Effect of Assembly Method on Nanoparticle Attachment Density, Growth Rate, and Motility of Nanoscale Bacteria Enabled Autonomous Drug Delivery System (NanoBEADS)

AbstractMicrobial-mediated drug delivery systems have the potential to significantly enhance the efficacy of nanomedicine for cancer therapy through improved specificity and interstitial transport. The Nanoscale Bacteria-Enabled Autonomous Drug Delivery System (NanoBEADS) is a bacteria-based bio-hybrid drug delivery system designed to carry nanotherapeutics cargo deep into poorly vascularized cancerous tissue. The effect of bacteria-nanoparticle conjugation method and NanoBEADS assembly parameters (i.e., mixing method, volume, and duration) was investigated to maximize particle attachment density. The nanoparticle attachment capacity, viability, growth rate and motility of the original NanoBEADS and an antibody-free variant NanoBEADS were characterized and compared. It is found that the assembly parameters affect the attachment outcome and the binding mechanism impacts the attachment number, the growth rate and motility of NanoBEADS. The NanoBEADS platform provides an opportunity to load nanoparticles with different materials and sizes for applications beyond cancer therapy, such as imaging agents for high-resolution medical imaging.

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Preparation and evaluation of gemcitabin and cisplatin-entrapped Folate-PEGylated liposomes as targeting co-drug delivery system in cancer therapy

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2021.102756 ◽

2021 ◽

pp. 102756

Author(s):

Pooneh Pakdaman Goli ◽

Maryam Bikhof Torbati ◽

Kazem Parivar ◽

Azim Akbarzadeh Khiavi ◽

Mohammad Yousefi

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery System ◽

Delivery System ◽

Pegylated Liposomes ◽

Preparation And Evaluation

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Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1714421115 ◽

2018 ◽

Vol 115 (3) ◽

pp. 501-506 ◽

Cited By ~ 356

Author(s):

Meng Qiu ◽

Dou Wang ◽

Weiyuan Liang ◽

Liping Liu ◽

Yin Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Near Infrared ◽

Black Phosphorus ◽

Deep Penetration ◽

Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

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