scholarly journals On the Boundary Conditions of Avoidance Memory Reconsolidation: An Attractor Network Perspective

2019 ◽  
Author(s):  
Rodrigo MM Santiago ◽  
Adriano BL Tort
Keyword(s):  
Boundary Condition ◽  
Boundary Conditions ◽  
Behavioral Outcomes ◽  
Inhibitory Avoidance ◽  
Contextual Fear Conditioning ◽  
Attractor Network ◽  
Hebbian Plasticity ◽  
Experimental Protocols ◽  
Fear And Anxiety ◽  
Experimental Findings

AbstractThe reconsolidation and extinction of aversive memories and their boundary conditions have been extensively studied. Knowing their network mechanisms may lead to the development of better strategies for the treatment of fear and anxiety-related disorders. In 2011, Osan et al. developed a computational model for exploring such phenomena based on attractor dynamics, Hebbian plasticity and synaptic degradation induced by prediction error. This model was able to explain, in a single formalism, experimental findings regarding the freezing behavior of rodents submitted to contextual fear conditioning. In 2017, through the study of inhibitory avoidance in rats, Radiske et al. showed that the previous knowledge of a context as non-aversive is a boundary condition for the reconsolidation of the shock memory subsequently experienced in that context. In the present work, by adapting the model of Osan et al. (2011) to simulate the experimental protocols of Radiske et al. (2017), we show that such boundary condition is compatible with the dynamics of an attractor network that supports synaptic labilization common to reconsolidation and extinction. Additionally, by varying parameters such as the levels of protein synthesis and degradation, we predict behavioral outcomes, and thus boundary conditions that can be tested experimentally.

scholarly journals Interfering with contextual fear memories by post-reactivation administration of propranolol in mice: a series of null findings

2021 ◽  
Author(s):  
Wouter R Cox ◽  
Leonidas Faliagkas ◽  
Rolinka van der Loo ◽  
Sabine Spijker ◽  
Merel Kindt ◽  
...  
Keyword(s):  
Boundary Conditions ◽  
Behavioral Outcomes ◽  
Fear Memory ◽  
Contextual Fear Conditioning ◽  
Mouse Strains ◽  
Conditioning Paradigm ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Series Of Experiments ◽  
Genetic And Environmental Factors

Post-reactivation amnesia of contextual fear memories by blockade of noradrenergic signaling has been shown to have limited replicability in rodents. This is usually attributed to several boundary conditions that gate the destabilization of memory during its retrieval. However, how these boundary conditions can be overcome, and what neural mechanisms underlie post-reactivation changes in contextual fear memory remain largely unknown. Here, we report a series of experiments in a contextual fear conditioning paradigm in mice, that were aimed at elucidating these matters. Towards this overarching goal, we first attempted to obtain a training paradigm that would consistently result in a contextual fear memory that could be destabilized upon reactivation, enabling robust amnesia by administration of propranolol. Unexpectedly, our attempts were unsuccessful to this end. Specifically, over a series of 11 experiments (including replicates) in which we varied different parameters of the fear acquisition procedure and administered propranolol or anisomycin, at best small and inconsistent effects were observed. These null findings are surprising, given that the training paradigms we implemented were previously shown to be vulnerable to post-reactivation amnestic agents. Additionally, we found that propranolol did not alter memory retrieval-induced neural activity, as measured by the number of c-Fos+ cells in the hippocampal dentate gyrus. Together, our findings illustrate the elusive nature of reactivation-dependent changes of non-human fear memory and underscore the need for better control over genetic and environmental factors that may influence behavioral outcomes of commonly used mouse strains.

Sturm-Liouville Problem for Stationary Differential Operator with Nonlocal Two-Point Boundary Conditions

2006 ◽  
Vol 11 (1) ◽  
pp. 47-78 ◽  
Author(s):  
S. Pečiulytė ◽  
A. Štikonas
Keyword(s):  
Boundary Condition ◽  
Differential Operator ◽  
Boundary Conditions ◽  
Nonlocal Boundary Condition ◽  
Nonlocal Boundary ◽  
Liouville Problem ◽  
Complex Case ◽  
Qualitative Behavior ◽  
Point Boundary ◽  
Sturm Liouville

The Sturm-Liouville problem with various types of two-point boundary conditions is considered in this paper. In the first part of the paper, we investigate the Sturm-Liouville problem in three cases of nonlocal two-point boundary conditions. We prove general properties of the eigenfunctions and eigenvalues for such a problem in the complex case. In the second part, we investigate the case of real eigenvalues. It is analyzed how the spectrum of these problems depends on the boundary condition parameters. Qualitative behavior of all eigenvalues subject to the nonlocal boundary condition parameters is described.

scholarly journals Stiffness Estimation and Equivalence of Boundary Conditions in FEM Models

2021 ◽  
Vol 11 (4) ◽  
pp. 1482
Author(s):  
Róbert Huňady ◽  
Pavol Lengvarský ◽  
Peter Pavelka ◽  
Adam Kaľavský ◽  
Jakub Mlotek
Keyword(s):  
Boundary Condition ◽  
Finite Element ◽  
Boundary Conditions ◽  
Model Updating ◽  
Element Model ◽  
Computational Time ◽  
Stiffness Coefficients ◽  
First Case ◽  
Numerical Approaches

The paper deals with methods of equivalence of boundary conditions in finite element models that are based on finite element model updating technique. The proposed methods are based on the determination of the stiffness parameters in the section plate or region, where the boundary condition or the removed part of the model is replaced by the bushing connector. Two methods for determining its elastic properties are described. In the first case, the stiffness coefficients are determined by a series of static finite element analyses that are used to obtain the response of the removed part to the six basic types of loads. The second method is a combination of experimental and numerical approaches. The natural frequencies obtained by the measurement are used in finite element (FE) optimization, in which the response of the model is tuned by changing the stiffness coefficients of the bushing. Both methods provide a good estimate of the stiffness at the region where the model is replaced by an equivalent boundary condition. This increases the accuracy of the numerical model and also saves computational time and capacity due to element reduction.

scholarly journals Electrically turning periodic structures in cholesteric layer with conical–planar boundary conditions

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Oxana Prishchepa ◽  
Mikhail Krakhalev ◽  
Vladimir Rudyak ◽  
Vitaly Sutormin ◽  
Victor Zyryanov
Keyword(s):  
Boundary Conditions ◽  
Periodic Structures ◽  
Cholesteric Liquid Crystal ◽  
Growth Direction ◽  
Smooth Transition ◽  
Defect Structures ◽  
Optical Cell ◽  
Elastic Continuum ◽  
The One ◽  
Experimental Findings

AbstractElectro-optical cell based on the cholesteric liquid crystal is studied with unique combination of the boundary conditions: conical anchoring on the one substrate and planar anchoring on another one. Periodic structures in cholesteric layer and their transformation under applied electric field are considered by polarizing optical microscopy, the experimental findings are supported by the data of the calculations performed using the extended Frank elastic continuum approach. Such structures are the set of alternating over- and under-twisted defect lines whose azimuthal director angles differ by $$180^\circ$$ 180 ∘ . The $$U^+$$ U + and $$U^-$$ U - -defects of periodicity, which are the smooth transition between the defect lines, are observed at the edge of electrode area. The growth direction of defect lines forming a diffraction grating can be controlled by applying a voltage in the range of $$0\le \, V \le 1.3$$ 0 ≤ V ≤ 1.3  V during the process. Resulting orientation and distance between the lines don’t change under voltage. However, at $$V>1.3$$ V > 1.3  V $$U^+$$ U + -defects move along the defect lines away from the electrode edges, and, finally, the grating lines collapse at the cell’s center. These results open a way for the use of such cholesteric material in applications with periodic defect structures where a periodicity, orientation, and configuration of defects should be adjusted.

scholarly journals Bootstrapping boundary-localized interactions

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Connor Behan ◽  
Lorenzo Di Pietro ◽  
Edoardo Lauria ◽  
Balt C. van Rees
Keyword(s):  
Boundary Condition ◽  
Scalar Field ◽  
Boundary Conditions ◽  
Parameter Space ◽  
Three Dimensional ◽  
Conformal Boundary ◽  
Dimensional Boundary ◽  
Dirichlet And Neumann Conditions ◽  
Boundary Fields ◽  
Boundary Dynamics

Abstract We study conformal boundary conditions for the theory of a single real scalar to investigate whether the known Dirichlet and Neumann conditions are the only possibilities. For this free bulk theory there are strong restrictions on the possible boundary dynamics. In particular, we find that the bulk-to-boundary operator expansion of the bulk field involves at most a ‘shadow pair’ of boundary fields, irrespective of the conformal boundary condition. We numerically analyze the four-point crossing equations for this shadow pair in the case of a three-dimensional boundary (so a four-dimensional scalar field) and find that large ranges of parameter space are excluded. However a ‘kink’ in the numerical bounds obeys all our consistency checks and might be an indication of a new conformal boundary condition.

scholarly journals An asymptotically compatible approach for Neumann-type boundary condition on nonlocal problems

2020 ◽  
Vol 54 (4) ◽  
pp. 1373-1413 ◽  
Author(s):  
Huaiqian You ◽  
XinYang Lu ◽  
Nathaniel Task ◽  
Yue Yu
Keyword(s):  
Boundary Condition ◽  
Boundary Conditions ◽  
Nonlocal Boundary ◽  
Nonlocal Diffusion ◽  
Order Convergence ◽  
Flux Boundary Condition ◽  
Nonlocal Interactions ◽  
Local Case ◽  
Neumann Type ◽  
Type Boundary

In this paper we consider 2D nonlocal diffusion models with a finite nonlocal horizon parameter δ characterizing the range of nonlocal interactions, and consider the treatment of Neumann-like boundary conditions that have proven challenging for discretizations of nonlocal models. We propose a new generalization of classical local Neumann conditions by converting the local flux to a correction term in the nonlocal model, which provides an estimate for the nonlocal interactions of each point with points outside the domain. While existing 2D nonlocal flux boundary conditions have been shown to exhibit at most first order convergence to the local counter part as δ → 0, the proposed Neumann-type boundary formulation recovers the local case as O(δ2) in the L∞ (Ω) norm, which is optimal considering the O(δ2) convergence of the nonlocal equation to its local limit away from the boundary. We analyze the application of this new boundary treatment to the nonlocal diffusion problem, and present conditions under which the solution of the nonlocal boundary value problem converges to the solution of the corresponding local Neumann problem as the horizon is reduced. To demonstrate the applicability of this nonlocal flux boundary condition to more complicated scenarios, we extend the approach to less regular domains, numerically verifying that we preserve second-order convergence for non-convex domains with corners. Based on the new formulation for nonlocal boundary condition, we develop an asymptotically compatible meshfree discretization, obtaining a solution to the nonlocal diffusion equation with mixed boundary conditions that converges with O(δ2) convergence.

Chaotic Vibration of a Two-dimensional Non-strictly Hyperbolic Equation

2018 ◽  
Vol 61 (4) ◽  
pp. 768-786 ◽  
Author(s):  
Liangliang Li ◽  
Jing Tian ◽  
Goong Chen
Keyword(s):  
Boundary Condition ◽  
Boundary Conditions ◽  
Hyperbolic Equation ◽  
Method Of Characteristics ◽  
Nonlinear Boundary ◽  
Chaotic Oscillation ◽  
Nonlinear Boundary Conditions ◽  
Rigorous Proof ◽  
Two Dimensional ◽  
Chaotic Vibration

AbstractThe study of chaotic vibration for multidimensional PDEs due to nonlinear boundary conditions is challenging. In this paper, we mainly investigate the chaotic oscillation of a two-dimensional non-strictly hyperbolic equation due to an energy-injecting boundary condition and a distributed self-regulating boundary condition. By using the method of characteristics, we give a rigorous proof of the onset of the chaotic vibration phenomenon of the zD non-strictly hyperbolic equation. We have also found a regime of the parameters when the chaotic vibration phenomenon occurs. Numerical simulations are also provided.

NEW MODELS IN MICROPOLAR FLUID AND THEIR APPLICATION TO LUBRICATION

2005 ◽  
Vol 15 (03) ◽  
pp. 343-374 ◽  
Author(s):  
GUY BAYADA ◽  
NADIA BENHABOUCHA ◽  
MICHÈLE CHAMBAT
Keyword(s):  
Boundary Condition ◽  
Friction Coefficient ◽  
Boundary Conditions ◽  
Existence And Uniqueness ◽  
Micropolar Fluid ◽  
Reynolds Equation ◽  
Slip Boundary Condition ◽  
Slip Boundary ◽  
New Models ◽  
Uniqueness Of The Solution

A thin micropolar fluid with new boundary conditions at the fluid-solid interface, linking the velocity and the microrotation by introducing a so-called "boundary viscosity" is presented. The existence and uniqueness of the solution is proved and, by way of asymptotic analysis, a generalized micropolar Reynolds equation is derived. Numerical results show the influence of the new boundary conditions for the load and the friction coefficient. Comparisons are made with other works retaining a no slip boundary condition.

Application of Generalized Differential Quadrature Method to the Bending of Thick Laminated Plates with Various Boundary Conditions

2006 ◽  
Vol 5-6 ◽  
pp. 407-414 ◽  
Author(s):  
Mohammad Mohammadi Aghdam ◽  
M.R.N. Farahani ◽  
M. Dashty ◽  
S.M. Rezaei Niya
Keyword(s):  
Boundary Condition ◽  
Boundary Conditions ◽  
Simple Procedure ◽  
Shear Deformation Theory ◽  
Laminated Plates ◽  
Differential Quadrature ◽  
Governing Equations ◽  
First Order ◽  
Various Boundary Conditions ◽  
Generalized Differential

Bending analysis of thick laminated rectangular plates with various boundary conditions is presented using Generalized Differential Quadrature (GDQ) method. Based on the Reissner first order shear deformation theory, the governing equations include a system of eight first order partial differential equations in terms of unknown displacements, forces and moments. Presence of all plate variables in the governing equations provide a simple procedure to satisfy different boundary condition during application of GDQ method to obtain accurate results with relatively small number of grid points even for plates with free edges .Illustrative examples including various combinations of clamped, simply supported and free boundary condition are given to demonstrate the accuracy and convergence of the presented GDQ technique. Results are compared with other analytical and finite element predictions and show reasonably good agreement.

Conduction of heat in a solid with periodic boundary conditions, with an application to the surface temperature of the moon

1953 ◽  
Vol 49 (2) ◽  
pp. 355-359 ◽  
Author(s):  
J. C. Jaeger
Keyword(s):  
Boundary Condition ◽  
Thermal Properties ◽  
Circular Cylinder ◽  
Boundary Conditions ◽  
Surface Temperature ◽  
Numerical Method ◽  
Periodic Boundary ◽  
Periodic Boundary Conditions ◽  
The Moon ◽  
Non Linear

The object of this note is to indicate a numerical method for finding periodic solutions of a number of important problems in conduction of heat in which the boundary conditions are periodic in the time and may be linear or non-linear. One example is that of a circular cylinder which is heated by friction along the generators through a rotating arc of its circumference, the remainder of the surface being kept at constant temperature; here the boundary conditions are linear but mixed. Another example, which will be discussed in detail below, is that of the variation of the surface temperature of the moon during a lunation; in this case the boundary condition is non-linear. In all cases the thermal properties of the solid will be assumed to be independent of temperature. Only the semi-infinite solid will be considered here, though the method applies equally well to other cases.

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