Human Papillomavirus Infection: Low-Risk and High-Risk Genotypes in Women in Catania, Sicily

2009 ◽  
Vol 19 (6) ◽  
pp. 1094-1098 ◽  
Author(s):  
Antonella Agodi ◽  
Martina Barchitta ◽  
Nadia La Rosa ◽  
Rosalba Cipresso ◽  
Mariella Guarnaccia ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Large Scale ◽  
Hpv Infection ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Screening Programs ◽  
Hpv Prevalence ◽  
Age Related ◽  
Related Pattern

Introduction:Human papillomavirus (HPV) infection has been strongly and consistently associated with cervical carcinoma and its cytologic precursors, such as squamous intraepithelial lesions. A cross-sectional survey was conducted with the aim of estimating the prevalence of cervical HPV infection in women attending a service of colposcopy in Catania, Eastern Sicily, Italy.Methods:The prevalence of type-specific HPV was examined in women with negative colposcopic results and cervical intraepithelial neoplasia grades 1, 2, or 3, with the aim of providing some cross-sectional figures on the local epidemiology of HPV infection.Results:Human papillomavirus DNA was found in 62.1% of women with negative colposcopic results and in 73.2% with positive colposcopic results. Among high-risk types, a predominance of HPV-16 (51.5% of infected women) was shown followed by HPV-56 (29.7%). An age-related pattern was described with a peak in HPV prevalence among women younger than 25 years, followed by the expected decline in prevalence and a second characteristic peak in the perimenopausal or postmenopausal years, useful to design future control strategies.Conclusions:The age-related pattern of HPV prevalence and the presence of uncommon high-risk genotypes and their role in the pathogenesis of cervical cancer need to be addressed by specific epidemiologic studies to design large-scale screening programs and multivalent vaccine strategies.

Prevalence and sociodemographic correlates of cervicovaginal human papillomavirus (HPV) carriage in a cross-sectional, multiethnic, community-based female Asian population

2017 ◽  
Vol 94 (4) ◽  
pp. 277-283 ◽  
Author(s):  
Su Pei Khoo ◽  
Nirmala Bhoo-Pathy ◽  
Siew Hwei Yap ◽  
Mohd Khairul Anwar Shafii ◽  
Nazrilla Hairizan Nasir ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Cancer Prevention ◽  
Hpv Vaccination ◽  
Hpv Infection ◽  
Cervical Cancer Prevention ◽  
Community Based ◽  
Cross Sectional ◽  
Hpv Prevalence

ObjectivesCervical cancer is a largely preventable disease, and the strategic implementation of a cervical cancer prevention programme is partly dependent on the impact of human papillomavirus (HPV) infection interpreted within the context of the country’s sociodemographic attributes. The objective of this study is to determine the prevalence of cervicovaginal HPV infection among a healthy, community-based, multiethnic Malaysian population. The HPV prevalence was subsequently correlated to the individual’s sociodemographics and sexual/reproductive history. Of significance, the observed prevalence captured was in a birth cohort not included in the national school-based HPV vaccination programme.MethodsThis was a cross-sectional study where 1293 healthy women aged between 18 and 60 years were recruited via convenience sampling from five community-based clinics in Selangor, Malaysia. Cervicovaginal self-samples were obtained and DNA was extracted for HPV detection and genotyping. A comprehensive questionnaire was administered to determine the sociodemographics and behavioural patterns of participants.ResultsThe median age at enrolment was 37 years old (IQR: 30–47). In total, 86/1190 (7.2%) of the samples collected were positive for HPV infection, with the highest HPV prevalence (11.9%) detected in the subgroup of 18–24 years old. The top three most prevalent HPV genotypes were HPV 16, 52 and 58. The independent risk factors associated with higher rates of HPV infection included Indian ethnicity, widowed status and women with partners who are away from home for long periods and/or has another sexual partner.ConclusionsThe overall prevalence of HPV infection in this Malaysian multiethnic population was 7.2%, with 6.5% being high-risk genotypes. The top three most common high-risk HPV types were HPV 16, 52 and 58. This information is important for the planning of primary (HPV vaccination) and secondary (screening) cervical cancer prevention programmes in Malaysia.

Carriage of high-risk human papillomavirus infection in male subjects in Ouagadougou, Burkina Faso

2019 ◽  
Author(s):  
Sya Forazoun Bienvenue Tamini ◽  
Theodora Mahoukèdè Zohoncon ◽  
Serge Theophile Soubeiga ◽  
Florencia Wendkuuni Djigma ◽  
Ina Marie Angele Traore ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Burkina Faso ◽  
Public Health Problem ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Multiple Infections ◽  
Cross Sectional ◽  
High Risk Hpv ◽  
Male Subjects

Abstract Background Human papillomavirus (HPV) infection is a public health problem in Africa because of its frequency and its various consequences in both men and women. In Burkina Faso, there is little data on the carriage of HPV infection in male subjects. This study aimed to determine the carriage of HPV infection in male subjects in Ouagadougou, Burkina Faso.Methods This was a cross-sectional study conducted from December 2015 to September 2016. During this study period, a total of 124 male subjects who gave informed consent were recruited as part of a fertility assessment. Semen samples were analyzed by Real- Time PCR using Real TM Quant High Risk Screen HPV kit to detect 14 high-risk HPV genotypes. The Chi square test was used for comparisons.Results Of the 124 male subjects, 22 were positive for at least one high-risk HPV, with a prevalence of 17.7%. HPV 56 was the most represented genotype with a frequency of 20%, followed by HPV 39 (11%) and HPV 68 (11%), HPV 16 (8%). The genotypes HPV 18, HPV33, HPV35, HPV51 and HPV52 also had the same frequency of 6% each and the HPV 31, 45, 59 and 66 had the same frequency of 3% each. Of the 22 positive cases, 10 were multiple infections. Spermocytogram of patients showed at least one abnormality in 87.9% of cases. Necrozoospermia and oligozoospermia were the most abnormalities observed with 42% and 40% respectively followed by asthenospermia (18%); teratozoospermia (16%) and azoospermia (14%).Conclusion This study showed that like women, men are infected by HPV with a relatively high prevalence. In addition, the predominant genotypes in the male subjects of this study are not those targeted by the HPV vaccines available in our countries. Hence the need to reinforce the strategies for controlling HPV infection and HPV prophylactic vaccination for young boys.

scholarly journals Challenges of Human Papillomavirus Infection and Associated Diseases in Low-Resource Countries

2018 ◽  
Vol 142 (6) ◽  
pp. 696-699 ◽  
Author(s):  
Michael Chukwugoziem Nweke ◽  
Clement Abu Okolo ◽  
Yara Daous ◽  
Olukemi Ayotunde Esan
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Developed Countries ◽  
Hpv Infection ◽  
Sub Saharan Africa ◽  
Morbidity And Mortality ◽  
Infection Prevalence ◽  
Screening Programs ◽  
Low Resource ◽  
Sub Saharan

Context.— The prevalence of human papillomavirus (HPV) infection varies worldwide. The high-risk viruses are usually associated with cancers of the cervix, vagina, and vulva in women, cancer of the penis in men, and cancers of the anus, tonsils, oropharynx, and base of the tongue in both sexes. Objectives.— To review literature about the challenges and burden associated with HPV infection in low-resource (ie, developing) countries, focusing on sub-Saharan Africa. To review the prevention, incidence, prevalence, morbidity, and mortality of HPV infections in sub-Saharan Africa. To review the therapy and management of HPV infections in low-resource countries in comparison to developed countries. Data Sources.— Peer-reviewed literature and experience of some of the authors. Conclusions.— Sub-Saharan Africa has high HPV infection prevalence rates, with predominance of high-risk subtypes 16, 18, and 45. The difficulty of access to health care has led to higher morbidity and mortality related to HPV-related cancers. Improvement in screening programs will help in monitoring the spread of HPV infections. Survival studies can be more informative if reliable cancer registries are improved. HPV vaccination is not yet widely available and this may be the key to curtailing the spread of HPV infections in resource-poor countries.

scholarly journals Differences in Factors Associated With High- and Low-Risk Oral Human Papillomavirus Genotypes in Men

2020 ◽  
Author(s):  
Deepti Bettampadi ◽  
Brittney Dickey ◽  
Martha Abrahamsen ◽  
Bradley Sirak ◽  
Maria Luiza Baggio ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Sexual Behaviors ◽  
Hpv Infection ◽  
Low Risk ◽  
Factors Associated ◽  
Hpv Prevalence ◽  
Oral Hpv ◽  
Multivariable Models ◽  
High Risk Hpv

Abstract Background Human papillomavirus (HPV) causes oral warts and oropharyngeal cancer (OPC). Human papillomavirus-attributable OPC incidence among men is significantly increasing worldwide, yet few studies have reported oral HPV across multiple countries or examined factors associated with low- and high-risk HPV separately. Methods Oral gargles from 3095 men in the multinational HPV Infection in Men (HIM) Study were HPV genotyped. Multivariable models assessed factors independently associated with high-risk and low-risk HPV prevalence. Results The prevalence of high-risk and low-risk HPV was 6.0% and 2.8%, respectively. Greater number of sexual partners was only associated with high-risk HPV (1.88; 95% confidence interval [CI], 1.22–2.90) prevalence. In multivariable models, residing in Mexico (1.66; 95% CI, 1.15–2.40) and smoking (1.66; 95% CI, 1.13–2.44) were significantly associated with high-risk HPV, and history of consistent gum bleeding (2.16; 95% CI, 1.35–3.45) was significantly associated with low-risk HPV. Gender of the sexual partner did not alter the results for either high- or low-risk HPV endpoints. Conclusions Different factors were independently associated with high- and low-risk oral HPV. Oral sexual behaviors were associated with high-risk HPV, and oral health was associated with low-risk HPV. High-risk HPV prevalence differed by country of residence, highlighting the need for additional studies in multiple countries.

scholarly journals Prevalence high risk Human Papillomavirus (HPV) in HIV-infected women from Belém, Pará, Amazon region of Brazil: A cross-sectional study

2020 ◽  
Author(s):  
Jacqueline Monteiro ◽  
Ricardo Roberto de Souza Fonseca ◽  
Tuane Ferreira ◽  
Luana Rodrigues ◽  
Andreza Silva ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Transmitted Disease ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
High Risk Hpv

Abstract Background: Human papillomavirus (HPV) is the most common sexually transmitted disease in the world. Several studies have shown a higher prevalence of HPV infection in HIV-infected women. The aim of this study was to determine the prevalence and the genotype diversity of HPV infection in HIV-infected women.Methods: From April 2010 to December 2012 cervical specimens were collected from 169 HIV-infected women who screening for cervical cancer at Reference Unit in Belém. The detection of HPV infection was performed by nested PCR and HPV type was performed using the commercial kit.Results: The prevalence of HPV infection was 63,3%. Of the 47 genotyped samples, 40,4% was found positive for high risk-HPV 16 and 12.8% for high risk-HPV 52. HPV infection was predominant in the group of women with no incidence of cytological abnormalities and more prevalent in women of reproductive age, unmarried, low education level and who used condoms during sexual intercourse. It was observed an association between HPV infection and independent variables, such as condom use, multiple sexual partners and history of sexually transmitted diseases.Conclusions: High-risk types of HPV infection were prevalent in our study. Infection with multiple high-risk HPV genotypes may potentiate the development of cervical cancer in HIV-infected women.

Heterogeneity in the prevalence of high-risk human papillomavirus infection in HIV-negative and HIV-positive men who have sex with men in West Africa

2021 ◽  
Author(s):  
Issifou Yaya ◽  
Véronique Boyer ◽  
Phyllis Amivi Ehlan ◽  
Alou Coulibaly ◽  
Mawuényégan Kouamivi Agboyibor ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
West Africa ◽  
Associated Factors ◽  
Hpv Infection ◽  
Hiv Positive ◽  
Hpv Prevalence ◽  
Study Country ◽  
Sex With Men ◽  
Hiv Negative

Abstract Background Men who have sex with men (MSM) are at high risk of human papillomavirus (HPV) infection. We assessed (i) the prevalence of high-risk HPV (HR-HPV) infection and associated factors, and (ii) the prevalence of vaccine-preventable HPV infections in MSM in Burkina Faso, Côte d’Ivoire, Mali, and Togo. Methods A cross-sectional study was conducted in 2017-2018 among MSM ≥18 years old followed in community-based clinics. HPV infection was investigated in oral and anal samples using the e-BRID system. Factors associated with HR-HPV infection were identified using multivariate logistic regressions. Results Among 631 participants, 425 were HIV-negative and 206 HIV-positive. HR-HPV prevalence ranged from 9.2 to 34.8% in the former, and 33.3 to 71.0% in the latter according to the study country. In multivariate analysis, HIV infection (adjusted odds ratio 3.61, 95% confidence interval 2.48–5.27) and study country (4.73, 2.66–8.43 for Mali; 3.12, 1.68–5.80 for Burkina Faso; 3.51, 1.92–6.42 for Togo) were associated with HR-HPV infection. Other associated factors were low educational level, self-defined homosexual identity and condomless anal sex. The prevalence of infections which can be prevented with bivalent, quadrivalent and nonavalent vaccines was 5.9, 27.1, and 34.6% in HIV-negative participants, and 18.9, 43.7, and 54.9% in HIV-positive participants, respectively. Conclusion HR-HPV prevalence was very heterogeneous between the study countries in both HIV-negative and HIV-positive MSM. Vaccine-preventable HPV infections predominated. Vaccination should be proposed to young MSM to reduce the burden of HPV infection in this vulnerable population and their female partners in West Africa.

scholarly journals Retrospective Analysis of Prevalence of High-risk and Low-risk Human Papillomavirus (HPV) Genotypes in Iranian Women During 2013-2016

2017 ◽  
Vol 2 (4) ◽  
pp. 85-90 ◽  
Author(s):  
Siavash Chalabiani ◽  
Mina Khodadad Nazari ◽  
Mahdi Shabani ◽  
Neda Razavi Davoodi ◽  
Abdolfattah Sarafnejad ◽  
...  
Keyword(s):  
High Risk ◽  
Age Groups ◽  
Hpv Infection ◽  
Low Risk ◽  
Age Group ◽  
Cancer Etiology ◽  
Cross Sectional ◽  
Hpv Dna ◽  
Hpv Prevalence ◽  
Hpv Genotypes

Background and objective: Considering the importance of HPV in cancer etiology, awareness of HPV prevalence and frequency of high-risk genotypes could help improve health care system management. We analyzed HPV prevalence in women forms different provinces of Iran that is the largest sample till now. Material and Methods: In this retrospective cross-sectional study, 2969 outpatient and suspicious women aged 17- 78 referred to Noor pathobiology laboratory from 24 provinces of Iran were studies. DNA extraction and PCR were performed on samples and then HPV genotypes were also determined using hybridization kit. Results: HPV DNA was detected in 29.3% of valid liquid-based samples. Among HPV positive cases, 67.2% and 52.0% accounted for high-risk and low-risk HPV subtypes, respectively. In patients with high-risk HPV types, HPV16 was confirmed as predominate type (30.5%) followed by HPV53 (17.3%) and HPV39 (13.3 %). HPV6 was found as the most common low-risk HPV type with 60.6% frequency rate followed by HPV11 (17.9%) and HPV81 (8.6%) in this age group. It was apparent that age group >25 years accounted the highest frequency of HPV positivity. The prevalence of HPV was significantly different among different age groups (p<0.0001). Conclusion: It can be concluded that HPV infection is currently at a considerable high level in Iran. Looking at the high risk and oncogenic HPV subtypes frequency especially in younger age groups, a concern could be noticed about HPV relevant cancers which can be prevented by commercial and approved HPV vaccines.

scholarly journals ASSOCIATION OF THE PERCEIVED SEVERITY OF THE HUMAN PAPILLOMAVIRUS WITH THE PREVENTIVE INTENTION OF HPV INFECTION IN MALE ADOLESCENTS: A CROSS-SECTIONAL SURVEY

2019 ◽  
Vol 15 (2) ◽  
pp. e47-e57 ◽  
Author(s):  
Hae Won Kim ◽  
Seung Eun Kim ◽  
Hae Young Ahn ◽  
Eun Ju Lee ◽  
Jung Lim Lee ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
School Health ◽  
Hpv Infection ◽  
Sexual Relationships ◽  
Cross Sectional Survey ◽  
Transmitted Infection ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
Male Adolescents ◽  
Preventive Vaccination

Background and objective The human papillomavirus (HPV) infection is usually asymptomatic, may affect both sexes, and is easily transmitted. Providing male adolescents with information about HPV prevention before sexually active state is important. This study was designed to gain a better understanding of the perceptions on HPV severity, knowledge on ways to prevent HPV infection, and influencing factors toward preventive measures in male adolescents. Materials and methods A self-administered questionnaire was completed by students aged 13–17 years from six schools in Seoul and the surrounding metropolitan area, from October to December 2014. A total of 615 male adolescents participated in this cross-sectional survey. Results Only 58 (9.5%) boys had heard of HPV. They perceived HPV infection as a disease more severe in girls. Perceptions of HPV as a sexually transmitted infection (STI) in boys (adjusted odds ratio [AOR] 1.79, 95% confidence interval [CI]: 1.00–3.19, p<0.05) and a cause of cancer in girls (AOR=2.69, 95% CI=1.26–5.84, p<0.05) were associated with the intention to maintain monogamous sexual relationships. Alcohol consumption was associated with the intention of postponing sexual intercourse (AOR=0.53, 95% CI=0.34–0.82, p<0.01) and having a sister was associated with the intention of being vaccinated against HPV (AOR=1.48, 95% CI=1.03–2.13, p<0.05). Conclusions Increasing awareness on the severity of HPV affected the intentions of male adolescents to prevent HPV infection. Efforts should be made to maximize awareness of HPV as a causative agent of cancer and a common STI in both boys and girls. Education materials on the influence of HPV infection and steps to be taken for proactive prevention should be included in school health subjects. Special consideration should be given for the preventive vaccination of male adolescents nationwide.

scholarly journals Prevalence and sociodemographic correlates of anogenital Human Papillomavirus (HPV) carriage in a cross-sectional, multi-ethnic, community-based Asian male population

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245731
Author(s):  
Su Pei Khoo ◽  
Mohd Khairul Anwar Shafii ◽  
Nirmala Bhoo-Pathy ◽  
Siew Hwei Yap ◽  
Shridevi Subramaniam ◽  
...  
Keyword(s):  
High Risk ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Public Health Issue ◽  
Male Population ◽  
Community Based ◽  
Cross Sectional ◽  
Hpv Dna ◽  
Hpv Prevalence ◽  
High Risk Hpv

Background Addressing the burden of HPV-associated diseases among men is increasingly becoming a public health issue. The main objective of this study was to determine HPV prevalence among a healthy community-based Malaysian men. Method This was a cross-sectional study that recruited 503 healthy males from 3 community-based clinics in Selangor, Malaysia. Genital and anal samples were collected from each participant for 14 high risk and 2 low risk HPV DNA detection and genotyping. All participants responded to a set of detailed sociodemographic and sexual behaviour questionnaire. Results The median age at enrolment was 40 years old (IQR: 31–50). The anogenital HPV6/11 prevalence was 3.2% whereas high risk HPV prevalence was 27.1%. The genital HPV prevalence for HPV6/11 was 2.9% while high risk HPV was 18.8%. HPV6/11 prevalence in the anal canal was 1.6% and high risk HPV was 12.7%. HPV 18 was the most prevalent genotype detected in the anogenital area. There was a significant independent association between genital and anal HPV infections. Conclusion Anogenital HPV infection is common among Malaysian men. These findings emphasize the ubiquity of HPV infection and thus the value of population-wide access to HPV prevention.

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