scholarly journals Conditional knockout of retinal determination genes in differentiating cells inDrosophila

FEBS Journal ◽  
2016 ◽  
Vol 283 (15) ◽  
pp. 2754-2766 ◽  
Author(s):  
Meng Jin ◽  
Aiden Eblimit ◽  
Merlyn Pulikkathara ◽  
Stuart Corr ◽  
Rui Chen ◽  
...  
Keyword(s):  
Conditional Knockout ◽  
Retinal Determination ◽  
Retinal Determination Genes

scholarly journals Retinal determination genes coordinate neuroepithelial specification and neurogenesis modes in theDrosophilaoptic lobe

Development ◽  
2016 ◽  
Vol 143 (13) ◽  
pp. 2431-2442 ◽  
Author(s):  
Holger Apitz ◽  
Iris Salecker
Keyword(s):  
Retinal Determination ◽  
Retinal Determination Genes

scholarly journals Retinal determination genes function along with cell-cell signals to regulate Drosophila eye development

BioEssays ◽  
2011 ◽  
Vol 33 (7) ◽  
pp. 538-546 ◽  
Author(s):  
Nicholas E. Baker ◽  
Lucy C. Firth
Keyword(s):  
Eye Development ◽  
Retinal Determination ◽  
Drosophila Eye ◽  
Retinal Determination Genes ◽  
Cell Cell ◽  
Cell Signals

scholarly journals Retinal determination genes as targets and possible effectors of extracellular signals

2009 ◽  
Vol 327 (2) ◽  
pp. 366-375 ◽  
Author(s):  
Lucy C. Firth ◽  
Nicholas E. Baker
Keyword(s):  
Extracellular Signals ◽  
Retinal Determination ◽  
Retinal Determination Genes

Pharmaceutical and Biotechnological Applications of Transgenic Technology

2018 ◽  
Vol 11 (4) ◽  
pp. 4145-4153
Author(s):  
D Samba Reddy ◽  
Tina Reddy
Keyword(s):  
Mammalian Species ◽  
Genetic Diseases ◽  
Transgenic Animals ◽  
Transgenic Animal ◽  
Pharmaceutical Products ◽  
Conditional Knockout ◽  
Knock Out ◽  
Transgenic Lines ◽  
Health And Disease ◽  
Or Genes

A transgenic animal is a genetically modified species in which researchers have modified an existing gene or genes by genetic engineering techniques. Genetic modification involves the mutation, insertion, or deletion of genes. Mouse is the most widely used mammalian species for creating transgenic lines. There are two types of transgenic animals: (i) gene deleted (“knock-out”) and (ii) gene overexpressed (“knock-in”). The loss or gain of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable characteristics. Knockout mice are key animal models for studying the role of genes which have been sequenced but whose functions have not been determined.  They include constitutive knockouts (gene deleted since birth) and conditional knockout (gene turned off later after birth).  The first knockout mouse was created in 1989 by Mario Capecchi, Martin Evans, and Oliver Smithies, for which they were awarded the 2007 Nobel Prize in Physiology or Medicine.  Transgenic mouse models have revolutionized the biomedical research and provided a power tool for understanding health and disease. Transgenic animals have been created for bulk production of biotechnology and pharmaceutical products.  In 2009, the FDA approved the first human biological drug ATryn, an anticoagulant extracted from the transgenic goat's milk. The recently discovered CRISPER gene editing technology is providing new frontiers in correcting abnormal genes and hopefully provide cures for genetic diseases in the future.    

Ankyrin-G heterozygous conditional knockout mice display increased sensitivity to social defeat stress

2021 ◽  
Author(s):  
Zachary A. Cordner ◽  
Seva G. Khambadkone ◽  
Shanshan Zhu ◽  
Justin Bai ◽  
Rasadokht Forati ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Social Defeat ◽  
Conditional Knockout ◽  
Social Defeat Stress ◽  
Conditional Knockout Mice ◽  
Ankyrin G ◽  
Increased Sensitivity

Conditional knockout of the PDK‐1 gene in osteoblasts affects osteoblast differentiation and bone formation

2020 ◽  
Author(s):  
Yiguang Bai ◽  
Qiong Zhang ◽  
Qiaoling Chen ◽  
Quan Zhou ◽  
Yanan Zhang ◽  
...  
Keyword(s):  
Bone Formation ◽  
Osteoblast Differentiation ◽  
Conditional Knockout
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