A longitudinal study of cerebrospinal fluid beta-endorphin-like immunoreactivity in delirium: changes at the acute stage and at one-year follow-up

SynopsisCerebrospinal fluid somatostatin-like immunoreactivity (CSF SLI) was determined for elderly delirious patients during the acute stage and after one-year follow-up. The SLI levels were compared with age-equivalent controls. For the group as a whole, and also when the group was subdivided according to the severity of cognitive decline at the acute stage, type of delirium, or the central nervous system disease, delirious patients showed significant reduction of SLI as compared with the controls. In the follow-up, we observed a further reduction of CSF SLI together with significant correlations in the second and third samples between SLI levels and Mini-Mental State Examination score. Our results suggest a role for somatostatinergic dysfunction in the genesis of some symptoms of delirium. This dysfunction may be a common phenomenon in various forms of delirium and dementia.

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A longitudinal study of cerebrospinal fluid acetylcholinesterase in delirium: Changes at the acute stage and at one-year followup

Psychiatry Research ◽

10.1016/0165-1781(91)90039-r ◽

1991 ◽

Vol 38 (2) ◽

pp. 135-142 ◽

Cited By ~ 5

Author(s):

Hannu Koponen ◽

Jouni Sirviö ◽

Kari J. Reinikainen ◽

Paavo J. Riekkinen

Keyword(s):

Cerebrospinal Fluid ◽

Longitudinal Study ◽

Acute Stage ◽

One Year

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The Iowa Longitudinal Study of Recent Onset Psychosis: One-year follow-up of first episode patients

Schizophrenia Research ◽

10.1016/s0920-9964(96)00078-3 ◽

1997 ◽

Vol 23 (1) ◽

pp. 1-13 ◽

Cited By ~ 67

Author(s):

Sanjay Gupta ◽

Nancy C. Andreasen ◽

Stephan Arndt ◽

Michael Flaum ◽

William C. Hubbard ◽

...

Keyword(s):

Longitudinal Study ◽

First Episode ◽

Recent Onset ◽

One Year

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Radiographic characteristics in the periapical healing post endodontic treatment in patients of the Autonomous University of Yucatan, School of Dentistry

Nova Scientia ◽

10.21640/ns.v10i21.1592 ◽

2018 ◽

Vol 10 (21) ◽

pp. 379-390

Author(s):

Oscar David Jurado Patrón ◽

Andrés Vargas López ◽

Elma María Vega Lizama ◽

Gabriel Alvarado Cárdenas ◽

María Eugenia López Villanueva ◽

...

Keyword(s):

Longitudinal Study ◽

Sinus Tract ◽

Complete Healing ◽

Endodontic Treatment ◽

Periapical Lesions ◽

Periapical Healing ◽

School Of Dentistry ◽

One Year ◽

Causes Of Failure

Introduction: The radiographic control of the root canal treatment can evaluate the healing of the periapical lesions. The objective of this study was to determinate the characteristics of the radiographic healing that was observed after one year, during follow-up sessions; so, the healing of the lesions according to the periapical pathology at the beginning of the treatment and the causes of failure of the endodontic treatments were recorded.Method: This is a prospective, observational, descriptive and longitudinal study, carried out in patients who attended control one year after endodontic treatment through the Periapical Index (PAI).Results: A total of 395 teeth of patients who underwent endodontic treatment one year prior to data collection, 87 presented radiogaphically observable periapical lesions; of these, 40 (45.97%) attended the control at one year. The frequency of cases in which some degree of radiographic healing was observed one year after treatment was 97.46%. The pathology with more cases of complete healing was periodontitis with sinus tract. In general, 84.61% of the cases decreased two levels in their PAI after one year. The 100% of the cases of failure presented vertical root fractures.Conclusion: The frequency of periapical healing after endodontic treatment is high. The main cause for the failure of the treatments documented in this study was the lack of coronal restoration that caused vertical fractures.

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Cerebrospinal fluid orexin-A levels in systemic lupus erythematosus patients presenting with excessive daytime sleepiness

Lupus ◽

10.1177/0961203318778767 ◽

2018 ◽

Vol 27 (11) ◽

pp. 1847-1853 ◽

Cited By ~ 2

Author(s):

K Suzuki ◽

M Miyamoto ◽

T Miyamoto ◽

T Matsubara ◽

Y Inoue ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Cerebrospinal Fluid ◽

Lupus Erythematosus ◽

Excessive Daytime Sleepiness ◽

Daytime Sleepiness ◽

Acute Stage ◽

Systemic Lupus ◽

Orexin A ◽

Hypothalamic Lesions

Objective Involvement of the hypothalamus is rare in patients with systemic lupus erythematosus (SLE). In this study, we measured cerebrospinal fluid (CSF) orexin-A levels in SLE patients with hypothalamic lesions to investigate whether the orexin system plays a role in SLE patients with hypothalamic lesions who present with excessive daytime sleepiness (EDS). Methods Orexin-A levels were measured in CSF from four patients with SLE who presented with hypothalamic lesions detected by MRI. Three patients underwent repeated CSF testing. All patients met the updated American College of Rheumatology revised criteria for SLE. Results Tests for serum anti-aquaporin-4 antibodies, CSF myelin basic protein and CSF oligoclonal bands were negative in all patients. All patients presented with EDS. Low to intermediate CSF orexin-A levels (92–180 pg/ml) were observed in three patients in the acute stage, two of whom (patients 1 and 2) underwent repeated testing and showed increased CSF orexin-A levels, reduced abnormal hypothalamic lesion intensities detected by MRI and EDS dissipation at follow-up. In contrast, CSF orexin-A levels were normal in one patient (patient 4) while in the acute stage and at follow-up, despite improvements in EDS and MRI findings. Patient 4 showed markedly increased CSF interleukin-6 levels (1130 pg/ml) and a slightly involved hypothalamus than the other patients. Conclusions Our findings suggest that the orexinergic system has a role in EDS in SLE patients with hypothalamic lesions. Furthermore, cytokine-mediated tissue damage might cause EDS without orexinergic involvement.

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P-1220 - Cognitive reserve predicts insight in psychosis when cannabis use moderate this relation: a longitudinal study one year follow-up

European Psychiatry ◽

10.1016/s0924-9338(12)75387-7 ◽

2012 ◽

Vol 27 ◽

pp. 1

Author(s):

J. Cartón Costa ◽

A. García Guerrero ◽

J.I. Eguíluz Uruchurtu ◽

I. Querejeta Ayerdi ◽

E. Bengoetxea Noreña ◽

...

Keyword(s):

Longitudinal Study ◽

Cognitive Reserve ◽

Cannabis Use ◽

One Year

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Depression following Myocardial Infarction: A One Year Longitudinal Study

The International Journal of Psychiatry in Medicine ◽

10.2190/u8r0-a61y-akrp-t24v ◽

1994 ◽

Vol 24 (4) ◽

pp. 357-369 ◽

Cited By ~ 31

Author(s):

Javier I. Travella ◽

Alfred W. Forrester ◽

Susan K. Schultz ◽

Robert G. Robinson

Keyword(s):

Myocardial Infarction ◽

Major Depression ◽

Activities Of Daily Living ◽

Social Functioning ◽

Daily Living ◽

Acute Stage ◽

First Year ◽

Minor Depression ◽

One Year

Objective: The purpose of this study was to examine the course and clinical correlates of depression during the first year after myocardial infarction. Method: A group of seventy patients hospitalized for the treatment of myocardial infarction (MI) were assessed for the presence of mood disorders during their hospital admission and at three, six, nine, and twelve months follow-up. Patients were evaluated and diagnosed using the Present State Examination and DSM-III criteria. Impairment in activities of daily living was measured by the Johns Hopkins Functioning Inventory and impairment in social functioning was measured by the Social Functioning Examination. Results: A total of twenty-four patients met DSM-III criteria for major depression at some time during the study (18 in the acute stage, 6 during follow-up). There were two patients with minor depression (dysthymia) at intake and six developed minor depression during the follow-up period. The median duration of major depression was 4.5 months. Patients with depression at intake had greater impairment in activities of daily living than non-depressed patients. Depressions lasting more than six months were more likely to be anxious depressions than those lasting less than six months. After the acute MI period, there was a consistent relationship between the existence of depression and impaired social functioning. Conclusions: This is a pilot study and needs further replication due to the low rate of follow-up participation. However, these data suggest that there may be two types of depression following MI: an acute depression associated with greater functional impairment, and a prolonged depression that may be associated with inadequate social support.

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Does How We Remember Predict How We Will Feel? A Longitudinal Study of the Influence of Overgeneral Memory on the Development of Depression in Young People

10.26686/wgtn.17007691.v1 ◽

2021 ◽

Author(s):

◽

Zara Mansoor

Keyword(s):

Depressive Symptoms ◽

Longitudinal Study ◽

Young People ◽

Longitudinal Research ◽

Community Sample ◽

Future Directions ◽

Overgeneral Memory ◽

One Year ◽

Over Time

<p>An increased tendency towards overgeneral memory (OGM) has been associated with depression in young people. How this may impact the early development of depressive symptoms is unclear. This has been difficult to determine due to the lack of longitudinal research in this area, in particular with young people in the community prior to the development of significant depressive symptoms. The current study aimed to investigate how OGM related to the development of depression in a community sample of 235 young people aged 10- to 15-years at baseline. Measures of depression, OGM, and rumination were obtained at baseline and follow-up, one year later. As predicted, and consistent with past findings, an increased tendency towards OGM at follow-up was associated with greater depressive symptoms. However, despite indications from previous work that OGM may also predict depression prior to the emergence of symptoms, the reverse was found with depression predicting OGM over time. This suggests that among the general population, while OGM may be an associated and possible maintaining feature of depression, it appears to be a consequence of experiencing depressive symptoms rather than a significant early predictive or vulnerability factor. Contrary to evidence that rumination may also increase OGM, rumination was not significantly associated with OGM. Limitations, strengths and future directions based on these findings are discussed.</p>

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TREATABLE VASCULAR RISK AND COGNITIVE PERFORMANCE IN PERSONS AGED 35 YEARS OR OLDER: LONGITUDINAL STUDY OF SIX YEARS

Journal of Prevention of Alzheimer's Disease ◽

10.14283/jpad.2018.47 ◽

2018 ◽

pp. 1-8

Author(s):

M.E.A. van Eersel ◽

H. Joosten ◽

R.T. Gansevoort ◽

J.P.J. Slaets ◽

G.J. Izaks

Keyword(s):

Longitudinal Study ◽

Cognitive Performance ◽

Clinical Symptoms ◽

Vascular Risk ◽

Framingham Risk ◽

One Year ◽

Ruff Figural Fluency Test ◽

Age Range ◽

Figural Fluency

Background: Poor cognitive performance is associated with high vascular risk. However, this association is only investigated in elderly. As neuropathological changes precede clinical symptoms of cognitive impairment by several decades, it is likely that cognitive performance is already associated with vascular risk at middle-age. OBJECTIVES: To investigate the association of cognitive performance with treatable vascular risk in middle-aged and old persons. DESIGN: Longitudinal study with three measurements during follow-up period of 5.5 years. SETTING: City of Groningen, the Netherlands. PARTICIPANTS: Cohort of 3,572 participants (age range, 35-82 years; mean age, 54 years; men, 52%). EXPOSURE: Treatable vascular risk as defined by treatable components of the Framingham Risk Score for Cardiovascular Disease at the first measurement (diabetes mellitus, smoking, hypercholesterolemia and hypertension). MEASUREMENTS: Change in cognitive performance during follow-up. Cognitive performance was measured with Ruff Figural Fluency Test (RFFT) and Visual Association Test (VAT), and calculated as the average of the standardized RFFT and VAT score per participant. RESULTS: The mean (SD) cognitive performance changed from 0.00 (0.79) at the first measurement to 0.15 (0.83) at second measurement and to 0.39 (0.82) at the third measurement (Ptrend<0.001). This change was negatively associated with treatable vascular risk: the change in cognitive performance between two measurements decreased with 0.004 per one-point increment of treatable vascular risk (95%CI, -0.008 to 0.000; P=0.05) and with 0.006 per one-year increment of age (95%CI, -0.008 to -0.004; P<0.001). CONCLUSIONS: Change in cognitive performance was associated with treatable vascular risk in persons aged 35 years or older.

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A case report on result of posterior fossa decompression on syringomyelia in a case of chiary type I malformation

Romanian Neurosurgery ◽

10.2478/romneu-2018-0020 ◽

2018 ◽

Vol 32 (1) ◽

pp. 160-163

Author(s):

Asheesh Kumar Gupta ◽

Avdhesh Shukla ◽

Anand Sharma ◽

S.N. Iyengar

Keyword(s):

Cerebrospinal Fluid ◽

Posterior Fossa ◽

Craniovertebral Junction ◽

Posterior Fossa Decompression ◽

Type I ◽

Csf Dynamics ◽

Prime Objective ◽

One Year

Abstract The prime objective in the surgical treatment of Chiari malformation (CM) and/or syringomyelia (SM) is based on the restoration of the normal cerebrospinal fluid (CSF) dynamics at the craniovertebral junction through the creation of a large artificial cisterna magna. In this case a patient came to our hospital with type 1 chiary malformation having large syrinx which underwent posterior fossa decompression by midline sub occipital craniectomy with subpial cerebellar tonsillar resection which after one year of follow up we have found significant resolution of syrinx radiologically.

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