scholarly journals Genetic tools weed out misconceptions of strain reliability inCannabis sativa: Implications for a budding industry

2018 ◽  
Author(s):  
Anna L. Schwabe ◽  
Mitchell E. McGlaughlin

AbstractCannabis sativais listed as a Schedule I substance by the United States Drug Enforcement Agency and has been federally illegal in the United States since 1937. However, the majority of states in the United States, as well as several countries, now have various levels of legalCannabis. Products are labeled with identifying strain names but there is no official mechanism to registerCannabisstrains, therefore the potential exists for incorrect identification or labeling. This study uses genetic analyses to investigate strain reliability from the consumer point of view. Ten microsatellite regions were used to examine samples from strains obtained from dispensaries in three states. Samples were examined for genetic similarity within strains, and also a possible genetic distinction between Sativa, Indica, or Hybrid types. The analyses revealed genetic inconsistencies within strains. Additionally, although there was strong statistical support dividing the samples into two genetic groups, the groups did not correspond to commonly reported Sativa/Hybrid/Indica types. Genetic differences have the potential to lead to phenotypic differences and unexpected effects, which could be surprising for the recreational user, but have more serious implications for patients relying on strains that alleviate specific medical symptoms.

2021 ◽  
Vol 40 (3) ◽  
pp. 463-478
Author(s):  
Henrique Fernandes Antunes

This article focuses on the legal disputes between the U.S. government and the Centro Espírita Beneficente União do Vegetal (UDV), as well as on the regulation of the religious use of ayahuasca by the Drug Enforcement Agency (DEA). Our aim is to present the main issues that were at stake throughout the dispute, especially the relationship between the limits of religious freedom when associated with the use of controlled substances.


2018 ◽  
Vol 42 ◽  
pp. 256-265
Author(s):  
Konstantin V. Simonov ◽  
Stanislav P. Mitrakhovich

The article examines the possibility of transfer to bipartisan system in Russia. The authors assess the benefits of the two-party system that include first of all the ensuring of actual political competition and authority alternativeness with simultaneous separation of minute non-system forces that may contribute to the country destabilization. The authors analyze the accompanying risks and show that the concept of the two-party system as the catalyst of elite schism is mostly exaggerated. The authors pay separate attention to the experience of bipartisan system implementation in other countries, including the United States. They offer detailed analysis of the generated concept of the bipartisanship crisis and show that this point of view doesn’t quite agree with the current political practice. The authors also examine the foreign experience of the single-party system. They show that the success of the said system is mostly insubstantial, besides many of such systems have altered into more complex structures, while commentators very often use not the actual information but the established myths about this or that country. The authors also offer practical advice regarding the potential technologies of transition to the bipartisan system in Russia.


1963 ◽  
Vol 16 (4) ◽  
pp. 389-398

In 1960 Hanssen and James described to the Institute a system developed and used by the United States Hydrographic Office for selecting the optimum track for transoceanic crossings by applying long-range predictions of winds, waves and currents to a knowledge of how the routed vessel reacts to these variables. The paper (Journal, 13, 253) described how, over a period of two years, an average reduction in travel time of 14 hours was achieved over 1000 optimum routes.In the present papers, presented at an Institute meeting held in London on 19 April, Captain Wepster of the Holland-America Line first of all goes into the benefits which effective ship routing offers the ship operator and then describes the results of the experimental routing programme undertaken by his Company in association with the Royal Netherlands Meteorological Institute. Mr. Verploegh of that Institute then discusses the programme from the forecaster's point of view.


2021 ◽  
Vol 704 (1) ◽  
pp. 91-104
Author(s):  
Maria Raczyńska

The article describes and explains a prior centric Bayesian forecasting model for the 2020 US elections.The model is based on the The Economist forecasting project, but strongly differs from it. From the technical point of view, it uses R and Stan programming and Stan software. The article’s focus is on theoretical decisions made in the process of constructing the model and outcomes. It describes why Bayesian models are used and how they are used to predict US presidential elections.


1918 ◽  
Vol 12 (1) ◽  
pp. 96-126 ◽  
Author(s):  
Denys P. Myers

The shade of distinction sought to be shown by the title of this paper may require explanation. Imperfect wording involves either carelessness or ignorance; bad faith indicates dishonesty; nonexecution or disregard implies laxness in the government, if not carelessness; adverse or hostile municipal or judicial action connotes lack of coordination between the internal and external affairs of the State. It follows that such adverse action may be considered from a practical point of view as almost a normal kind of violence against international contracts. It is not to be excused on that account, but it may be considered as a frictional incident almost inseparable under some conditions from the existence of a State. Given either a government of definitely separated elements, such as the United States, or a government without much stability, or a State founded on a type of civilization different from the European order, and this sort of violation of treaty may be forecasted with certainty. Fortunately, however, the instances that cause contractual friction of this sort are of the grosser kinds of personal violence, or are commercial; they are not of a political character, cannot be said to involve policy, and only by a stretch of the imagination involve the tweedledum and tweedledee of international relations, “national honor and vital interest.” They are consequently extremely susceptible to simple and orderly solution.


2019 ◽  
Vol 17 ◽  
pp. 211
Author(s):  
Alireza Jalilifar ◽  
Yasamin Moradi

Today, studying tourism discourse has become widespread among scholars in the field of text analysis. However, few, if any, studies which have addressed the language of tourism have examined the verbal content of travel brochures from the point of view of the appraisal model. The major questions addressed in this study pertain to Graduation strategies as part of appraisal strategies in the discourse of tourism as well as the lexico-grammatical resources for the coding of these strategies in texts. The dataset comprised 50 e-brochures released by tour operators across the United States within the period 2012 to 2013. First, the data were examined quantitatively to identify the statistical variations in utilizing Graduation strategies in tourist brochures. The preferences for lexico-grammatical resources for the construal of these strategies were also illustrated in light of a qualitative analysis. The results of the study revealed that the discourse of travel brochures is loaded with Graduation strategies. The subsystems within the system of Graduation were shown to serve as strong tools in promoting various aspects of tourist destinations such as the number and distribution of tourist sites over an area.


2020 ◽  
Author(s):  
John A. Furst ◽  
Nicholas J. Mynarski ◽  
Kenneth L. McCall ◽  
Brian J. Piper

AbstractObjectiveMethadone is an evidence based treatment for opioid use disorder and is also employed for acute pain. The primary objective of this study was to explore methadone distribution patterns between the years 2017 and 2019 across the United States (US). This study builds upon previous literature that has analyzed prior years of US distribution patterns, and further outlines regional and state specific methadone trends.MethodsThe Drug Enforcement Administration’s Automated Reports and Consolidated Ordering System (ARCOS) was used to acquire the number of narcotic treatment programs (NTPs) per state and methadone distribution weight in grams. Methadone distribution by weight, corrected for state populations, and number of NTPs were compared from 2017 to 2019 between states, within regions, and nationally.ResultsBetween 2017 and 2019, the national distribution of methadone increased 12.30% for NTPs but decreased 34.57% for pain, for a total increase of 2.66%. While all states saw a decrease in distribution for pain, when compared regionally, the Northeast showed a significantly smaller decrease than all other regions. Additionally, the majority of states experienced an increase in distribution for NTPs and most states demonstrated a relatively stable or increasing number of NTPs, with an 11.49% increase in NTPs nationally. The number of NTPs per 100K in 2019 ranged from 2.08 in Rhode Island to 0.00 in Wyoming.ConclusionAlthough methadone distribution for OUD was increasing in the US, there were pronounced regional disparities.


1992 ◽  
Vol 86 (4) ◽  
pp. 736-746 ◽  
Author(s):  
Malvina Halberstam

In United States v. Alvarez-Machain, the Supreme Court sustained the jurisdiction of a U.S. court to try a Mexican national, charged with various counts of conspiracy, kidnaping and the murder of a U.S. drug enforcement agent in Mexico, even though his presence in the United States was the result of abduction rather than extradition pursuant to the Extradition Treaty between the United States and Mexico. The Court did not hold, as widely reported in the media, that the Treaty permits abduction, that abduction is legal, or that the United States had a right to kidnap criminal suspects abroad. On the contrary, the Court acknowledged that the abduction may have been a violation of international law. It stated, “Respondent and his amici may be correct that respondent’s abduction was ’shocking’ and that it may be in violation of general international law principles.”


Author(s):  
Marc Trachtenberg

This chapter focuses on a document formally adopted by the NATO Council in December 1954, called MC 48, a report by the Alliance's Military Committee on “The Most Effective Pattern of NATO Military Strength for the Next Few Years.” In approving this document, the Council authorized the military authorities of the Alliance to “plan and make preparations on the assumption that atomic and thermonuclear weapons will be used in defense from the outset.” One very important consequence of the new strategy from the European point of view had to do with what was called “nuclear sharing”—that is, with the provision of American nuclear weapons to the NATO allies. This policy of nuclear sharing was one of the key elements in the history of this period.


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