Functionalization of titanium implants using a modular system for binding and release of VEGF enhances bone-implant contact in a rodent model

2015 ◽  
Vol 42 (3) ◽  
pp. 302-310 ◽  
Author(s):  
Henning Schliephake ◽  
Jennifer Rublack ◽  
Anne Förster ◽  
Bernd Schwenzer ◽  
Judith Reichert ◽  
...  
Keyword(s):  
Titanium Implants ◽  
Rodent Model ◽  
Modular System ◽  
Bone Implant ◽  
Bone Implant Contact

scholarly journals Anodisation Increases Integration of Unloaded Titanium Implants in Sheep Mandible

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Warwick J. Duncan ◽  
Min-Ho Lee ◽  
Tae-Sung Bae ◽  
Sook-Jeong Lee ◽  
Jennifer Gay ◽  
...  
Keyword(s):  
Titanium Implant ◽  
Titanium Implants ◽  
Implant Stability ◽  
Bone Implant ◽  
Implant Stability Quotient ◽  
Phosphate Ions ◽  
Surface Control ◽  
Bone Implant Contact ◽  
The Subject ◽  
Clinically Significant

Spark discharge anodic oxidation forms porous TiO2films on titanium implant surfaces. This increases surface roughness and concentration of calcium and phosphate ions and may enhance early osseointegration. To test this, forty 3.75 mm × 13 mm titanium implants (Megagen, Korea) were placed into healed mandibular postextraction ridges of 10 sheep. There were 10 implants per group: RBM surface (control), RBM + anodised, RBM + anodised + fluoride, and titanium alloy + anodised surface. Resonant frequency analysis (RFA) was measured in implant stability quotient (ISQ) at surgery and at sacrifice after 1-month unloaded healing. Mean bone-implant contact (% BIC) was measured in undemineralised ground sections for the best three consecutive threads. One of 40 implants showed evidence of failure. RFA differed between groups at surgery but not after 1 month. RFA values increased nonsignificantly for all implants after 1 month, except for controls. There was a marked difference in BIC after 1-month healing, with higher values for alloy implants, followed by anodised + fluoride and anodised implants. Anodisation increased early osseointegration of rough-surfaced implants by 50–80%. RFA testing lacked sufficient resolution to detect this improvement. Whether this gain in early bone-implant contact is clinically significant is the subject of future experiments.

Advanced Glycation Endproducts and Rat Dental Implant Osseointegration

2010 ◽  
Vol 36 (2) ◽  
pp. 97-103 ◽  
Author(s):  
David G. Quintero ◽  
Julia N. Winger ◽  
Rania Khashaba ◽  
James L. Borke
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Marker ◽  
Advanced Glycation Endproducts ◽  
Biomechanical Properties ◽  
Titanium Implants ◽  
Contact Ratio ◽  
Advanced Glycation ◽  
Bone Implant ◽  
Glycation Endproducts ◽  
Bone Implant Contact

Abstract Advanced glycation endproducts (AGEs) are a diverse group of molecular adducts formed in environments high in reducing sugars that accumulate with aging and in diabetes. This study tests the hypothesis that AGEs inhibit the stabile osseointegration of dental implants through tissue interactions that interfere with bone turnover and compromise the biomechanical properties at the bone-implant interface. Maxillary first molars were extracted from 32 rats and allowed to heal for 4 weeks. Titanium implants (1 mm × 3 mm) were placed in the healed sockets of 2 groups of 16 rats consisting of 8 rats injected 3 times/wk for 1 month with AGE (prepared from glucose and lysine) and 8 rats injected with vehicle as a control. AGE injections continued for an additional 14 or 28 days before sacrifice. X-ray images, blood, and tissues were collected to examine bone/implant contact ratio, serum pyridinoline ([PYD] a collagen breakdown marker), osteocalcin ([OSC] a bone formation marker), and for immunohistochemistry with antibodies to AGE and the bone turnover-marker protein matrix metalloproteinase1. Compared with the AGE-treated groups, the controls showed significantly higher bone/implant contact at both 14- and 28-day time points. PYD (P < .05) and OSC (trend) levels from controls showed decreases at 28 days when compared with AGE-treated groups. Immunohistochemistry with AGE-specific and bone turnover marker antibodies showed stronger staining associated with the implant/tissue interface in AGE-treated rats. Our studies indicate an association between AGE and inhibition of bone turnover, suggesting that the formation of AGE in high glycemic conditions, such as diabetes, may contribute to a slower rate of osseointegration that negatively affects implant stability.

Influence of Surface Nano-Roughness on Osseointegration of Zirconia Implants in Rabbit Femur Heads Using Selective Infiltration Etching Technique

2013 ◽  
Vol 39 (5) ◽  
pp. 583-590 ◽  
Author(s):  
Moustafa N. Aboushelib ◽  
Noha A. Salem ◽  
Ahmed L. Abo Taleb ◽  
Naglaa M. Abd El Moniem
Keyword(s):  
Bone Density ◽  
White Male ◽  
Titanium Implants ◽  
Implant Surface ◽  
Etching Technique ◽  
Bone Implant ◽  
Bone Implant Contact ◽  
Zirconia Implants ◽  
Rabbit Femur ◽  
Zirconia Implant

This study evaluates osseous healing of selective infiltration-etched (SIE) zirconia implants compared to as-sintered zirconia and titanium implants. Twenty implants of each group were inserted in 40 adult New Zealand white male rabbits. After 4 and 6 weeks, bone blocks containing the implants were retrieved, sectioned, and processed to evaluate bone-implant contact (BIC) and peri-implant bone density. SIE zirconia implants had significantly higher BIC and marginally higher bone density. The results suggest that selective infiltration-etched zirconia implant surface may improve implant osseointegration.

scholarly journals Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study

Materials ◽  
2020 ◽  
Vol 13 (16) ◽  
pp. 3613 ◽  
Author(s):  
Antonio Scarano ◽  
Francesco Carinci ◽  
Tiziana Orsini ◽  
Luca Valbonetti ◽  
Erda Qorri ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Titanium Implants ◽  
P Value ◽  
Implant Surface ◽  
Bone Implant ◽  
Bifunctional Molecule ◽  
Significant Difference ◽  
Bone Implant Contact ◽  
Antimicrobic Activity

Background: Various surface treatments have been tested for titanium implants aiming at increasing their surface biocompatibility and their biological characteristics, but also the efficiency of the implant surface will have to be improved to drastically decrease peri-implantite and mucosite. In fact, the peri-implantitis and peri-implant mucositis have a high incidence in clinical practice. The nanofabrication techniques that offer the possibility to achieve the implant surface that reduces bacterial colonization could influence the osteointegration. The aim of this research was to evaluate the bone response to titanium implants coated with a bifunctional molecule with antimicrobic activity consisting of a combination of silver ions covalently bound to titanium dioxide nanoparticles. Methods: A total of 36 implants were inserted into 18 older New Zealand white male rabbits. They had two different surfaces. The implants Control group was characterized by an acid-etched and sandblasted surface treatment, and the Test implants had an acid-etched and sandblasted surface coated with a silver ion covalently bound to titanium dioxide nanoparticles in the solution. Results: No statistically significant difference of the bone density was evidenced between Control and Test implants at two weeks (p-value = 0.623), four weeks (p-value = 0.339), and eight weeks (p-value = 0.461). Moreover, no statistically significant difference of the bone-implant contact percentage was evidenced between Control and Test implants at two weeks (p-value = 0.938), four weeks (p-value = 0.307), and eight weeks (p-value = 0.294). The effectiveness of the present investigation demonstrated no adverse effects on osseointegration, and no statistically significant differences were observed in the bone density and percentage of bone-implant contact between Test and Control implants at all the experimental time points (two, four, and eight weeks). Conclusions: Titanium implants coated with the silver-anatase solution bind very well to the bone and did not have an adverse effect on the bone tissue in a rabbit model. These facts suggest possible clinical applications for the silver composition.

Bone-Implant Contact of Surface-Modified Titanium Implants

2008 ◽  
Vol 47-50 ◽  
pp. 1294-1297
Author(s):  
Nam Gyu Kim ◽  
Il Song Park ◽  
Ho Keun Yi ◽  
Seung Geun Ahn ◽  
Kwang Yeob Song ◽  
...  
Keyword(s):  
Titanium Implants ◽  
Bone Implant ◽  
Bone Implant Contact ◽  
Surface Modified

scholarly journals In Vivo Characterization of Titanium Implants Coated with Synthetic Hydroxyapatite by Electrophoresis

2005 ◽  
Vol 16 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Cristina Costa de Almeida ◽  
Lídia Ágata Sena ◽  
Marcelo Pinto ◽  
Carlos Alberto Muller ◽  
José Henrique Cavalcanti Lima ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Titanium Implants ◽  
Bone Implant ◽  
Bone Implant Contact ◽  
Bone Content ◽  
Synthetic Hydroxyapatite ◽  
Cp Ti ◽  
Scanning Electron

This study compared in vivo the performances of commercially pure titanium (cp Ti) screw dental implants either uncoated or coated with synthetic hydroxyapatite (HA) by electrophoresis. The HA coating was characterized by scanning electron microscopy, energy dispersive spectroscopy (EDS) and Fourier-transform infrared (FT-IR) spectroscopy. Well-adhered carbonated-hydroxyapatite layers (4- to-8-µm-thick) were obtained. In vivo tests were carried out by insertion of both uncoated and HA-coated implants into rabbit tibiae for 8 or 12 weeks. Histomorphometric analysis was performed by scanning electron microscopy with the aid of image-processing software. Results showed significantly greater bone-implant contact for HA-coated implants (p<0.05) than cp Ti implants. Comparison of bone content inside the screw implants showed no significant differences (p>0.05) between both types of implants, although cp Ti had numerically higher percentage of bone content than HA-coated implants. In conclusion, the HA-coated implants had better performance regarding the bone-implant contact area than the uncoated implants; coating by electrophoresis proved to be a valuable process to coat metallic implants with an osteoconductive material such as hydroxyapatite.

Biomechanical and Microscopic Response of Bone to Titanium Implants in the Presence of Inorganic Grafts

2011 ◽  
Vol 37 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Etiene Andrade Munhoz ◽  
Augusto Bodanezi ◽  
Tania Mary Cestari ◽  
Rumio Taga ◽  
Osny Ferreira Junior ◽  
...  
Keyword(s):  
Treatment Condition ◽  
Titanium Implants ◽  
Tissue Response ◽  
Control Groups ◽  
Removal Torque ◽  
Bone Implant ◽  
Bone Implant Contact ◽  
Paired Control ◽  
And Control ◽  
Mature Bone

Abstract This study evaluated the biomechanical and microscopic response of previously grafted bone to titanium implants. The lower incisors of 16 rabbits were surgically extracted, and bilateral perforations communicating with the remaining sockets were created distally. A socket/perforation defect on each mandible was chosen at random to be immediately filled with a xenogenic graft, whereas the contralateral perforation was left to heal naturally and served as a paired control. After 60 days, titanium implants were installed in the previously operated areas. After periods of 2 and 6 months, the animals were killed, and the force necessary to retrieve implants as well as the bone-implant contact (BIC) and bone mass (BM) were quantified and statistically compared by 2-way analysis of variance and Tukey's test (α  =  .05). No significant differences in removal torque were observed, either by time or by treatment condition. Differences in BIC and BM between experimental and control groups were not statistically significant through the intervals studied (P &lt; .05). The presence of a xenogenic graft did not influence the microscopic tissue response to titanium implants or fixation into newly formed or mature bone.

scholarly journals Macrophagic Inflammatory Response Next to Dental Implants with Different Macro- and Micro-Structure: An In Vitro Study

2021 ◽  
Vol 11 (12) ◽  
pp. 5324
Author(s):  
Maria Menini ◽  
Francesca Delucchi ◽  
Domenico Baldi ◽  
Francesco Pera ◽  
Francesco Bagnasco ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Dental Implants ◽  
In Vitro Study ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone Implant ◽  
Optimal Outcomes ◽  
Negative Controls ◽  
Inflammatory Effect

(1) Background: Intrinsic characteristics of the implant surface and the possible presence of endotoxins may affect the bone–implant interface and cause an inflammatory response. This study aims to evaluate the possible inflammatory response induced in vitro in macrophages in contact with five different commercially available dental implants. (2) Methods: one zirconia implant NobelPearl® (Nobel Biocare) and four titanium implants, Syra® (Sweden & Martina), Prama® (Sweden & Martina), 3iT3® (Biomet 3i) and Shard® (Mech & Human), were evaluated. After 4 h of contact of murine macrophage cells J774a.1 with the implants, the total RNA was extracted, transcribed to cDNA and the gene expression of the macrophages was evaluated by quantitative PCR (qPCR) in relation to the following genes: GAPDH, YWHAZ, IL1β, IL6, TNFα, NOS2, MMP-9, MMP-8 and TIMP3. The results were statistically analyzed and compared with negative controls. (3) Results: No implant triggered a significant inflammatory response in macrophages, although 3iT3 exhibited a slight pro-inflammatory effect compared to other samples. (4) Conclusions: All the samples showed optimal outcomes without any inflammatory stimulus on the examined macrophagic cells.

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