression in the SH-SY5Y cell, but no effect was detected with the LA essential oil. Therefore, the LA essential oil and linalool may be considered as useful alternative tools to the available traditional treatments for social stress-induced mental illnesses.

Why Not Everyone Gets Their Fair Share of Stress: Adolescent'S Perceived Relationship Affection Mediates Associations between Temperament and Subsequent Stressful Social Events

2015 ◽  
Vol 29 (2) ◽  
pp. 125-137 ◽  
Author(s):  
O. M. Laceulle ◽  
B. F. Jeronimus ◽  
M. A. G. van Aken ◽  
J. Ormel
Keyword(s):  
Social Stress ◽  
Stressful Life Events ◽  
Large Population ◽  
Romantic Partners ◽  
Personality Psychology ◽  
Domain Specific ◽  
Social Events ◽  
The Social ◽  
Social Domains ◽  
Prospective Association

Temperamental differences are associated with subsequent stressful life events, a phenomenon that has in part been attributed to evocation. However, we remain ignorant about the mechanisms that mediate this process. In the current paper, we test whether differences in ‘perceived relationship affection’ accounted for part of the prospective association between temperament and stressful social event evocation in three social domains, viz. parents, peers and romantic partners. Data were derived from the Tracking Adolescents’ Individual Lives Survey, a large population cohort of Dutch adolescents ( n = 1158). Parent–reported adolescent temperament and adolescent's perceived affection were assessed at age 11 years. Stressful social events that occurred between age 11 and 16 years were captured using the event history calendar. Results indicate that adolescents evoke subsequent stressful social events based on their temperament, and that this association is partially mediated by perceived affection. Importantly, we found evidence for both generic and domain–specific associations, which indicates that social domains are related yet distinct. Taken together, the findings suggest that a search for mediating variables may be a promising way to increase our understanding of the mechanisms that underlie the social stress selection principle, and that perceived relationship affection is one of the candidates. Copyright © 2015 European Association of Personality Psychology

scholarly journals Abnormal Sleep Signals Vulnerability to Chronic Social Defeat Stress

2021 ◽  
Vol 14 ◽  
Author(s):  
Basma Radwan ◽  
Gloria Jansen ◽  
Dipesh Chaudhury
Keyword(s):  
Sleep Disturbances ◽  
Social Defeat ◽  
Nrem Sleep ◽  
Social Avoidance ◽  
Chronic Social Defeat Stress ◽  
The Social ◽  
Before And After ◽  
Tight Association ◽  
Abnormal Sleep

There is a tight association between mood and sleep as disrupted sleep is a core feature of many mood disorders. The paucity in available animal models for investigating the role of sleep in the etiopathogenesis of depression-like behaviors led us to investigate whether prior sleep disturbances can predict susceptibility to future stress. Hence, we assessed sleep before and after chronic social defeat (CSD) stress. The social behavior of the mice post stress was classified in two main phenotypes: mice susceptible to stress that displayed social avoidance and mice resilient to stress. Pre-CSD, mice susceptible to stress displayed increased fragmentation of Non-Rapid Eye Movement (NREM) sleep, due to increased switching between NREM and wake and shorter average duration of NREM bouts, relative to mice resilient to stress. Logistic regression analysis showed that the pre-CSD sleep features from both phenotypes were separable enough to allow prediction of susceptibility to stress with >80% accuracy. Post-CSD, susceptible mice maintained high NREM fragmentation while resilient mice exhibited high NREM fragmentation, only in the dark. Our findings emphasize the putative role of fragmented NREM sleep in signaling vulnerability to stress.

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