Validation of the midface volume deficit scale using a new photo‐guideline in the Asian population

Human leukocyte antigen (HLA) loci are highly polymorphic and determine differential features of the immune response in subjects from different regions. HLA genes have been proposed to determine genetic susceptibility to several diseases, particularly to viral infections. Moreover, it has been suggested that each ethnic group could have a different specificity of T-lymphocyte reactivity to the same viral infections. In this review, we analyzed the distribution of HLA types in countries of the Asian, European and North African region. Also, we studied the relation between these HLA polymorphisms and susceptibility to infection by the coronavirus. Our findings indicated that homozygosity would increase susceptibility to viral infections and, in some cases, to coronavirus infection. HLA types showing higher susceptibility were reported in Asian population, including China, Singapore, and Taiwan. In contrast, lower susceptibility HLA variants were detected among African populations, some Asian populations, and Mediterranean populations. The presented evidence along with the spread pattern of COVID-19 infection suggests that HLA genetic variants might be related to its infection susceptibility and severity. The investigation of HLA genetic variants distribution would be a useful tool to predict different populations’ susceptibility to viral infections.

Identification of High-risk Patients for Implantable Cardioverter–Defibrillator Therapy in Asia

Asia Pacific Cardiology ◽

10.15420/apc.2011:3:1:77 ◽

2011 ◽

Vol 3 (1) ◽

pp. 77

Author(s):

Cyril YK Ko ◽

Jeffrey WH Fung ◽

◽

Keyword(s):

Heart Disease ◽

Implantable Cardioverter Defibrillator ◽

Asian Population ◽

Structural Heart Disease ◽

Medical Problem ◽

Western World ◽

Asian Countries ◽

Cardioverter Defibrillator ◽

Asian Patients ◽

Risk Patients

Sudden cardiac death (SCD) is a serious medical problem worldwide. Multiple landmark studies have demonstrated the benefit of implantable cardioverter–defibrillator (ICD) therapy in preventing SCD in at-risk patients. Although the data available in Asia are limited, the disease pattern seems to be different from that in the western world. The Asian population seems to have a lower incidence of SCD. Coronary heart disease, which is the major underlying cause of SCD in the west, may play a less important role in Asian countries. In addition, non-structural heart disease seems to be a more prevalent cause of SCD in Asia. It is thus questionable whether the results of ICD trials can be applied directly to Asian countries, as most of these trials seldom recruited Asian patients. This article will review SCD in Asia, focusing on the epidemiology and risk factors for SCD in Asia and highlighting some unique features that may be different from those seen in the western world.

PORT-SITE METASTASES AFTER LAPAROSCOPIC SURGERY FOR GYNAECOLOGICAL MALIGNANCIES IN A SOUTHEAST ASIAN POPULATION

10.26226/morressier.5770e29dd462b80290b4c428 ◽

2016 ◽

Author(s):

Alexander Chuang

Keyword(s):

Laparoscopic Surgery ◽

Asian Population ◽

Southeast Asian ◽

Port Site ◽

Southeast Asian Population ◽

Port Site Metastases ◽

Gynaecological Malignancies

Incidence of Down's Syndrome by Maternal Age of Asian Population

SSRN Electronic Journal ◽

10.2139/ssrn.3566180 ◽

2020 ◽

Author(s):

Song Yi ◽

Jieping Song ◽

Feng Liu ◽

Xu Liu ◽

Chengcheng Zhang ◽

...

Keyword(s):

Maternal Age ◽

Down's Syndrome ◽

Asian Population ◽

Down’S Syndrome

The GSTM1 and GSTT1 Null Genotypes Increase the Risk for Type 2 Diabetes Mellitus and the Subsequent Development of Diabetic Complications: A Meta-analysis

Current Diabetes Reviews ◽

10.2174/1573399814666171215120228 ◽

2018 ◽

Vol 15 (1) ◽

pp. 31-43 ◽

Cited By ~ 6

Author(s):

Sayantan Nath ◽

Sambuddha Das ◽

Aditi Bhowmik ◽

Sankar Kumar Ghosh ◽

Yashmin Choudhury

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Meta Analysis ◽

Subsequent Development ◽

Asian Population ◽

Gstm1 Null Genotype ◽

Increased Risk

Background:Studies pertaining to association of GSTM1 and GSTT1 null genotypes with risk of T2DM and its complications were often inconclusive, thus spurring the present study.Methods:Meta-analysis of 25 studies for evaluating the role of GSTM1/GSTT1 null polymorphisms in determining the risk for T2DM and 17 studies for evaluating the role of GSTM1/GSTT1 null polymorphisms in development of T2DM related complications were conducted.Results:Our study revealed an association between GSTM1 and GSTT1 null polymorphism with T2DM (GSTM1; OR=1.37;95% CI =1.10-1.70 and GSTT1; OR=1.29;95% CI =1.04-1.61) with an amplified risk of 2.02 fold for combined GSTM1-GSTT1 null genotypes. Furthermore, the GSTT1 null (OR=1.56;95%CI=1.38-1.77) and combined GSTM1-GSTT1 null genotypes (OR=1.91;95%CI=1.25- 2.94) increased the risk for development of T2DM related complications, but not the GSTM1 null genotype. Stratified analyses based on ethnicity revealed GSTM1 and GSTT1 null genotypes increase the risk for T2DM in both Caucasians and Asians, with Asians showing much higher risk of T2DM complications than Caucasians for the same. </P><P> Discussion: GSTM1, GSTT1 and combined GSTM1-GSTT1 null polymorphism may be associated with increased risk for T2DM; while GSTT1 and combined GSTM1-GSTT1 null polymorphism may increase the risk of subsequent development of T2DM complications with Asian population carrying an amplified risk for the polymorphism.Conclusion:Thus GSTM1 and GSTT1 null genotypes increases the risk for Type 2 diabetes mellitus alone, in combination or with regards to ethnicity.

Fibroblast Growth Factor 20 Gene Polymorphism in Parkinson’s Disease in Asian Population: A Meta-Analysis

Genes ◽

10.3390/genes12050674 ◽

2021 ◽

Vol 12 (5) ◽

pp. 674

Author(s):

Han-Lin Chiang ◽

Yih-Ru Wu ◽

Yi-Chun Chen ◽

Hon-Chung Fung ◽

Chiung-Mei Chen

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Meta Analysis ◽

Lewy Bodies ◽

Asian Population ◽

Protective Role ◽

Lewy Neurites ◽

Chinese Populations ◽

Study Results

Parkinson’s disease (PD) is a neurodegenerative disease with the pathological hallmark of Lewy bodies and Lewy neurites composed of α-synuclein. The SNP rs591323 is one of the risk loci located near the FGF20 gene that has been implicated in PD. The variation of FGF20 in the 3′ untranslated region was shown to increase α-synuclein expression. We examined the association of rs591323 with the risk of PD in a Taiwanese population and conducted a meta-analysis, including our study and two other studies from China, to further confirm the role of this SNP in Taiwanese/Chinese populations. A total of 586 patients with PD and 586 health controls (HCs) were included in our study. We found that the minor allele (A) and the AA + GA genotype under the dominant model are significantly less frequent in PD than in controls. The meta-analysis consisted of 1950 patients with PD and 2073 healthy controls from three studies. There was significant association between rs591323 and the risk of PD in the additive (Z = −3.96; p < 0.0001) and the dominant models (Z = −4.01; p < 0.0001). Our study results and the meta-analysis support the possible protective role of the rs591323 A allele in PD in Taiwanese/Chinese populations.

Psoriasis epidemiology screening tool (PEST) is useful for the detection of psoriatic arthritis in the Japanese population

Scientific Reports ◽

10.1038/s41598-021-95620-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Ayako Setoyama ◽

Yu Sawada ◽

Natsuko Saito-Sasaki ◽

Shun Ohmori ◽

Daisuke Omoto ◽

...

Keyword(s):

Psoriatic Arthritis ◽

Screening Tool ◽

Multivariate Analyses ◽

Asian Population ◽

Japanese Patients ◽

Inflammatory Skin Disease ◽

Severe Arthritis ◽

Different Types ◽

Erythematous Skin ◽

Independent Variable

AbstractPsoriasis is a chronic inflammatory skin disease that involves various systemic organs and tissues and is characterized by scaly erythematous skin. Among the different types of psoriasis, psoriatic arthritis (PsA) is frequently reported, and occasionally develops into severe arthritis leading to joint dysfunction. There are various tools, especially questionnaires, to identify the presence of PsA in European and American populations; however, little is known about the utility of these tools in the Asian population. In this study, we investigated the utility of a representative tool, the psoriasis epidemiology screening tool (PEST) questionnaire, to identify PsA among Japanese patients with psoriasis. A total of 143 patients with psoriasis were enrolled in this study. Among them, 29 patients were diagnosed with PsA. The frequency of PsA was significantly increased in patients with PEST scores > 3, with a sensitivity of 93.1% and a specificity of 78.9%. Among the questions in the PEST questionnaire, “Have you ever had a swollen joint?” showed the highest frequency to answer “Yes” among patients with PsA. Univariate and multivariate analyses revealed that high PEST scores (> 3) was an independent variable in PsA patients. Taken together, our study suggests that the PEST questionnaire is a useful tool to identify PsA among Japanese patients with psoriasis.

Long-term outcomes after renal denervation in an Asian population: results from the Global SYMPLICITY Registry in South Korea (GSR Korea)

Hypertension Research ◽

10.1038/s41440-021-00683-5 ◽

2021 ◽

Author(s):

Byeong-Keuk Kim ◽

Hyo-Soo Kim ◽

Seung-Jung Park ◽

Chang Gyu Park ◽

Ki Bae Seung ◽

...

Keyword(s):

South Korea ◽

Renal Denervation ◽

Asian Population ◽

Long Term Outcomes

The Diagnosis and Treatment of Lichen Sclerosus and Bulbous Urethral Squamous Cell Carcinoma: A Case Report

American Journal of Men s Health ◽

10.1177/1557988320982710 ◽

2020 ◽

Vol 14 (6) ◽

pp. 155798832098271

Author(s):

Jun Wang ◽

Wei Zhang ◽

Xiaodong Li

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Radiation Treatment ◽

Lichen Sclerosus ◽

Asian Population ◽

Perineal Wound ◽

Perineal Abscess ◽

Penile Squamous Cell Carcinoma

Lichen sclerosus (LS) is a rare disease with malignant potential and has been identified by the European Society of Urology Guidelines as a risk factor for penile squamous cell carcinoma (SCC) cancer. LS combined with urethral squamous cell carcinoma (USCC) is extremely rare. There has been only one case report of this combination in China over the last decade. The prevalence of this combination in East Asian population is unclear. In this report, a 49-year-old patient with the presence of LS, perineal masses, and abscesses was hospitalized. He underwent anti-infectious therapy, meatotomy, perineal abscess incision, and drainage and debridement of the perineal wound. USCC was diagnosed following a series of biopsies and treated with radiation therapy. The patient remains well and alive with no recurrence of USCC 13 months after radiation treatment.