Normal serum biochemical and hematological parameters in Macaca fascicularis

1991 ◽  
Vol 20 (7) ◽  
pp. 345-351 ◽  
Author(s):  
Gemma Perretta ◽  
Anneo Violante ◽  
Manuela Scarpulla ◽  
Marta Beciani ◽  
Vincenzo Monaco
Keyword(s):  
Macaca Fascicularis ◽  
Hematological Parameters ◽  
Normal Serum ◽  
Serum Biochemical

scholarly journals Assessment of Toxicity and Therapeutic Effects of Goose Bone in a Rat Model

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Md. Yousuf Ali ◽  
Alamgir Kabir ◽  
Shahad Saif Khandker ◽  
Tareq Hossan ◽  
Md. Salman Shakil ◽  
...  
Keyword(s):  
Rat Model ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Atherogenic Index ◽  
Control Group ◽  
Histopathological Study ◽  
Therapeutic Effects ◽  
Related Disorder ◽  
Serum Biochemical ◽  
Hematological And Biochemical Parameters

Goose bone is traditionally used in the treatment of many ailments including in bone fracture. The aim of the present study was to evaluate the subacute toxicity of goose bone in a rat model by investigating some hematological and biochemical parameters in rats. Subsequently, a histopathological study was performed to confirm the presence of pathological lesions in the rat’s vital organs including the liver, kidney, heart, brain, pancreas, lung, spleen, and stomach. Adult Wistar rats were divided into four groups (n = 8) and were orally administrated with three doses (30, 60, and 120 mg/kg) of goose bone once daily for 21 days as compared to control animals (received only drinking water). Goose bone did not cause any significant changes on body weight, relative organ weight, and percentage water content at any of the administered doses. There were also no significant alterations in hematological parameters seen. All three doses administered significantly reduced the triglyceride levels as well as the atherogenic index of plasma (AIP). Animals treated with 120 mg/kg doses had significantly reduced alkaline phosphatase (ALP) activity as compared to the control group. There was no significant alteration on other serum biochemical parameters seen. Additionally, histopathological findings confirmed that there was no inflammatory, necrotic, or other toxicological feature seen for all three doses. It is concluded that goose bone is nontoxic and is safe for consumption besides having the potential to be investigated for the treatment of high triglycerides or liver-related disorder.

scholarly journals Setting for “Normal” Serum Ferritin Levels in Patients with Transfusion-Dependent Thalassemia: Our Current Strategy

2021 ◽  
Vol 10 (24) ◽  
pp. 5985
Author(s):  
Anna Spasiano ◽  
Antonella Meloni ◽  
Silvia Costantini ◽  
Emilio Quaia ◽  
Filippo Cademartiri ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Hematological Parameters ◽  
Cross Sectional Study ◽  
Normal Serum ◽  
Cardiac Complications ◽  
Cross Sectional ◽  
Group 2 ◽  
Group 1

This cross-sectional study aimed to establish the association between serum ferritin levels and organ iron overload (IO) and overall morbidity in transfusion-dependent thalassemia (TDT) patients. One hundred and three TDT patients (40.03 ± 9.15 years; 57.3% females) with serum ferritin < 2500 ng/mL were included. IO was assessed by T2* magnetic resonance imaging. Three groups were identified based on mean serum ferritin levels: <500 ng/mL (group 0; N = 32), 500–1000 ng/mL (group 1; N = 43), and 1000–2500 ng/mL (group 2; N = 28). All demographic and biochemical parameters were comparable among the three groups, with the exception of the triglycerides being significantly lower in group 0 than in group 2. No difference was found in the frequency of hepatic, endocrine, and cardiac complications. Hepatic IO was significantly less frequent in group 0 versus both groups 1 and 2. No patient with a serum ferritin level < 500 ng/mL had significant myocardial IO and alterations in the main hematological parameters. No difference in the distribution of the different chelation regimens was found. Serum ferritin < 500 ng/mL appears to be achievable and safe for several TDT patients. This target is associated with the absence of significant cardiac iron and significantly lower hepatic IO and triglycerides that are well-demonstrated markers for cardiac and liver complications.

scholarly journals Safe, Efficient and Environmentally Friendly Fungicide Against Aflatoxin-producing Fungi in Nourishment Cereal (P04-133-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Hala Awney ◽  
Asmaa Salah ◽  
Ghada Amin ◽  
El-Moatazbellah El-Naggar
Keyword(s):  
Essential Oils ◽  
Biochemical Analysis ◽  
Hematological Parameters ◽  
Inhibitory Effect ◽  
Male Rats ◽  
Diffusion Method ◽  
Control Group ◽  
Toxicity Evaluation ◽  
Wide Range ◽  
Serum Biochemical

Abstract Objectives Aflatoxins are highly toxic, carcinogenic, mutagenic and teratogenic metabolites produced by some Aspergillus species that contaminate a wide range of nourishment cereal and pose serious health problems for human and livestock with nanograms limits of acceptability in foods. This study aimed to extract, identify and assess essential oils extracted from ginger rhizomes (Zingiber officinale Rose) (EOG) and flower head of Chamomile (Chamomilla recutita L.) (EOC) against aflatoxin producing fungi. Toxicity evaluation was conducted to ensure their safety. Methods Essential oils were extracted by hydrodistillation using Clevenger apparatus and identified by Gas Chromatography-Mass Spectrometry (GCMS). The fungicidal effect was assessed against penicillium chrysogenum, Aspergillus niger and Aspergillus flavus isolated from bean, corn and rice using agar disc diffusion method to determine maximum inhibition zone (MIZ) and minimum inhibitory concentration (MIC) for each extract. Toxicity evaluation was conducted on two groups of 10 male rats treated with EOG or EOC at a dose of 0.1 g/kg (1/50 LD) for 28 consecutive days against control group. Serum biochemical analysis, hematological parameters and liver histological investigations were considered. Results The phytochemical analysis identified 20 compounds in EOG and 26 compounds in EOC. The most common compounds were monoterpenes and sesquiterpenes in EOG and EOC respectively. The highest MIZ showed by EOC (5.15 ± 0.07 cm) and EOG (4.15 ± 0.07 cm) against P. chrysogenum. The MIC showed that EOG has greater inhibitory effect against P. chrysogenum (2.5 μg/ml) whereas EOC exhibit strong inhibitory effect against all tested fungi with lower MIC values ranged from 1.25 to 2.5 μg/ml. Serum biochemical analysis and hematological parameters indicated minor changes in EOC and EOC group while liver histological features showed marked improvement in hepatic tissues of EOC and EOG groups compared with control. Conclusions Promising fungicidal effects of both EOC and EOG against aflatoxin producing fungi have been demonstrated, however further evaluation is needed concerning its safety. Funding Sources College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia. Supporting Tables, Images and/or Graphs

scholarly journals Effect of Breed and Gender on Hematological Parameters and Some Serum Biochemical Profiles of Apparently Healthy indigenous Sheep of Nepal

2017 ◽  
Vol 34 ◽  
pp. 85-94
Author(s):  
N. Amatya Gorkhali ◽  
S. Khanal ◽  
S. Sapkota ◽  
M. Prajapati ◽  
Y.K. Shrestha ◽  
...  
Keyword(s):  
Hematological Parameters ◽  
Animal Health ◽  
Haemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Physiological Range ◽  
Gender Variation ◽  
Indigenous Sheep ◽  
Indigenous Breed ◽  
Serum Biochemical ◽  
Apparently Healthy

This research was conducted to investigate the effect of some factors such as breed and sex on biochemical and serum parameters as well as to establish normal physiological reference values for indigenous breed of sheep of Nepal. Blood sample were collected from 25 apparently healthy sheep (11 males and 14 females) from on station flock at Khumaltar, Nepal Agriculture Research Council (NARC) were used. In case of serum biochemical parameters, overall LS mean for total Protein (TP) was less than physiological range while Albumin (Alb) was recorded higher than normal physiological range. The breed differences were observed in TP where Lampuchhre sheep (lowland sheep) showed the lower value than hill sheep breeds (Baruwal and Kage sheep) taken in the study. The same breed exhibited gender variation in the same parameter with values in males were significantly higher (P<0.05) than females. Comparing LS Mean for Alb and Phosphrous (P) for Nepalese sheep, value recorded for females were found to be significantly higher P (<0.05) than males in case of serum Alb while serum P was significantly lower (P<0.05) in females. For RBC indices, Nepalese sheep exhibited higher Mean Corpuscular Haemoglobin Concentration (MCHC) was higher than normal physiological range. LYM and NE value was significantly higher in Kage breed in comparison to Lampuchhre and Baruwal. The highly significant gender variation for Mean Corpuscular Volume (MCV) (P<0.01) and Mean Corpuscular Hemoglobin MCH (P<0.05) where female showed the higher value than males. The result of the preliminary study revealed the breed and sex variation in case of hematological and biochemical indices Further research with more number of samples is warranted for concrete information which could be used to monitor animal health status to improve the management and conservation of these breeds.

scholarly journals Hemato-Biochemical Analyses of Lactating Cross-Bred Jersey Cattle at Kaski District, Nepal

2018 ◽  
Vol 35 (1) ◽  
pp. 243-247
Author(s):  
B. Regmi ◽  
K. R. Pande
Keyword(s):  
Hematological Parameters ◽  
Reference Value ◽  
Normal Range ◽  
Serum Samples ◽  
Jersey Cattle ◽  
Mineral Profile ◽  
Serum Biochemical ◽  
Biochemical Profiles ◽  
Biochemical Analyses ◽  
Set Up

Hemato-biochemical profiles have been used widely to identify the health problems associated with productive and reproductive disorders. The objective of this study was to set up a baseline hematological and serum biochemical values. The study was carried out in 50 lactating cross bred Jersey cattle of Kaski district ranging in age from 3-7 years. Non-pregnant, lactating, apparently healthy and stall-fed cattle were selected for sampling and these animals were regularly dewormed and vaccinated against common diseases. All the hematological parameters were determined on the same day of collection using auto analyzer. The samples were also tested for blood protozoans (Anaplasma, Babesia, Theleria and Trypanosoma), using thin and thick smears. The serum samples were collected in a sterile vial for serum biochemical analysis and preserved at -200C until used for the assays. All the hematological parameters were within the normal range. However, 2% of the total animals tested appeared Theleria positive. Eosinophil and basophils were within the normal range suggesting that the deworming was effective and there was no allergic reaction. Mineral profile particularly glucose (11.75±0.87) was found significantly (P<0.05) low. This suggests that cross Jersey cattle were prone to hypoglycemia related metabolic disorders and corrective measures should be employed for better production. The values obtained in this study within the range can be used cautiously as reference value at lactating stage of cross-bred Jersey cattle. Further detail study is needed to exacting the standard reference value for this breed of cattle.

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