scholarly journals Accelerated optimisation of chemotherapy dose schedules using fitness inheritance

Author(s):  
Robert Barbour ◽  
David Corne ◽  
John McCall
2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Florence Trivin ◽  
Eveline Boucher ◽  
Elodie Vauléon ◽  
Isabelle Cumin ◽  
Elisabeth Le Prisé ◽  
...  

Objectives. Esophageal carcinoma and cirrhosis have the overlapping etiologic factors.Methods. In a retrospective analysis conducted in 2 Breton institutions we wanted to asses the frequency of this association and the outcome of these patients in a case-control study where each case (cirrhosis and esophageal cancer) was paired with two controls (esophageal cancer).Results. In a 10-year period, we have treated 958 esophageal cancer patients; 26 (2.7%) had a cirrhosis. The same treatments were proposed to the 2 groups; cases received nonsignificantly different radiation and chemotherapy dose than controls. Severe toxicities and deaths were more frequent among the cases. At the end of the treatment 58% of the cases and 67% of the controls were in complete remission; median and 2-year survival were not different between the 2 groups. All 4 Child-Pugh B class patients experienced severe side effects and 2 died during the treatment.Conclusions. This association is surprisingly infrequent in our population! Child-Pugh B patients had a dismal prognosis and a bad tolerance to radiochemotherapy; Child-Pugh A patients have the same tolerance and the same prognosis as controls and the evidence of a well-compensated cirrhosis has not modified our medical options.


Sensors ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 3818
Author(s):  
Raul Fernandez-Fernandez ◽  
Juan Victores ◽  
David Estevez ◽  
Carlos Balaguer

One of the most important challenges of Smart City Applications is to adapt the system to interact with non-expert users. Robot imitation frameworks aim to simplify and reduce times of robot programming by allowing users to program directly through action demonstrations. In classical robot imitation frameworks, actions are modelled using joint or Cartesian space trajectories. They accurately describe actions where geometrical characteristics are relevant, such as fixed trajectories from one pose to another. Other features, such as visual ones, are not always well represented with these pure geometrical approaches. Continuous Goal-Directed Actions (CGDA) is an alternative to these conventional methods, as it encodes actions as changes of any selected feature that can be extracted from the environment. As a consequence of this, the robot joint trajectories for execution must be fully computed to comply with this feature-agnostic encoding. This is achieved using Evolutionary Algorithms (EA), which usually requires too many evaluations to perform this evolution step in the actual robot. The current strategies involve performing evaluations in a simulated environment, transferring only the final joint trajectory to the actual robot. Smart City applications involve working in highly dynamic and complex environments, where having a precise model is not always achievable. Our goal is to study the tractability of performing these evaluations directly in a real-world scenario. Two different approaches to reduce the number of evaluations using EA, are proposed and compared. In the first approach, Particle Swarm Optimization (PSO)-based methods have been studied and compared within the CGDA framework: naïve PSO, Fitness Inheritance PSO (FI-PSO), and Adaptive Fuzzy Fitness Granulation with PSO (AFFG-PSO). The second approach studied the introduction of geometrical and velocity constraints within the CGDA framework. The effects of both approaches were analyzed and compared in the “wax” and “paint” actions, two CGDA commonly studied use cases. Results from this paper depict an important reduction in the number of required evaluations.


2015 ◽  
Vol 39 (1) ◽  
pp. 30-32 ◽  
Author(s):  
Mary-Elizabeth M. Percival ◽  
Bruno C. Medeiros
Keyword(s):  

1991 ◽  
Vol 9 (6) ◽  
pp. 1050-1058 ◽  
Author(s):  
N V Cheung ◽  
G Heller

We examined the efficacy of five commonly used drugs, teniposide (VM26), cisplatin (CDDP), cyclophosphamide (CPM), doxorubicin (DOXO), and vincristine (VCR) in a retrospective analysis of 44 clinical trials of induction chemotherapy for stage IV neuroblastoma patients newly diagnosed at older than 1 year of age. Dose intensity (DI) of each drug was calculated as milligrams per square meter per week. Linear regression analyses showed that the Dls of VM26 and CDDP had the greatest influence on clinical outcomes (ie, proportion of major response, median survival, and median progression-free survival [PFS]), while those of CPM and DOXO were less significant. VCR had no influence on the three clinical end points. Although many protocols extended treatment to more than 1 year, none of these end points correlated positively with the duration of therapy. Twenty-one weeks appeared adequate for achieving superior response, median survival, and median PFS. These results suggest that maximal dose intensification of selective drugs over a short duration may improve the outcome of patients with poor-risk neuroblastoma.


2019 ◽  
Vol 26 (3) ◽  
pp. 747-753 ◽  
Author(s):  
Dimitra Ioanna Lampropoulou ◽  
Konstantinos Laschos ◽  
Anna-Lea Amylidi ◽  
Ariadni Angelaki ◽  
Nikolaos Soupos ◽  
...  

Fluoropyrimidine-based regimens are among the most commonly used chemotherapy combinations for the treatment of solid tumors. Several genetic polymorphisms that are implicated with fluoropyrimidine anabolism and catabolism have been associated with the development of life-threatening toxicities. Uridine triacetate is an FDA-approved antidote for 5-fluorouracil or capecitabine overdose and early-onset, life-threatening toxicity within 96 h of last chemotherapy dose. To date, it is not accessible for Greek patients as per the current summary of product characteristic's time restrictions. We report and discuss the course and outcome of capecitabine toxicity in a 66-year-old female colorectal cancer patient with heterozygous dihydropyrimidine dehydrogenase deficiency. This paper highlights the difficulty in timely access of this lifesaving medication for Greek and possibly other European patients.


1984 ◽  
Vol 2 (1) ◽  
pp. 21-27 ◽  
Author(s):  
M E Lippman ◽  
A S Lichter ◽  
B K Edwards ◽  
C R Gorrell ◽  
T d'Angelo ◽  
...  

The impact of primary irradiation of localized breast cancer on the ability to administer Adriamycin-cytoxan adjuvant chemotherapy to patients with stage II breast cancer was examined. Patients were prospectively randomized to receive either irradiation or mastectomy as local therapy and did not differ with respect to other prognostic variables that might influence tolerance to chemotherapy. All of the patients received chemotherapy dose escalations (or reductions) until maximal tolerated drug doses were established. Patients receiving irradiation had minimally greater myelosuppression which was nearly totally explainable by lymphopenia. Irradiated patients required dose reduction nearly twice as often as mastectomy patients although commonly their dose could be reescalated. Patients managed with radiotherapy received slightly less drug than patients treated with mastectomy when treated to an identical degree of bone marrow suppression. The primary management of breast cancer by irradiation does not induce substantial changes in the ability of patients to tolerate adjuvant chemotherapy.


Blood ◽  
1996 ◽  
Vol 88 (9) ◽  
pp. 3363-3370 ◽  
Author(s):  
A Grossmann ◽  
J Lenox ◽  
TA Deisher ◽  
HP Ren ◽  
JM Humes ◽  
...  

Severe suppression of the hematopoietic system is a major factor in limiting chemotherapy dose escalation. To determine whether a combination of human recombinant granulocyte colony-stimulating factor (G-CSF) and thrombopoietin (TPO) would alter recovery of platelets, red blood cells (RBCs), or neutrophils after myeloablative therapy, myelosuppressed mice were treated with sc injections of TPO (90 micrograms/kg), G-CSF (250 micrograms/kg). TPO plus G-CSF or vehicle and complete blood counts were measured. Marrow and spleen cells were obtained at various times and assayed for erythroid, myeloid, and megakaryocytic progenitors. The prolonged neutropenia in vehicle controls (14 days) was significantly shortened in mice treated with G-CSF or TPO for 14 days. The combination of TPO plus G-CSF further reduced the duration of neutropenia. TPO and TPO plus G-CSF treatments also significantly shortened thrombocytopenia compared to vehicle. Recovery of RBCs was also enhanced in mice treated with either G-CSF or TPO, or the combination. Furthermore, treatment with G-CSF and/or TPO hastened myeloid, erythroid, and megakaryocyte progenitor recovery compared to vehicle controls. These results show that the combination of TPO plus G-CSF acts synergistically to accelerate neutrophil recovery in myelosuppressed mice and does not compromise the platelet or RBC response to TPO therapy.


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