Lactobacillus plantarum and Lactobacillus fermentum alone or in combination regulate intestinal flora composition and systemic immunity to alleviate obesity syndrome in high‐fat diet rat

2017 ◽  
Vol 53 (1) ◽  
pp. 137-146 ◽  
Author(s):  
Xiuliang Li ◽  
Yong Song ◽  
Xiuyan Ma ◽  
Yanyan Zhang ◽  
Xinyang Liu ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
Intestinal Flora ◽  
Lactobacillus Fermentum ◽  
High Fat ◽  
Systemic Immunity ◽  
Obesity Syndrome

scholarly journals Ginkgolide B treatment regulated intestinal flora to improve high-fat diet induced atherosclerosis in ApoE−/− mice

2021 ◽  
Vol 134 ◽  
pp. 111100
Author(s):  
Zhiyang Lv ◽  
Xin Shan ◽  
Qingbo Tu ◽  
Jie Wang ◽  
Jing Chen ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Intestinal Flora ◽  
Ginkgolide B ◽  
High Fat

Lactobacillus plantarum DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways

2020 ◽  
Vol 11 (8) ◽  
pp. 753-766
Author(s):  
A.I. Zaydi ◽  
L.-C. Lew ◽  
Y.-Y. Hor ◽  
M.H. Jaafar ◽  
L.-O. Chuah ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
Cognitive Functions ◽  
High Fat Diet ◽  
Normal Diet ◽  
Sprague Dawley ◽  
Brain Health ◽  
High Fat ◽  
Dietary Strategy ◽  
Apoptosis Pathways ◽  
Insight Into

Aging processes affect the brain in many ways, ranging from cellular to functional levels which lead to cognitive decline and increased oxidative stress. The aim of this study was to investigate the potentials of Lactobacillus plantarum DR7 on brain health including cognitive and memory functions during aging and the impacts of high fat diet during a 12-week period. Male Sprague-Dawley rats were separated into six groups: (1) young animals on normal diet (ND, (2) young animals on a high fat diet (HFD), (3) aged animals on ND, (4) aged animals on HFD, (5) aged animals on HFD and L. plantarum DR7 (109 cfu/day) and (6) aged animals receiving HFD and lovastatin. To induce ageing, all rats in group 3 to 6 were injected sub-cutaneously at 600 mg/kg/day of D-galactose daily. The administration of DR7 has reduced anxiety accompanied by enhanced memory during behavioural assessments in aged-HFD rats (P<0.05). Hippocampal concentration of all three pro-inflammatory cytokines were increased during aging but reduced upon administration of both statin and DR7. Expressions of hippocampal neurotransmitters and apoptosis genes showed reduced expressions of indoleamine dioxygenase and P53 accompanied by increased expression of TPH1 in aged- HFD rats administered with DR7, indicating potential effects of DR7 along the pathways of serotonin and oxidative senescence. This study provided an insight into potentials of L. plantarum DR7 as a prospective dietary strategy to improve cognitive functions during aging. This study provided an insight into potentials of L. plantarum DR7 as a prospective dietary strategy to improve cognitive functions during aging.

Gallotannins and Lactobacillus plantarum WCFS1 Mitigate High‐Fat Diet‐Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice

2019 ◽  
Vol 63 (9) ◽  
pp. 1800937 ◽  
Author(s):  
Chuo Fang ◽  
Hyemee Kim ◽  
Lora Yanagisawa ◽  
William Bennett ◽  
Maritza A. Sirven ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
High Fat ◽  
Gnotobiotic Mice

scholarly journals Saturated hydrogen improves lipid metabolism disorders and dysbacteriosis induced by a high-fat diet

2020 ◽  
Vol 245 (6) ◽  
pp. 512-521 ◽  
Author(s):  
Xiangjie Qiu ◽  
Qiaona Ye ◽  
Mengxing Sun ◽  
Lili Wang ◽  
Yurong Tan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
Metabolic Diseases ◽  
Isocitrate Lyase ◽  
Intestinal Flora ◽  
Glyoxylic Acid ◽  
Density Lipoprotein ◽  
High Fat ◽  
Acid Cycle

Studies have shown that metabolic diseases, such as obesity, are significantly associated with intestinal flora imbalance. The amplification of opportunistic pathogens induced by the glyoxylic acid cycle contributes to intestinal flora imbalance. Promising, though, is that saturated hydrogen can effectively improve the occurrence and development of metabolic diseases, such as obesity. However, the specific mechanism of how saturated hydrogen operates is still not very clear. In this study, after a high-fat diet, the level of total cholesterol, total glyceride, and low-density lipoprotein in the peripheral blood of mice increased, and that of high-density lipoprotein decreased. Intestinal fatty acid metabolism-related gene Apolipoprotein E (ApoE), fatty acid synthase (FAS), intestinal fatty acid-binding protein (I-FAPB), acetyl-CoA carboxylase 1 (ACC1), peroxisome proliferator-activated receptor γ (PPARγ), and stearoyl-CoA desaturase 1 (SCD1) increased significantly. Bacteroides, Bifidobacteria, and Lactobacillus counts in feces decreased considerably, while Enterobacter cloacae increased. The activity of isocitrate lyase in feces increased markedly. Treatment of mice with saturated hydrogen led to decreased total cholesterol, total glyceride, and low-density lipoprotein and increased high-density lipoprotein in the peripheral blood. FAS and I-FAPB gene expression in the small intestine decreased. Bacteroides, Bifidobacteria, and Lactobacillus in feces increased significantly, whereas Enterobacter cloacae decreased. The activity of isocitrate lyase also diminished remarkably. These results suggest that saturated hydrogen could improve intestinal structural integrity and lipid metabolism disorders by inhibiting the glyoxylic acid cycle of the intestinal flora. Impact statement Past studies have shown that hydrogen can improve metabolic disorders, but its mechanism of action remains unclear. It is well known that metabolic diseases, such as obesity, are significantly associated with changes in the intestinal flora. The glyoxylic acid cycle is an essential metabolic pathway in prokaryotes, lower eukaryotes, and plants and could be the portal for mechanisms related to metabolic disorders. Many opportunistic pathogenic bacteria can recycle fatty acids to synthesize sugars and other pathogenic substances using the glyoxylic acid cycle. So, the glyoxylic acid cycle may be involved in intestinal dysbacteriosis under high-fat diet. This study, therefore, seeks to provide the mechanism of how hydrogen improves metabolic diseases and a new basis for the use of hydrogen in the treatment of metabolic disorders.

Sorghum resistant starch reduces adiposity in high-fat diet-induced overweight and obese rats via mechanisms involving adipokines and intestinal flora

2014 ◽  
Vol 26 (1) ◽  
pp. 120-130 ◽  
Author(s):  
Rui-Ling Shen ◽  
Wen-Li Zhang ◽  
Ji-Lin Dong ◽  
Gui-Xing Ren ◽  
Ming Chen
Keyword(s):  
Resistant Starch ◽  
High Fat Diet ◽  
Intestinal Flora ◽  
High Fat ◽  
Obese Rats

Supplementation of Lactobacillus plantarum Improves Markers of Metabolic Dysfunction Induced by a High Fat Diet

2018 ◽  
Vol 17 (8) ◽  
pp. 2790-2802 ◽  
Author(s):  
Alice Martinic ◽  
Javad Barouei ◽  
Zach Bendiks ◽  
Darya Mishchuk ◽  
Dustin D. Heeney ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
Metabolic Dysfunction ◽  
High Fat

scholarly journals Lactobacillus plantarum LMT1-48 exerts anti-obesity effect in high-fat diet-induced obese mice by regulating expression of lipogenic genes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Woo Jin Choi ◽  
Hye Jin Dong ◽  
Hyun Uk Jeong ◽  
Dong Wook Ryu ◽  
Soo Min Song ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Lipogenic Genes
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