Effect of Naloxone on the Pulsatile Secretion of Luteinizing Hormone in Gonadectomized Male and Female Ferrets Before and After Oestradiol Replacement

1990 ◽  
Vol 2 (5) ◽  
pp. 701-705 ◽  
Author(s):  
G. M. Lambert ◽  
M. S. Erskine ◽  
M. J. Baum
Keyword(s):  
Luteinizing Hormone ◽  
Male And Female ◽  
Pulsatile Secretion ◽  
Before And After

The Clinical, Roentgenological and Morphological Effects of an Acute Exposure of Phosgene on the Lungs of Dogs

1971 ◽  
Vol 29 ◽  
pp. 236-237
Author(s):  
R. F. Bils ◽  
W. F. Diller ◽  
F. Huth
Keyword(s):  
Latent Period ◽  
Chemical Industry ◽  
Toxic Substance ◽  
Lung Edema ◽  
X Rays ◽  
Beagle Dogs ◽  
Male And Female ◽  
Morphological Alterations ◽  
Before And After ◽  
Electron Microscopes

Phosgene still plays an important role as a toxic substance in the chemical industry. Thiess (1968) recently reported observations on numerous cases of phosgene poisoning. A serious difficulty in the clinical handling of phosgene poisoning cases is a relatively long latent period, up to 12 hours, with no obvious signs of severity. At about 12 hours heavy lung edema appears suddenly, however changes can be seen in routine X-rays taken after only a few hours' exposure (Diller et al., 1969). This study was undertaken to correlate these early changes seen by the roengenologist with morphological alterations in the lungs seen in the'light and electron microscopes.Forty-two adult male and female Beagle dogs were selected for these exposure experiments. Treated animals were exposed to 94.5-107-5 ppm phosgene for 10 min. in a 15 m3 chamber. Roentgenograms were made of the thorax of each animal before and after exposure, up to 24 hrs.

scholarly journals Spinal Muscular Atrophy after Nusinersen Therapy: Improved Physiology in Pediatric Patients with No Significant Change in Urine, Serum, and Liquor 1H-NMR Metabolomes in Comparison to an Age-Matched, Healthy Cohort

Metabolites ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 206
Author(s):  
Leon Deutsch ◽  
Damjan Osredkar ◽  
Janez Plavec ◽  
Blaž Stres
Keyword(s):  
Machine Learning ◽  
Spinal Muscular Atrophy ◽  
1H Nmr ◽  
Pediatric Patients ◽  
Muscular Atrophy ◽  
Male And Female ◽  
Before And After ◽  
Healthy Cohort ◽  
Males And Females ◽  
Urine Serum

Spinal muscular atrophy (SMA) is a genetically heterogeneous group of rare neuromuscular diseases and was until recently the most common genetic cause of death in children. The effects of 2-month nusinersen therapy on urine, serum, and liquor 1H-NMR metabolomes in SMA males and females were not explored yet, especially not in comparison to the urine 1H-NMR metabolomes of matching male and female cohorts. In this prospective, single-centered study, urine, serum, and liquor samples were collected from 25 male and female pediatric patients with SMA before and after 2 months of nusinersen therapy and urine samples from a matching healthy cohort (n = 125). Nusinersen intrathecal application was the first therapy for the treatment of SMA by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA). Metabolomes were analyzed using targeted metabolomics utilizing 600 MHz 1H-NMR, parametric and nonparametric multivariate statistical analyses, machine learning, and modeling. Medical assessment before and after nusinersen therapy showed significant improvements of movement, posture, and strength according to various medical tests. No significant differences were found in metabolomes before and after nusinersen therapy in urine, serum, and liquor samples using an ensemble of statistical and machine learning approaches. In comparison to a healthy cohort, 1H-NMR metabolomes of SMA patients contained a reduced number and concentration of urine metabolites and differed significantly between males and females as well. Significantly larger data scatter was observed for SMA patients in comparison to matched healthy controls. Machine learning confirmed urinary creatinine as the most significant, distinguishing SMA patients from the healthy cohort. The positive effects of nusinersen therapy clearly preceded or took place devoid of significant rearrangements in the 1H-NMR metabolomic makeup of serum, urine, and liquor. Urine creatinine was successful at distinguishing SMA patients from the matched healthy cohort, which is a simple systemic novelty linking creatinine and SMA to the physiology of inactivity and diabetes, and it facilitates the monitoring of SMA disease in pediatric patients through non-invasive urine collection.

THE URINARY EXCRETION OF GONADOTROPHINS BY SHEEP: EXTRACTION PROCEDURE AND DAY-TO-DAY FLUCTUATION IN EXCRETION BY MALE AND FEMALE CASTRATED SHEEP

1964 ◽  
Vol 29 (3) ◽  
pp. 215-228 ◽  
Author(s):  
R. B. SYMINGTON
Keyword(s):  
Luteinizing Hormone ◽  
Urinary Excretion ◽  
Follicle Stimulating Hormone ◽  
Extraction Procedure ◽  
Slight Modification ◽  
Original Method ◽  
Male And Female ◽  
Diethylaminoethyl Cellulose ◽  
Daily Excretion ◽  
Rate Of Recovery

SUMMARY The application of Johnsen's tannic acid method to the extraction of gonadotrophins from ovine urine was studied using the urine of castrated sheep. Slight modification of the original method increased the efficiency of extraction. Rate of recovery was measured at several levels of added pituitary and urinary gonadotrophins and was similar to recovery rates reported for human urines (30–81 %). Reproducibility of the extraction procedure was excellent. Further purification of the final ethanol precipitate without loss in potency was effected by chromatography using diethylaminoethyl cellulose. The daily excretion of total gonadotrophic activity, follicle stimulating hormone and luteinizing hormone by two male and one female castrated sheep was estimated for four periods each of 3 weeks. In all instances excretory levels fluctuated considerably and randomly. Levels of excretion of all types of gonadotrophic activity were much lower than in man.

scholarly journals Concurrent Pulsatile Secretion of Luteinizing Hormone and Follicle-Stimulating Hormone during Different Phases of the Estrous Cycle and Anestrus in Beagle Bitches

1999 ◽  
Vol 60 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Hans S. Kooistra ◽  
Auke C. Okkens ◽  
Mart M. Bevers ◽  
Corrie Popp-Snijders ◽  
Bas van Haaften ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Estrous Cycle ◽  
Follicle Stimulating Hormone ◽  
Pulsatile Secretion ◽  
Stimulating Hormone

scholarly journals Sex Difference in the Suppressive Effect of Cortisol on Pulsatile Secretion of Luteinizing Hormone in Sheep

Endocrinology ◽  
2006 ◽  
Vol 147 (12) ◽  
pp. 5921-5931 ◽  
Author(s):  
Catherine A. Stackpole ◽  
Iain J. Clarke ◽  
Kellie M. Breen ◽  
Anne I. Turner ◽  
Fred J. Karsch ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Sex Difference ◽  
Suppressive Effect ◽  
Pulsatile Secretion

Chronic physical stress differences between genders in a military training on the Amazon jungle

2015 ◽  
Vol 11 (1) ◽  
pp. 17-21
Author(s):  
Y.R. de Souza ◽  
F.B. Feitosa
Keyword(s):  
Plasma Levels ◽  
Scientific Literature ◽  
Military Training ◽  
Female Gender ◽  
Physical Stress ◽  
Male Gender ◽  
Normal Range ◽  
Male And Female ◽  
Normal Limits ◽  
Before And After

This study aimed to investigate the gender difference in the manifestation of physical stress in a strenuous military training on Amazon jungle, using alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase (LDH) markers, measured before and after an adaptation to jungle training. The sample consisted of 49 military volunteers, 35 male and 14 female, recently moved to the Amazon region. All plasma levels rose after the training. Serum ALT (male and female) and AST (male and female), although borderline, remained within normal limits. Already plasma levels of CK (both male and female) and LDH (male and female) largely exceeded the normal range. The average of all markers listed in female gender remained below the levels of the male gender. However, significant differences in biomarkers ALT, AST and CK between genders were found. The study points out that, in a jungle environment, biometric markers ALT, AST, CK and LDH are efficient for monitoring chronic physical stress in both genders, when used in combination. The influence of the weather on the occurrence of physical stress in unacclimated people of both genders, and the lower responses in the levels of ALT, AST, LDH and CK in females were discussed basing on the scientific literature.

THE CONCENTRATIONS OF ANDROGENS, OESTROGENS, PROGESTERONE AND LUTEINIZING HORMONE IN THE SERUM OF FOETAL CALVES THROUGHOUT THE COURSE OF GESTATION

1974 ◽  
Vol 60 (1) ◽  
pp. 107-115 ◽  
Author(s):  
J. R. G. CHALLIS ◽  
C. K. KIM ◽  
F. NAFTOLIN ◽  
H. L. JUDD ◽  
S. S. C. YEN ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Maternal Plasma ◽  
Male And Female ◽  
Hormone Levels

SUMMARY The concentrations of luteinizing hormone (LH), progesterone, testosterone, androstenedione, oestrone and oestradiol in mixed umbilical cord blood taken from foetal calves during months 3 to 9 of gestation have been measured by radioimmunoassay. The levels of progesterone were low (compared with those in maternal plasma) and constant during pregnancy. There were large variations in the concentrations of androstenedione, oestrone, oestradiol and LH, with lower values found during months 7 to 8 of gestation. Significant differences (P < 0·05–< 0·001) in hormone levels between male and female foetuses were found for testosterone, LH, and the oestrogens during months 3 to 7, 3 and 4, and 7 and 8, respectively. No significant differences (P > 0·05) between sexes were found at any time between the concentrations of progesterone and androstenedione.

scholarly journals The voice quality of sports coaches

Logopedija ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Anđela Bučević ◽  
Ana Bonetti ◽  
Luka Bonetti
Keyword(s):  
Voice Quality ◽  
Training Session ◽  
Acoustic Method ◽  
Male And Female ◽  
Significant Difference ◽  
Before And After ◽  
Sports Coaches ◽  
The Voice ◽  
Female Coaches

The aim of this research paper was to examine the voice quality of sports coaches using the objective (acoustic) method. A total of 28 sports coaches (mean age 28.58, SD=5.08), from the City of Zagreb participated in this research. Recordings of the phonation of the vowel /a/ before and after one training session were obtained and analyzed using the PRAAT Program. Mean, minimal and maximal values of fundamental frequency, shimmer, jitter and harmonics-to-noise ratio were observed. The statistical analyses showed no statistically significant difference in acoustic voice quality of male and female coaches before and after the training session, or between male and female coaches. However, intra-individual differences among participants were observed, which may be significant in terms of their potential to affect the quality of their voices in the future.

scholarly journals The difference in saliva pH before and after brushing with fluoride containing toothpaste and without toothpaste

2008 ◽  
Vol 20 (3) ◽  
Author(s):  
Samuel Setiawan ◽  
Edeh Rolleta Haroen ◽  
Dede Hadidjah
Keyword(s):  
Drinking Water ◽  
Research Method ◽  
Control Group ◽  
Research Subjects ◽  
Male And Female ◽  
Significant Difference ◽  
Salivary Ph ◽  
Before And After ◽  
Quasi Experimental ◽  
The Difference

In administering fluoride through drinking water there is the risk of overdose, higher cost and inadequate availability of drinking water containing fluoride in developing countries like Indonesia. A safe fluoride source is contained in toothpaste. The purpose of this research was to obtain data concerning difference in saliva pH before and after brushing with toothpaste containing fluoride and without toothpaste. The research method used was the quasi-experimental method. Samples were collected by the way of purposive sampling, conducted on 43 male and female research subjects. The data were analyzed by statistical analysis using the t test at 95% confidence level. In this research a control group consisting of 43 people was used. Research results indicated that the average saliva pH before brushing was 7.174; after brushing with fluoride containing toothpaste salivary pH was 7.593. Result research of brushing without toothpaste showed an average saliva of 7.163 before brushing and 7.379 after brushing without toothpaste. The average changes in saliva pH before and after brushing using fluoride containing toothpaste was 0.216. The conclusion of this research was that there was significant difference in saliva pH before and after brushing with toothpaste containing fluoride; there was significant difference in saliva pH before and after brushing without toothpaste, and there was significant difference in saliva pH before and after brushing with toothpaste containing fluoride and without toothpaste.

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