A 180 MHz direct access read 4.6Mb embedded flash in 90nm technology operating under wide range power supply from 2.1V to 3.6V

The COVID-19 pandemic is still active around the globe despite the newly introduced vaccines. Hence, finding effective medications or repurposing available ones could offer great help during this serious situation. During our anti-COVID-19 investigation of microbial natural products (MNPs), we came across α-rubromycin, an antibiotic derived from Streptomyces collinus ATCC19743, which was able to suppress the catalytic activity (IC50 = 5.4 µM and Ki = 3.22 µM) of one of the viral key enzymes (i.e., MPro). However, it showed high cytotoxicity toward normal human fibroblasts (CC50 = 16.7 µM). To reduce the cytotoxicity of this microbial metabolite, we utilized a number of in silico tools (ensemble docking, molecular dynamics simulation, binding free energy calculation) to propose a novel scaffold having the main pharmacophoric features to inhibit MPro with better drug-like properties and reduced/minimal toxicity. Nevertheless, reaching this novel scaffold synthetically is a time-consuming process, particularly at this critical time. Instead, this scaffold was used as a template to explore similar molecules among the FDA-approved medications that share its main pharmacophoric features with the aid of pharmacophore-based virtual screening software. As a result, cromoglicic acid (aka cromolyn) was found to be the best hit, which, upon in vitro MPro testing, was 4.5 times more potent (IC50 = 1.1 µM and Ki = 0.68 µM) than α-rubromycin, with minimal cytotoxicity toward normal human fibroblasts (CC50 > 100 µM). This report highlights the potential of MNPs in providing unprecedented scaffolds with a wide range of therapeutic efficacy. It also revealed the importance of cheminformatics tools in speeding up the drug discovery process, which is extremely important in such a critical situation.

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Encouraging millennials to collaborate and learn on the job

Strategic HR Review ◽

10.1108/shr-06-2015-0042 ◽

2015 ◽

Vol 14 (4) ◽

pp. 118-123 ◽

Cited By ~ 10

Author(s):

Lauren Trees

Keyword(s):

Knowledge Management ◽

Best Practices ◽

Social Networking ◽

Age Groups ◽

Lessons Learned ◽

Retention Rates ◽

Direct Access ◽

Content Type ◽

Business Outcomes ◽

Wide Range

Purpose – The purpose of this paper is to present enterprise social networking and gamification as two potential tools to help organizations engage Millennial employees in collaboration and learning. Design/methodology/approach – The research provides general descriptions of enterprise social networking and gamification approaches, shares data on adoption of these approaches from APQC’s “2015 Knowledge Management Priorities Data Report” (based on a January 2015 survey of 524 knowledge management professionals) and includes four company examples adapted from APQC’s Connecting People to Content and Transferring and Applying Critical Knowledge best practices studies. The methodology for APQC’s best practices studies involves screening 50 or more organizations with potential best practices in a given research scope area and identifying five or six with proven best practices. APQC then conducts detailed site visits with the selected organizations and publishes case studies based on those site visits. Findings – Enterprise social networking platforms are in place at 50 per cent of organizations, with another 25 per cent planning to implement them by the end of 2015. By providing near-immediate access to information and answers, enterprise social networking helps Millennials learn the ropes at their new workplaces, gives them direct access to more knowledgeable colleagues who can assist and mentor them, and helps them improve their business outcomes by reusing knowledge and lessons learned across projects. Younger workers can also harness the power of social networking to create a sense of belonging and build their reputations in large, dispersed firms, where it is particularly difficult for them to gain visibility. A recent APQC survey indicates that 54 per cent of organizations either currently employ gamification to encourage collaboration or expect to implement it within the next three years. The rush to gamify the enterprise is, at least in part, a reflection of employers’ desire to satisfy Millennials and make them feel connected to a community of co-workers. Although games appeal to a wide range of age groups, Millennials grew up with digital interaction and tend to prefer environments that emphasize teamwork, social learning and frequent feedback – all of which can be delivered through gamification. Originality/value – The value of this paper is to introduce the value of and relationship between enterprise social networking and gamification platforms to human resource (HR) professionals looking to increase engagement and retention rates for Millennial employees.

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A LOW DROPOUT REGULATOR WITH LOW QUIESCENT CURRENT AND HIGH POWER SUPPLY REJECTION OVER WIDE RANGE OF FREQUENCY FOR SOC

Journal of Circuits System and Computers ◽

10.1142/s0218126611007037 ◽

2011 ◽

Vol 20 (01) ◽

pp. 1-13 ◽

Cited By ~ 3

Author(s):

CHENCHANG ZHAN ◽

WING-HUNG KI

Keyword(s):

High Power ◽

Power Supply ◽

Cmos Process ◽

High Loop ◽

Wide Range ◽

Quiescent Current ◽

Low Dropout Regulator ◽

Output Capacitor ◽

Large Output ◽

Supply Rejection

A CMOS low quiescent current low dropout regulator (LDR) with high power supply rejection (PSR) and without large output capacitor is proposed for system-on-chip (SoC) power management applications. By cascoding a power NMOS with the PMOS pass transistor, high PSR over a wide frequency range is achieved. The gate-drive of the cascode NMOS is controlled by an auxiliary LDR that draws only 1 μA from a small charge pump, thus helping in reducing the quiescent current. Adaptive biasing is employed for the multi-stage error amplifier of the core LDR to achieve high loop gain hence high PSR at low frequency, low quiescent current at light load and high bandwidth at heavy load. A prototype of the proposed high-PSR LDR is fabricated using a standard 0.35 μm CMOS process, occupying an active area of 0.066 mm2. The lowest supply voltage is 1.6 V and the preset output voltage is 1.2 V. The maximum load current is 10 mA. The measured worst-case PSR at full load without using large output capacitor is -22.7 dB up to 60 MHz. The line and load regulations are 0.25 mV/V and 0.32 mV/mA, respectively.

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Imperceptible Simplification on Mobile Displays

International Journal of Handheld Computing Research ◽

10.4018/jhcr.2012010103 ◽

2012 ◽

Vol 3 (1) ◽

pp. 37-54 ◽

Cited By ~ 1

Author(s):

Fan Wu ◽

Emmanuel Agu ◽

Clifford Lindsay ◽

Chung-han Chen

Keyword(s):

Mobile Devices ◽

Pareto Distribution ◽

Level Of Detail ◽

Direct Access ◽

Mobile Graphics ◽

Knee Point ◽

Wide Range ◽

System Resources ◽

Battery Energy ◽

Visual Realism

Graphics on mobile devices is becoming popular because untethered computing is convenient and makes workers more productive. Mobile displays have a wide range of resolutions that affect the scene Level-of-Detail (LoD) that users can perceive: smaller displays show less detail, therefore lower resolution meshes and textures are acceptable. Mobile devices frequently have limited battery energy, low memory and disk space. To minimize wasting limited system resources, the authors render mobile graphics scenes at the lowest LoD at which users do not perceive distortion due to simplification. This is called LoD the Point of Imperceptibility (PoI). Increasing the mesh or texture resolution beyond the PoI wastes valuable system resources without increasing perceivable visual realism. The authors propose a perceptual metric that can easily be evaluated to identify the LoD corresponding to a target mobile display’s PoI and accounts for object geometry, lighting and shading. Previous work did not directly compute changes in the PoI due to target screen resolution. The perceptual metric generates a screen-dependent Pareto distribution with a knee point that corresponds to the PoI. We employ wavelets for simplification, which gives direct access to the mesh undulation frequency that we then use to parameterize the CSF curve.

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Power supply for mid-frequency magnetron sputtering with a wide-range control of pulses parameters

Journal of Physics Conference Series ◽

10.1088/1742-6596/1488/1/012003 ◽

2020 ◽

Vol 1488 ◽

pp. 012003 ◽

Cited By ~ 1

Author(s):

V O Oskirko ◽

A Z Zakharov ◽

A A Solovyev ◽

A P Pavlov ◽

S V Rabotkin

Keyword(s):

Magnetron Sputtering ◽

Power Supply ◽

Wide Range

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Study on Topology and Control Strategy of High-Precision and Wide-Range Hybrid Converter for Photovoltaic Cell Simulator

Energies ◽

10.3390/en12010039 ◽

2018 ◽

Vol 12 (1) ◽

pp. 39

Author(s):

Jianfei Zhao ◽

Minqi Hua ◽

Tingzhang Liu ◽

Tao Yu

Keyword(s):

Control Strategy ◽

Power Supply ◽

High Performance ◽

Photovoltaic Cell ◽

Programmable Logic ◽

Motor Simulation ◽

Hybrid Topology ◽

Wide Range ◽

Cell Simulation ◽

And Control

Aiming at the function and technical requirements of high-power photovoltaic cell simulation, high-performance programmable logic power supply and dc motor simulation, a high frequency isolation hybrid topology and control strategy based on current-source/voltage-source converter was studied and proposed. Firstly, according to the performance requirements of photovoltaic cell analog power supply, the control strategy requirements of the high-precision wide-range hybrid topology were proposed. Secondly, the working principle of the new hybrid topology was analyzed. At the same time, the equivalent model of the new hybrid topology was simplified and established, and the overall control strategy of the hybrid topology based on current compensation and sliding mode variable structure was proposed. Finally, simulation and experimental research on the hybrid topology was carried out, and the experimental test of photovoltaic cell simulation was completed. The simulation and experimental results show that the hybrid topology and control strategy proposed in this paper has the characteristics of wide-range output regulation, fast dynamic response, high efficiency and high power factor, and can be used for high performance photovoltaic cell simulation, programmable logic power supply and DC motor simulation.

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Hydrate and Wax Prevention in Flowlines by Electrical Heating

Volume 2: Integrity and Corrosion; Offshore Issues; Pipeline Automation and Measurement; Rotating Equipment ◽

10.1115/ipc2000-229 ◽

2000 ◽

Author(s):

Jens Kristian Lervik ◽

Harald Kulbotten ◽

Gunnar Klevjer ◽

Øyvind Iversen

Keyword(s):

Power Supply ◽

Hydrate Formation ◽

Magnetic Characteristic ◽

Heating System ◽

Electrical Heating ◽

Oil Companies ◽

Direct Heating ◽

The North ◽

Wide Range ◽

The Difference

Traditional chemical treatment methods have considerable operation costs and represent a risk to the environment. Since 1987 Norwegian oil companies have been investigating alternative electrical heating methods for prevention of hydrate and wax plugs. A joint industry project ‘Concept Verification – Direct Heating of Oil & Gas Pipelines’ was initiated in 1996 and terminated in October 1999. During this work an electrical heating system was proved to be feasible on several fields in the North Sea. It will be installed on 7 flowlines of 13% Chromium (Crl3) with lengths between 6 km and 16 km. Electrical heating is used to maintain or raise the thermally insulated steel pipe temperature above the critical value for hydrate formation (typically 15–25 °C) or wax formation (typically 20–40°C). A single-phase power supply for the heating system is based on commercial components and connected to the platform power supply. The qualification work for the direct heating system has included full scale testing for single and parallel pipes, end termination at the template, bypass of a template and aspects concerning corrosion control. The rating of the system is dependent on the magnetic and electrical characteristics of the steel material. Such data is not commonly available. Measurements performed during the qualification program confirm that the magnetic characteristic may vary within a wide range for a specific steel quality and that mechanical stress and heat treatment can effect the magnetic characteristic. The difference in magnetic characteristic of individual Crl3 pipes results in variation of the pipe temperature and problems concerning differential pressure during melting. The problem can be handled by dividing the pipeline into a number of sections, each with a limited variation of the magnetic characteristic, thus keeping the temperature for the whole pipeline within acceptable limits. As a part of the pipe specification both electrical and magnetic characteristic should be available. These data can be determined by measuring arrangements in the production line of the mill. Measures to limit the variation of magnetic characteristic should be discussed.

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High-Precision Noncontact Guided Wave Tomographic Imaging of Plate Structures Using a DHB Algorithm

Applied Sciences ◽

10.3390/app10124360 ◽

2020 ◽

Vol 10 (12) ◽

pp. 4360

Author(s):

Junpil Park ◽

Jaesun Lee ◽

Zong Le ◽

Younho Cho

Keyword(s):

Nuclear Power ◽

Power Plants ◽

Detection Efficiency ◽

Detection System ◽

Automatic Detection ◽

Guided Wave ◽

Direct Access ◽

Experimental Conditions ◽

Plate Structures ◽

Wide Range

The safety diagnostic inspection of large plate structures, such as nuclear power plant containment liner plates and aircraft wings, is an important issue directly related to the safety of life. This research intends to present a more quantitative defect imaging in the structural health monitoring (SHM) technique by using a wide range of diagnostic techniques using guided ultrasound. A noncontact detection system was applied to compensate for such difficulties because direct access inspection is not possible for high-temperature and massive areas such as nuclear power plants and aircraft. Noncontact systems use unstable pulse laser and air-coupled transducers. Automatic detection systems were built to increase inspection speed and precision and the signal was measured. In addition, a new Difference Hilbert Back Projection (DHB) algorithm that can replace the reconstruction algorithm for the probabilistic inspection of damage (RAPID) algorithm used for imaging defects has been successfully applied to quantitative imaging of plate structure defects. Using an automatic detection system, the precision and detection efficiency of data collection has been greatly improved, and the same results can be obtained by reducing errors in experimental conditions that can occur in repeated experiments. Defects were made in two specimens, and comparative analysis was performed to see if each algorithm can quantitatively represent defects in multiple defects. The new DHB algorithm presented the possibility of observing and predicting the growth direction of defects through the continuous monitoring system.

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New Control Strategy for High-Frequency Digital Inverter Power Supply

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.772.443 ◽

2013 ◽

Vol 772 ◽

pp. 443-447

Author(s):

Yi Wang Wang

Keyword(s):

Induction Heating ◽

Control Strategy ◽

Power Supply ◽

High Frequency ◽

Effective Control ◽

Strong Nonlinearity ◽

Wide Range ◽

Inverter Power Supply ◽

Control Technologies ◽

High Frequency Induction

The inverter power supply system has strong nonlinearity and parameter variability, especially in the non-linear loads, conventional control technology is difficult to achieve effective control and get the ideal control effect. Aiming at the control requirements of single-phase high-frequency induction heating inverter supply power control applications, uses a novel multiple and composite control technologies to achieve rapid power modulation control of inverter. The components and design principles of proposed control system were introduced in detail. The inverter power system model based on the new control strategy has been built, and inverter prototype used for high-frequency induction heating was designed. The experimental results show that the proposed control method to obtain better dynamic characteristics than the conventional control technologies, and has good advantages of system steady-state accuracy, robustness and control qualities, which has wide range of application.

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