scholarly journals Classification of hospital and urban wastewater resistome and microbiota over time and their relationship to the eco-exposome

2019 ◽  
Author(s):  
Elena Buelow ◽  
Andreu Rico ◽  
Margaux Gaschet ◽  
José Lourenço ◽  
Sean P. Kennedy ◽  
...  
Keyword(s):  
Significant Variation ◽  
Urban Wastewater ◽  
Related Risk ◽  
Variate Analysis ◽  
One Year ◽  
The Impact ◽  
Micro Pollutants ◽  
Over Time

AbstractWastewaters (WW) are important sources for the dissemination of antimicrobial resistance (AMR) into the environment. Hospital WW (HWW) contain higher loads of micro-pollutants and AMR markers than urban WW (UWW). Little is known about the long-term dynamics of H and U WW and the impact of their joined treatment on the general burden of AMR. Here, we characterized the resistome, microbiota and eco-exposome signature of 126 H and U WW samples treated separately for three years, and then mixed, over one year. Multi-variate analysis and machine learning revealed a robust signature for each WW with no significant variation over time before mixing, and once mixed, both WW closely resembled U signatures. We demonstrated a significant impact of pharmaceuticals and surfactants on the resistome and microbiota of H and U WW. Our results present considerable targets for AMR related risk assessment of WW.

Influence of internal and external risks on sustainability of financial system of Аltai krai

2018 ◽  
Vol 35 (4) ◽  
pp. 133-136
Author(s):  
R. N. Ibragimov
Keyword(s):  
Sustainable Development ◽  
Financial Stability ◽  
Management Strategy ◽  
Financial System ◽  
Risk Management Strategy ◽  
The Sustainable Development ◽  
The Stability ◽  
The Impact

The article examines the impact of internal and external risks on the stability of the financial system of the Altai Territory. Classification of internal and external risks of decline, affecting the sustainable development of the financial system, is presented. A risk management strategy is proposed that will allow monitoring of risks, thereby these measures will help reduce the loss of financial stability and ensure the long-term development of the economy of the region.

Gender, mobility and contact

2021 ◽  
Vol 7 (2) ◽  
pp. 142-167
Author(s):  
Catherine E. Travis ◽  
Inas Ghina
Keyword(s):  
Older Women ◽  
High Mobility ◽  
Spontaneous Speech ◽  
Social Changes ◽  
Change Over Time ◽  
Aceh Province ◽  
Rural Variety ◽  
The Impact ◽  
Over Time

Abstract We examine variation in a rural variety of Acehnese spoken in Aceh Province, to better understand the impact of long-term contact with Indonesian and increasing urbanization. The Great Aceh variety is characterized by variable realization of word-final (t) as a dental vs. glottal stop. Analyses of over 2,000 tokens of this variable from a corpus of spontaneous speech from 35 speakers indicate that the variability is relatively stable among men, and among women of high mobility, measured in terms of education, occupation, and time spent outside Great Aceh. Women with low mobility produce the lowest rates of [t̪], and in this group we observe a higher rate of [t̪] by younger than older women, suggesting change over time. We thus find both stability – among those who have long enjoyed high levels of mobility – and change – among those most affected by recent social changes, namely low-mobility women.

scholarly journals THE IMPACT OF REGIONAL INEQUALITY ON MIGRATION TRENDS IN LATVIA

2021 ◽  
Vol 6 ◽  
pp. 79-91
Author(s):  
Anastasija Jeršova ◽  
Iveta Mietule
Keyword(s):  
Research Methods ◽  
Synthesis Method ◽  
Constructive Method ◽  
Territorial Development ◽  
Integral Index ◽  
Index Method ◽  
Regional Inequalities ◽  
The Impact ◽  
Over Time

The topic of current research and key findings are topical, taking into the consideration the territorial development tendencies of Latvia, which is characterized by the long-term regional inequalities and the tendencies of the migration of the population. The aim of the research is to analyse the impact of the regional inequalities on the migration tendencies of population in Latvia. The following research methods have been used in the research- logically constructive method, content analysis, monographic method, synthesis method, statistical analysis of interrelations, integral index method. Within the research, by using the selected research methods, authors have evaluated the influence of migration indicators-stimulators and indicators-de-stimulators on the migration trends in Latvia over time.

scholarly journals Long Term Implications in Surgical Re-assisting (L.I.S.A. study) During Covid-19 Outbreak: A Retrospective Observational Study on a Rural Population.

2021 ◽  
Author(s):  
Nicolò Fabbri ◽  
Antonio Pesce ◽  
Lisa Uccellatori ◽  
Salvatore Greco ◽  
Francesco D'Urbano ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Operative Management ◽  
Surgical Interventions ◽  
Male Sex ◽  
Non Operative Management ◽  
The Impact ◽  
Colorectal Resections ◽  
Surgical Operations ◽  
Over Time

Abstract BackgroundThe spread of the COVID-19 is having a worldwide impact on surgicaltreatment. Our aim was to investigate the impact of the pandemic in a rural hospital in a lowdensely populated area.MethodsWe investigated the volume and type of surgical operations during the pandemic(March 2020 - February 2021) versus pre-pandemic period (March 2019 - February 2020) aswell as during the first and second pandemic waves compared to the pre-pandemic period.We compared the volume and timing of emergency appendectomy and cholecystectomyduring the pandemic versus pre-pandemic period, the volume, timing and stages of electivegastric and colorectal resections for cancer during the pandemic versus the pre-pandemicperiod.ResultsIn the prepandemic versus pandemic period, 42 versus 24 appendectomies and 174versus 126 cholecystectomies (urgent and elective) were performed. Patients operated onbefore as opposed to during the pandemic were older (58 vs. 52 years old, p=0.006),including for cholecystectomy (73 vs. 66 years old, p=0.01) and appendectomy (43 vs. 30years old, p = 0.04).The logistic regression analysis with regard to cholecystectomy and appendectomy performedin emergency showed that male sex and age were both associated to gangrenous typehistology, both in pandemic and prepandemic period. Finally, we found a reduction in cancerstage I and IIA in pandemic versus prepandemic period, with no increase in the moreadvanced stages.Conclusionsthe reduction in services imposed by governments during the first months oftotal lock down did not justify the whole decrease in surgical interventions in the year of thepandemic. Data suggest that greater "non-operative management" for cases of appendicitisand acute cholecystitis does not lead to an increase in cases operated over time, nor to anincrease in the "gangrenous" pattern, which seems to depend on age advanced and malepopulation.

Transitions in Technology Mediated Cardiac Rehabilitation and Self-management: A Qualitative Study using the Theoretical Domains Framework (Preprint)

2021 ◽  
Author(s):  
Shreya Tadas ◽  
Claudette Pretorius ◽  
Emma J. Foster ◽  
Trish Gorely ◽  
Stephen J. Leslie ◽  
...  
Keyword(s):  
Cardiac Rehabilitation ◽  
Behaviour Change ◽  
Theoretical Domains Framework ◽  
Self Management ◽  
Normal Life ◽  
Use Of Technology ◽  
Holistic Understanding ◽  
The Impact ◽  
Over Time

BACKGROUND An acute cardiac incident is a life changing event, often necessitating surgery. While surgery has high success rates, rehabilitation, behaviour change, and self-care are critical to long-term health. Recent systematic reviews highlight the potential of technology in this area, but significant shortcomings are also identified, particularly in regard to patient experience. OBJECTIVE To improve future systems this paper explores the experiences of cardiac patients during key phases post-hospitalisation: recuperation, initial rehabilitation and long term self-management. The key objective is to provide a holistic understanding of behavioural factors that impact people across these phases, understand how experiences evolve over time, and provide user-centred recommendations to improve the design of cardiac rehabilitation and self-management technologies. METHODS Semi-structured interviews were conducted with people who attended rehabilitation programs following hospitalisation for an acute cardiac event. Interviews were developed and data is analysed via the Theoretical Domains Framework (TDF), a pragmatic framework that synthesizes prior theories of behaviour change. RESULTS Three phases that arise post-hospitalisation are examined: recuperation, rehabilitation, and long-term self-management. Through these phases we describe the impact of key factors and important changes that occur in patients’ experiences over time, including: a desire for and redefinition of normal life; the need for different types of formal and informal knowledge; the benefits of safe-zoning and connectedness; and the need to recognise capability. The use of the TDF allows us to show how factors that influence behaviour evolve over time and identify potential sources of tension. CONCLUSIONS The paper provides empirically grounded recommendations for the design of technology-mediated cardiac rehabilitation and self-management systems. Key recommendations include the use of technology to support a normal life; leveraging social influences to extend participants’ sense of normality; the use of technology to provide a safe zone; the need to support both emotional and physical wellbeing; and a focus on recognizing capability and providing recommendations that are positive and reinforce this capability.

“We Begin 300 Metres Behind the Starting Line”

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
Sara Hosseini-Nezhad ◽  
Saba Safdar ◽  
Lan Anh Nguyen Luu
Keyword(s):  
International Students ◽  
Well Being ◽  
Psychosocial Adaptation ◽  
Structured Interviews ◽  
One Year ◽  
Iranian Students ◽  
Almost All ◽  
The Impact ◽  
Longitudinal Qualitative Research ◽  
Over Time

This longitudinal qualitative research aimed to investigate the psychosocial adaptation trajectory of Iranian international students in Hungary and the challenges they encountered. Semi-structured interviews were conducted at seven-month to one-year intervals with 20 Iranian students; inductive content analysis was utilized to analyze the interview transcripts. Three topics were identified: (1) visa and banking challenges, (2) the impact of the currency crisis in Iran on mental health, and (3) positive and negative changes in psychological well-being over time. The results revealed that almost all students’ well-being improved over time, despite facing challenges related to visas, banking, and Iran’s recent economic crisis (specifically, the drastic plunge of the Iranian currency).

scholarly journals The Price Impact of Lending Relationships

2015 ◽  
Vol 16 (3) ◽  
pp. 367-389 ◽  
Author(s):  
Ingrid Stein
Keyword(s):  
Strong Relationship ◽  
Price Impact ◽  
Bank Debt ◽  
Relationship Strength ◽  
Borrowing Costs ◽  
Lending Relationships ◽  
Relationship Length ◽  
The Impact ◽  
Over Time

Abstract This study analyzes the impact of bank relationships on a firm’s borrowing costs. We find that a firm’s borrowing costs decrease with relationship strength, proxied by the share of bank debt provided by the lender. Borrowing costs, however, rise with relationship length. While the increase over time is weak on average, bank-dependent borrowers face a substantial premium after several relationship years. Switching the lender initially leads to only a small price discount on average. However, the discount is considerable for borrowers that switch and had a strong relationship with their previous lender. Our results suggest that close lending relationships lead to benefits for the firm, but may also imply hold-up costs in the long term.

scholarly journals Understanding the Impact of Stent and Scaffold Material and Strut Design on Coronary Artery Thrombosis from the Basic and Clinical Points of View

2018 ◽  
Vol 5 (3) ◽  
pp. 71 ◽  
Author(s):  
Atsushi Sakamoto ◽  
Hiroyuki Jinnouchi ◽  
Sho Torii ◽  
Renu Virmani ◽  
Aloke Finn
Keyword(s):  
Material Design ◽  
Coronary Intervention ◽  
Radial Force ◽  
Late Time ◽  
Clinical Complications ◽  
Scaffold Thrombosis ◽  
Absorb Bvs ◽  
One Year ◽  
The Impact

The technology of percutaneous coronary intervention (PCI) is constantly being refined in order to overcome the shortcomings of present day technologies. Even though current generation metallic drug-eluting stents (DES) perform very well in the short-term, concerns still exist about their long-term efficacy. Late clinical complications including late stent thrombosis (ST), restenosis, and neoatherosclerosis still exist and many of these events may be attributed to either the metallic platform and/or the drug and polymer left behind in the arterial wall. To overcome this limitation, the concept of totally bioresorbable vascular scaffolds (BRS) was invented with the idea that by eliminating long-term exposure of the vessel wall to the metal backbone, drug, and polymer, late outcomes would improve. The Absorb-bioabsorbable vascular scaffold (Absorb-BVS) represented the most advanced attempt to make such a device, with thicker struts, greater vessel surface area coverage and less radial force versus contemporary DES. Unfortunately, almost one year after its initial approval by the U.S. Food and Drug Administration, this scaffold was withdrawn from the market due to declining devise utilization driven by the concerns about scaffold thrombosis (ScT) seen in both early and late time points. Additionally, the specific causes of ScT have not yet been fully elucidated. In this review, we discuss the platform, vascular response, and clinical data of past and current metallic coronary stents with the Absorb-BVS and newer generation BRS, concentrating on their material/design and the mechanisms of thrombotic complications from the pre-clinical, pathologic, and clinical viewpoints.

Multiple Attachments of OSCs in Residential Care

2020 ◽  
Vol 7 (2) ◽  
pp. 191-206
Author(s):  
Arthi Shankar Kozhumam ◽  
Riti Chandrashekhar ◽  
Ananya Rattani ◽  
Sumedha Gupta Ariely
Keyword(s):  
Social Relationships ◽  
Residential Care ◽  
Social Relations ◽  
Family Relationships ◽  
Time Span ◽  
Predictive Relationships ◽  
One Year ◽  
Caregiver Attachment ◽  
Over Time

This study describes evidence for multiple attachments by orphaned and separated children (OSC) to caregivers and explores predictive relationships between attachment and family social relationships. A sample of forty-three longitudinal children residing in residential care between 15 and 144 months at the time of assessment and forty-two newer-to-care children (entering one to thirteen months before testing) was interviewed in summer 2019. Caregiver attachment was measured using the IPPA Guardian scale, and family social relations were measured using the PROMIS Pediatric Family Relationships scale. Longitudinal children displayed similar attachment scores across a one-year time span regardless of whether they nominated the same or different favourite caretaker. Results are discussed in the context of evidence for multiple attachments and the way attachment can predict social relations for new but not longitudinal children. This paper supports that OSCs form multiple attachments to caregivers over time, with attachment starting and remaining relatively strong in the long-term.

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